Download or read book Mass Spectrometry in Sports Drug Testing written by Mario Thevis and published by John Wiley & Sons. This book was released on 2010-12-13 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.
Download or read book Mass Spectrometry in Sports Drug Testing written by Mario Thevis and published by Wiley. This book was released on 2010-08-02 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables you to detect, identify, and characterize hundreds of drugs that may be used by athletes Mass spectrometry has become essential to sports drug testing. This book examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance. The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds. Mass Spectrometry in Sports Drug Testing begins with a full chapter dedicated to the history of sports drug testing. Next, the book provides the principles and techniques needed to maximize the specificity and sensitivity of mass spectrometric assays, including: Detailed, step-by-step assays with sample preparation Discussion of both chromatographic separation and mass spectrometric analysis Characterization of analytes in order to unequivocally identify banned substances Mass spectrometric behavior of low- and high-molecular weight analytes Throughout the book, descriptive examples illustrate the principles, advantages, and limitations of different assays. Mass Spectrometry in Sports Drug Testing not only sets forth the role mass spectrometry plays in detecting drug use among athletes, it also adds new insights into the health and ethical issues of doping in sports.
Download or read book Critical Issues in Alcohol and Drugs of Abuse Testing written by Amitava Dasgupta and published by Academic Press. This book was released on 2019-01-10 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians
Download or read book LC MS in Drug Analysis written by Loralie J. Langman and published by Humana Press. This book was released on 2012-07-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.
Download or read book Technology in Forensic Science written by Deepak Rawtani and published by John Wiley & Sons. This book was released on 2020-11-02 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Technology in Forensic Science" provides an integrated approach by reviewing the usage of modern forensic tools as well as the methods for interpretation of the results. Starting with best practices on sample taking, the book then reviews analytical methods such as high-resolution microscopy and chromatography, biometric approaches, and advanced sensor technology as well as emerging technologies such as nanotechnology and taggant technology. It concludes with an outlook to emerging methods such as AI-based approaches to forensic investigations.
Download or read book Mass Spectrometry in Drug Metabolism and Pharmacokinetics written by Ragu Ramanathan and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Download or read book Karch s Drug Abuse Handbook written by Steven Karch and published by CRC Press. This book was released on 2022-11-29 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Karch’s Drug Abuse Handbook, Third Edition remains the quintessential compendium addressing the pharmacological, medical, and legal aspects of drugs and informing the forensic community of the latest scientific advances and emergent practices. For this edition, Dr. Karch has brought on clinical and forensic toxicology expert Dr. Bruce Goldberger, editor-in-chief of the Journal of Analytical Toxicology and president of the American Board of Forensic Toxicology, to serve as co-editor. In addition, world-renowned scientists and medical professionals have contributed their work and expertise in tackling the latest developments in drug testing, drug-related medical emergencies, and the drug toxicology. Topics addressed include genetic testing in drug death investigation, pathology, toxicogenetics, alcohol, post-mortem toxicology, new psychoactive substances, the latest legal issues and challenges as well as drugs and drug testing in sports, and the ethical, legal, and practical issues involved. Vivid pictures and diagrams throughout illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. With unparalleled detail, the latest research and the highest level of authoritative medical scientific information, The Drug Abuse Handbook, Third Edition remains the definitive resource for drug related issues.
Download or read book High Performance Gradient Elution written by Lloyd R. Snyder and published by John Wiley & Sons. This book was released on 2007-01-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gradient elution demystified Of the various ways in which chromatography is applied today, few have been as misunderstood as the technique of gradient elution, which presents many challenges compared to isocratic separation. When properly explained, however, gradient elution can be less difficult to understand and much easier to use than often assumed. Written by two well-known authorities in liquid chromatography, High-Performance Gradient Elution: The Practical Application of the Linear-Solvent-Strength Model takes the mystery out of the practice of gradient elution and helps remove barriers to the practical application of this important separation technique. The book presents a systematic approach to the current understanding of gradient elution, describing theory, methodology, and applications across many of the fields that use liquid chromatography as a primary analytical tool. This up-to-date, practical, and comprehensive treatment of gradient elution: * Provides specific, step-by-step recommendations for developing a gradient separation for any sample * Describes the best approach for troubleshooting problems with gradient methods * Guides the reader on the equipment used for gradient elution * Lists which conditions should be varied first during method development, and explains how to interpret scouting gradients * Explains how to avoid problems in transferring gradient methods With a focus on the use of linear solvent strength (LSS) theory for predicting gradient LC behavior and separations by reversed-phase HPLC, High-Performance Gradient Elution gives every chromatographer access to this useful tool.
