Download or read book Membrane Physiology written by Thomas E. Andreoli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Physiology (Second Edition) is a soft-cover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the first three sections: The Nature of Biological Membranes, Methods for Studying Membranes, and General Problems in Membrane Biology. We hope that this smaller volume will be helpful to individuals interested in general physiology and the methods for studying general physiology. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ vii Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.

Download or read book Membrane Physiopathology written by Ghassan Bkaily and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for publishing acomprehensive review ofa number ofdifferent membrane pathologiesofmuscleand non-musclecells inillnesses ranging from diabetes toheart disease and cancer lies on to the fact that there are several books dealing with the properties ofnormal cell membranes, although there are very few books focussing on the abnormal membrane behavior. Since the membrane is the critical outer barrier of a cell, this membrane could be the first structure to be affected in some diseases. Research is advancing at the cellular level at a very rapid rate. We can now address questions such as: "How and by what is the mechanism underlying membrane ion channel and receptor dysfunction leading to abnormal cell function?" and "What substances cause dysfunction in specific ion channels or receptors?". Such questions bring together the microscopic worldofthecell with the macroscopic manifestation of disease. We believe that a book such as this one would help researchers, physicians, and students to better understand the relationship between cell membrane dysfunction and abnormal function of the cell and tissue. This book is intended for practicing clinicians and academic researchers, as well as resident physicians, medical studentsandgraduatestudents. Hopefully, suchtreatisewillhelp to fill an important gap between basic science and clinical science. We are greatly indebted to all thedistinguishedandhigWy-qualified researchers from university and industrial milieus who contributed to this book. Finally, we would like to thank the publishers for their confidenceand cooperation in making this book available for the medical sciences.

Download or read book Capillary Fluid Exchange written by Joshua Scallan and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation

Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuromorphic Olfaction written by Krishna C. Persaud and published by CRC Press. This book was released on 2016-04-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

Download or read book The Physiology of Inflammation The Final Common Pathway to Disease written by Alexandrina Ferreira Mendes and published by Frontiers Media SA. This book was released on 2019-02-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions. The editorial that precedes these articles not only summarizes each one, but provides a broader interpretation of the role of inflammation in health and a variety of disease conditions, the underlying mechanisms and the targets more promising for therapy. Finally, it also highlights the most relevant and emerging research topics that are already shaping future directions for the development of more fine-tuned and innovative therapies.

Download or read book Basic Physiology for Anaesthetists written by David Chambers and published by Cambridge University Press. This book was released on 2019-07-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.

Download or read book Fibrosis and Inflammation in Tissue Pathophysiology written by Elvira Forte and published by Frontiers Media SA. This book was released on 2022-02-23 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Download or read book Etiology of Parkinson s Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Download or read book Membrane Physiology written by T.E. Andreoli and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Physiology is a soft-cover book containing portions of Physiology of Membrane Disorders, published in larger, hard-cover form in 1978. The parent volume was divided into five parts, described in detail in the Preface to the hard-cover edition, which is reproduced in this volume. The present version of Membrane Physiology incorporates the first three of these parts, including a section on the Nature of Biological Membranes, a section on Methods for Studying Membranes, and a section on General Problems in Membrane Biology. It is the hope of the Editors that this smaller volume will be of value to individuals interested in general physiology, the methods for studying general physiology, and its potential application to problems of clinical and physiological relevance. The Preface to Physiology of Membrane Disorders indicates our general reasoning for developing such a volume. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL Vll Preface to Physiology of Membrane Disorders The purpose of this book is to provide the reader with a rational frame of reference for assessing the pathophysiology of those disorders in which derangements of membrane transport processes are a major factor responsible for the clinical manifestations of disease.

