Download or read book Mechanisms for the Differential Effects of Dietary Fatty Acids and Cholesterol on High Density Lipoprotein HDL and Non high Density Lipoprotein NHDL Metabolism in the Golden Syrian Hamster written by Suzanne Erin Dorfman and published by . This book was released on 2004 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease (CVD) is the leading cause of death and disability in the United States. Its genesis can be attributed, in part, to dietary and lifestyle patterns. Fat in the diet is comprised of different classes of fatty acids: saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), trans, each having characteristic effects on both high density lipoprotein (HDL) and non-HDL [(nHDL) total - HDL cholesterol] cholesterol concentrations. Investigated first was the time course and response of Charles River (CR) and Bio Breeders (F1B) Golden-Syrian hamsters to dietary SFA (butter) on serum lipoproteins and aortic cholesteryl ester in. After 12 weeks, CR hamsters had significantly lower serum total and nHDL cholesterol concentrations, but higher aortic cholesteryl ester deposition than the F1B hamsters (P

Download or read book Effects of Dietary Fat and Cholesterol on High Density Lipoprotein Metabolism in Humans and Golden Syrian Hamsters written by Young-Shin Ahn and published by . This book was released on 1993 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effects of Dietary Protein and Fat on Cholesterol Metabolism in the Golden Syrian Hamster written by Nathalie Goyette and published by . This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lipids in Human Nutrition written by Germain J. Brisson and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout its history, medicine has benefited from scientific discov eries made in complementary fields such as chemistry, physics and biology. Thus, in the middle of the last century, the works of Pasteur, a chemist and biologist, by revealing the world of micro-organisms, bacteria and viruses, made it possible to control a considerable number of often fatal diseases. Guided by the work of this inspired biologist, the English surgeon, Sir Joseph Lister, developed aseptic techniques which have rendered possible the spectacular achievements of modern surgery. It is largely due to such advances that the life-expectancy of man, 50 years at the turn of the century (1900), approaches 75 years in 1981. Even today, however, in spite of this, two groups of ailments, arter iosclerosis and cancer, are responsible for 70 per cent of human deaths both in Canada and in the United States of America. The former is a degenerative process of the arterial system, the latter an uncontrolled and destructive cellular proliferation. Although several predisposing factors are known, the essential cause of these conditions is wholly unknown. As long as this ignorance of the etiology persists, all forms of therapy can be no more than palliative.

Download or read book The Effect of Long Chain Saturated Fatty Acids 12 0 14 0 16 0 18 0 on Hepatic Cholesterol Metabolism written by Jeong-Sook Lee Kim and published by . This book was released on 1997 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Determinants of Cholesterol and Lipoprotein Metabolism as Influenced by Dietary Fatty Acid Profile and Cholesterol Status in the F1B Golden Syrian Hamster written by Jaime Lynn Lecker and published by . This book was released on 2008 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanisms by which Dietary Fatty Acids Regulate Human Low Density Lipoprotein Metabolism written by Stephen Charles Rumsey and published by . This book was released on 1993 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dietary Proteins Cholesterol Metabolism and Atherosclerosis written by Michihiro Sugano and published by S. Karger AG (Switzerland). This book was released on 1990 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzes the effects of dietary animal, vegetable and fish proteins on serum cholesterol levels in animal models and humans. Explores the possible mechanisms which have been advanced to date and reports the results of original research inquiries.

