Download or read book Mechanisms of Selenomethionine and Hypersaline Developmental Toxicity in Japanese Medaka Oryzias Latipes written by Allison Justine Kupsco and published by . This book was released on 2016 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selenium toxicity to oviparous vertebrates is often attributed to selenomethionine (SeMet), which can maternally transfer to developing embryos. The mechanism of SeMet toxicity is unclear. Furthermore, salinity of fresh waterways is increasing due to climate change and anthropogenic disturbance. Hypersalinity can potentiate SeMet toxicity to Japanese medaka (Oryzias latipes). The current study aimed to characterize the molecular mechanisms of SeMet and hypersalinity at sensitive developmental stages. Developmental toxicity of seawater was compared to desalination brine (DSB) and artificial water based on the San Joaquin River (SJR), CA. DSB toxicity was equal to seawater, while SJR water was the most toxic to embryos and larvae. Flavin-containing monooxygenases (FMOs) initiate SeMet toxicity and are induced by hypersalinity. However, developmental expression and regulation of FMOs in fish are unknown. Five putative medaka FMOs were identified with differential developmental mRNA expression patterns: two FMOs increased during mid-organogenesis; two FMOs decreased beginning at early organogenesis; and one FMO remained constant. Promoter analysis indicated regulation by developmental factors and the UPR. Treatments with UPR-inducer tunicamycin increased expression of two FMOs. In contrast, dithiothreitol inhibited the UPR and three FMOs, suggesting that FMOs are differentially regulated by the UPR. The developmental stage sensitivity of medaka embryos to SeMet was investigated in freshwater and SJR water. Stages 9-25 were most sensitive to SeMet; and hypersalinity potentiated SeMet toxicity during the onset of liver organogenesis, osmoregulation, and chondrogenesis. The mechanisms behind the potentiation of SeMet toxicity by hypersalinity indicated no involvement of oxidative stress or apoptosis; however, results suggested a role for the unfolded protein response (UPR) when animals were treated with 50[Mu]M SeMet for 12hrs. Mechanisms of SeMet-induced spinal deformities (5[Mu]M and 2.5[Mu]M for 24hrs) were further elucidated using imaging methods and showed increased oxidative stress and apoptosis in tails of embryos with spinal malformations. Gene expression analysis demonstrated a UPR activation pattern unique from UPR positive controls. Furthermore, these effects prematurely repressed chondrogenesis and induced osteogenesis. Overall, results will be useful for the risk assessment of hypersalinity and Se under hypersaline conditions; and inform studies on developmental mechanisms of toxicity.

Download or read book Advances in Water Purification Techniques written by Satinder Ahuja and published by Elsevier. This book was released on 2018-11-29 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Water Purification Techniques: Meeting the Needs of Developed and Developing Countries provides a variety of approaches to water purification that can help assist readers with their research and applications. Water contamination problems occur frequently worldwide, hence the most updated knowledge on water purification systems can be helpful in employing the right type of filter or other mechanism of decontamination. The problems with arsenic contamination of water in Bangladesh and the lead problem in Flint, Michigan remind us of the need to monitor water pollution rigorously, from both point and non-point sources. Provides a valuable resource on how to solve water contamination problems or develop new approaches to water purification Presents advanced methods for monitoring water contamination Describes various approaches to water purification Encourages new developments in water purification techniques Includes methods for assessing and monitoring environmental contaminants Covers recent advancement in molecular techniques

Download or read book Japanese Medaka Oryzias Latipes Embryo Assay for Developmental Toxicity Incorporating Individual Embryo Incubations written by Christine Gettys Hull and published by . This book was released on 1993 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medaka written by Kiyoshi Naruse and published by Springer Science & Business Media. This book was released on 2011-05-30 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

Download or read book The Toxicology of Fishes written by Richard T. Di Giulio and published by CRC Press. This book was released on 2008-02-25 with total page 1102 pages. Available in PDF, EPUB and Kindle. Book excerpt: When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on

Download or read book Ecological Assessment of Selenium in the Aquatic Environment written by Peter M. Chapman and published by CRC Press. This book was released on 2010-05-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the work and contributions of 46 scientists, managers, and policymakers, Ecological Assessment of Selenium in the Aquatic Environment documents the state of the science and explores how to use this information when assessing and managing the environmental effects of Se. A focused discussion on the fate and effects of Se in aquatic ecosyste

Download or read book Selenium in Biology and Medicine written by Albrecht Wendel and published by Springer. This book was released on 2011-12-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In July, 1988, more than 300 scientists from 29 different countries gathered at Tiibingen, W. Germany, in order to spend 4 days discussing their favourite trace element, selenium. This meeting continued the good tradition of three previous meetings held in Corvallis/Oregon, 1976, in Lubbock/Texas, 1980, and in Beijing/China, in 1984. Incidentally, the University of Tiibingen provided a unique historical background for a Symposium devoted to recent advances in biochemistry, pharmacology, human nutrition and human health; here, the first independent depart ment of Physiological Chemistry in Germany was founded in 1845. Pro fessor H9Ppe-Seyler elucidated here the hemin structure and his student Friedrich Miescher discovered the nucleic acids. This book contains one-half of the oral or poster presentations which were selected before the meeting was held on the basis of a one page abstract. It is the reader who will have to decide whether this time consuming policy of quality assessment was warranted or not.

