Download or read book McIndoo Family History written by Norman Eugene McIndoo and published by . This book was released on 1983 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Census of the City of Charleston South Carolina written by Charleston (S.C.). City Council and published by . This book was released on 1861 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibiotics and Antimicrobial Resistance Genes written by Muhammad Zaffar Hashmi and published by Springer Nature. This book was released on 2020-04-07 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes and updates information about antibiotics and antimicrobial resistance (AMR)/antibiotic resistant genes (ARG) production, including their entry routes in soil, air, water and sediment, their use in hospital and associated waste, global and temporal trends in use and spread of antibiotics, AMR and ARG. Antimicrobial/antibiotic resistance genes due to manure and agricultural waste applications, bioavailability, biomonitoring, and their Epidemiological, ecological and public health effects. The book addresses the antibiotic and AMR/ARG risk assessment and treatment technologies, for managing antibiotics and AMR/ARG impacted environments The book's expert contributions span 20 chapters, and offer a comprehensive framework for better understanding and analyzing the environmental and social impacts of antibiotics and AMR/ARGs. Readers will have access to recent and updated models regarding the interpretation of antibiotics and AMR/ARGs in environment and biomonitoring studies, and will learn about the management options require to appropriately mitigate environmental contaminants and pollution. The book will be of interest to students, teachers, researchers, policy makers and environmental organizations.
Download or read book Gram positive Pathogens written by Vincent A. Fischetti and published by . This book was released on 2000 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the only single volume to deal with all aspects of gram–positive pathogens. It addresses the mechanisms of gram–positive bacterial pathogenicity, including the current knowledge on gram–positive structure and mechanisms of antibiotic resistance. Emphasizing streptococci, staphylococci, listeria, and spore–forming pathogens, Gram–Positive Pathogens includes chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically in an attempt to understand the strategies used by these bacteria to cause human disease.
Download or read book The Churches of Christ in Owen County Indiana written by Alfred Thomas DeGroot and published by . This book was released on 1935 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book History of Fresno County California written by Paul E. Vandor and published by . This book was released on 1919 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Introduction to Single Cell Omics written by Xinghua Pan and published by Frontiers Media SA. This book was released on 2019-09-19 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Single-cell omics is a progressing frontier that stems from the sequencing of the human genome and the development of omics technologies, particularly genomics, transcriptomics, epigenomics and proteomics, but the sensitivity is now improved to single-cell level. The new generation of methodologies, especially the next generation sequencing (NGS) technology, plays a leading role in genomics related fields; however, the conventional techniques of omics require number of cells to be large, usually on the order of millions of cells, which is hardly accessible in some cases. More importantly, harnessing the power of omics technologies and applying those at the single-cell level are crucial since every cell is specific and unique, and almost every cell population in every systems, derived in either vivo or in vitro, is heterogeneous. Deciphering the heterogeneity of the cell population hence becomes critical for recognizing the mechanism and significance of the system. However, without an extensive examination of individual cells, a massive analysis of cell population would only give an average output of the cells, but neglect the differences among cells. Single-cell omics seeks to study a number of individual cells in parallel for their different dimensions of molecular profile on genome-wide scale, providing unprecedented resolution for the interpretation of both the structure and function of an organ, tissue or other system, as well as the interaction (and communication) and dynamics of single cells or subpopulations of cells and their lineages. Importantly single-cell omics enables the identification of a minor subpopulation of cells that may play a critical role in biological process over a dominant subpolulation such as a cancer and a developing organ. It provides an ultra-sensitive tool for us to clarify specific molecular mechanisms and pathways and reveal the nature of cell heterogeneity. Besides, it also empowers the clinical investigation of patients when facing a very low quantity of cell available for analysis, such as noninvasive cancer screening with circulating tumor cells (CTC), noninvasive prenatal diagnostics (NIPD) and preimplantation genetic test (PGT) for in vitro fertilization. Single-cell omics greatly promotes the understanding of life at a more fundamental level, bring vast applications in medicine. Accordingly, single-cell omics is also called as single-cell analysis or single-cell biology. Within only a couple of years, single-cell omics, especially transcriptomic sequencing (scRNA-seq), whole genome and exome sequencing (scWGS, scWES), has become robust and broadly accessible. Besides the existing technologies, recently, multiplexing barcode design and combinatorial indexing technology, in combination with microfluidic platform exampled by Drop-seq, or even being independent of microfluidic platform but using a regular PCR-plate, enable us a greater capacity of single cell analysis, switching from one single cell to thousands of single cells in a single test. The unique molecular identifiers (UMIs) allow the amplification bias among the original molecules to be corrected faithfully, resulting in a reliable quantitative measurement of omics in single cells. Of late, a variety of single-cell epigenomics analyses are becoming sophisticated, particularly single cell chromatin accessibility (scATAC-seq) and CpG methylation profiling (scBS-seq, scRRBS-seq). High resolution single molecular Fluorescence in situ hybridization (smFISH) and its revolutionary versions (ex. seqFISH, MERFISH, and so on), in addition to the spatial transcriptome sequencing, make the native relationship of the individual cells of a tissue to be in 3D or 4D format visually and quantitatively clarified. On the other hand, CRISPR/cas9 editing-based In vivo lineage tracing methods enable dynamic profile of a whole developmental process to be accurately displayed. Multi-omics analysis facilitates the study of multi-dimensional regulation and relationship of different elements of the central dogma in a single cell, as well as permitting a clear dissection of the complicated omics heterogeneity of a system. Last but not the least, the technology, biological noise, sequence dropout, and batch effect bring a huge challenge to the bioinformatics of single cell omics. While significant progress in the data analysis has been made since then, revolutionary theory and algorithm logics for single cell omics are expected. Indeed, single-cell analysis exert considerable impacts on the fields of biological studies, particularly cancers, neuron and neural system, stem cells, embryo development and immune system; other than that, it also tremendously motivates pharmaceutic RD, clinical diagnosis and monitoring, as well as precision medicine. This book hereby summarizes the recent developments and general considerations of single-cell analysis, with a detailed presentation on selected technologies and applications. Starting with the experimental design on single-cell omics, the book then emphasizes the consideration on heterogeneity of cancer and other systems. It also gives an introduction of the basic methods and key facts for bioinformatics analysis. Secondary, this book provides a summary of two types of popular technologies, the fundamental tools on single-cell isolation, and the developments of single cell multi-omics, followed by descriptions of FISH technologies, though other popular technologies are not covered here due to the fact that they are intensively described here and there recently. Finally, the book illustrates an elastomer-based integrated fluidic circuit that allows a connection between single cell functional studies combining stimulation, response, imaging and measurement, and corresponding single cell sequencing. This is a model system for single cell functional genomics. In addition, it reports a pipeline for single-cell proteomics with an analysis of the early development of Xenopus embryo, a single-cell qRT-PCR application that defined the subpopulations related to cell cycling, and a new method for synergistic assembly of single cell genome with sequencing of amplification product by phi29 DNA polymerase. Due to the tremendous progresses of single-cell omics in recent years, the topics covered here are incomplete, but each individual topic is excellently addressed, significantly interesting and beneficial to scientists working in or affiliated with this field.