Download or read book Mass Spectrometry written by Mahmood Aliofkhazraei and published by BoD – Books on Demand. This book was released on 2017-06-07 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is an analytical technique that can be used for the structural characterization and quantification of a wide range of molecules. The technique is extensively used by chemists for the analysis of small and volatile organic compounds. Mass spectrometry has long been an important technique for the identification of materials ranging from pure compounds to complex mixtures. Mass spectrometry can be used to determine molecular weight of compounds or using different ionization conditions, can provide more structural details through the analysis of fragmentation patterns. This level of detail can be attained for pure compounds and some mixtures. Mass spectrometry can also be combined with separation techniques such as gas chromatography or liquid chromatography to allow more complex mixtures to be examined. These hyphenated techniques provide a range of options for the characterization of complex materials.
Download or read book Sports Ethics for Sports Management Professionals written by Patrick Thornton and published by Jones & Bartlett Publishers. This book was released on 2011-04-22 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Directed at future sports executives and sports managers, the book contains numerous case studies that allow students to apply the ethical decision-making process to a sports-related ethical dispute. Unlike other texts that spend too much time discussing ethical theories, Sports Ethics for Sports Management Professionals addresses the important issues sports professionals may actually encounter during their career --Book Jacket.
Download or read book Doping in Sports written by Detlef Thieme and published by Springer Science & Business Media. This book was released on 2009-12-18 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doping in sports and the fight against it has gained increasing attention in recent years. The pharmacological basis for a possible performance enhancement in competitive sport through the administration of prohibited substances and methods as well as the analytical disclosure of such practices are comprehensively covered in 21 contributions by outstanding and distinctive authors.
Download or read book Doping Performance Enhancing Drugs and Hormones in Sport written by Anthony C Hackney and published by Elsevier. This book was released on 2017-11-23 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doping, Performance-Enhancing Drugs, and Hormones in Sport: Mechanisms of Action and Methods of Detection examines the biochemistry and bioanalytical aspects of performance-enhancing drugs (PEDs) and other questionable procedures used by athletes to enhance performance. The book informs the specialist of emerging knowledge and techniques and allows the non-specialist to grasp the underlying science and current practice of the discipline. With clear and compelling language appropriate for a broad spectrum of readers, this book provides background on prevalence, types of agents, their actual or supposed benefits, and their negative effects on health. The technical aspects of detection are discussed, followed by a discussion of why detection is a problematic and still-evolving science. To facilitate comprehension, each chapter is organized in a uniform way with six sections: (1) standard medical uses, (2) why the drugs are used by athletes, (3) biological mechanism of action, (4) what research says about efficacy in improving performance, (5) major health side effects from use and abuse in sport, and 6) concluding key points. Presents the scientific concepts of how performance enhancers work, how they are used, and how they are detected and masked from detection Features language that is neither simplistic to scientists nor too sophisticated for a large, diverse global audience Provides a short “close-up” in each chapter to illustrate key topics that engage, entertain, and create a novel synthesis of thought
Download or read book Mass Spectrometry written by Agnieszka Kraj and published by John Wiley & Sons. This book was released on 2008-12-01 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.
Download or read book Chemical Analysis of Non antimicrobial Veterinary Drug Residues in Food written by Jack F. Kay and published by John Wiley & Sons. This book was released on 2016-11-14 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Provides a comprehensive set of information in the area of consumer food safety and international trade Covers general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods Details many techniques including nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Provides guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists
Download or read book Interpretation of MS MS Mass Spectra of Drugs and Pesticides written by Wilfried M. A. Niessen and published by John Wiley & Sons. This book was released on 2017-01-09 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
Download or read book Liquid Chromatography Time of Flight Mass Spectrometry written by Imma Ferrer and published by John Wiley & Sons. This book was released on 2009-05-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants—such as antibiotics, steroids, analgesics—using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.
Download or read book Acute Topics in Anti Doping written by O. Rabin and published by Karger Medical and Scientific Publishers. This book was released on 2017-06-02 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doping represents the dark side of amateur and professional sports – in order to protect athletes around the globe, anti-doping rules are continuously revised and improved. This publication reviews the current regulatory framework, scientific aspects, future approaches, and social and ethical dimensions of the fight against doping in sport. Prominent experts on the implementation of anti-doping strategies, as well as leading researchers in science and medicine, have contributed to this publication. In keeping with its interdisciplinary origin, the book is intended for athletes, coaches, students, scientists, anti-doping officials, and all others interested in anti-doping and sports. Ranging from legal and educational to scientific and medical issues, this collection emphasizes the need for a multidisciplinary approach and the importance of preventative strategies in the fight against doping in sports.
