Download or read book Translational Medicine written by Dennis Cosmatos and published by CRC Press. This book was released on 2008-12-17 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines Critical Decisions for Transitioning Lab Science to a Clinical SettingThe development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in

Download or read book Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes written by Luigi Marchionni and published by DIANE Publishing. This book was released on 2009-05 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assesses the evidence that three marketed gene expression-based assays improve prognostic accuracy, treatment choice, and health outcomes in women diagnosed with early stage breast cancer. Three gene expression assays were evaluated; Oncotype DX¿, MammaPrint® and the Breast Cancer Profiling (BCP or H/I ratio) test, and for gene expression signatures underlying the assays. They sought evidence on: analytic performance of tests; clinical validity; clinical utility; harms; and impact on clinical decision making and health care costs. Conclusions: Oncotype DX is furthest along the validation pathway, with retrospective evidence that it predicts distant spread and chemotherapy benefit to a clinically relevant extent over standard predictors. Illus.

Download or read book Handbook of Therapeutic Biomarkers in Cancer written by Sherry X. Yang and published by CRC Press. This book was released on 2013-06-21 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests

Download or read book Molecular Diagnostics written by Jan Trost Jorgensen and published by CRC Press. This book was released on 2019-05-08 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

Download or read book Diagnostic Molecular Pathology in Practice written by Iris Schrijver and published by Springer Science & Business Media. This book was released on 2011-09-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. This book will be ideal for trainees in MGP and clinical molecular genetics who require a practice-based preparation for board examinations. It will also be very useful for residents and fellows in medical specialties to which MGP is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.

Download or read book Breast Pathology E Book written by David J Dabbs and published by Elsevier Health Sciences. This book was released on 2016-11-04 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now completely updated with the latest classifications of breast pathology and molecular diagnosis, David J. Dabbs’ Breast Pathology, 2nd Edition, remains your go-to source for integrated, comprehensive coverage of this fast-changing field. Written by internationally acclaimed pathologists, this definitive reference incorporates genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, immunohistochemistry, and theranostics – providing complete, authoritative information for pathology trainees, practitioners, and oncologists. Approximately 2,000 full-color pathological images clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. Quick reference points at the beginning of each chapter conveniently list all relevant diagnostic, theranostic, and genomic data for fast retrieval. Immunohistochemistry for each entity is mapped according to diagnostic, theranostic, and genomic applications with specific regards to disease entities in each chapter. Breast specimen handling is discussed in detail to ensure proper sampling and processing for optimal molecular and immunohistochemistry resulting. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. All chapters have been updated with the latest breast pathology classifications and the most recent information on molecular diagnosis. New chapter on next generation DNA sequencing and management of clinically advanced breast cancer.

Download or read book Breast Pathology E Book written by David J Dabbs and published by Elsevier Health Sciences. This book was released on 2023-05-19 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. - Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. - Incorporates the latest classifications of breast pathology and molecular diagnosis. - Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. - Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. - Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. - Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. - Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. - Includes biomarker guideline updates throughout. - Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.

Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer. This book was released on 2016-02-02 with total page 989 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues. The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

Download or read book Molecular Diagnostics in Cytopathology written by Sinchita Roy-Chowdhuri and published by Springer. This book was released on 2018-11-21 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding. The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms. In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information. Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as Translational researchers with an interest in molecular cytopathology.

Download or read book The Breast E Book written by Kirby I. Bland and published by Elsevier Health Sciences. This book was released on 2017-06-29 with total page 1280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a single, convenient volume, The Breast: Comprehensive Management of Benign and Malignant Diseases, 5th Edition covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. Building upon the strengths of previous editions, this updated volume by Drs. Kirby I. Bland, Edward M. Copeland III, V. Suzanne Klimberg, and William J Gradishar, includes the latest innovations in breast cancer detection and treatment in a practical, easy-to-use format ideal for today’s surgeons. Delivers step-by-step clinical guidance highlighted by superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures. Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, surgeons, oncologists, and other health care professionals who contribute to the management of patients with breast disease. Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. Covers the latest developments in receptor modulation, targeted monoclonal antibodies, evolving inhibitors with triple-negative disease, and more. Discusses recent minimally invasive surgical techniques and new developments in oncoplastic breast conservation techniques. Contains significant updates to the "Management of Systemic Disease" section that reflect the latest advances in chemotherapy, hormonal resistance, and therapy.

Download or read book Detecting Living with Breast Cancer For Dummies written by Marshalee George and published by John Wiley & Sons. This book was released on 2017-08-28 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Your trusted, no-nonsense guide to detecting and managing breast cancer From the breast health experts at the American Breast Cancer Foundation comes a sensitive and authoritative guide to the most common cancer in women: breast cancer. Covering everything from prevention to dealing with a diagnosis to coping with life after cancer, it serves as a trusted resource for anyone whose life has been touched by this dreaded disease. Advancements in breast cancer prevention, detection, and treatment are being made every day, but it can be overwhelming and confusing knowing where to turn and who to trust. Detecting & Living with Breast Cancer For Dummies distills the information into one easy-to-follow guide, giving you quick, expert advice on everything you'll face as you manage your breast health. From getting to know your treatment options to talking to loved ones about breast cancer—and everything in between—it does the legwork for you so you can take a deep breath and focus on your health. Perform regular self-exams the right way Cope with the many decisions that need to be made if you're diagnosed Ask the right questions about surgery, chemotherapy, radiation, and breast reconstruction Decipher complicated pathology reports with confidence Whether you're at risk for breast cancer or have been diagnosed and want to know your options, Detecting & Living with Breast Cancer For Dummies empowers you to take your health into your own hands.

Download or read book The Bethesda Handbook of Clinical Oncology written by Jame Abraham and published by Lippincott Williams & Wilkins. This book was released on 2018-04-12 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The Bethesda Handbook of Clinical Oncology is a comprehensive review of the management of numerous cancer types, emphasizing practical information that can be applied in everyday, fast-moving patient care situations. With contributions from experts and scholars at the National Cancer Institute, National Institutes of Health, Cleveland Clinic, and other renowned institutions, this latest edition has been thoroughly revised with new content and continues to provide practical guidance on how to evaluate, diagnose, and treat cancer patients.

Download or read book Modern Breast Cancer Imaging written by Su Jin Kim Hsieh and published by Springer Nature. This book was released on 2021-10-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The available information on breast cancer has evolved so rapidly that a textbook understanding is no longer sufficient to make sound therapeutic decisions. Further, the latest findings and data are spread throughout the scientific literature of various medical fields, making it difficult for medical professionals to keep abreast of these advances, and to apply them in their day-to-day work. This book provides updated information on breast cancer, such as the modern molecular classification and staging, and demonstrates how imaging with pathologic correlation can be used in management decisions. In addition, it identifies the most suitable imaging modalities for screening, diagnosis and monitoring for each clinical case. Given its scope, the book offers a valuable resource for all medical professionals (practicing or still in training) whose work involves breast cancer, including radiologists, breast surgeons, pathologists, radiotherapists and nuclear medicine professionals.

Download or read book The Bethesda Handbook of Clinical Oncology written by Sayan Paul and published by Wolters Kluwer India Pvt. Ltd.. This book was released on 2020-09-01 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bethesda handbook of clinical oncology has been thoroughly reviewed and Ed it Ed by a group of renowned oncologists from reputed government and private cancer institutes of India to make the contents relevant and useful for the students and practitioners of oncology of the Indian subcontinent and South Asia. Salient features: data and evidences from India and South Asia have been added. All the chapters have been edited and updated as per most recent availableevidences and guidelines. More emphasis has been given to the type of cancers more commonly seen in this part of the world such as head and neck cancer, cancer cervix, breast cancer, etc. Chapters of basics of Radiation oncology and medical oncology have been revised. Additional and relevant information on cancer surgery has been added in each br>Chapter a management Flowchart has been added at the end of each br>Chapter for easy understanding and ready reference in the clinic.

Download or read book Personalized Medicine written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Personalized Medicine A medical model known as personalized medicine, which is also known as precision medicine, categorizes patients into distinct groups, and then tailors medical decisions, practices, interventions, and/or products to each individual patient based on how they are expected to react to treatment or their likelihood of developing a disease. Personalized medicine is also known as precision medicine. Although the terms personalized medicine, precision medicine, stratified medicine, and P4 medicine are often used interchangeably to describe this concept, some authors and organizations use these expressions separately to indicate particular nuances. Personalized medicine refers to the practice of tailoring medical treatment to each individual patient. Precision medicine refers to the practice of treating patients based How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Personalized medicine Chapter 2: Pharmacogenomics Chapter 3: MammaPrint Chapter 4: Medical genetics Chapter 5: Biomarker (medicine) Chapter 6: Biomarker (cell) Chapter 7: Predictive medicine Chapter 8: Public health genomics Chapter 9: Cancer Genome Project Chapter 10: Personal genomics Chapter 11: Cancer biomarker Chapter 12: Icahn Genomics Institute Chapter 13: Molecular pathological epidemiology Chapter 14: Molecular diagnostics Chapter 15: Precision medicine Chapter 16: Toxgnostics Chapter 17: Predictive genomics Chapter 18: Clinicogenomics Chapter 19: Elective genetic and genomic testing Chapter 20: Personalized onco-genomics Chapter 21: Cancer pharmacogenomics (II) Answering the public top questions about personalized medicine. (III) Real world examples for the usage of personalized medicine in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of personalized medicine' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of personalized medicine.

Download or read book An Omics Perspective on Cancer Research written by William C.S. Cho and published by Springer Science & Business Media. This book was released on 2010-04-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers – cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.

Download or read book Handbook of Breast Cancer and Related Breast Disease written by Katherine H. R. Tkaczuk, MD and published by Springer Publishing Company. This book was released on 2016-12-28 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Breast Cancer and related Breast Disease is a practical guide to the management of patients with breast malignancies and related non-neoplastic lesions. Written and edited by leading experts, this handbook focuses on the application of conventional and novel treatment strategies to the care of patients with nonmalignant breast disease and all stages of breast cancer. The handbook is organized chronologically, from screening, through diagnosis and management, to survivorship care and related medical issues. The bulk of these chapters provide evidence-based treatment strategies for all patient subsets, including how to manage patients with high risk breast lesions, invasive breast carcinoma at each stage, and with all known molecular subtypes of breast cancer. Surgical, radiation, and medical treatment options are all discussed for each stage of breast cancer including treatment approaches in pregnancy and for high risk lesions and Phyllodes. This handbook is a comprehensive yet concise resource for residents, fellows, and early-career practitioners. Community oncologists, breast surgeons, radiation oncologists, primary care practitioners, and OBGYNs will also find its concise review of new research and procedures to be very useful in this dynamic field of medicine. Key Features: Includes discussion of genomic testing in management of early stage breast cancer Covers adjuvant and neoadjuvant treatment approaches Includes short clinical trial reviews for quick update of study endpoints and results for reference in management of breast cancer Outlines strategies for survivorship issues Key points in each chapter highlight clinical pearls and summarize other important concepts