Download or read book Mechanisms of Conditional Fear Extinction in Mice written by Christopher Kenneth Cain and published by . This book was released on 2004 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Download or read book Obsessive compulsive Disorder written by Christopher Pittenger and published by Oxford University Press. This book was released on 2017 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications.
Download or read book Fear Extinction written by Mohammed R. Milad and published by Springer Nature. This book was released on 2023-11-16 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears. The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.
Download or read book Unsupervised Feature Extraction Applied to Bioinformatics written by Y-h. Taguchi and published by Springer Nature. This book was released on 2019-08-23 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes applications of tensor decomposition to unsupervised feature extraction and feature selection. The author posits that although supervised methods including deep learning have become popular, unsupervised methods have their own advantages. He argues that this is the case because unsupervised methods are easy to learn since tensor decomposition is a conventional linear methodology. This book starts from very basic linear algebra and reaches the cutting edge methodologies applied to difficult situations when there are many features (variables) while only small number of samples are available. The author includes advanced descriptions about tensor decomposition including Tucker decomposition using high order singular value decomposition as well as higher order orthogonal iteration, and train tenor decomposition. The author concludes by showing unsupervised methods and their application to a wide range of topics. Allows readers to analyze data sets with small samples and many features; Provides a fast algorithm, based upon linear algebra, to analyze big data; Includes several applications to multi-view data analyses, with a focus on bioinformatics.
Download or read book Mechanisms of Memory written by J. David Sweatt and published by Academic Press. This book was released on 2009-09-28 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader's understanding. - More than 25% new content, particularly expanding the scope to include new findings in translational research. - Unique in its depth of coverage of molecular and cellular mechanisms - Extensive cross-referencing to Comprehensive Learning and Memory - Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
Download or read book Encyclopedia of Psychopharmacology written by Ian Stolerman and published by Springer Science & Business Media. This book was released on 2010-07-31 with total page 1433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Download or read book The Social Transmission of Associative Fear in Rats written by Carolyn Eagan Jones and published by . This book was released on 2015 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pairing a neutral cue (e.g., a tone) with an inherently aversive unconditioned stimulus (US; e.g., a foot-shock) leads to future presentations of the now conditioned stimulus (CS) alone eliciting a conditioned response (e.g., freezing). This direct associative learning is only one technique under which individuals can learn about potential threats, but its convenient design and the robust production of responses makes direct fear conditioning the most frequently used paradigm in the research of fear and anxiety disorders. Fear can also be acquired from a social context, such as through observing the fear expression of a conspecific (Mineka et al., 1984, Mineka and Cook, 1993, Olsson et al., 2007, Olsson and Phelps, 2007). Utilizing a modified demonstrator-observer paradigm (fear conditioning by proxy) that allows for free interaction between subjects (see Bruchey et al., 2010; Jones et al., 2014), I explore the ability of rats to learn an associative fear response vicariously. In the experiments presented here, I (i) investigate the subject traits that bias rats to engage a social learning strategy; (ii) examine the neural mechanisms involved in this form of observational learning; and (iii) demonstrate how this paradigm can be incorporated into translationally-relevant tests of long term behavioral deficits resulting from early life trauma, in line with the health goals of the fear learning field in general (e.g., fear reduction). My results indicate that the identity of demonstrator animals as well as prior experience of the observer contributes to the expression of fear acquired vicariously. Additionally, I show that the social behaviors of caged rats are indicators of a social dominance hierarchy and are predictors of the potency of social fear transmission. This method of fear learning conserves some of the pathways necessary for direct fear learning (e.g., lateral amygdala) but is unique in that it requires regions necessary for executive control (e.g., anterior cingulate cortex) making the fear conditioning by proxy paradigm a novel tool for evaluating learning and behavior in the laboratory setting.
Download or read book Understanding Behavior Disorders written by Douglas W. Woods and published by . This book was released on 2007 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because traditional behaviorism overlooked function-altering behavior processes that are critical to understanding many behavior disorders, other theoretical models took the lead in the explanation of pathological human behavior. Current trends in behavior analysis, however, account for these processes, retuning behavior analysis to a strong position in this area of research. This book presents a cogent and comprehensive theory of behavior disorders from a behavior analytic perspective.
Download or read book Extinction Learning from a Mechanistic and Systems Perspective written by Denise Manahan-Vaughan and published by Frontiers Media SA. This book was released on 2016-08-08 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout their lifetime, animals learn to associate stimuli with their consequences. Following memory acquisition and consolidation, circumstances may arise that necessitate that initially learned behaviour is no longer relevant. The ensuing process is called extinction learning and involves a novel and complex learning procedure that involves a large number of neural entities. While the neural fundaments of the initial acquisition are well studied, our understanding of the behavioural and neural basis of extinction is still limited and derives mostly from rodent data acquired through fear conditioning paradigms. Fear conditioning and extinction in rodents is a spectacularly successful paradigm within behavioral neuroscience. However, in recent years, new approaches have been emerging that examine the mechanisms of extinction learning in different setting that also involve appetitive models, a broader comparative perspective, a focus on other brain systems, an examination of hormonal factors, and conditioning of immune responses. Only a broader analysis of the neural fundaments of extinction learning will finally uncover shared and distinct mechanisms that underlie extinction learning in different functional systems. The papers compiled in this Research Topic offer new and valuable insights into the mechanisms and functional implementation of extinction learning at its different levels of complexity, and form the basis for new concepts and research ideas in this field.
