Download or read book Matrix Metalloproteinases and Tissue Remodeling in Health and Disease Cardiovascular Remodeling written by and published by Academic Press. This book was released on 2017-04-14 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling, Volume 147 contains up-to-date information on the biology and function of matrix metalloproteinases and how their effects on tissue remodeling are altered in diseases of the cardiovascular, pulmonary, and musculoskeletal systems and in other tissues and organs, and in cancer. This latest release covers such highly evolving topics as Biochemical and Biological Attributes of Matrix Metalloproteinases, Matrix Metalloproteinases in Myocardial Infarction and Heart Failure, The Balance Between Metalloproteinases and TIMPs: Critical Regulator of Microvascular Endothelial Cell Function in Health and Disease, and Matrix Metalloproteinases and Platelet Function. As part of the Progress in Molecular Biology and Translational Science, users will find contributions from prominent scientists and highly-recognized experts who have major accomplishments in the research field of matrix metalloproteinases. Focuses on matrix metalloproteinases and their role in tissue remodeling under physiological and pathological conditions Contains up-to-date information on matrix metalloproteinases that is clearly presented in a concise fashion with helpful illustrations and supporting references Includes comprehensive reviews written by prominent scientists and highly-recognized experts in the field of matrix metalloproteinases and tissue remodeling

Download or read book Matrix Metalloproteinases and Tissue Remodeling in Health and Disease Target Tissues and Therapy written by and published by Academic Press. This book was released on 2017-06-26 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Volume, Volume 148, the latest volume in the Progress in Molecular Biology and Translational Science series covers a variety of timely topics, with chapters focusing on The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs, Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target, Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy, Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia, and Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology. This volume is the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease. It focuses on the role of MMPs in other systems, target tissues, and pathological disorders and the potential benefits of MMP inhibitors in various disorders. Serves as the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease Focuses on cardiovascular remodeling Contains contributions from leading authorities on the topics Publishes cutting-edge reviews in molecular biology

Download or read book Mechanisms of Cardiac Remodeling and Failure microform Role of the Tissue Inhibitor of Matrix Metalloproteinase 3 written by Paul William Michael Fedak and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: TIMPs (tissue inhibitors of metalloproteinases) are complex endogenous biomolecules that contribute to the regulation of tissue architecture and remodeling in both health and disease. Of the four TIMP species, TIMP-3 is unique and its role in the adult heart is undefined. We hypothesized that TIMP-3 plays a key role in initiating, coordinating, and maintaining maladaptive cardiac remodeling in the failing heart. To establish a proof-of-concept that TIMP-3 influences myocardial remodeling and dysfunction, mutant mice lacking TIMP-3 by gene deletion were assessed for altered cardiac structure and function with aging. Cardiomyopathic human and hamster myocardium was similarly assessed for architectural, cellular, and molecular indices of maladaptive remodeling in relation to TIMP-3 expression. The profile of TIMP expression was then assessed in vascular smooth muscle cell-transplanted cardiomyopathic hamster hearts to identify a mechanism through which cell transplantation limits the progression of heart failure. TIMP-3 gene deletion in mice triggered progressive cardiac dilatation and dysfunction consistent with human dilated cardiomyopathy. At the cellular level, loss of TIMP-3 expression resulted in profound cardiac matrix disruption and cell death. At the molecular level, loss of TIMP-3 activated matrix metalloproteinase-9 and the pro-inflammatory TNF-alpha cytokine system. TIMP-3 was reduced in both human and dilated cardiomyopathic hamster myocardium in association with maladaptive cardiac remodeling. In hamster cardiomyopathy, cell transplantation partially restored deficient TIMP-3 and limited maladaptive matrix remodeling. These results suggest that TIMP-3 directly influences matrix homeostasis and cytokine bioactivation in the heart. Altered TIMP-3 expression in the failing heart may directly contribute to maladaptive myocardial tissue remodeling, cardiac dysfunction, and the progression to heart failure. Replacement of deficient TIMP-3 by gene or cell therapy may provide a novel approach to prevent disease progression in patients at risk of heart failure.

