Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Download or read book Multiple Sclerosis Therapeutics written by Richard Rudick and published by CRC Press. This book was released on 1999-09-01 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.

Download or read book Experimental Models of Multiple Sclerosis written by Ehud Lavi and published by Springer Science & Business Media. This book was released on 2008-01-03 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

Download or read book Optic Nerve Disorders written by Jane W. Chan and published by Springer. This book was released on 2014-07-16 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optic Nerve Disorders: Diagnosis and Management, Second Edition, is a thoroughly revised and updated reference, including new information on diagnostic techniques such as genetic testing for hereditary optic neuropathies, new data on toxic/drug-related optic neuropathies and recent data from clinical trial studies. Additional novel therapies, including stem cell therapies, the use of nanotechnology and gene therapies are featured highlights, as is spectral domain optical coherence tomography (OCT) for imaging of the optic nerve. The way in which OCT is used in differentiating optic nerve disorders from other retinal disorders and how OCT is used in monitoring the course of the disease, is also discussed. This practical reference focuses on common optic nerve disorders. It addresses diagnosis, pathophysiology, management and prognosis and is written in a clear, concise style for quick, easy reference in the clinic. With additional color photographs to better illustrate the material, the second edition will prove to be the go-to reference for ophthalmologists, neurologists and neurosurgeons working with optic nerve disorders.

Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer. This book was released on 2016-12-22 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

Download or read book McAlpine s Multiple Sclerosis written by Alastair Compston and published by . This book was released on 1998 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.

Download or read book Medical Imaging in Clinical Trials written by Colin G. Miller and published by Springer Science & Business Media. This book was released on 2014-01-30 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years the use of medical imaging has increased exponentially in routine clinical practice. This has been reflected in a rapidly increasing use of medical imaging in clinical trials, through all phases. More recently this has culminated in a number of inter-disciplinary meetings with the various stake holders, including the FDA. Changes in the regulatory process has resulted, when it comes to the submission of data to the FDA, in a therapeutic agent where one or more of the trial end-points is the assessment of a radiological end-point. No longer is it sufficient to have the images read by the local investigator site. The FDA has also identified Medical Imaging as one of the key 6 points in the Critical Path initiative which was launched in 2004. This puts a keen focus on the role of imaging and the need to clearly identify and understand this aspect of clinical trials. As the pharmaceutical, biotech and medical device industry continues to identify ways to improve and speed up product development, medical imaging plays a more significant role. An understanding of the methodology and the metrics is therefore required but difficult to ascertain in one easy to read volume for individuals entering this field. This book will therefore fulfill this void, be it for the pharmaceutical personnel from medical director to monitor, or the Principal Investigator who is having to understand the complexities of the imaging and why it is having to be sent off-site for a 'central read.'

Download or read book Nutrition and Lifestyle in Neurological Autoimmune Diseases written by Ronald Ross Watson and published by Academic Press. This book was released on 2016-12-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis discusses important discoveries relating to the types of, and efficacy of, nutritional and lifestyle responses to symptoms and reoccurrence of MS. Each chapter defines a new approach to use in foods, dietary supplements, exercise, behavior, and/or lifestyle in health promotion and symptoms management for MS. This book presents the role of non-pharmaceutical approaches and is essential reading for neurologists, physicians, nurses, nutritionists, dietitians, healthcare professionals, research scientists, biochemists, and general practitioners. - Presents a comprehensive overview that details the role of nutrition and exercise in Multiple Sclerosis - Written for researchers and clinicians in neurology, neuroscience, and exercise and nutrition - Defines a new approach that focuses on foods, dietary supplements, exercise, behavior, and lifestyle in health promotion and symptoms management for MS

Download or read book Quality of Fresh and Processed Foods written by Fereidoon Shahidi and published by Springer Science & Business Media. This book was released on 2003-12-31 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quality is a composite term encompassing many characteristics of foods. These include color, aroma, texture, general nutrition, shelf-life, stability, and possible presence of undesirable constituents. Obviously deterioration of quality may lead to changes in the attributes that characterize the food in its fresh or freshly processed state. In addition, quality enhancement of products may be carried out using appropriate processing techniques. Interaction of different components present with one another could have a profound effect on sensory quality of products. Meanwhile, presence of extraneous matter such as pesticides and debris may also contribute to a compromise in the quality of foods. In addition, processing often brings about changes in many attributes of food including its nutritional value. Thus, examination of process-induced changes in food products is important. In this book, a cursory account of quality attributes of fresh and processed foods is provided. The book is of interest to food scientists, nutritionists and biochemists in academia, government and industry.

