Download or read book Mechanical Properties of Collagen based Scaffolds for Tissue Regeneration written by Biraja Prasad Kanungo and published by . This book was released on 2009 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: (cont.) The mechanical properties were lower for the more highly mineralized scaffolds as a result of an increase in the number of defects such as cracked and disconnected walls. Next, we attempted to increase the mechanical properties by increasing the relative density of the MCG scaffolds. The volume fraction of solids in the slurry was increased by a vacuum-filtration technique. The slurry was then freeze-dried in the conventional manner to produce scaffolds with increased relative densities. Increasing the relative density by a factor of 3 increased the dry Young's modulus and crushing strength roughly by 9 and 7 times, respectively, allowing the dry scaffolds to withstand hard thumb pressure. The Young's modulus for the densest scaffold in the hydrated state was in the optimum range for MSC to differentiate into bone cells. Further, we attempted to improve the mechanical properties of the CG scaffold using the same technique. We were able to achieve an increase in its tensile Young's modulus in the dry state by a factor of aboutl0 times. Finally, the fraction of MC3T3 cells attaching to the CG scaffolds was found to increase linearly with the specific surface area of the scaffold, or with the number of binding sites available for cell attachment.
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Materials Engineering for Enhanced Tissue Scaffold Mechanical Properties written by Jason W. Drexler and published by . This book was released on 2010 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: As the body's natural scaffolding is largely comprised of collagen, a significant amount of research is being conducted focused on how to engineer collagen scaffolds with properties identical to natively derived collagen. A major benefit of utilizing collagen as the source material for tissue engineering scaffolds is its bioactive chemistry and ability to support cell attachment and growth. Currently, the only commercially successful tissue engineered product, Apligraf®, utilized a collagen scaffolds to form temporary skin. Despite the benefits of collagen-based tissue engineering scaffolds, many challenges are associated with the use of these materials including low strength, low stiffness and long processing times.
Download or read book Manipulating the Mechanical Strength and Biological Stability of Collagen based Scaffolds for Tissue Engineering written by Grahame Busby and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen, the most abundant structural protein in the body, has become the most widely used matrix for tissue engineering. Implanted collagen undergoes a constant process of remodelling, and it is the balance of collagen synthesis and its gradual breakdown by the cells of the body that will determine its strength and effectiveness as a scaffold. It has been shown that collagen for implantation is degraded more quickly than cells are able to synthesise new collagen, resulting in a rapid reduction in matrix strength. The collagen is broken down by tissue/cell derived collagenases, which are members of the matrix metalloproteinase (MMP) family of enzymes. Angiotensin converting enzyme (ACE) inhibitors have long been used successfully to treat hypertension. More recently, some ACE inhibitors have also been shown to inhibit certain MMPs. The purpose of this thesis was to investigate the potential of the ACE inhibitors captopril and enalapril to inhibit enzymatic collagen degradation, and ultimately slow down the rate at which collagen is degraded by cells of the body. Both captopril and enalapril were shown to inhibit enzymatic collagen degradation in a dose-dependent manner, at concentrations that are non-toxic to cells in culture. To determine whether the ACE inhibitors were able to affect the mechanical properties of fibroblast-populated collagen lattices (FPCLs), a technique was developed for the characterisation of their time-dependent properties. The technique, which facilitates estimation of the stiffness and hydraulic permeability of hydrogel samples via confined compression and biphasic theory, may also be suitable for characterising other inherently weak hydrated tissues, and therefore may be of great value to anyone interested in doing so. Having demonstrated that the technique was sensitive to small variations in collagen content, it was used to compare the mechanical properties of FPCLs, where it was shown that FPCLs treated with captopril or enalapril were stiffer than control FPCLs after 6 days in culture. It seems likely that the retention of matrix stiffness is attributable to a reduction in the rate of substrate degradation by collagenolytic enzymes, which in turn can be attributed to their inhibition by the ACE inhibitors, though the mechanism of inhibition is still not fully understood. The potential to manipulate the strength and stability of collagen implants by treating them with ACE inhibitors has major implications throughout the fields of tissue engineering, regenerative medicine and cosmetic surgery.
Download or read book Tissue Engineering and Regenerative Medicine written by Phuc Van Pham and published by Springer. This book was released on 2019-08-14 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.
Download or read book Cutting Edge Enabling Technologies for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.
