Download or read book Mathematical modelling and electrophysiological monitoring of the regulation of cochlear amplification written by Greg A. O'Beirne and published by The University of Western Australia. This book was released on 2005-08-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cochlea presumably possesses a number of regulatory mechanisms to maintain cochlear sensitivity in the face of disturbances to its function. Evidence for such mechanisms can be found in the time-course of the recovery of CAP thresholds during experimental manipulations, and in observations of slow oscillations in cochlear micromechanics following exposure to low-frequency tones (the “bounce phenomenon”) and other perturbations. To increase our understanding of the these oscillatory processes within the cochlea, and OHCs in particular, investigations into cochlear regulation were carried out using a combination of mathematical modelling of the ionic and mechanical interactions likely to exist within the OHCs, and electrophysiological experiments conducted in guinea pigs. The electrophysiological experiments consisted of electrocochleographic recordings and, in some cases, measurement of otoacoustic emissions, during a variety of experimental perturbations, including the application of force to the cochlear wall, exposure to very-low-frequency tones, injection of direct current into scala tympani, and intracochlear perfusions of artificial perilymph containing altered concentrations of potassium, sodium, and sucrose. To obtain a panoramic view of cochlear regulation under these conditions, software was written to enable the interleaved and near-simultaneous measurement of multiple indicators of cochlear function, including the compound action potential (CAP) threshold, amplitude and waveshape at multiple frequencies, the OHC transfer curves derived from low-frequency cochlear microphonic (CM) waveforms, distortion-product otoacoustic emissions (DPOAEs), the spectrum of the round-window neural noise (SNN), and the endocochlear potential (EP). The mathematical model takes into account the known electrical properties of OHC, and includes the effect of fast and slow-motility of the cell body on transducer operating point and apical conductance. Central to the operation of the model is a putative intracellular 2nd-messenger system based on cytosolic calcium, which is involved in regulation of i) the operating point of OHC MET channels via slow motility and axial stiffness; ii) the permeability of the basolateral wall to potassium (via calcium-sensitive potassium channels); and iii) the cytosolic concentration of calcium itself, via modulation of its own sequestration into (and release from) intracellular storage organelles, and extrusion from the cell. The model was constructed in a manner which allowed simulation of different cochlear perturbations, and the comparison of results from these simulations to experimental data. The mathematical model we have developed provided a physiologically-plausible and internally-consistent explanation for the time-courses of the cochlear changes observed during a number of different perturbations. We show that much of the oscillatory behaviour within the cochlea is consistent with underlying oscillations in cytosolic calcium concentration. We conclude that a number of the discrepancies between the simulation results and the experimental data can be resolved if the cytosolic calcium functions as two distinct pools: one which controls basolateral permeability and one which controls slow motility. This two-calcium-pool model is discussed.
Download or read book Mathematical Physiology written by James Keener and published by Springer Science & Business Media. This book was released on 2009-01-06 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing. New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included.
Download or read book The Auditory System and Human Sound Localization Behavior written by John van Opstal and published by Academic Press. This book was released on 2016-03-29 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Auditory System and Human Sound-Localization Behavior provides a comprehensive account of the full action-perception cycle underlying spatial hearing. It highlights the interesting properties of the auditory system, such as its organization in azimuth and elevation coordinates. Readers will appreciate that sound localization is inherently a neuro-computational process (it needs to process on implicit and independent acoustic cues). The localization problem of which sound location gave rise to a particular sensory acoustic input cannot be uniquely solved, and therefore requires some clever strategies to cope with everyday situations. The reader is guided through the full interdisciplinary repertoire of the natural sciences: not only neurobiology, but also physics and mathematics, and current theories on sensorimotor integration (e.g. Bayesian approaches to deal with uncertain information) and neural encoding. - Quantitative, model-driven approaches to the full action-perception cycle of sound-localization behavior and eye-head gaze control - Comprehensive introduction to acoustics, systems analysis, computational models, and neurophysiology of the auditory system - Full account of gaze-control paradigms that probe the acoustic action-perception cycle, including multisensory integration, auditory plasticity, and hearing impaired
Download or read book Research Awards Index written by and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book From Sound to Synapse written by C. Daniel Geisler and published by . This book was released on 1998 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This readable, well-illustrated text describes the exquisite job that the mammalian ear does in transforming sound into nerve impulses. The reader is led along the same pathway followed by an acoustic signal--from the outer ear, through the middle ear, and into the inner ear where the minuscule vibrations of the sound waves are transformed into nerve impulses. At each stage, the basic mechanisms are described qualitatively in terms of current theory and illustrated with experimental data.