Download or read book Cardiac Remodeling written by Bodh I. Jugdutt and published by Springer Science & Business Media. This book was released on 2013-02-15 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

Download or read book Matrix Metalloproteinases in Left Ventricular Remodeling written by Mytsi L. Coker and published by . This book was released on 2000 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Matrix Metalloproteinases in Tissue Remodeling Regeneration and Prostate Cancer written by William Winston Chu and published by . This book was released on 1998 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Metalloproteinases in the Development of Hypertension and Cardiac Remodeling written by Xiang Wang and published by . This book was released on 2013 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite many decades of research and drug development, the diseases of the cardiovascular system remain a major health threat in the modern world. Hypertensive cardiac disease is a cardiovascular condition characterized by the co-occurrence of hypertension and pathological cardiac remodeling (hypertrophy and fibrosis). Causative factors of hypertensive cardiac disease range from environmental stress to metabolic morbidities. However, these detrimental factors have a common effector mechanism: the sustained activation of G protein-coupled receptors (GPCRs) due to pathological levels of cognate agonists which elevate systemic blood pressure and promote pathological cardiovascular remodeling. GPCR agonists can trigger the activation of metalloproteinases, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs). These metalloproteinases are multifunctional enzymes that transactivate many intracellular signaling pathways including those leading to hypertension and cardiac remodeling. Therefore, MMPs and ADAMs have been widely speculated to be potential treatment targets for hypertensive cardiac disease. In the current studies, we use angiotensin II and adrenoceptor ligands as prototypes of GPCR agonists to gain insights into mechanisms of hypertensive heart disease in rodent models. We determine various new roles played by MMP-2, MMP-7, ADAM-12 and ADAM-17. We demonstrate that: 1. MMP-7 mediates GPCR agonist-induced signaling with MMP-7 inhibition by pharmacological blockade, RNA interference or genetic knockout protecting against hypertensive cardiac remodeling. 2. ADAM-17 also contributes to GPCR agonist-induced cardiac hypertrophy and fibrosis. These effects of ADAM-17 are signaledby ADAM-12, a major effector metalloproteinase in cardiac hypertrophy signaling. 3. MMP-2 contributes to the development of GPCR agonist-induced hypertension such that partial blockade of MMP-2 by inhibitors and RNA interference attenuates angiotensin II-induced hypertension. 4. MMP-2 protects against hypertensive cardiac remodeling. To explain the cardioprotection rendered by MMP-2, we evoke a novel mechanism of negative regulation of the sterol-regulatory element binding protein (SREBP)-2 / 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) pathway of cardiac remodeling. These findings are a major contribution to our current understanding of the cardiovascular biology of metalloproteinases. Our data show the diverse roles of metalloproteinases in hypertensive cardiac disease and the potential and limitations of therapeutic approaches based on metalloproteinase inhibition for management of cardiovascular disease.

Download or read book Matrix Metalloproteinases and TIMPs written by J. F. Woessner and published by Oxford University Press on Demand. This book was released on 2000 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: The matrix metalloproteinases (MMPs) are a large family of enzymes that breakdown different components of the extracellular matrix. Their catalytic activity is dependent a metal ion, usually zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this, is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the 4 known classes of TIMP. Matrix metalloproteinases will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPs.

Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Download or read book Cardiovascular Medicine written by James T. Willerson and published by Springer Science & Business Media. This book was released on 2007-12-06 with total page 2877 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease. The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine. The book has consistent chapter organization relevant to modern cardiovascular practice, clear design and engaging text. The reader will have all the guidance to diagnose and manage the full range of cardiovascular conditions in one textbook resource, while also benefiting from access to additional video material from the integral DVD-ROM. This includes over 100 individual heart sounds.

Download or read book Mechanisms of Heart Failure written by Pawan K. Singal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Download or read book Airway Remodeling written by Peter Howarth and published by CRC Press. This book was released on 2001 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias! Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodelingdescribes the contribution of inflammatory cells in the development of airway structural changes examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling reviews the action of cytokines and growth factors on ASM signaling outlines novel approaches to regulating smooth muscle growth clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation and more!Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Download or read book Matrix Metalloproteinases in Health and Disease written by Raffaele Serra and published by . This book was released on 2020-09-11 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual's disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems.

Download or read book Wound Healing written by Vlad Alexandrescu and published by BoD – Books on Demand. This book was released on 2016-10-12 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Outstanding scientific advances over the last decades unceasingly reveal real complexity of wound-healing process, astonishing in its staged progression, as life is unfolding itself. This natural course of tissue repair seems to bear thousands of overlapping molecular and macroscopic processes that nowadays only start to unfold to our knowledge. The present volume collecting recent scientific references proposes to readers a two-folded audacious goal. First, an updated design of intimate cellular mechanisms is entailed in tissue regeneration that emanates from the first section of the book. Next, a multidisciplinary therapeutic perspective that focuses on macroscopic healing throughout the second part of this work adds clinically integrated observation. Practical diagnostic and treatment information is appended in each chapter that may equally help experienced clinicians or dedicated students and researchers in broadening essential breaking points of their work. It is the wish of all multidisciplinary experts who gather prominent author's panel of this volume to incorporate latest medical reports and compel limits of current understanding for better tissue regeneration, limb salvage, and improved quality of life of our patients.

Download or read book Congestive Heart Failure and Cardiac Transplantation written by Daniel J. Garry and published by Springer. This book was released on 2017-06-01 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students.