Download or read book Mechanisms of Shear Stress induced Atherosclerotic Plaque Regression written by Stefania Simeone and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Background Differences in shear stress form the basis of the differences in atherosclerosis predilection. Plaques form in regions of low, oscillating flow, whereas vessels exposed to high, steady shear stress tend to remain lesion-free due to the release of protective factors from the endothelial layer, primarily nitric oxide. While progressing plaques are characterized by the persistent entry of immune cells in the vascular wall, regressing plaques are characterized by 2 key features, effective emigration and efferocytosis of these immune cells. We hypothesize that shear stress reverses atherosclerosis by promoting macrophage exit from plaque (emigration) and more efficient uptake of cellular debris (efferocytosis). Methods In vivo: The arteriovenous fistula (AVF) is a surgical model established in the laboratory, whereby the right carotid artery is anastomosed into the right jugular vein, creating an arterio-venous shunt. We studied atherosclerotic plaques in the brachiocephalic artery (BCA), the plaque-prone vessel that links the aorta with the right carotid artery. Low density lipoprotein receptor (LDLR) knockout (KO) mice were placed on a high-fat diet. Sham and AVF surgery was performed at week 12 and mice were kept on a high-fat diet for a further 4 weeks (week 16). Control mice were sacrificed at week 12. In vitro: Endothelial cells (ECs) were co-cultured with macrophages in a shear stress cone system wherein ECs were exposed to high or low shear stress and macrophages were exposed to the EC effluent. Results The AVF procedure increases the shear stress in the BCA but does not alter serum lipid levels. Using this AVF model in mice, we found that elevated shear stress can reverse the atherosclerotic process, reducing plaque size. This increased shear stress also leads to decreased necrotic core size, increased matrix metalloproteinase (MMP) activity, increased MMP-9 expression and decreased collagen IV in addition to increased macrophage migration. MMP or endothelial nitric oxide synthase inhibition abolished shear stress-induced plaque regression. MMP inhibition also decreases macrophage migration with specific MMP-9 inhibition having the same effect. Using the in vitro shear stress co-culture apparatus to mimic the plaque environment, we found that uptake of apoptotic cells by macrophages was higher in the high shear conditions with MMP inhibition having no effect. However, a cytokine array on the co-culture effluent revealed a potential role for specific cytokines. Conclusions Our findings suggest that not only is shear stress protective against plaque development but it can effectively reverse the atherosclerotic process without interfering with plasma lipid levels. Shear stress acting on ECs may influence the cells within the plaque by increasing macrophage mobility and efferocytosis, the combination of which likely leads to plaque regression. These results and future work will help us further identify the molecular mechanisms that cause the atheroprotective effects of shear stress, in hopes of identifying new therapeutic targets for the treatment of atherosclerosis and cardiovascular diseases. " --

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Download or read book Elucidating the Anti Inflammatory Roles of Heparin and Shear Stress in Atherosclerosis written by Joshua B. Slee and published by . This book was released on 2014 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis, an inflammatory disease characterized by the hardening of the arteries and often attributed to poor life style choices, is the leading cause of death in the United States, Europe, and most of Asia. This disease is caused by injury to the arterial wall, causing an inflammatory response which can become misregulated, and over the lifetime of an individual can lead to plaque formation. Hallmarks of atherosclerotic plaque formation include the proliferation and migration of vascular smooth muscle cells (VSMCs) to the injured site in the arterial wall and endothelial cell dysfunction, both of which contribute to plaque formation. In an attempt to control this unwarranted inflammation and cellular proliferation, heparin has been studied because of its anti-inflammatory and anti-proliferative effects. Unfortunately, the mechanisms by which heparin induces these effects are not well understood. In this study, experiments aimed at identification of a receptor for heparin furthered the understanding of the signaling mechanisms underlying heparin's anti-inflammatory and anti-proliferative effects. To gain a better understanding of the underlying signaling cascade induced by heparin, various gene expression analyses were performed in heparin-treated VSMCs. While heparin is one of the major signals opposing vascular disease progression, other signals including laminar shear stress also provide similar opposing actions. Along with investigation of heparin signaling, experiments demonstrating a role for cofilin in actin remodeling during laminar shear stress have been completed. Cofilin, a member of the Actin Depolymerizing Factor family of proteins, is an actin severing protein which promotes actin depolymerization from the actin minus end when cofilin is unphosphorylated. This work also underscored the importance of cofilin and actin realignment in shear stress-induced endothelial barrier integrity. The culmination of this work has unveiled a deeper understanding of the molecular mechanisms underlying atherosclerosis and the anti-inflammatory effects of heparin and laminar shear stress.

Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.