Download or read book The Wahls Protocol written by Terry Wahls M.D. and published by Penguin. This book was released on 2014-03-13 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrative approach to healing chronic autoimmune conditions by a doctor, researcher, and sufferer of progressive multiple sclerosis (MS) whose TEDx talk is already a web sensation Like many physicians, Dr. Terry Wahls focused on treating her patients’ ailments with drugs or surgical procedures—until she was diagnosed with multiple sclerosis (MS) in 2000. Within three years, her back and stomach muscles had weakened to the point where she needed a tilt-recline wheelchair. Conventional medical treatments were failing her, and she feared that she would be bedridden for the rest of her life. Dr. Wahls began studying the latest research on autoimmune disease and brain biology, and decided to get her vitamins, minerals, antioxidants, and essential fatty acids from the food she ate rather than pills and supplements. Dr. Wahl’s adopted the nutrient-rich paleo diet, gradually refining and integrating it into a regimen of neuromuscular stimulation. First, she walked slowly, then steadily, and then she biked eighteen miles in a single day. In November 2011, Dr. Wahls shared her remarkable recovery in a TEDx talk that immediately went viral. Now, in The Wahls Protocol, she shares the details of the protocol that allowed her to reverse many of her symptoms, get back to her life, and embark on a new mission: to share the Wahls Protocol with others suffering from the ravages of multiple sclerosis and other autoimmune conditions.

Download or read book Sex Differences in Cardiovascular Physiology and Pathophysiology written by Babbette LaMarca and published by Academic Press. This book was released on 2019-04-11 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women.

Download or read book The Growth Hormone Insulin Like Growth Factor Axis during Development written by Isabel Varela-Nieto and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.

Download or read book Molecular Neurosurgery with Targeted Toxins written by Ronald G. Wiley and published by Springer Science & Business Media. This book was released on 2007-10-10 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Download or read book Suppression and Regulation of Immune Responses written by Maria Cristina Cuturi and published by Humana. This book was released on 2015-11-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume expands upon the previous edition with new research and objectives in immunoregulation and immune tolerance. Chapters cover topics ranging from new molecular and cellular mechanisms of tolerance; generation and characterization of mice regulatory macrophages; recent advances in the treatment of immune-mediated inflammatory disorders; and novel mechanisms and therapeutic perspectives on food allergies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II is a great resource for current research and inspiration for new studies in immune tolerance.

Download or read book Electrophoresis Immunofixation written by Najat Rashid and published by Jaypee Brothers,Medical Publishers Pvt. Limited. This book was released on 2013-06-30 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunofixation electrophoresis is the process of separating proteins in the blood (serum) or urine using an electric current to move them across a thin layer of gel. It is used to identify the presence or absence of abnormal proteins and to detect, diagnose and monitor the course and treatment of conditions associated with these proteins, including multiple myeloma and other related diseases. (Lab Test Online UK). This manual guides practitioners through the technique and interpretation of immunofixation electrophoresis. Beginning with an introduction, the book provides a step by step description of the techniques, instruments, electrophoresis patterns and their interpretation, stains used, and diseases that may be diagnosed with this process. More than 200 full colour images and illustrations enhance learning. Key points Step by step guide to immunofixation electrophoresis Describes different methods and their interpretation Covers diseases that may be diagnosed using electrophoresis, including multiple myeloma Includes more than 200 full colour images and illustrations

Download or read book Myelin Repair and Neuroprotection in Multiple Sclerosis written by Ian D. Duncan and published by Springer Science & Business Media. This book was released on 2012-08-31 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.