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Polyunsaturated Fatty Acids in Metabolic Phenotypes and Genetic Associations with Cardiovascular Health written by Carmen Arrington and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart disease continues to be the leading cause of death in the United States, killing about 695,000 people in 2021, ahead of cancer and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)1. In the United States, the average annual direct and indirect cost of cardiovascular disease (CVD) was an estimated $378.0 billion in 2017-2018; the estimated direct costs have more than doubled in the last two decades2. Fatty acids (FAs), which can be obtained exogenously through the diet or produced endogenously through de novo lipogenesis (DNL), play a critical role in heart health by helping maintain lipid balance and regulate inflammatory processes. FAs can be oxygenated to produce oxylipins which are bioactive, act as lipid mediators, and are thought to be a potential explanation for the diverse effects of polyunsaturated FAs (PUFAs)3, 4. FA and oxylipin synthesis are highly regulated processes in which genes exert substantial influence. Genetic variation contributes to the activity and efficiency of enzymes responsible for FA and oxylipin metabolism as well as the functionality of receptors specific to FAs and oxylipins. The field of precision nutrition has developed to understand how one's diet and their genes interact to affect the way the body responds to food. This dissertation aims to address how a person's genes affect the way the body responds to food, specifically fats and FAs, to provide individualized nutrition guidance in CVD prevention and treatment. In Study 1, we explore the pivotal role of free fatty acid receptor 4 (FFAR4 (human); Ffar4 (mouse)) in the context of myocardial infarction (MI), focusing particularly on its impact on the early oxylipin response to cardiac ischemia/reperfusion (I/R) injury. Previous research has established the relevance of Ffar4 in metabolic and inflammatory pathways and found cardiac function improves 7 days after ischemic insult, prompting an in-depth analysis of the complex milieu of cardiac ischemia. To unravel the intricate connections, a murine model was employed, subjecting mice to cardiac ischemia followed by only 3 days of reperfusion while scrutinizing the influence of Ffar4 on oxylipin dynamics. The study was designed to meticulously assess the response to I/R injury, unraveling gene- and sex-specific variations in the oxylipin response. Additionally, to bridge the translational gap, the analysis extended to the UK Biobank (UKB) cohort. This human component aimed to elucidate the association of FFAR4 single nucleotide polymorphisms (SNPs) with MI and ischemic CVDs. The murine experimentation uncovered a Ffar4-dependent response, particularly concerning LA-derived oxylipins, to I/R injury. While animals with systemic deletion of Ffar4 had higher LA alcohols and epoxides than wildtype prior to injury, I/R injury ablated the differences in oxylipin profile. Sex-specific differences also emerged from the analysis, shedding light on distinct molecular mechanisms operating in male and female mice. However, the human analysis found FFAR4-dependent higher risk for stroke in women; no other FFAR4-dependent differences in disease incidence were found which may suggest genetic variation is not the cause of downstream differences due implicating FFAR4. In essence, this research underscores the intricate involvement of FFAR4 in the oxylipin responses to cardiac ischemia. The study provides valuable insights into potential sex-specific mechanisms of oxylipin response while acknowledging the inherent disparities between murine and human response to cardiovascular (CV) challenges. These complexities emphasize the multifaceted role of the FFAR4 in CVD. In Study 2, we investigate substrate competition between saturated FAs (SFAs) and PUFAs as ligands for FFAR4 and the downstream impact on metabolic outcomes, specifically related to metabolic syndrome (MetSyn), MI, and death. The study utilizes data from the UKB cohort including various demographic and health-related variables as well as FA measurements. The statistical methods involve linear regression models and Cox-proportional hazard models to explore the relationships between SFAs and PUFAs, as well as their interaction on MetSyn risk factors, MI, and death. The study reveals that the association of PUFAs with lower triglycerides (TG), higher high-density lipoprotein cholesterol (HDL-c), lower waist circumference (WC), and lower blood pressure (BP) depends on the levels of SFAs. Unexpectedly, when stratified by PUFA level higher SFAs are associated with metabolically beneficial outcomes, contrary to common perceptions. The study also uncovers differences by racial/ethnic group membership, showing distinct responses to SFAs and PUFAs among White, Black, and Asian participants. The findings challenge the simplistic view that reducing SFAs and increasing PUFAs uniformly benefit metabolic health. Instead, the findings suggest that individual differences in participant characteristics, including in racial/ethnic group membership, play a crucial role in how SFAs and PUFAs influence metabolic outcomes. A more nuanced approach to dietary recommendations that considers the intricate interplay between specific FAs and their impact on diverse populations may allow researchers to better address the risks for CVD. In Study 3, we focus on the fatty acid desaturase (FADS) genes, which play a regulatory role in PUFA metabolism. The FADS genes (FADS1 and FADS2) have two major haplotypes (haplotype D and haplotype A) which vary in prevalence across populations. Functional analyses indicate that haplotype D is more efficient in synthesis of longer chain PUFA in both the omega-3 ([omega]3) and omega-6 ([omega]6) pathways. The study specifically examines variant rs174547 in FADS1 as a proxy for the FADS genes. This variant has been associated with CV health outcomes leading to the hypothesis that 1) the association between FADS and lipid outcomes depends on FAs (moderation) and 2) the effect of FADS on outcomes occurs through FAs (mediation). The analysis uses the UKB dataset to explore the interplay between FADS and FAs on lipid outcomes including total cholesterol (TC), HDL-c, low-density lipoprotein cholesterol (LDL-c), and TGs. The research employs a statistical framework to quantify the extent to which FAs mediate or moderate the relationship between FADS and lipid biomarkers. Results reveal evidence of moderation and/or mediation (or suppression) effects. For instance, out of the 28 tests of moderation, 19 models have evidence that a FA modifies the effect of FADS on lipid outcomes. Additionally, there are 12 models with evidence of mediation; for example, DHA acts as a mediator for the association between FADS and HDL-c, indicating that the influence of FADS on HDL-c is explained by the level of DHA, and non-LA [omega]6-PUFA suppresses the association between FADS and LDL-c. The study provides valuable insights into the complex interactions between FADS, FAs, and CV health. By analyzing FADS as a case study, the research demonstrates an analytical framework that can be applied to understand similar relationships in other genetic contexts. The findings underscore the need to consider individual variations in FA metabolism to optimize dietary recommendations for CV health. Collectively, this research sheds light on the multifaceted interplay between PUFAs, genetic factors, and CV health. The conditional associations based on FA profiles emphasize the potential for dietary modifications to address health disparities rooted in individual genotypes, as well as social and environmental factors. These findings challenge broad dietary recommendations and advocate for a more personalized approach to disease prevention and treatment strategies. The implications extend beyond CV health, prompting a reevaluation of how individualized nutrition guidance can be integrated into broader public health initiatives.