Download or read book Asia Pacific Conference on Science and Management of Coastal Environment written by Yuk-Shan Wong and published by Springer Science & Business Media. This book was released on 1997-11-30 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human beings have a long historical relationship with the coast. Initially it provided food and security, later forming important locations for industrial and commercial development. Now the emphasis has shifted towards leisure and conservation, although the former functions remain crucial. However, it is only very recently that people have started viewing the coast as a common and valuable resource that requires rational utilisation and scientific management in order to sustain its attractiveness. Of course, enlightened management comes only through understanding of the complicated coastal regions, which enables coastal managers to balance pressures from different sectors and to minimize risks. Scientific knowledge will continue to be the most important basis for resolving the conflicts between coastal users and interest groups such as developers and ecologists. Coastal management has also shifted from traditional restorative or remedial actions towards planned avoidance of other conflicts. Despite rapid advancement in coastal sciences over recent decades, most of the major coastal issues have remained outstanding in the agenda. Control of shoreline erosion and protecting sea level rise continue to be crucial problems facing coastal scientists. Destructive coastal storms still cause tremendous damage, particularly in low altitudes. Wetland and estuary reclamation have led to the loss of the most valuable estuary wetlands which are required to sustain biological productivity and biodiversity. This volume includes papers on marine and coastal pollution, eutrophication, aquaculture, conservation and utilization, coastal wetlands, and coastal zone management.

Download or read book Methods in Reproductive Aquaculture written by Elsa Cabrita and published by CRC Press. This book was released on 2008-08-22 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The large amount of information on fish reproduction available is not always readily accessible to all interested parties. Written to appeal to aquaculturalists, conservation managers, and scientific researchers, Methods in Reproductive Aquaculture provides an overview of available techniques and addresses ways to improve depleted stocks of endange

Download or read book The Unfolded Protein Response written by Roberto Pérez Torrado and published by . This book was released on 2022 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Natural Compounds as Drugs Volume II written by Frank Petersen and published by Springer Science & Business Media. This book was released on 2008-07-29 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.

Download or read book Environmental Contaminants Ecological Implications and Management written by Ram Naresh Bharagava and published by Springer. This book was released on 2019-11-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: As we know, rapid industrialization is a serious concern in the context of a healthy environment. Various physico-chemical and biological approaches for the removal of toxic pollutants are available, but unfortunately these are not very effective. Biological approaches using microorganisms (bacterial/fungi/algae), green plants or their enzymes to degrade/detoxify environmental contaminants such as endocrine disrupting chemicals, toxic metals, pesticides, dyes, petroleum hydrocarbons and phenolic compounds are eco-friendly and low cost. This book provides a much-needed, comprehensive overview of the various types of contaminants, their toxicological effects on the environment, humans, animals and plants as well as various eco-friendly approaches for their management (degradation/detoxification). As such it is a valuable resource for a wide range of students, scientists and researchers in microbiology, biotechnology, environmental sciences.

Download or read book Desalination written by Mohammad Hossein Davood Abadi Farahani and published by BoD – Books on Demand. This book was released on 2020-07-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Undoubtedly, drinking water of an acceptable quality has become a scarce commodity. Water shortage is becoming a major concern all around the world due to limited freshwater resources as well as the high cost of freshwater transportation from freshwater-rich areas to arid areas. As a result, solutions such as water recycling and desalination of saline or brackish water are being introduced and emerging worldwide as alternative ways of supplying water. Desalination of seawater is known to be one of mankind’s earliest forms of water treatment, and it has become one of the most sustainable alternative solutions to provide freshwater for many communities and industrial sectors. This book aims to cover the challenges and opportunities in desalination processes.

Download or read book Fish Physiology Homeostasis and Toxicology of Essential Metals written by and published by Academic Press. This book was released on 2011-08-11 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. The companion volume, Homeostasis and Toxicology of Non-Essential Metals, Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers. All major essential metals of interest are covered in metal-specific chapters Each metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metal A common format is featured throughout this two volume edition

Download or read book Social Learning written by William Hoppitt and published by Princeton University Press. This book was released on 2013-07-21 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many animals, including humans, acquire valuable skills and knowledge by copying others. Scientists refer to this as social learning. It is one of the most exciting and rapidly developing areas of behavioral research and sits at the interface of many academic disciplines, including biology, experimental psychology, economics, and cognitive neuroscience. Social Learning provides a comprehensive, practical guide to the research methods of this important emerging field. William Hoppitt and Kevin N. Lala define the mechanisms thought to underlie social learning and demonstrate how to distinguish them experimentally in the laboratory. They present techniques for detecting and quantifying social learning in nature, including statistical modeling of the spatial distribution of behavior traits. They also describe the latest theory and empirical findings on social learning strategies, and introduce readers to mathematical methods and models used in the study of cultural evolution. This book is an indispensable tool for researchers and an essential primer for students. Provides a comprehensive, practical guide to social learning research Combines theoretical and empirical approaches Describes techniques for the laboratory and the field Covers social learning mechanisms and strategies, statistical modeling techniques for field data, mathematical modeling of cultural evolution, and more

Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...

Download or read book Functional Genomics in Aquaculture written by Marco Saroglia and published by John Wiley & Sons. This book was released on 2012-05-25 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics has revolutionized biological research over the course of the last two decades. Genome maps of key agricultural species have offered increased understanding of the structure, organization, and evolution of animal genomes. Building upon this foundation, researchers are now emphasizing research on genome function. Published with the World Aquaculture Society, Functional Genomics in Aquaculture looks at the advances in this field as they directly relate to key traits and species in aquaculture production. Functional Genomics in Aquaculture opens with two chapters that provide a useful general introduction to the field of functional genomics. The second section of the book focuses on key production traits such as growth, development, reproduction, nutrition, and physiological response to stress and diseases. The final five chapters focus on a variety of key aquaculture species. Examples looking at our understanding of the functional genomes of salmonids, Mediterranean sea bass, Atlantic cod, catfish, shrimp, and molluscs, are included in the book. Providing valuable insights and discoveries into the functional genomes of finfish and shellfish species, Functional Genomics in Aquaculture, will be an invaluable resource to researchers and professionals in aquaculture, genetics, and animal science.