Download or read book Medical Genetics of Endometrial Cancer written by Garden Grove Garden Grove Press and published by . This book was released on 2017-03-25 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews the medical genetics of endometrial cancer and includes 20 papers by various authors. Topics include: Genetic variants in MUTYH are not associated with endometrial cancer risk; Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium; Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families; Genetic testing in a gynaecological oncology care in developing countries - knowledge, attitudes and perception of Nepalese clinicians; New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care; PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study; Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk; Genetic variations of MUC17 are associated with endometriosis development and related infertility; Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma; Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer; Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach; Potential contribution of the uterine microbiome in the development of endometrial cancer; The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor; Common mitochondrial polymorphisms as risk factor for endometrial cancer; Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma; Immunotherapy in endometrial cancer - an evolving therapeutic paradigm; HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study; Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome; Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report; The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer. Proceeds from the sale of this book go to the support of an elderly disabled person.

Download or read book Molecular Genetics of Endometrial Carcinoma written by Lora Hedrick Ellenson and published by Springer. This book was released on 2016-12-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

Download or read book Management of Endometrial Cancer written by Mansoor R. Mirza and published by Springer. This book was released on 2019-08-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.

Download or read book Recent Advances in Endometrial Cancer written by Sumita Mehta and published by Springer Nature. This book was released on 2020-07-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Download or read book A Guide to Cancer Genetics in Clinical Practice written by Sue Clark, and published by tfm Publishing Limited. This book was released on 2009-05-01 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.

Download or read book Precision Molecular Pathology of Uterine Cancer written by Michael T. Deavers and published by Springer. This book was released on 2017-10-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.

Download or read book Uterine Cancer written by Franco Muggia and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications. The Editors first met in May 2003 at a stimulating Italian symposium on endometrial cancer (organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni, with participation of the deans of Italian Gynecologic Oncology, Ugo Bianchi and Constantino Mangioni) that took place at Bergamo and Caravaggio. The impressive gains in biology and clinical trials were further discussed by the two editors and others that are co-authors in this venture on this side of the Atlantic at a 2004 Educational Session at the American Society of Clinical Oncology (ASCO). The pace of progress in various aspects of management of uterine cancer was no- worthy, not only was tumor biology fueling novel hypotheses such as questioning the mesenchymal origin of carcinosarcomas, but knowledge of molecular pathways was beginning to be applied as prognostic and as predictive factors portending benefit from systemic therapies. Surgical staging and sensitive imaging provided the underpinning for refining our treatment algorithms. Finally, a role for che- therapy had finally become established, principally through phase III studies c- paring chemotherapy to radiation in mostly locally advanced stages III and IV that had undergone resection.

Download or read book Hereditary Gynecologic Cancer written by Karen H. Lu and published by CRC Press. This book was released on 2008-08-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hereditary Gynecologic Cancer: Risk, Prevention and Management fills the need that exists for a book addressing highly relevant clinical issues associated with the new field of hereditary gynecologic cancers. Written with the clinician in mind, the authors will cover a broad range of topics, beginning with an overview discussing clinical relevance of hereditary ovarian and hereditary endometrial cancers. Succeeding sections will provide in-depth analyses of Hereditary Breast Ovarian Cancer Syndrome, Lynch Syndrome, and other syndromes with gynecologic cancer components, and genetic risk assessment. Hereditary Gynecologic Cancer: Risk, Prevention and Management: is the first clinically focused reference detailing gynecologic patient management issues of BRCA1 and BRCA2 mutation carriers includes a practical section on genetic risk assessment and genetic testing examines case studies to demonstrate management techniques and decision-making provides detailed discussion of ovarian cancer screening, prevention and risk reducing surgery

Download or read book Genetics for Health Professionals in Cancer Care written by Chris Jacobs and published by Oxford University Press, USA. This book was released on 2014 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics for Health Professionals in Cancer Care equips health professionals with the knowledge and skills required for all aspects of managing cancer family history, including discussing the challenges raised, and provides practical guidance on setting up a cancer family history clinic in primary and secondary care.

