Download or read book Mechanistic Investigation of Trifunctional Organocatalysts for the Aza Morita Baylis Hillman Reaction written by Ryan Thomas Kenny and published by . This book was released on 2014 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aza-Morita-Baylis-Hillman (aza-MBH) reaction couples an activated alkene with an imine using a phosphine or amine catalyst. In this work, a series of trifunctional organocatalysts and their corresponding ketones were synthesized, tested and characterised by NMR spectroscopy.
Download or read book Mechanistic Investigations of the Counterion Promoted Trifunctional Organocatalysis of the Asymmetric Aza Morita Baylis Hillman Reaction written by and published by . This book was released on 2011 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MAP based Multifunctional Organocatalysts for Asymmetric Aza and Generic Morita Baylis Hillman Reactions written by Sviatoslav Sergeevich Eliseenko and published by . This book was released on 2016 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: MAP-based trifunctional organocatalysts, containing a phosphine Lewis base, amino Brønsted base, and phenol or N-tosyl Brønsted acid, have demonstrated highly proficient catalysis of asymmetric aza-MBH reactions with an acid additive. The phosphine nucleophile (Lewis base) initiates the aza-MBH reaction by addition to an activated alkene (e.g. MVK). The Brønsted base, activated by the acid additive, in conjunction with the Brønsted acid, promotes the subsequent aldol and proton-transfer elimination steps by H-bonding interactions to provide high rate and enantioselectivity. However, the reaction scope of this catalysis is limited to aza-MBH and not amenable to generic MBH reactions. In order to improve the proficiency and expand the substrate scope, new Brønsted acid motifs, such as substituted phenol, N-tosyl and pyrrole groups, were incorporated into the MAP-structure for testing in aza-MBH and generic MBH reactions. Change of Brønsted acidity in the phenol- and N-tosyl-containing catalysts did not improve on catalytic proficiency while pyrrole-containing catalysts provided the improvement in enantioselectivity in generic MBH reactions.
Download or read book Organic Reaction Mechanisms 2010 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2012-10-10 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2010, the 46th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2010. It details the latest progress in a wide range of classes of organic reaction mechanisms, including reactions of different compounds and acids and their derivatives, oxidation and reduction, aliphatic substitutions, elimination reactions, and molecular rearrangements, to name a few. An experienced team of authors compiled these reviews, ensuring the quality of selection and presentation.
Download or read book Issues in Chemistry and General Chemical Research 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 6582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Chemistry and General Chemical Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemistry and General Chemical Research. The editors have built Issues in Chemistry and General Chemical Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chemistry and General Chemical Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemistry and General Chemical Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Bifunctional Organocatalysis in the Asymmetric Aza Baylis Hillman Reaction written by Pascal Buskens and published by . This book was released on 2006 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sulfur Chemistry written by Xuefeng Jiang and published by Springer Nature. This book was released on 2019-08-28 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Download or read book Organocatalysis written by Manfred Reetz and published by Springer Science & Business Media. This book was released on 2008-05-27 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
Download or read book Proton Transfer Reactions written by E. F. Caldin and published by Springer. This book was released on 2013-11-11 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Green Synthesis of Heterocycles written by Fabio Arico and published by Frontiers Media SA. This book was released on 2020-03-09 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stereoselective Organocatalysis written by Ramon Rios Torres and published by John Wiley & Sons. This book was released on 2013-04-29 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sets forth an important group of environmentally friendly organic reactions With contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (C–C), carbon-nitrogen (C–N), and carbon-halogen (C–X) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the standards of green chemistry. Stereoselective Organocatalysis begins with an historical overview and a review of activation modes in asymmetric organocatalysis. The next group of chapters is organized by bond type, making it easy to find bonds according to their applications. The first of these chapters takes a detailed look at the many routes to C–C bond formation. Next, the book covers: Organocatalytic C–N bond formation C–O bond formation C–X bond formation C–S, C–Se, and C–B bond formation Enantioselective organocatalytic reductions Cascade reactions forming both C–C bonds and C–heteroatom bonds The final chapter is devoted to the use of organocatalysis for the synthesis of natural products. All the chapters in the book are extensively referenced, serving as a gateway to the growing body of original research reports and reviews in the field. Based on the most recent findings and practices in organic synthesis, Stereoselective Organocatalysis equips synthetic chemists with a group of organocatalytic reactions that will help them design green reactions and overcome many challenges in organic synthesis.
