Download or read book Medical Materials Research and Applications of Free Electron Laser and Related Technologies written by and published by . This book was released on 1991 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: To investigate biomedical and materials laser-optical systems that have potential clinical and industrial applications. To develop clinical and industrial applications of Free-Electron laser technology and related broadly wavelength tunable, short pulse, ultrafast, high peak power, high average power laser systems that are efficient, compact, reliable and clinically and commercially practical systems. To carry out actual FEL experiments with collaborators at existing FEL facilities at Duke, Vanderbilt and Stanford Universities.
Download or read book A Center for Medical and Materials Science Research with Free Electron Lasers written by and published by . This book was released on 1994 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this program was to develop an integrated laboratory dedicated to the exploration of the medical applications and materials of free-electron lasers with the capability to: (a) develop and apply advanced FEL and medical technologies and techniques; (b) provide user faclities to qualified un-affiliated researchers through an applications program; and (c) carry out an ongoing, high level critical review of the current and possible future applications of FELs in medicine. This report summarizes the accomplishments of the program, including: (a) design, construction, commissioning, and upgrades of the Duke short and long wavelength FELs; (b) FEL technology research, including hole-coupling, fourth-harmonic generation, giant laser pulses, RF photocathode guns, mode selection, IR fiber optics, and dynamic aperture physics; and (c) applications research in areas such as infrared two-photon spectroscopy of organic semiconductors and porphyrins, mode-selective chemistry, narrow-line spectroscopy, low collateral damage surgical incisions in cornea, brain, spinal cord, peripheral nerve, teeth, and skin.
Download or read book Development and Applications of Free Electron Lasers written by Jia Chen and published by CRC Press. This book was released on 1997-05-22 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of the field of free electron lasers. Each chapter is based on a graduate-level lecture given by an internationally-known expert in the field, and is self-contained, beginning with introductory background material and culminating in an in-depth discussion of the author's current research. Written with both the student physicist and the active researcher in mind, this book is sure to be an invaluable reference for graduate students and professionals alike.
Download or read book Synchrotron Light Sources and Free Electron Lasers written by Eberhard J. Jaeschke and published by Springer. This book was released on 2016-05-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardly any other discovery of the nineteenth century did have such an impact on science and technology as Wilhelm Conrad Röntgen’s seminal find of the X-rays. X-ray tubes soon made their way as excellent instruments for numerous applications in medicine, biology, materials science and testing, chemistry and public security. Developing new radiation sources with higher brilliance and much extended spectral range resulted in stunning developments like the electron synchrotron and electron storage ring and the freeelectron laser. This handbook highlights these developments in fifty chapters. The reader is given not only an inside view of exciting science areas but also of design concepts for the most advanced light sources. The theory of synchrotron radiation and of the freeelectron laser, design examples and the technology basis are presented. The handbook presents advanced concepts like seeding and harmonic generation, the booming field of Terahertz radiation sources and upcoming brilliant light sources driven by laser-plasma accelerators. The applications of the most advanced light sources and the advent of nanobeams and fully coherent x-rays allow experiments from which scientists in the past could not even dream. Examples are the diffraction with nanometer resolution, imaging with a full 3D reconstruction of the object from a diffraction pattern, measuring the disorder in liquids with high spatial and temporal resolution. The 20th century was dedicated to the development and improvement of synchrotron light sources with an ever ongoing increase of brilliance. With ultrahigh brilliance sources, the 21st century will be the century of x-ray lasers and their applications. Thus, we are already close to the dream of condensed matter and biophysics: imaging single (macro)molecules and measuring their dynamics on the femtosecond timescale to produce movies with atomic resolution.
Download or read book Insertion Devices for Synchrotron Radiation and Free Electron Laser written by F. Ciocci and published by World Scientific. This book was released on 2000 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basic properties of charged beam transport and the theory of accelerators with radiative damping. The characteristics of the third generation synchrotron radiation sources are analyzed and compared to those of the first and second generations. This is followed by the conceptual and technological problems associated with the discovery of the fourth generation sources. Within this framework, the role played by free electron laser devices is discussed and relevant theoretical and technological aspects of storage-ring and Linac-based sources are analyzed.
Download or read book Development of a Free Electron Laser Center and Research in Medicine Biology and Materials Science written by and published by . This book was released on 1992 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free-Electron Laser Construction and Operation under the direction of C.A. Brau, Department of Physics, College of Arts and Science. The objective of this effort has been to commission the free-electron laser and the optical beamline required to distribute the laser beam to the laboratories. Nonthermal and Selective Effects of Free-Electron Laser Irradiation of Tissue. Under the direction of R.H. Ossoff, Department of Otolaryngology, School of Medicine, the objective of this research has been to examine the effects of lasers on tissue, including the effect on wound healing. Free-Electron Laser Based Studies of Biomembrane Dynamics and Drug Interactions. Under the direction of S. Fleischer, Department of Molecular Biology, College of Arts and Science, the objective of this research has been to understand the dynamics of membrane proteins, and how they are related to membrane function. Free-Electron Laser Applications in Neurosurgery. Under the direction of R.J. Maciunas, Department of Neurosurgery, School of Medicine, the objective of this effort has been to study the interaction of pulsed lasers with brain tissue, and to develop the techniques of sterotactic laser neurosurgery.