Download or read book Uterine Cancer written by Arlan F. Fuller and published by PMPH-USA. This book was released on 2004 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an overview of the most frequently diagnosed gynecologic malignancy, endometrial carcinoma, as well as a collection of mesenchymal tumors. Reviews epidemiology, genetics, diagnosis, staging, prognosis, treatment, postsurgical management, and pathologic evaluation.

Download or read book Cancer of the Uterine Endometrium written by J.S. Saldivar and published by BoD – Books on Demand. This book was released on 2012-02-29 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Cancer of the Uterine Endometrium - Advances and Controversies brings together an international collaboration of authors who share their contributions for the management of endometrial carcinoma. The scope of the text is not basic, but rather aims to provide a comprehensive and updated source of advances in the diagnosis and therapeutic strategies in this field of gynecologic cancer. Each section in the book attempts to provide the most relevant evidence-based information in the biology and genetics, modern imaging, surgery and staging, and therapies for endometrial cancer. It is hoped that future editions will bring additional authors to contribute to this endeavor. To this end, it is our patients who will benefit from this work.

Download or read book Endometrial Cancer A Comprehensive Medical Treatise written by Dr. Spineanu Eugenia and published by Dr. Spineanu Eugenia. This book was released on 2024-03-03 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometrial cancer, a malignancy originating from the inner lining of the uterus, stands as a significant health concern for women worldwide. This treatise offers an exhaustive exploration of endometrial cancer, weaving together historical context, cutting-edge research, and holistic approaches to both treatment and prevention. Designed for medical professionals, researchers, and patients alike, the content delves deep into the intricacies of the disease, ensuring a thorough understanding for all readers. The treatise begins by tracing the historical evolution of endometrial cancer research, highlighting key milestones and breakthroughs that have shaped our current understanding. This historical perspective sets the stage for a detailed examination of the global epidemiology and demographics of the disease, emphasizing its prevalence, risk factors, and the populations most affected. A deep dive into the anatomy and physiology of the endometrium provides readers with a foundational understanding of its structure, function, and the hormonal dynamics that influence its health. This section is particularly crucial, as it lays the groundwork for understanding the cellular and molecular mechanisms that drive cancer development and progression. The heart of the treatise delves into the pathogenesis of endometrial cancer. From DNA mutations and chromosomal aberrations to hormonal pathways and the tumor microenvironment, readers are guided through the complex interplay of factors that contribute to the disease. Special attention is given to the metabolic alterations observed in cancer cells and the role of the immune system in tumor progression. Risk factors and preventative measures are explored in depth, with a focus on both genetic predispositions and lifestyle factors. The treatise emphasizes the importance of a holistic approach to prevention, incorporating diet, environmental exposures, and integrative medicine practices. Diagnostic methods, from symptomatic manifestations to advanced imaging techniques and molecular diagnostic tools, are meticulously detailed. This comprehensive overview ensures that readers are well-equipped to understand the nuances of diagnosis, from initial symptoms to confirmatory tests. Treatment modalities form a significant portion of the treatise, covering surgical techniques, radiation, chemotherapy, and emerging therapies like immunotherapy and targeted treatments. The content underscores the importance of personalized medicine, tailoring treatments to the unique genetic and molecular profile of each patient. Post-treatment care and rehabilitation are addressed with equal rigor. From surveillance protocols to physical therapy and nutritional guidance, the treatise offers a roadmap for patients navigating life after treatment. Psychological support, integrative medicine, and mind-body practices are highlighted, emphasizing the importance of holistic care in recovery. Special topics, including endometrial cancer in younger women, aggressive variants, and management in immunocompromised patients, are explored in detail, ensuring that readers are equipped to handle even the most challenging cases.