Download or read book The Future of Physiology 2020 and Beyond written by George E. Billman and published by Frontiers Media SA. This book was released on 2021-07-30 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic eBook includes articles from Volume I and II of The Future of Physiology: 2020 and Beyond series: Research Topic “The Future of Physiology: 2020 and Beyond, Volume I” Research Topic “The Future of Physiology: 2020 and Beyond, Volume II” The term Physiology was introduced in the 16th century by Jean Francois Fernel to describe the study of the normal function of the body as opposed to pathology, the study of disease. Over the ensuing centuries, the concept of physiology has evolved and a central tenet that unites all the various sub-disciplines of physiology has emerged: the quest to understand how the various components of an organism from the sub-cellular and cellular domain to tissue and organ levels work together to maintain a steady state in the face of constantly changing and often hostile environmental conditions. It is only by understanding normal bodily function that the disruptions that leads to disease can be identified and corrected to restore the healthy state. During the summer of 2009, I was invited by Dr. Henry Markram, one of the founders of the “Frontiers In” series of academic journals, to serve as the Field Chief Editor and to launch a new Open-access physiology journal that would provide a forum for the free exchange of ideas and would also meet the challenge of integrating function from molecules to the intact organism. In considering the position, I needed to answer two questions: 1) What exactly is Open-access publishing?; and 2) What could Frontiers in Physiology add to the already crowded group of physiology related journals? As a reminder, the traditional model of academic publishing “is a process by which academic scholars provide material, reviewing, and editing expertise for publication, free of charge, then pay to publish their work” and, to add insult to injury, they and their colleagues must pay the publisher a fee (either directly or via an institutional subscription) to read their published work [slightly modified from the “The Devil’s Dictionary of Publishing” Physiology News (the quarterly newsletter of the Physiological Society) Spring 2019: Issue 114, page 8]. In the traditional model, the publisher, not the authors, owns the copyright such that the author must seek permission and may even be required to pay a fee to re-use their own material (such as figures) in other scholarly articles (reviews, book chapters, etc.). In contrast, individuals are never charged a fee to read articles published in open-access journals. Thus, scholars and interested laymen can freely access research results (that their tax dollars paid for!) even if their home institution does not have the resources to pay the often exorbitant subscription fees. Frontiers takes the open-access model one step further by allowing authors (rather than the publisher) to retain ownership (i.e., the copyright) of their intellectual property. Having satisfied the first question, I then considered whether a new physiology journal was necessary. At that point in time there were no open-access physiology journals, and further, many aspects of physiology were not covered in the existing journals. Frontiers afforded the unique opportunity to provide a home for more specialized sections under the general field journal, Frontiers in Physiology, with each section having an independent editor and editorial board. I therefore agreed to assume the duties of Field Chief Editor in November 2009. Frontiers in Physiology was launched in early 2010 and the first articles were published in April 2010. Since these initial publications, we have published over 10,000 articles and have become the most cited physiology journal. Clearly we must be fulfilling a critical need. Now that it has been over a decade since Frontiers in Physiology was launched, it is time to reflect upon what has been accomplished in the last decade and what questions and issues remain to be addressed. Therefore, it is the goal of this book to evaluate the progress made during the past decade and to look forward to the next. In particular, the major issues and expected developments in many of the physiology sub-disciplines will be explored in order to inspire and to inform readers and researchers in the field of physiology for the year 2020 and beyond. A brief summary of each chapter follows: In chapter 1, Billman provides a historical overview of the evolution of the concept of homeostasis. Homeostasis has become the central unifying concept of physiology and is defined as a self-regulating process by which a living organism can maintain internal stability while adjusting to changing external conditions. He emphasizes that homeostasis is not static and unvarying but, rather, it is a dynamic process that can change internal conditions as required to survive external challenges and can be said to be the very basis of life. He further discusses how the concept of homeostasis has important implications with regards to how best to understand physiology in intact organisms: the need for more holistic approaches to integrate and to translate this deluge of information obtained in vitro into a coherent understanding of function in vivo. In chapter 2, Aldana and Robeva explore the emerging concept of the holobiont: the idea that every individual is a complex ecosystem consisting of the host organism and its microbiota. They stress the need for multidisciplinary approaches both to investigate the symbiotic interactions between microbes and multicellular organisms and to understand how disruptions in this relationship contributes to disease. This concept is amplified in chapter 3 in which Pandol addresses the future of gastrointestinal physiology ,emphasizing advances that have been made by understanding the role that the gut microbiome plays in both health and in disease. Professor Head, in chapter 4, describes areas in the field of integrative physiology that remain to be examined, as well as the potential for genetic techniques to reveal physiological processes. The significant challenges of developmental physiology are enumerated by Burggren in chapter 5. In particular, he analyzes the effects of climate change (environmentally induced epigenetic modification) on phenotype expression. In chapter 6, Ivell and Annad-Ivell highlight the major differences between the reproductive system and other organ systems. They conclude that the current focus on molecular detail is impeding our understanding of the processes responsible for the function of the reproductive organs, echoing and amplifying the concepts raised in chapter 1. In chapter 7, Costa describes the role of both circadian and non-circadian biological “clocks” in health and disease, thereby providing additional examples of integrated physiological regulation. Coronel, in chapter 8, provides a brief history of the development of cardiac electrophysiology and then describes areas that require further investigation and includes tables that list specific questions that remain to be answered. In a similar manner, Reiser and Janssen (chapter 9) summarize some of the advancements made in striated muscle physiology during the last decade and then discuss likely trends for future research; to name a few examples, the contribution of gender differences in striated muscle function, the mechanisms responsible of age-related declines in muscle mass, and role of exosome-released extracellular vesicles in pathophysiology. Meininger and Hill describe the recent advances in vascular physiology (chapter 10) and highlight approaches that should facilitate our understanding of the vascular processes that maintain health (our old friend homeostasis) and how disruptions in these regulatory mechanisms lead to disease. They also stress the need for investigators to exercise ethical vigilance when they select journals to publish in and meetings to attend. They note that the proliferation of profit driven journals of dubious quality threatens the integrity of not only physiology but science in general. The pathophysiological consequences of diabetes mellitus are discussed in chapters 11 and 12. In chapter 11, Ecelbarger addresses the problem of diabetic nephropathy and indicates several areas that require additional research. In chapter 12, Sharma evaluates the role of oxidative damage in diabetic retinopathy, and then proposes that the interleukin-6-transsignaling pathway is a promising therapeutic target for the prevention of blindness in diabetic pateints. Bernardi, in chapter 13, after briefly reviewing the considerable progress that has been achieved in understanding mitochondrial function, lists the many questions that remain to be answered. In particular, he notes several areas for future investigation including (but not limited to) a more complete understanding of inner membrane permeability changes, the physiology of various cation channels, and the role of mitochondrial DNA in disease. In chapter 14, using Douglas Adam’s “The Hitchhikers Guide to the Universe” as a model, Bogdanova and Kaestner address the question why a young person should study red blood cell physiology and provide advice for early career scientists as they establish independent laboratories. They the, describe a few areas that merit further attention, not only related to red blood cell function, but also to understanding the basis for blood related disease, and the ways to increase blood supplies that are not dependent on blood donors. Finally, the last two chapters specifically focus on non-mammalian physiology. In chapter 15, Scanes asks the question, are birds simply feathered mammals, and then reviews several of the significant differences between birds and mammals, placing particular emphasis on differences in gastrointestinal, immune, and female reproductive systems. In the final chapter (chapter 16) Anton and co-workers stress that since some 95% of living animals species are invertebrates, invertebrate physiology can provide insights into the basic principles of animal physiology as well as how bodily function adapts to environmental changes. The future of Physiology is bright; there are many important and interesting unanswered questions that will require further investigation. All that is lacking is sufficient funding and a cadre of young scientists trained to integrate function from molecules to the intact organism. George E. Billman, Ph.D, FAHA, FHRS, FTPS Department of Physiology and Cell Biology The Ohio State University Columbus OH, United States

