Download or read book Measures of Interobserver Agreement and Reliability written by Mohamed M. Shoukri and published by CRC Press. This book was released on 2010-12-14 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Measures of Interobserver Agreement and Reliability, Second Edition covers important issues related to the design and analysis of reliability and agreement studies. It examines factors affecting the degree of measurement errors in reliability generalization studies and characteristics influencing the process of diagnosing each subject in a reliabil

Download or read book Measures of Interobserver Agreement and Reliability Second Edition written by Mohamed M. Shoukri and published by CRC Press. This book was released on 2010-12-14 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Measures of Interobserver Agreement and Reliability, Second Edition covers important issues related to the design and analysis of reliability and agreement studies. It examines factors affecting the degree of measurement errors in reliability generalization studies and characteristics influencing the process of diagnosing each subject in a reliability study. The book also illustrates the importance of blinding and random selection of subjects. New to the Second Edition New chapter that describes various models for methods comparison studies New chapter on the analysis of reproducibility using the within-subjects coefficient of variation Emphasis on the definition of the subjects’ and raters’ population as well as sample size determination This edition continues to offer guidance on how to run sound reliability and agreement studies in clinical settings and other types of investigations. The author explores two ways of producing one pooled estimate of agreement from several centers: a fixed-effect approach and a random sample of centers using a simple meta-analytic approach. The text includes end-of-chapter exercises as well as a CD-ROM of data sets and SAS code.

Download or read book Measures of Interobserver Agreement and Reliability written by Mohamed M. Shoukri and published by CRC Press. This book was released on 2003-07-28 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Agreement among at least two evaluators is an issue of prime importance to statisticians, clinicians, epidemiologists, psychologists, and many other scientists. Measuring interobserver agreement is a method used to evaluate inconsistencies in findings from different evaluators who collect the same or similar information. Highlighting applications o

Download or read book Measures of Interobserver Agreement written by Mohamed M. Shoukri and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Observational Measurement of Behavior written by Paul Yoder, PhD and published by Springer Publishing Company. This book was released on 2010-02-16 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yoder and Symons bring decades of work to bear and it shows....[The book is] presented with broad scholarship and conceptual depth." óRoger Bakeman, PhD Professor Emeritus Georgia State University "This outstanding volume transcends the typical treatment of behavior observation methods in introductory research texts. Yoder and Symons articulate a set of measurement principles that serve as the foundation for behavior observation as a scientific tool." óWilliam E. MacLean Jr., PhD Executive Director Wyoming Institute for Disabilities University of Wyoming This comprehensive textbook introduces graduate students to the competent conduct of observational research methods and measurement. The unique approach of this book is that the chapters delineate not only the techniques and mechanics of observational methods, but also the theoretical and conceptual underpinnings of these methods. The observational methods presented can be used for both single-subject and group-design perspectives, showing students how and when to use both methodologies. In addition, the authors provide many practical exercises within chapters as well as electronic media files of a sample observation session to code with multiple behavior sampling methods. Key topics: Improving measurement of generalized characteristics through direct observation and the generalizability theory Developing coding schemes and designing or adapting coding manuals Determining sampling methods and metrics for observational variables Training observers and assessing their agreement Performing sequential analysis on observational data Assessing the validity of observational variables

Download or read book Theory of Drug Development written by Eric B. Holmgren and published by CRC Press. This book was released on 2013-10-24 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying drug development, the book shows how to systematically address problems, such as: Sizing a phase 2 trial and choosing the range of p-values that will trigger a follow-up phase 3 trial Deciding whether a drug should receive marketing approval based on its phase 2/3 development program and recent experience with other drugs in the same clinical area Determining the impact of adaptive designs on the quality of drugs that receive marketing approval Designing a phase 3 pivotal study that permits the data-driven adjustment of the treatment effect estimate Knowing when enough information has been gathered to show that a drug improves the survival time for the whole patient population Drawing on his extensive work as a statistician in the pharmaceutical industry, the author focuses on the efficient development of drugs and the quantification of evidence in drug development. He provides a rationale for underpowered phase 2 trials based on the notion of efficiency, which leads to the identification of an admissible family of phase 2 designs. He also develops a framework for evaluating the strength of evidence generated by clinical trials. This approach is based on the ratio of power to type 1 error and transcends typical Bayesian and frequentist statistical analyses.

Download or read book Applied Meta Analysis with R written by Ding-Geng (Din) Chen and published by CRC Press. This book was released on 2013-05-03 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: In biostatistical research and courses, practitioners and students often lack a thorough understanding of how to apply statistical methods to synthesize biomedical and clinical trial data. Filling this knowledge gap, Applied Meta-Analysis with R shows how to implement statistical meta-analysis methods to real data using R. Drawing on their extensiv

Download or read book Survival Analysis in Medicine and Genetics written by Jialiang Li and published by CRC Press. This book was released on 2013-06-04 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using real data sets throughout, Survival Analysis in Medicine and Genetics introduces the latest methods for analyzing high-dimensional survival data. It provides thorough coverage of recent statistical developments in the medical and genetics fields. The text mainly addresses special concerns of the survival model. After covering the fundamentals, it discusses interval censoring, nonparametric and semiparametric hazard regression, multivariate survival data analysis, the sub-distribution method for competing risks data, the cure rate model, and Bayesian inference methods. The authors then focus on time-dependent diagnostic medicine and high-dimensional genetic data analysis. Many of the methods are illustrated with clinical examples. Emphasizing the applications of survival analysis techniques in genetics, this book presents a statistical framework for burgeoning research in this area and offers a set of established approaches for statistical analysis. It reveals a new way of looking at how predictors are associated with censored survival time and extracts novel statistical genetic methods for censored survival time outcome from the vast amount of research results in genomics.