Download or read book Endometrial Cancer From Biological to Clinical Approaches written by Massimo Nabissi and published by Frontiers Media SA. This book was released on 2019-09-26 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: In developed countries, cancer of the endometrium (EC) is the most common cancer of the female reproductive organs, affecting mainly postmenopausal women. The highest incidence of EC is in Northern America and Europe, but its incidence is growing around the world. Several factors influence the risk of developing EC, including: impaired hormone levels, obesity, physical activity, family history, and having been diagnosed with breast or ovarian cancer in the past. For EC, a standard screening test does not exist. It is often diagnosed at stage I/II due to frequent vaginal bleeding, while invasive EC (stage III/IV) is mainly diagnosed in its advanced stage. Despite the different clinical improvements when EC is progressed to the advanced/metastatic stage, the patients still have poor prognoses and unsatisfactory outcomes with conventional chemotherapy. The need for precision drugs is underscored by the limited number of options these patients have. So, the introduction of new techniques and the discovery of new biological characteristics, such as identification of transcriptome, proteome and metabolomics profiles, and new potential diagnostic/prognostic biomarkers are fundamental to improve our knowledges on EC. The scope of this Research Topic is to welcome articles and reviews from clinicians and scientists around the world in order to give an updated vision of the recent clinical insights, technical advances, and cellular and molecular targets related to endometrial cancer. Dedicated to Mr. Dario Conti, which supported endometrial cancer research.

Download or read book Modern Medical Genetics and Genomics written by Israel Gomy and published by BoD – Books on Demand. This book was released on 2019-12-18 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of medical genetics and genomics has been constantly revolutionized by new breakthroughs, which bring more knowledge into the etiology and help improve the health care of individuals with either rare or common diseases. Nevertheless, as technologies evolve, novel challenges emerge, both technically and ethically, so they must be prudentially addressed. Among the myriad applications of genomics in medicine, this book depicts a glimpse of the advances achieved that have been leading us to the personalized/precision medicine era.

Download or read book Fast Facts Endometrial Cancer written by Sarah J. Kitson and published by Karger Medical and Scientific Publishers. This book was released on 2022-11-30 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometrial cancer (EC) is the most common cancer of the uterus and the only gynecologic malignancy that is increasing in incidence and mortality. Early-stage EC generally has a good prognosis but 5-year survival is poor for those with advanced-stage disease or recurrent disease. This resource provides the latest information on epidemiology, risk factors and diagnosis, including the implications of Lynch syndrome in younger women, and the latest thinking on classification, grading, staging and prognostic risk groups, made possible by major advances in the molecular characterization of EC. The therapeutic implications of these advances are still being discovered and here we outline the latest evidence-based therapies and management of the disease. Table of Contents: • Epidemiology and risk factors • Diagnosis • Grading, staging and prognosis • Molecular characterization • Treatment of early-stage disease • Management of advanced and recurrent disease • Research directions

Download or read book Cancer Principles and Practice of Oncology Handbook of Clinical Cancer Genetics written by Ellen Matloff and published by Lippincott Williams & Wilkins. This book was released on 2013-03-25 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, user-friendly guidebook will allow the clinician to search under disease site for the hereditary cancer syndromes relevant for his/her patient's cancer. For example, a gynecologist oncologist whose patient has ovarian cancer can turn to the Ovary chapter and quickly read a summary of all of the hereditary cancer syndromes that include ovarian cancer. She can learn the questions she should be asking when expanding that patient's personal and family history, which genes are most relevant, whether to refer that patient on for genetic counseling and testing, and how to manage that patient long-term if the patient is mutation positive or negative. The same holds true for the practicing oncologist, surgeon, urologist, endocrinologist, gynecologist, primary care physician, physician's assistant, advanced practice nurse and any other clinician seeing a patient who has had cancer. This guidebook also contains an overview article on genetic counseling and testing and several in depth articles on issues that are up and coming in the field of hereditary cancer.