Download or read book Fundamentals of Vascular Biology written by Margarethe Geiger and published by Springer. This book was released on 2019-05-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-structured textbook offers essential knowledge on the vascular system. The reader will learn the properties, basic cellular mechanisms and development of the different parts of the vascular system (including the heart), gain knowledge on vascular and related diseases, and will be made familiar with common and most current methods and techniques applied to analyze the vascular system in patients, in animal models, and ex vivo. This book is based on a PhD Course for students from various bioscientific backgrounds given at the Medical University of Vienna, and it will be a valuable resource for Master ́s Students in vascular biology and biomedicine in general and a helpful tool for young researchers world-wide wishing to gain or refresh their knowledge in this field.

Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Download or read book PanVascular Medicine written by Peter Lanzer and published by Springer. This book was released on 2015-03-30 with total page 5004 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

Download or read book Atherosclerosis written by Luigi Gianturco and published by BoD – Books on Demand. This book was released on 2018-08-01 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis is a subject of enormous contention for cardiologists and in general for all medical doctors. With this publication we have given you a concise "state-of-the-art" look at the world of atheroma. Many other elements could be included and so it is only a brief analysis of "today" (the preventive medicine era) and "tomorrow" (transforming the cure medicine era into the care medicine era) but also remembering "yesterday" (the ex-cathedra medicine era). Let's hope our arteries are free from atherosclerotic events: have a good read!

Download or read book Coronary Angioscopy written by Kyoichi Mizuno and published by Springer. This book was released on 2015-07-03 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough review of coronary angioscopy, ranging from instructions on its use to the latest advances. Starting with the structure and fundamental principles of angioscopy, it shows readers how to apply the image to comprehensive care of coronary-artery patients. Plentiful color photos and illustrations will enable readers to investigate and classify plaques and thrombi and to evaluate coronary stent- and drug-based therapies. The authors are leading researchers on angioscopy. This book offers the perfect guide not only for new clinicians but also for cardiologists who have already adopted this technique for medical examination and treatment. Angioscopy is a unique medical technique for visualizing the interior of blood vessels and helps physicians not only to diagnose the pathology but also to measure the effectiveness of Percutaneous coronary intervention (PCI) or antiarteriosclerotic drugs. Furthermore, the recently developed molecular angioscopy approach allows us to observe Low-density lipoprotein (LDL) oxide, collagen, and macrophages, and is rapidly growing in importance.

Download or read book Cardiovascular Mathematics written by Luca Formaggia and published by Springer Science & Business Media. This book was released on 2010-06-27 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Download or read book Physiologic and Pathologic Angiogenesis written by Dan Simionescu and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Download or read book Nanoengineering of Biomaterials written by Sougata Jana and published by John Wiley & Sons. This book was released on 2022-04-18 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.

Download or read book The Vulnerable Plaque Second Edition written by Ron Waksman and published by CRC Press. This book was released on 2007-06-13 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventional cardiologists treating vulnerable patients by providing the physician with comprehensive insight into the world of the vulnerable plaque.

Download or read book Stress and Cardiovascular Disease written by Paul Hjemdahl and published by Springer Science & Business Media. This book was released on 2011-10-01 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main aim of this book is to evaluate the concept of stress and provide tools for physicians to identify patients who might benefit from stress management. This will incorporate a detailed description of the physiological and pathophysiological consequences of acute and chronic stress that might lead to cardiovascular disease. The book will aim to critically evaluate interventional research (behavioural and other therapies) and provide evidence based recommendations on how to manage stress in the cardiovascular patient. Our intentions are to define and highlight stress as an etiological factor for cardiovascular disease, and to describe an evidence based "tool box" that physicians may use to identify and manage patients in whom stress may be an important contributing factor for their disease and their risk of suffering cardiovascular complications.

Download or read book Bioresorbable Scaffolds written by Yoshinobu Onuma and published by CRC Press. This book was released on 2017-10-02 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the coronary bioresorbable scaffold, a new interventional treatment for coronary artery disease, differentiated from a permanent metallic stent. The book provides an overview of the technology including non-clinical studies and clinical evidences in order to help clinicians understand the appropriate application of the technology and the optimal techniques of implantation. It covers the basics of bioresorbable scaffolds; bench test results; preclinical studies; clinical evidences; and tips and tricks of implantation.

Download or read book Dental Caries written by Zhou Xuedong and published by Springer. This book was released on 2015-10-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a well-illustrated and comprehensive guide to the etiology, clinical manifestations, diagnosis, clinical management and prevention of dental caries. Current challenging problems in the field are analyzed and the latest research findings, presented. After an introductory chapter on tooth development, the relationships of biofilm and saliva to dental caries and the significance of the balance between demineralization and remineralization for the development of carious lesions are discussed. Subsequent chapters address the state of the art in diagnosis and treatment, the implications of disease burden for prevention and the association between systemic diseases and dental caries. Dental Caries: Principles and Management is intended for dental school students, practicing dentists and researchers in dentistry.