Download or read book Free electron Laser Spectroscopy in Biology Medicine and Materials Science written by H. Alan Schwettman and published by . This book was released on 1993 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synchrotron Light Sources and Free Electron Lasers written by Eberhard J. Jaeschke and published by Springer. This book was released on 2020-05-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook presents the development of synchrotron light sources and free-electron lasers as well as new scientific applications. Hardly any other discovery of the nineteenth century had such an impact on science and technology as Wilhelm Conrad Röntgen’s seminal discovery of X-rays in the year 1895. X-ray tubes soon became established as excellent instruments for numerous applications in medicine, biology, materials science and testing, chemistry and even public security. Developing new radiation sources with higher and higher brilliance and much extended spectral range for an ever widening field of research resulted in stunning developments like the electron storage ring and the free-electron laser. This second edition includes both updated chapters and new contributions highlighting the most recent developments in the field. Reports on operation experience of the new FEL facilities are complemented by discussions of new developments in X-ray beamline optics and detectors. Contributions on applications now include high pressure work, catalytic processes and engineering materials, medical applications and studies of cultural heritage. New contributions on IR spectroscopy, resonant inelastic X-ray scattering (RIXS) and studies of liquids complete this second edition.
Download or read book Free Electron Lasers 2000 written by V.N. Litvinenko and published by Gulf Professional Publishing. This book was released on 2005-12-27 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 22nd International Free Electron Laser Conference and 7th FEL User Workshop were held August 13-18, 2000 at Washington Duke Inn and Golf Club in Durham, North Carolina, USA. The conference and the workshop were hosted by Duke University's Free Electron laser (FEL) Laboratory. Following tradition, the FEL prize award was announced at the banquet. The year 2000 FEL prize was awarded to three scientists propelling the limits of high power FELs: Steven Benson, Eisuke Minehara and George Neill. The conference program was comprised of traditional oral sessions on First Lasing, FEL theory, storage ring FELs, linac and high power FELs, long wavelength FELs, SASE FELs, accelerator and FEL physics and technology, and new developments and proposals. Two sessions on accelerator and FEL physics and technology reflected the emphasis on the high quality of accelerators and components for modern FELs. The breadth of the applications was presented in the workshop oral sessions on materials processing, biomedical and surgical applications, physics and chemistry as well as on instrumentation and methods for FEL applications. A special oral session was dedicated to FEL center status reports for users to learn more about the opportunities with FELs. As usual, the oral sessions were supplemented by poster sessions with in-depth discussions and communications. The FEL physicists and FEL users had excellent opportunities to interact throughout the duration of the event, culminating a Joint Sessions. The year 2000 was very successful being marked by lasing with two SASE and one storage ring short-wavelength FELs, and by the first human surgery with the use of FEL, to mention but a few. The International Program Committee and chairs of the sessions had the challenging and exciting problem of selecting invived and contributed talks for the conferences and the workshop from the influx of abstracts mentioning new results and ideas. The success of the conference was determined by these contributions. Scientists from 15 countries gave 70 talks, presented 176 posters and submitted 146 papers, which are published in the present volume of proceedings.
Download or read book Vanderbilt Free Electron Laser Center for Research in Surgery Medicine Photobiology and Materials Science written by and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This program is designed to explore the militarily-relevant medical applications of high-power, tunable infrared radiation available from unique accelerator-based light sources, the Mark Ill FEL, the monochromatic X-ray system, and a new Smith-Purcell THz FEL. As applications mature, we also develop cost-efficient, dedicated systems to expand the use of these applications beyond the FEL Center. During the last funding period, we have developed a comprehensive research program directed towards a thorough understanding of militarily-relevant laser medicine applications. These studies involve substantial collaborations with all the other FEL centers: dermatology with the Wellman Laboratories, infection and cancer diagnosis with Stanford, bone and cartilage ablation with UC Irvine, neurosurgery with Duke. Since the Vanderbilt center has the only FEL that is coupled to an FDA-approved human operating rooms, all FEL clinical applications developed within the MFEL program are carried out at Vanderbilt. In particular, our researchers have concentrated on the development of three new surgical approaches using the FEL, 1) decrease of wound healing and scar minimization, 2) ophthalmological surgery in the back of the eye without removing the eye from the socket, and 3) laser-based non-contact nerve stimulation.
Download or read book Synchrotron Light Sources and Free Electron Lasers written by Eberhard J. Jaeschke and published by Springer. This book was released on 2020-05-06 with total page 2509 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook presents the development of synchrotron light sources and free-electron lasers as well as new scientific applications. Hardly any other discovery of the nineteenth century had such an impact on science and technology as Wilhelm Conrad Röntgen’s seminal discovery of X-rays in the year 1895. X-ray tubes soon became established as excellent instruments for numerous applications in medicine, biology, materials science and testing, chemistry and even public security. Developing new radiation sources with higher and higher brilliance and much extended spectral range for an ever widening field of research resulted in stunning developments like the electron storage ring and the free-electron laser. This second edition includes both updated chapters and new contributions highlighting the most recent developments in the field. Reports on operation experience of the new FEL facilities are complemented by discussions of new developments in X-ray beamline optics and detectors. Contributions on applications now include high pressure work, catalytic processes and engineering materials, medical applications and studies of cultural heritage. New contributions on IR spectroscopy, resonant inelastic X-ray scattering (RIXS) and studies of liquids complete this second edition.