Download or read book Applied Mechanics Reviews written by and published by . This book was released on 1979 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Intraoperative Neurophysiologic Monitoring written by Gloria M. Galloway and published by Cambridge University Press. This book was released on 2010-10-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraoperative neurophysiologic monitoring has shown a steady increase in use for surgeries in which neural structures may be at risk of injury. Some of the surgical techniques used carry inherent risks, and these risks have changed the way in which neurophysiologic monitoring has impacted patient safety and quality of care during surgical procedures. It is therefore crucial that those performing and interpreting intraoperative neurophysiologic monitoring are adequately trained. This book is a comprehensive guide to the current practice of intraoperative neurophysiology with chapters on various modalities and clinical uses. Separate chapters devoted to anesthesia, operating room environment, special considerations in pediatrics and the interpretation and reporting of neurophysiologic data are useful and complementary. Questions and detailed answers on the topics covered can be found on the accompanying website for study review. This book will be useful to the trainee as well as the neurophysiologist already in practice.
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biophysics of the Cochlea written by Ernst Dalhoff and published by World Scientific. This book was released on 2003 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of an international hearing-research conference held in Germany 2002. The conference brought together experts in genetics, molecular and cellular biology, physiology, engineering, physics, mathematics, audiology and medicine to synthesize and extend our understanding of how the cochlea works. Topics are discussed experimentally and theoretically at the molecular, cellular and whole-organ levels. Some of the topics are: mechanosensitivity of motor proteins; mechanochemical transduction by motor proteins; mechanoelectrical transduction in the stereocilia of hair cells; electromechanical transduction in the stereocilia, soma and synapses of hair cells; multidimensional vibration of the organ of Corti; and otoacoustic emissions. This book will be invaluable to researchers and students in auditory science.
Download or read book CSA Neurosciences Abstracts written by and published by . This book was released on 1993 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Models of the Auditory System written by Ray Meddis and published by Springer Science & Business Media. This book was released on 2010-06-16 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The v- umes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in pe- reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beg- ning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.
Download or read book A Computational Perspective on Visual Attention written by John K. Tsotsos and published by MIT Press. This book was released on 2021-06-22 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The derivation, exposition, and justification of the Selective Tuning model of vision and attention. Although William James declared in 1890, "Everyone knows what attention is," today there are many different and sometimes opposing views on the subject. This fragmented theoretical landscape may be because most of the theories and models of attention offer explanations in natural language or in a pictorial manner rather than providing a quantitative and unambiguous statement of the theory. They focus on the manifestations of attention instead of its rationale. In this book, John Tsotsos develops a formal model of visual attention with the goal of providing a theoretical explanation for why humans (and animals) must have the capacity to attend. He takes a unique approach to the theory, using the full breadth of the language of computation—rather than simply the language of mathematics—as the formal means of description. The result, the Selective Tuning model of vision and attention, explains attentive behavior in humans and provides a foundation for building computer systems that see with human-like characteristics. The overarching conclusion is that human vision is based on a general purpose processor that can be dynamically tuned to the task and the scene viewed on a moment-by-moment basis. Tsotsos offers a comprehensive, up-to-date overview of attention theories and models and a full description of the Selective Tuning model, confining the formal elements to two chapters and two appendixes. The text is accompanied by more than 100 illustrations in black and white and color; additional color illustrations and movies are available on the book's Web site.
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1976 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulative Subject Index to Psychological Abstracts written by and published by . This book was released on 1969 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signals and Systems in Biomedical Engineering written by Suresh R. Devasahayam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years Biomedical Engineering has received a great deal of attention as one of the emerging technologies in the last decade and for years to come, as witnessed by the many books, conferences, and their proceedings. Media attention, due to the applications-oriented advances in Biomedical Engineering, has also increased. Much of the excitement comes from the fact that technology is rapidly changing and new technological adventures become available and feasible every day. For many years the physical sciences contributed to medicine in the form of expertise in radiology and slow but steady contributions to other more diverse fields, such as computers in surgery and diagnosis, neurology, cardiology, vision and visual prosthesis, audition and hearing aids, artificial limbs, biomechanics, and biomaterials. The list goes on. It is therefore hard for a person unfamiliar with a subject to separate the substance from the hype. Many of the applications of Biomedical Engineering are rather complex and difficult to understand even by the not so novice in the field. Much of the hardware and software tools available are either too simplistic to be useful or too complicated to be understood and applied. In addition, the lack of a common language between engineers and computer scientists and their counterparts in the medical profession, sometimes becomes a barrier to progress.
Download or read book Cochlear Mechanics written by Frank Böhnke and published by S. Karger AG (Switzerland). This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue collects our current knowledge of the mechanical processing of acoustic signals by the cochlea and its containing structures. Many workers in diverse disciplines in otology use the facts from cochlear mechanics for the interpretation of their results. Presented here for the first time is the development of a three-dimensional mechanical model of the curved cochlea including fluid-structure couplings. An important approach for future cochlear modeling is shown by the provision of geometrical data for the input of three-dimensional finite element models by microtomographic imaging. A remarkable article tries to demonstrate a connection between outer hair cell mechanics and the complex phenomenon of tinnitus and will be of special interest for stress engineers. Owing to its strong interdisciplinarity, this issue is not only intended for biophysicists, ENT clinicians and audiologists but also for radiologists, biomechanical engineers and computer engineers.