Download or read book The Core Concepts of Physiology written by Joel Michael and published by Springer. This book was released on 2017-02-20 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers physiology teachers a new approach to teaching their subject that will lead to increased student understanding and retention of the most important ideas. By integrating the core concepts of physiology into individual courses and across the entire curriculum, it provides students with tools that will help them learn more easily and fully understand the physiology content they are asked to learn. The authors present examples of how the core concepts can be used to teach individual topics, design learning resources, assess student understanding, and structure a physiology curriculum.

Download or read book Pathophysiology of Rare Hemolytic Anemias written by Richard Van Wijk and published by Frontiers Media SA. This book was released on 2020-12-23 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Cardiovascular Diseases written by Nikolaos Papageorgiou and published by Academic Press. This book was released on 2016-08-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors. The book provides a much needed reference for this rapidly growing field of study. By combining the latest research within the structured chapters of this reference, a better understanding of genetic and environmental contribution to cardiovascular disease is found, helping to substantiate further investigations in the field and design prevention and treatment strategies. - Provides an overview of the genetic basis of cardiovascular disease and its risk factors - Reviews several large population-based studies which indicate that exposure to several environmental factors may increase CVD morbidity and mortality, exploring the plausibility of this association by data from animal studies - Reflects on future studies to help understanding the role of genes and environmental factors in the development and progression of cardiovascular disease