Download or read book Male Fertility and Lipid Metabolism written by Stephanie R. De Vriese and published by The American Oil Chemists Society. This book was released on 2003-05-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in lipid metabolism and polyunsaturated fatty acids in relation to sperm production has increased during the last decade. The motivation for the research described in this book originates from the discovery that sperm lipids contain extremely high proportions of long-chain polyunsaturated fatty acids, thus establishing a link between lipid biochemistry and male fertility. Moreover, the fact that polyunsaturated fatty acids must, in some form, be supplied in the diet suggests a relationship between fertility and nutrition and raises the possibility of improving male fertility by dietary means. This book gives the reader an up-to-date view of several aspects of male fertility in relation to lipid and fatty acid metabolism. Researchers in the domain of male fertility, fatty acid metabolism, and antioxidants; medical personnel involved in the treatment of male infertility; fat technologists; students in nutrition, dietetics, biochemistry, pharmacy, and medicine; and everybody interested in the field will find this book useful.

Download or read book Studies on Men s Health and Fertility written by Ashok Agarwal and published by Springer Science & Business Media. This book was released on 2012-03-17 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.

Download or read book Studies on Men s Health and Fertility written by Ashok Agarwal and published by Humana Press. This book was released on 2012-03-17 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.

Download or read book Infertility in the Male written by Larry I. Lipshultz and published by Cambridge University Press. This book was released on 2009-09-24 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.

Download or read book The Sperm Cell written by Christopher J. De Jonge and published by Cambridge University Press. This book was released on 2006-04-06 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 2006, this is a comprehensive and definitive account of the human male gamete. The volume summarizes many unique and revealing characteristics of the sperm cell. It provides a detailed overview of human sperm production, maturation and function, and looks at how these processes affect and influence fertility, infertility and ART. The volume thus provides a detailed review of the most important research and developments, augmented with pertinent references. This book will appeal to all practitioners and scientists in reproductive medicine and in particular to clinical scientists, graduate and post-graduate scientists, and laboratory personnel.

Download or read book Lipids in Plant and Algae Development written by Yuki Nakamura and published by Springer. This book was released on 2016-03-29 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in understanding the functions of plant and algal lipids in photosynthesis, in development and signaling, and in industrial applications. As readers will discover, biochemistry, enzymology and analytical chemistry, as well as gene knock-out studies have all contributed to our rapidly increasing understanding of the functions of lipids. In the past few decades, distinct physical and biochemical properties of specific lipid classes were revealed in plant and algal lipids and the functional aspects of lipids in modulating critical biological processes have been uncovered. These chapters from international authors across relevant research fields highlight the underlying evolutionary context of lipid function in photosynthetic unicellular and multicellular organisms. The book goes on to encompass what lipids can do for industrial applications at a time of fascination with plants and algae in carbon fixation and as sources for production of food, energy and novel chemicals. The developmental context is a part of the fresh and engaging perspective that is presented in this work which graduate students and scientists will find both illuminating and useful.

Download or read book Clinical Management of Male Infertility written by Giorgio Cavallini and published by Springer. This book was released on 2014-10-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasing importance. Clinicians will find that the book’s straightforward approach ensures that it can be easily and rapidly consulted.

Download or read book Spermatogenesis written by Lori Barnard and published by Humana Press. This book was released on 2012-09-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deficiencies in sperm function are usually the result of spermatogenic defects. Spermatogenesis is a biologically complex and essential process during which spermatogonia undergo meiotic recombination, reduction of the genome to a haploid state, and extensive cellular modifications that result in a motile cell capable of traversing the female reproductive tract, withstanding various potential assaults to viability, and finally successfully fertilizing a mature oocyte to give rise to an embryo. Defects in any step of spermatogenesis or spermatogenesis can lead to male infertility, a disease that affects approximately 5-7% of the population. Spermiogenesis and Spermatogenesis: Methods and Protocols details protocols used in the study of spermatogenesis, clinical analytical protocols, and basic techniques used in clinical andrology laboratories, such as obtaining accurate results for a sperm count, and advanced procedures, such as genome-wide genetic study tools and evaluation of nuclear proteins. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Spermiogenesis and Spermatogenesis: Methods and Protocols is unique in its breadth, and will be a useful reference for clinicians and researchers alike.

Download or read book The Genetics of Male Infertility written by Douglas T. Carrell and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Download or read book The Role of RAB like2 RABL2 in Male Fertility and Protein Transport written by Chi Yi Lo and published by . This book was released on 2013 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects 1 in 20 men in reproductive age [1]. In an effort to identify key pathways and proteins involved in male fertility, a random mouse mutagenesis screen was carried out. In doing so, the O'Bryan lab identified a male sterile mouse line called Mot1. Mot1 homozygous mutants carry an A to G substitution point mutation in the Rab-like 2 (Rabl2) gene which affects two RABL2 isoforms (hereafter called Rabl2Mot/Mot) [2]. Mot1 homozygous male sterility was a result of reduced sperm production, shorter sperm tails and compromised sperm motility. This project aimed to characterise the biochemical mechanism of RABL2 function. Functional studies using unicellular organism have shown the role of RAB-like proteins in flagellum formation but the role of these proteins in mammals remain unknown [3,4]. