Download or read book Marrow Protection written by Joseph R. Bertino and published by Karger Medical and Scientific Publishers. This book was released on 1999-01-01 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity. General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations. This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice.

Download or read book Studies on Homologous Bone Marrow Protection in X irradiated Mice written by L. J. Cole and published by . This book was released on 1958 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Autologous Bone Marrow Protection After Fast Neutron Irradiation of Dogs written by Edward L. Alpen and published by . This book was released on 1958 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bone Marrow Therapy and Protection in Irradiated Primates written by Gezondheidsorganisatie T.N.O. Radiobiological Institute and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Download or read book Protection of superoxide sensitive bone marrow cells by superoxide dismutase written by A. Petkau and published by . This book was released on 1983 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fundamental and Clinical Aspects of Radiation Protection and Recovery written by and published by . This book was released on 1957 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modification of X radiation Lethality by Autologous Marrow Infusion in Dogs written by E. L. Alpen and published by . This book was released on 1958 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fundamental and Clinical Aspects of Radiation Protection and Recovery with Special Emphasis on Chemical Protection and Bone Marrow Transplantation in Mammals written by and published by . This book was released on 1960 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterisation and Mechanism of Bone Marrow Cell induced Myocardial Protection written by Vien Khach Lai and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: It is controversial whether the administration of bone marrow cells (BMCs) can repair the heart after an ischaemic insult and whether the mechanism of the putative beneficial effect is due to a paracrine action. By using an experimental model of simulated ischaemia of the atrial myocardium, I set up this thesis to understand the protective properties of BMCs on the human myocardium with different clinical conditions and to investigate the underlying mechanism. The results provide clear data that myocardial protection of BMCs is dose-dependent with a maximal protection, comparable to that of ischemic preconditioning, at a dose of ~1.5x106 cells/mg wet myocardium and that the similar effect can be achieved when BMCs were present before, during or after ischaemia. Allogeneic BMCs are as protective as the autologous cells and their capacity is unaffected by frozen storage or culture, but lost by magnetic isolation. In addition, the conditioned media, obtained after 30min of incubation of BMCs, can induce a protection similar to that of BMCs, an effect that is abolished by selective blockade of the insulin-like growth factor-1 receptor. Furthermore, disease states such as diabetes and poor left ventricular function or the long-term administration of the mitochondrial KATP channel opener nicorandil prevents the protective effect of BMCs, a consequence that appears to be due to an alteration in the myocardium for diabetes and nicorandil and mainly due to a defect in BMCs and also to a less responsive myocardium in heart failure. A final clinical study aimed to elucidate the effect of BMCs during cardiac surgery showed that BMCs have no additive protection to conventional cardioplegia during coronary artery bypass grafting. In this thesis I have characterised the cardioprotective potential of BMCs and identified some of the underlying mechanisms. The results are of clinical interest and they should generate novel hypotheses.

Download or read book Proceedings of the International Symposium on Bone Marrow Therapy and Chemical Protection in Irradiated Primates written by and published by . This book was released on 1962 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

Download or read book Non regenerative Benefits of Adult Bone Marrow Derived Stem Cells for Myocardial Protection written by Mohammed Yasin and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Marrow Thieves written by Cherie Dimaline and published by DCB. This book was released on 2017-05-10 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Just when you think you have nothing left to lose, they come for your dreams. Humanity has nearly destroyed its world through global warming, but now an even greater evil lurks. The indigenous people of North America are being hunted and harvested for their bone marrow, which carries the key to recovering something the rest of the population has lost: the ability to dream. In this dark world, Frenchie and his companions struggle to survive as they make their way up north to the old lands. For now, survival means staying hidden — but what they don't know is that one of them holds the secret to defeating the marrow thieves.

Download or read book Bone Marrow Transplantation and Chemical Protection written by James P. OKunewick and published by . This book was released on 1969 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.