Download or read book House Reports written by and published by Government Printing Office. This book was released on with total page 1290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research to Develop Biomedical Applications of Free Electron Laser Technology written by and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific Aim 1: Develop and test plaque characterization criteria based on bireftingence. Coronary artenes were obtained at autopsy and imaged with the existing OCT system in our laboratory. The specimens were opened and imaged at normal body temperature (37-C) in saline. To ensure proper registration of OCT images with histolog the image location was marked with ink viewable on the OCT image and in the histology section. Routine histologic processing was performed using H & E, Elastic and Movat's pentachrome stains. Trichrome was used for fibrous tissue identification. Individual images were oriented and scaled to match histology. In the OCT images, the axial periodicity of the birefringence banding was measured using image processing software. A set of 20 correlated OCT and histology pairs were used to identify characterization criteria basal on birefringence. Our results indicated that fibrous plaque provides a strong birefringence as measured by OCT while lipid rich and calcific plaques can be identified by a complete loss of birefringenee.
Download or read book Report to the Congress on the Strategic Defense Initiative written by Strategic Defense Initiative Organization (U.S.) and published by . This book was released on with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Opportunities in Intense Ultrafast Lasers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-31 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The laser has revolutionized many areas of science and society, providing bright and versatile light sources that transform the ways we investigate science and enables trillions of dollars of commerce. Now a second laser revolution is underway with pulsed petawatt-class lasers (1 petawatt: 1 million billion watts) that deliver nearly 100 times the total world's power concentrated into a pulse that lasts less than one-trillionth of a second. Such light sources create unique, extreme laboratory conditions that can accelerate and collide intense beams of elementary particles, drive nuclear reactions, heat matter to conditions found in stars, or even create matter out of the empty vacuum. These powerful lasers came largely from U.S. engineering, and the science and technology opportunities they enable were discussed in several previous National Academies' reports. Based on these advances, the principal research funding agencies in Europe and Asia began in the last decade to invest heavily in new facilities that will employ these high-intensity lasers for fundamental and applied science. No similar programs exist in the United States. Opportunities in Intense Ultrafast Lasers assesses the opportunities and recommends a path forward for possible U.S. investments in this area of science.
Download or read book Vanderbilt Free Electron Laser Project in Biomedical and Materials Research written by Richard F. Haglund and published by . This book was released on 1988 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Medical Free Electron Laser Program was awarded to develop, construct and operate a free-electron laser facility dedicated to biomedical and materials studies, with particular emphases on: fundamental studies of absorption and localization of electromagnetic energy on and near material surfaces, especially through electronic and other selective, non-statistical processes; non-thermal photon-materials interactions (e.g., electronic bond-breaking or vibrational energy transfer) in physical and biological materials as well as in long-wavelength biopolymer dynamics; development of FEL-based methods to study drug action and to characterize biomolecular properties and metabolic processes in biomembranes; clinical applications in otolaryngology, neurosurgery, ophthalmology and radiology stressing the use of the laser for selective laser-tissue, laser-cellular and laser-molecule interactions in both therapeutic and diagnostic modalities.
Download or read book Physics of Free Electron Laser Applications in the Visible and Infrared written by and published by . This book was released on 1991 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now eighteen years since John Madey published a paper pointing out that a high-brightness relativistic electron beam traversing a spatially periodic magnetic field could stimulate the emission of photons over a broad range of wavelengths, indeed, from the far infrared to the ultraviolet. In a way, the free-electron laser was the ultimate homage paid by the laser, viewed as an optical device, to its antecedents in radar and electron-beam science and technology dating back into the 1940's. In the intervening years, successful infrared and visible free-electron-laser (FEL) experiments, for example, at Stanford, Orsay, Santa Barbara, and Los Alamos, have shown significant promise for applications based on the unique optical characteristics of the FEL. A variety of accelerators can provide the high-brightness electron beams necessary for the FEL: room-temperature pulsed linear accelerators, superconducting accelerators, storage rings, and Van de Graaff generators have all been successfully used so far for this purpose. The existence of this variegated collection of pumps for the stimulated emission generated in the FEL implies a correspondingly broad range of temporal pulse shapes, interpulse spacings, pulse-repetition frequencies, output powers, and spectral ranges for users. With the increasing maturity of the free-electron laser comes a new phase of scientific opportunity for those who are primarily laser users rather than laser physicists. During the past two years, FEL users' facilities at Stanford University and the University of California at Santa Barbara began to provide significant quantities of time to photon users, particularly in surface and materials science and bio-medical studies.