Download or read book Joint Models for Longitudinal and Time to Event Data written by Dimitris Rizopoulos and published by CRC Press. This book was released on 2012-06-22 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: Wit

Download or read book Applied Surrogate Endpoint Evaluation Methods with SAS and R written by Ariel Alonso and published by CRC Press. This book was released on 2016-11-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.

Download or read book Statistical Design and Analysis of Clinical Trials written by Weichung Joe Shih and published by CRC Press. This book was released on 2015-07-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Design and Analysis of Clinical Trials: Principles and Methods concentrates on the biostatistics component of clinical trials. Developed from the authors' courses taught to public health and medical students, residents, and fellows during the past 15 years, the text shows how biostatistics in clinical trials is an integration of many fu

Download or read book Quantitative Methods for HIV AIDS Research written by Cliburn Chan and published by CRC Press. This book was released on 2017-08-07 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research; the second section focuses on the analysis of laboratory data used for immune monitoring, biomarker discovery and vaccine development; the final section focuses on statistical issues in the mathematical modeling of HIV/AIDS pathogenesis, treatment and epidemiology. This book brings together a broad perspective of new quantitative methods in HIV/AIDS research, contributed by statisticians and mathematicians immersed in HIV research, many of whom are current or previous leaders of CFAR quantitative cores. It is the editors’ hope that the work will inspire more statisticians, mathematicians and computer scientists to collaborate and contribute to the interdisciplinary challenges of understanding and addressing the AIDS pandemic.

Download or read book Bayesian Designs for Phase I II Clinical Trials written by Ying Yuan and published by CRC Press. This book was released on 2017-12-19 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.

Download or read book Medical Biostatistics written by Abhaya Indrayan and published by CRC Press. This book was released on 2012-08-07 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedic in breadth, yet practical and concise, Medical Biostatistics, Third Edition focuses on the statistical aspects of medicine with a medical perspective, showing the utility of biostatistics as a tool to manage many medical uncertainties. The author concludes "Just as results of medical tests, statistical results can be false negative or

Download or read book Design and Analysis of Bridging Studies written by Jen-pei Liu and published by CRC Press. This book was released on 2012-07-26 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the development of medicines has become more globalized, the geographic variations in the efficacy and safety of pharmaceutical products need to be addressed. To accelerate the product development process and shorten approval time, researchers are beginning to design multiregional trials that incorporate subjects from many countries around the world under the same protocol. Design and Analysis of Bridging Studies addresses the issues arising from bridging studies and multiregional clinical trials. For bridging studies, the book explores ethnic sensitivity, the necessity of bridging studies, types of bridging studies, and the assessment of similarity between regions based on bridging evidence. For multiregional clinical trials, the text considers regional differences, assesses the consistency of treatment effect across regions, and discusses sample size determination for each region. Taking into account the International Conference Harmonisation (ICH) E5 framework for bridging studies, the book provides a unified summary of the growing literature and research activities in this area. It covers the regulatory requirements, scientific and practical issues, and statistical methodology for designing and evaluating bridging studies and multiregional clinical trials, with the goal of inspiring new research activities in the field.

Download or read book Exposure Response Modeling written by Jixian Wang and published by CRC Press. This book was released on 2015-07-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the Latest Statistical Approaches for Modeling Exposure-Response RelationshipsWritten by an applied statistician with extensive practical experience in drug development, Exposure-Response Modeling: Methods and Practical Implementation explores a wide range of topics in exposure-response modeling, from traditional pharmacokinetic-pharmacody

Download or read book Prediction and Recognition of Piracy Efforts Using Collaborative Human Centric Information Systems written by E. Bossé and published by IOS Press. This book was released on 2013-03-21 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maritime piracy is the cause of widespread international concern, and the number of pirate attacks has increased substantially in recent years. Many commercial vessels are inherently vulnerable to attack because of their size and relative slowness, and technological improvements have resulted in smaller crews on large vessels, whilst the absence of enforcement agencies in international waters has served only to make pirates more daring. Collaborative human-centric information support systems can significantly improve the ability of every nation to predict and prevent pirate attacks, or to recognize the nature and size of an attack rapidly when prevention fails, and improve the collective response to an emergency. This book presents the papers delivered at the NATO Advanced Study Institute (ASI) Prediction and Recognition of Piracy Efforts Using Collaborative Human-Centric Information Systems, held in Salamanca, Spain, in September 2011. A significant observation from previous NATO Advanced Study Institutes and Workshops was that domain experts responsible for maritime security were not fully aware of the wide variety of technological solutions available to enhance their support systems, and that although technology experts have a general understanding of the requirements in security systems, they often lacked knowledge concerning the operational constraints affecting those who implement security procedures. This ASI involved both technology and domain experts, as well as students from related fields of study. It offered an opportunity for them to discuss the issues surrounding the prediction, recognition and deterrence of maritime piracy, and will be of interest to all those whose work is related to this internationally important issue.