Download or read book Life Threatening Dermatoses and Emergencies in Dermatology written by Jean Revuz and published by Springer Science & Business Media. This book was released on 2009-04-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since extensive dermatoses can be life threatening, it is important to recognize and treat skin emergencies rapidly. This book covers all cutaneous emergencies and life threatening dermatoses, as well as true and false emergencies in the dermatologic office. It provides treatment advice for the management of major life threatening dermatoses, such as severe infections, severe drug eruptions and bullous diseases. In addition, it describes the manifestations in acutely ill patients in the ICU, as well as severe cutaneous manifestations occurring during pregnancy, after sun exposure, in cold weather, as a result of extreme poverty, and in other situations. With diagnostic clues, reader-friendly charts and clinical photographs, this clinical guide will not only benefit the hospital-based dermatologist, but will also be a helpful guide for non-dermatologists, such as ER and ICU physicians.
Download or read book Midland 125 Cemetery Project written by and published by Midland, Ont. : D. Ladouceur. This book was released on 2004 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Death Finds a Way written by Lorine McGinnis Schulze and published by . This book was released on 2016-05-25 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Janie Riley is an avid genealogist with a habit of stumbling on to dead bodies. With her husband Steven, Janie heads to Salt Lake City Utah to track down her elusive fourth great-grandmother. But her search into the past leads her to more than she bargained for. Her discovery of a dark secret brings her closer to danger. Can she solve the mysteries of the past and the present, and untangle a web of lies before disaster strikes?
Download or read book The Brown Duvel Moisture Tester and how to Operate it written by Roy Ralph Graves and published by . This book was released on 1928 with total page 1084 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Intratumor Diversity and Clonal Evolution in Cancer written by David Gisselsson and published by Academic Press. This book was released on 2011-09-29 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise
Download or read book Complexities 1 written by Jean-Pierre Briffaut and published by John Wiley & Sons. This book was released on 2024-01-11 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complexity is not a new issue. In fact, in their day, William of Ockham and René Descartes proposed what can best be described as reductionist methods for dealing with it. Over the course of the twentieth century, a science of complexity has emerged in an ever-increasing number of fields (computer science, artificial intelligence, engineering, among others), and has now become an integral part of everyday life. As a result, everyone is confronted with increasingly complex situations that need to be understood and analyzed from a global perspective, to ensure the sustainability of our common future. Complexities 1 analyzes how complexity is understood and dealt with in the fields of cybersecurity, medicine, mathematics and information. This broad spectrum of disciplines shows that all fields of knowledge are challenged by complexity. The following volume, Complexities 2, examines the social sciences and humanities in relation to complexity.
Download or read book A Selected Guide to the Literature of the Flowering Plants of Mexico written by Ida Kaplan Langman and published by University of Pennsylvania Press. This book was released on 2018-01-09 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: This bibliography is a guide to the literature on Mexican flowering plants, beginning with the days of the discovery and conquest of Mexico by the Spaniards in the early sixteenth century.
Download or read book The Valley s Legends Legacies written by Catherine Morison Rehart and published by Quill Driver Books. This book was released on 1996 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: A community without knowledge of its history is like a man without knowledge of his soul. Catherine Morison Rehart's captivating vignettes extend to all of us an invitation to learn something of California's Central Valley history. It is here in Rehart's near near-magical journey through time that we are privileged to view the sacrifices and successes, the toils and triumphs of those who preceded us, each contributing his or her measure to the legacy of this extraordinary place. In Legends & Legacies, a five volume series, Rehart sojourns at the wellspring of local history, chronicling with warmth and affection the intriguing, exciting, humorous, and poignant stories of the vibrant, colorful Valley inhabitants who created the legends and bestowed the legacies on those of us who now roam the same cherished ground.
Download or read book American Bee Journal written by and published by . This book was released on 1915 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes summarized reports of many bee-keeper associations.
Download or read book Hutchinson s Washington and Georgetown Directory written by and published by . This book was released on 1920 with total page 2054 pages. Available in PDF, EPUB and Kindle. Book excerpt:
