Download or read book Metabolic Drug Interactions written by René H. Levy and published by . This book was released on 2000 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases. The book focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions. Major sections present information on specific therapeutic classes of drugs as substrates, inhibitors, and inducers of metabolic enzymes. Other chapters discuss the clinical and pharmacoeconomic implications of metabolic drug interactions and the significance of in vitro metabolic studies in new drug development.
Download or read book Drug Metabolism written by Corina Ionescu and published by Springer Science & Business Media. This book was released on 2006-02-28 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Download or read book Interindividual Variability in Human Drug Metabolism written by Gian Maria Pacifici and published by CRC Press. This book was released on 2001-05-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction. Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.
Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Download or read book Nutrient Drug Interactions written by Kelly Anne Meckling and published by CRC Press. This book was released on 2006-06-23 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current research has given us a more complete understanding of how the chemicals in foods and herbs interact with natural and synthetic drugs. In some cases a single food or supplement can profoundly increase or decrease the toxicity and/or efficacy of a single drug. Although it is standard practice to examine the effects of food consumption on the
Download or read book Encyclopedia of Drug Metabolism and Interactions written by Alexander Lyubimov and published by Anchor Books. This book was released on 2012 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multi-volume, state-of-the-art encyclopedia discusses all preclinical, clinical, toxicological, regulatory and marketing perspectives of drug metabolism and interactions. Methods and detailed protocols describing how to perform studies of metabolism and drug interactions are presented in one of the volumes. All aspects of drug metabolism and interactions in silico, in laboratory animals and in humans, are backed with a range of examples. This reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians including practitioners and physicians.
Download or read book Drug drug Interactions in the Metabolic Syndrome written by Gianluca Iacobellis and published by Nova Publishers. This book was released on 2006 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports updated data from the literature on potential drug-drug interactions occurring between drugs used to treat each individual disease of the metabolic syndrome. The manual is focused on metabolic syndrome drugs. Possible drug-drug interactions and their potential mechanisms are summarised and discussed. Chemical characteristics and mechanisms of action of each drug are also briefly described. Some new anti-obesity, anti-diabetes, lipid lowering and anti-hypertensive drugs were also reported and briefly discussed.
Download or read book Handbook of Drug Nutrient Interactions written by Joseph I. Boullata and published by Springer Science & Business Media. This book was released on 2004-04-17 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there is agreat deal ofliterature regarding drug-nutrientinteractions (DNis ), there are limited sources of up-to-date comprehensive information. The Handbook of Drug-Nutrient Interactions admirably fills this gap. The editors, Dr. Joseph 1. Boullata and Dr. Vincent T. Armenti, ha ve a wealth of experience in this therapeutic ar ea and ha ve assembled a fine cadre of chapter authors who have individually contributed their high level of expertise. As treatment for many diseases becomes increasingly complex with multiple drug therapies scheduled at varying times, the need to identify clinically significant DNis is an essential part of medication management. This is a shared responsibility between health care professionals to interpret available data and individualize an approach to therapy that is compatible with the patient' s disease state, life stage, and dietary intake. Awareness ofthe significance of drug-food interactions is generally lacking. Although many texts contain lengthy lists of possible interactions, few data are provided for the clinician to gain an understanding of the mechanism of action of the interaction and subsequently apply the information to a particular patient or group of patients. For example, in the management of patients with HN -AIDS who are taking complex prescribed drug regimens, herbal products, and nutritional supplements, many of which are affected by dietary intake, careful attention to D Nls is a critic al component of therapy. Clinicians need to take account of not only the well-documented interactions between drugs and nutrients, but also the less obvious effects on drug-nutrient disposition and metabolism.
Download or read book Drug Metabolism in Diseases written by Wen Xie and published by Academic Press. This book was released on 2016-09-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. - Written and edited by leaders in drug metabolism from academia and industry - Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more - Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Clinical Pharmacology Current Topics and Case Studies written by Markus Müller and published by Springer Science & Business Media. This book was released on 2011-02-04 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.
Download or read book Encyclopedia of Drug Metabolism and Interactions Clinical Aspects written by and published by Wiley. This book was released on 2012-07-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ideal place to begin researching any question involving drug metabolism and interactions The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction within the human body. This six-volume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written and edited by leading international experts in the field. By collecting and reviewing the current literature in the field in one expertly organized work, this encyclopedia is the ideal place to begin researching any question involving drug metabolism and interactions. Readers will find such important topics and working tools as: Inhibited or induced enzymes and their impact on drug toxicity and altered response in both animal and human models Effects of both genetic and non-genetic factors on drug metabolism Relationships between a drug metabolism, its activation or inactivation, and a drug's potential toxicity/safety Examples demonstrating all aspects of drug metabolism and interactions in silico, in vitro, in laboratory animals, and in humans Methods and protocols enabling readers to perform seamless studies of metabolism and drug interactions All articles are based on recent findings and standards of practice. By reviewing and contextualizing the current literature, the authors offer new perspectives on our current state of knowledge as well as future directions for research in drug metabolism and interactions. References at the end of each article serve as a gateway to the literature. The Encyclopedia of Drug Metabolism and Interactions is recommended for researchers, physicians, and students at all levels. It introduces the basics to novices and explores the latest science and applications for more experienced investigators.
Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Metabolism Handbook written by Ala F. Nassar and published by John Wiley & Sons. This book was released on 2009-01-28 with total page 1059 pages. Available in PDF, EPUB and Kindle. Book excerpt: A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Download or read book Topics on Drug Metabolism written by James Paxton and published by BoD – Books on Demand. This book was released on 2012-02-22 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
Download or read book Drug Drug Interactions written by A. David Rodrigues and published by CRC Press. This book was released on 2001-10-19 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents comprehensive coverage of the preclinical, clinical, toxicological, regulatory, and marketing perspectives of metabolism-based drug-drug interactions-relating pharmacokinetic concepts to Michaelis-Menten kinetics. The book provides helpful examples, representative enzyme systems, and computer-aided modeling to clarify key concepts. It offers nearly 200 useful tables, equations, drawings, and photographs, and contributions by world-renowned experts in the field. They discuss kinetics-based in vitro-in vivo correlations, methods for the development of a metabolic drug interaction (MDI) database, and more.
Download or read book Enzyme and Transporter Based Drug Drug Interactions written by K. Sandy Pang and published by Springer Science & Business Media. This book was released on 2009-12-17 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.