Download or read book Orthopedic Biomaterials written by Bingyun Li and published by Springer. This book was released on 2018-03-22 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest advances, applications, and challenges in orthopedic biomaterials. Topics covered include materials for orthopedic applications, including nanomaterials, biomimetic materials, calcium phosphates, polymers, biodegradable metals, bone grafts/implants, and biomaterial-mediated drug delivery. Absorbable orthopedic biomaterials and challenges related to orthopedic biomaterials are covered in detail. This is an ideal book for graduate and undergraduate students, researchers, and professionals working with orthopedic biomaterials and tissue engineering. This book also: Describes biodegradable metals for orthopedic applications, such as Zn-based medical implants Thoroughly covers various materials for orthopedic applications, including absorbable orthopedic biomaterials with a focus on polymers Details the state-of-the-art research on orthopedic nanomaterials and nanotechnology
Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Download or read book Tissue Repair written by Xiaoming Li and published by Springer. This book was released on 2017-06-15 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the effective reinforcement of scaffolds by means of different kinds of fibers and tubes to meet different needs in the context of tissue repair. It covers the fabrication of the reinforced scaffolds, the factors influencing their properties, and their applications for hard and soft tissue repair. Further, it presents a range of concrete examples, case studies and research frontiers, providing readers a better understanding of how the respective fibers or tubes influence the mechanical properties, biodegradability, biocompatibility and bioactivity of scaffolds, and how they fulfill specific medical requirements. As such, the book provides a valuable and informative resource for researchers, technicians and students in the fields of biomaterials, tissue engineering and regenerative medicine.
Download or read book In Situ Tissue Regeneration written by Sang Jin Lee and published by Academic Press. This book was released on 2016-07-17 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
Download or read book Development and Validation of a Collagen based Scaffold for Vascular Tissue Engineering electronic Resource written by Habermehl, Jason and published by Québec : Université Laval. This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellulose Based Superabsorbent Hydrogels written by Md. Ibrahim H. Mondal and published by Springer. This book was released on 2019-02-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the prospect of revolutionizing specific technologies, this book highlights the most exciting and impactful current research in the fields of cellulose-based superabsorbent hydrogels with their smart applications. The book assembles the newest synthetic routes, characterization methods, and applications in the emergent area. Leading experts in the field have contributed chapters representative of their most recent research results, shedding light on the enormous potential of this field and thoroughly presenting cellulose-based hydrogel functioning materials. The book is intended for the polymer chemists, academic and industrial scientists and engineers, pharmaceutical and biomedical scientists and agricultural engineers engaged in research and development on absorbency, absorbent products and superabsorbent hydrogels. It can also be supportive for undergraduate and graduate students.
Download or read book A Collagen Based Scaffold for the Repair of Annulus Fibrosus Defects written by Leonide Camile Saad and published by . This book was released on 2007 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) However, there was no significant improvement in the gross morphology of the disc. The results of this thesis recommend the use of an autologous AF cell-seeded type II collagen scaffold in the perspective of regeneration of defects of the annulus fibrosus. Future animal experiments should aim at locating the cells in the implant, evaluate the mechanical properties of the regenerated tissue and compare AF cells to stem cells that are easier to be harvested.
Download or read book Tissue Regeneration written by Hussein Abdelhay Essayed Kaoud and published by BoD – Books on Demand. This book was released on 2018-06-06 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).
Download or read book Biopolymer Composites in Electronics written by Kishor Kumar Sadasivuni and published by Elsevier. This book was released on 2016-09-10 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymer Composites in Electronics examines the current state-of-the-art in the electronic application based on biopolymer composites. Covering the synthesis, dispersion of fillers, characterization and fabrication of the composite materials, the book will help materials scientists and engineers address the challenges posed by the increased use of biopolymeric materials in electronic applications. The influence of preparation techniques on the generation of micro, meso, and nanoscale fillers, and the effect of filler size and dispersion on various biopolymers are discussed in detail. Applications covered include sensors, actuators, optics, fuel cells, photovoltaics, dielectrics, electromagnetic shielding, piezoelectrics, flexible displays, and microwave absorbers. In addition, characterization techniques are discussed and compared, enabling scientists and engineers to make the correct choice of technique. This book is a ‘one-stop’ reference for researchers, covering the entire state-of-the-art in biopolymer electronics. Written by a collection of expert worldwide contributors from industry, academia, government, and private research institutions, it is an outstanding reference for researchers in the field of biopolymer composites for advanced technologies. Enables researchers to keep up with the rapid development of biopolymer electronics, which offer light, flexible, and more cost-effective alternatives to conventional materials of solar cells, light-emitting diodes, and transistors Includes thorough coverage of the physics and chemistry behind biopolymer composites, helping readers to become rapidly acquainted with the fiel Provides in-depth information on the range of biopolymer applications in electronics, from printed flexible conductors and novel semiconductor components, to intelligent labels, large area displays, and solar panels
Download or read book Cardiac Tissue Engineering written by Milica Radisic and published by Humana Press. This book was released on 2014-07-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.
Download or read book Physical Properties and Cell Interactions of Collagen based Scaffolds and Films for Use in Myocardial Tissue Engineering written by Chloe Natasha Grover and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