Download or read book Comprehensive Guide to Post Traumatic Stress Disorders written by Colin R. Martin and published by Springer. This book was released on 2016-06-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an all-embracing reference that offers analyses and discussions of contemporary issues in the field of PTSD. The book brings together scientific material from leading experts in the field relating to a wide range of important current topics across disciplines. These include the early identification of PTSD and subsequent treatment, to social and behavioral studies, to biochemical, molecular and genetic research. With more than 125 chapters organized in 12 major sections, this is the most complete single resource on PTSD.
Download or read book Contemporary Issues in Modeling Psychopathology written by Michael S. Myslobodsky and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite considerable progress in clinical and basic neurosciences, the cure of psychiatric disorders is still remote, little is known about their prevention, and the etiology and molecular mechanisms of mental disorders are still obscure. Diagnoses are still guided by patients' stories. The mission of animal models is to bridge the gap between `the story and the synapse.' Contemporary Issues in Modeling of Psychopathology attempts to do this by examining such questions as `What good might come from such a model? Are we wasting our time? How far can we carry results from model animals, such as rats and mice, without causing a highly distorted view of the field and its goals?' This book serves as the opening volume for a new series, Neurobiological Foundation of Aberrant Behaviors.
Download or read book The Psychology of Animal Learning written by Nicholas John Mackintosh and published by . This book was released on 1974 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fear and Learning written by Michelle G. Craske and published by American Psychological Association (APA). This book was released on 2006 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The goal of this volume is to bring together the most recent empirical and theoretical developments in the basic science of fear learning and to translate these developments to the clinical understanding and treatment of fears and phobias. A major impetus for the volume was the recognition that basic science in fear learning is advancing far more rapidly than the clinical application of this knowledge. The book is structured to cover three main areas. The first presents the history of fear learning theory and fear measurement. The second area examines the acquisition and maintenance of fear, including neural circuitry, associative pathways, and cognitive mechanisms; the role of avoidance; and individual differences in fear learning. The third area covers the extinction, renewal, and reinstatement of fear, including neural circuitry and context dependency. The volume developed out of the Special Interest Meeting on Fear and Learning in Lignely, Belgium (May 2003), sponsored by the Fund for Scientific Research in Flanders, Belgium, and inspired by Paul Eelen. This volume is intended for both basic scientists and clinical scientists at undergraduate, graduate, and more advanced levels, as well as practicing clinicians who are interested in gaining an in-depth understanding of learning theory as it applies to fear and anxiety"--Preface. (PsycINFO Database Record (c) 2007 APA, all rights reserved)
Download or read book The Amygdala written by Barbara Ferry and published by BoD – Books on Demand. This book was released on 2017-07-05 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amygdala is a central component of the limbic system, which is known to play a critical role in emotional processing of learning and memory. Over these last 20 years, major advances in techniques for examining brain activity greatly helped the scientific community to determine the nature of the contribution of the amygdala to these fundamental aspects of cognition. Combined with new conceptual breakthroughs, research data obtained in animals and humans have also provided major insights into our understanding of the processes by which amygdala dysfunction contributes to various brain disorders, such as autism or Alzheimer's disease. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in the mechanisms underlying emotional learning and memory, we hope it will also help stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.
Download or read book The Effects of Overexpressing CREB in the Lateral Amygdala on the Consolidation of Auditory Fear Extinction Memory written by Huy Tran and published by . This book was released on 2006 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fear extinction refers to the ability of organisms to adapt as circumstances change by learning to inhibit a previously learned fear. This process is characterized by a progressive reduction in the capacity of the CS to elicit fear following repeated presentations of the CS in the absence of an aversive US. Although the process by which fear memories are acquired and consolidated has been extensively studied, little is known about the neural mechanisms underlying fear extinction. One important advance made towards understanding fear extinction derives from studies showing that extinction represents a form of new learning that actively inhibits, rather than erases, the original CS-US association. As such, it is thought that fear extinction usurps similar mechanisms as fear acquisition. Here, we show that mice receiving CREB infusions in the LA exhibit less conditioned fear than GFP controls during an extinction test given 24 hours following training for extinction. In contrast, both groups of mice displayed a similar reduction in conditioned fear in a training session. Collectively, these results support the notion that overexpressing CREB in the LA facilitates the consolidation of extinction learning.