Download or read book Lipoproteins in Diabetes Mellitus written by Alicia J. Jenkins and published by Springer Science & Business Media. This book was released on 2014-01-08 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin-signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.

Download or read book Introduction to Food Toxicology written by Takayuki Shibamoto and published by Academic Press. This book was released on 2012-12-02 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of food toxicology currently has a high profile of interest in the food industry, universities, and government agencies, and is certainly of great concern to consumers. There are many books which cover selected toxins in foods (such as plant toxins, mycotoxins, pesticides, or heavy metals), but this book represents the first pedagogic treatment of the entire range of toxic compounds found naturally in foods or introduced by industrial contamination or food processing methods. Featuring coverage of areas of vital concern to consumers, such as toxicological implications of food adulteration (as seen in ethylene glycol in wines or the Spanish olive oil disaster) or pesticide residues, Introduction to Food Toxicology will be of interest to students in toxicology, environmental studies, and dietetics as well as anyone interested in food sources and public health issues. The number of students who are interested in toxicology has increased dramatically in the past several years. Issues related to toxic materials have received more and more attention from the public. The issues and potential problems are reported almost daily by the mass media, including television, newspapers, and magazines. Major misunderstandings and confusion raised by those reports are generally due to lack of basic knowledge about toxicology among consumers. This textbook provides the basic principles of food toxicology in order to help the general public better understand the real problems of toxic materials in foods. - Principles of toxicology - Toxicities of chemicals found in foods - Occurrence of natural toxins in plant and animal foodstuffs - Food contamination caused by industry - Toxic chemicals related to food processing - Food additives - Microbial toxins in foods

Download or read book Dorland s Dictionary of Medical Acronyms and Abbreviations written by Dorland and published by Elsevier Health Sciences. This book was released on 2015-07-24 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical acronyms and abbreviations offer convenience, but those countless shortcuts can often be confusing. Now a part of the popular Dorland's suite of products, this reference features thousands of terms from across various medical specialties. Its alphabetical arrangement makes for quick reference, and expanded coverage of symbols ensures they are easier to find. Effective communication plays an important role in all medical settings, so turn to this trusted volume for nearly any medical abbreviation you might encounter. - Symbols section makes it easier to locate unusual or seldom-used symbols. - Convenient alphabetical format allows you to find the entry you need more intuitively. - More than 90,000 entries and definitions. - Many new and updated entries including terminology in expanding specialties, such as Nursing; Physical, Occupational, and Speech Therapies; Transcription and Coding; Computer and Technical Fields. - New section on abbreviations to avoid, including Joint Commission abbreviations that are not to be used. - Incorporates updates suggested by the Institute for Safe Medication Practices (ISMP).

Download or read book Dictionary of Medical Acronyms and Abbreviations written by Stanley Jablonski and published by Hanley & Belfus. This book was released on 2004-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dictionary lists acronyms and abbreviations occurring with a reasonable frequency in the literature of medicine and the health care professions. Abbreviations and acronyms are given in capital letters, with no punctuation, and with concise definitions. The beginning sections also include symbols, genetic symbols, and the Greek alphabet and symbols.

Download or read book America s National Game written by Albert Goodwill Spalding and published by . This book was released on 1911 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is Albert Spaldings work of "historic facts concerning the beginning, evolution, development and popularity of base ball, with personal reminiscences of its vicissitudes, its victories and its votaries." It is one of the defining books in the early formative years of modern baseball.

Download or read book Yvain written by Chretien de Troyes and published by Yale University Press. This book was released on 1987-09-10 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A twelfth-century poem by the creator of the Arthurian romance describes the courageous exploits and triumphs of a brave lord who tries to win back his deserted wife's love

Download or read book Galactic Pot healer written by Philip K. Dick and published by Vintage. This book was released on 1994 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: What could an omnipresent and seemingly omnipotent entity want with a humble pot-healer? Or with the dozens of other odd creatures it has lured to Plowman's Planet? And if the Glimmung is a god, are its ends positive or malign? Combining quixotic adventure, spine-chilling horror, and deliriously paranoid theology, Galactic Pot-Healer is a uniquely Dickian voyage to alternate worlds of the imagination.