Download or read book Comprehensive Organic Reactions in Aqueous Media written by Chao-Jun Li and published by John Wiley & Sons. This book was released on 2007-06-04 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extensive update of the classic reference on organic reactions in water Published almost a decade ago, the first edition has served as the guide for research in this burgeoning field. Due to the cost, safety, efficiency, and environmental friendliness of water as a solvent, there are many new applications in industry and academic laboratories. More than forty percent of this extensively updated second edition covers new reactions. For ease of reference, it is organized by functional groups. A core reference, Comprehensive Organic Reactions in Aqueous Media, Second Edition: * Provides the most comprehensive coverage of aqueous organicreactions available * Covers the basic principles and theory and progresses to applications * Includes alkanes, alkenes, aromatics, electrophilic substitutions, carbonyls, alpha, beta-unsaturated carbonyls, carbon-nitrogen bonds, organic halides, pericyclic reactions, photochemical reactions, click chemistry, and multi-step syntheses? * Provides examples of applications in industry This is the premier reference for chemists and chemical engineers in industry or research, as well as for students in advanced-level courses.
Download or read book Lewis Base Catalysis in Organic Synthesis written by Edwin Vedejs and published by John Wiley & Sons. This book was released on 2016-08-03 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Download or read book Anion Binding Catalysis written by Olga Garcia-Mancheno and published by John Wiley & Sons. This book was released on 2022-03-21 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores the potential of new types of anion-binding catalysts to solve challenging synthetic problems Anion-Binding Catalysis introduces readers to the use of anion-binding processes in catalytic chemical activation, exploring how this approach can contribute to the future design of novel synthetic transformations. Featuring contributions by world-renowned scientists in the field, this authoritative volume describes the structure, properties, and catalytic applications of anions as well as synthetic applications and practical analytical methods. In-depth chapters are organized by type of catalyst rather than reaction type, providing readers with an accessible overview of the existing classes of effective catalysts. The authors discuss the use of halogens as counteranions, the combination of (thio)urea and squaramide-based anion-binding with other types of organocatalysis, anion-binding catalysis by pnictogen and tetrel bonding, nucleophilic co-catalysis, anion-binding catalysis by pnictogen and tetrel bonding, and more. Helping readers appreciate and evaluate the potential of anion-binding catalysis, this timely book: Illustrates the historical development, activation mode, and importance of anion-binding in chemical catalysis Explains the analytic methods used to determine the anion-binding affinity of the catalysts Describes catalytic and synthetic applications of common NH- and OH-based hydrogen-donor catalysts as well as C-H triazole/triazolium catalysts Covers amino-catalysis involving enamine, dienamine, or iminium activation approaches Discusses new trends in the field of anion-binding catalysis, such as the combination of anion-binding with other types of catalysis Presenting the current state of the field as well as the synthetic potential of anion-binding catalysis in future, Anion-Binding Catalysis is essential reading for researchers in both academia and industry involved in organic synthesis, homogeneous catalysis, and pharmaceutical chemistry.
Download or read book Axially Chiral Compounds written by Bin Tan and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.
Download or read book Comprehensive Enantioselective Organocatalysis written by Peter I. Dalko and published by Wiley-VCH. This book was released on 2013-12-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications. Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.
Download or read book Dienamine Catalysis for Organic Synthesis written by Kengadarane Anebouselvy and published by Royal Society of Chemistry. This book was released on 2018-03-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade a new era in asymmetric catalysis has been realised by the discovery of L-proline induced chiral enamines from carbonyls. Inspired by this, researchers have developed many other primary catalytic species in situ, more recently secondary catalytic species such as aminals have been identified for use in asymmetric synthesis. High-yielding asymmetric synthesis of bioactive and natural products through mild catalysis is an efficient approach in reaction engineering. In the early days, synthetic chemists mainly focused on the synthesis of complex molecules, with less attention on the reaction efficiency and eco-friendly conditions. Recent investigations have been directed towards the development of atom economy, eco-friendly and enantioselective synthesis for more targeted and efficient synthesis. Building on the momentum of this rapidly expanding research area, Dienamine catalysis for organic synthesis will provide a comprehensive introduction, from the preformed species, in situ generation and onto their applications in the synthesis of bioactive molecules and natural products.
