Download or read book Membrane Dynamics and Calcium Signaling written by Joachim Krebs and published by Springer. This book was released on 2018-03-28 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field. Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology.
Download or read book Membrane dynamics and signaling written by E. Edward Bittar and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Membrane Dynamics and Signaling written by E. Edward Bittar and published by JAI Press(NY). This book was released on 1992 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes 5A and 5B of Fundamentals of Medical Cell Biology are a treatment of several key subjects, including cellular signaling. One profitable way to tackle both volumes is to read them with care but without endeavouring to master most of the details. Then should follow a more plodding study, chapter by chapter. Such a strategy is also urged in respect of the preceding volumes. Although each chapter is only as detailed as space permits, it should in the case of the student serve as an incentive to the study of the original papers.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Membrane Dynamics and Domains written by Peter J. Quinn and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.
Download or read book Membrane Dynamics and Signal Transduction in Megakaryocytes written by Annelies Schootemeijer and published by . This book was released on 1993 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Membrane Organization and Dynamics written by Amitabha Chattopadhyay and published by Springer. This book was released on 2017-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states. In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used. This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes.
Download or read book Fundamentals of Medical Cell Biology pt A Membrane dynamics and signaling written by E. Edward Bittar and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plasma Membrane Dynamics and Pattern Formation During T Cell Activation written by Adam D. Douglass and published by . This book was released on 2006 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cell activation entails a complex series of signal transduction events that begin with ligation of the T cell receptor by a cognate antigen, displayed on the surface of an antigen presenting cell. During T cell signaling proteins in the cell surface partition from one another into large, stereotyped molecular pattern that is known as the immunological synapse. This thesis attempts to understand the mechanisms by which this segregation occurs, and uses a number of fluorescence imaging techniques---in particular, single molecule microscopy---to this end. Contrary to reports that suggest a role for lipid raft domains in patterning the synapse, we find that protein-protein interactions, and not putative lipid raft associations, are a strong driving force in synapse formation. We also develop a method for reconstituting synapse formation in an immortalized T cell line that allows us to perform single molecule imaging on a fluid substrate of a defined composition. A common finding is that both passive mechanisms, involving diffusional trapping and exclusion, as well as active mechanisms, involving actin-driven transport, can act in concert to shape the immunological synapse.
Download or read book Molecular Organization of Membranes Where Biology Meets Biophysics written by Marek Cebecauer and published by Frontiers Media SA. This book was released on 2018-02-07 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities. Such knowledge can contribute to biomedical fields such as pharmacology, immunology, neurobiology and many others. The goal of the Research Topic entitled ‘Molecular organisation of membranes: where biology meets biophysics’ was to provide a comprehensive platform for publishing articles, reviews and opinions focused on membrane organisation and the forces behind its heterogeneous and dynamic structure. We collected 11 works which cover topics as diverse as general membrane organisation models, membrane trafficking and signalling regulation, biogenesis of caveolae, protein-lipid interactions and the importance of membrane-associated tetraspanins networks. The prevalent theme was the existence of membrane nanodomains. To this point, new emerging technologies are presented which own the power to bring a novel insight on how membrane nanodomains are formed and maintained and what is their function. We believe that the collection of works in this Research Topic brings forward some important questions which will stimulate further research in this difficult but exciting field.
Download or read book Cell Membrane Dynamics and Signal Transduction in Human Ageing written by Jane Mary Noble and published by . This book was released on 2000 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Membrane Protein Structure and Dynamics written by Nagarajan Vaidehi and published by Humana Press. This book was released on 2016-05-01 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Methods in Molecular Biology book details approaches to the structure, dynamics and interactions of membrane proteins, including measurement procedures and computational methods for structure prediction and insight on the dynamics of membrane receptors."
Download or read book Phosphoinositide Regulation of Endolysosomal Membrane Dynamics and Nutrient Signaling written by Alexander Wallroth and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Membranes Structure Biogenesis and Dynamics written by Jos A.F. Op den Kamp and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advanced Study Institute on "Structure, Biogenesis and Dynamics of Biological Membranes, held in Cargese from June 14-26, 1993, has been dealing with four major topics in membrane biochemistry today: lipid dynamics and lipid-protein interactions, protein translocation and insertion, intracellular traffic aud protein structure and folding. The lecturers discussed these topics starting from several disciplines, including biochemistry, cell biology, genetics, and biophysics. This wayan interdisciplinary and very inte~sting view on biological membrane systems was obtained. At first an extensive overview of -mainly biophysical -techniques which can be used to study dynamic processes in membranes was presented. Sophisticated approaches such as ESR and NMR have been applied succesfully to unravel details of specific lipid-protein interactions. x ray analysis provides detailed structural information of several proteins and the possible implications for protein functions. Information obtained this way is complemented by studies on mechanisms and kinetics of protein folding. The latter information is indispensable when discussing protein translocation and insertion: proces:;es in which folding and unfolding play essential roles. Extensive insight was offered in the complicated machinery of phospholipid biosynthesis. In particular, the application of sophisticated genetic techniques has allowed a better understanding of the mechanisms regulating the synthetic machinery and detailed studies on a variety of mutants, lacking one or more of the essential enzymes, have resulted in the beginning of a bL!:
Download or read book Dynamics of Membrane Proteins and Cellular Energetics written by Norbert Latruffe and published by Springer. This book was released on 1988-08-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual on "Dynamics of Membrane Proteins and Cellular Energetics" is the result of a FEBS-CNRS Course held in Grenoble and Besanc;{on in September 1987.' It appears to be, after the first, published in 1979 the fifth of the series. After focussing on the "Biochemistry of Membranes" (1979) it was the turn of "Membrane Proteins" (1981) and of Enzymes, Receptors and Carriers of Biological Membranes (1983), fo1- wed by "Membrane Proteins Isolation and Characterization" ( 1986) . Al though the central issue has always been the its components and its functions, each biological membrane, manual has put the accent on somewhat different issues corresponding to the most innovative, interesting research in the field. After almost a decade this new manual appears, which stresses the aspect of the integration of membrane research at a cellular level. Such a novel emphasis is the consequence of the common interest of cell biology and biochemistry to understand the results of the biochemical analysis of membrane proteins in the context of the cell complexity. Consequently most of the experimental protocols are dealing with cellular models, but with clear reference to the function and structure of isolated membrane proteins.
Download or read book Probing Cell Membrane Dynamics Using Plasmon Coupling Microscopy written by Guoxin Rong and published by . This book was released on 2013 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The plasma membrane of mammalian cells is depicted as a two-dimensional hybrid material which is compartmentalized into submicron-sized domains. These membrane domains play a pivotal role in cellular signaling processes due to selective recruitment of specific cell surface receptors. The structural dynamics of the membrane domains and their exact biological functions are, however, still unclear, partially due to the wave nature of light, which limits the optical resolution in the visible light to approximately 400 nm in conventional optical microscopy. Here, we provide a non-fluorescence based approach for monitoring distance changes on subdiffraction limit length scales in a conventional far-field optical microscope. This approach, which is referred to as plasmon coupling microscopy (PCM), utilizes the distance dependent near-field coupling between noble metal nanoparticle (NP) labels to resolve close contacts on the length scale of approximately one NP diameter. We firstly utilize this PCM strategy to resolve interparticle separations during individual encounters of gold NP labeled fibronectin-integrin complexes in living HeLa cells. We then further refine this ratiometric detection methodology by augmenting it with a polarization-sensitive detection, which enables simultaneous monitoring of the distance and conformation changes in NP dimers and clusters. We apply this polarization resolved PCM approach to characterize the structural lateral heterogeneity of cell membranes on sub-micron length scales. Finally, we demonstrate that PCM can provide quantitative information about the structural dynamics of individual epidermal growth factor receptor (ErbB1)-enriched membrane domains in living cells.
Download or read book Plasma Membrane Dynamics in Immune Signalling written by Falk Schneider and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
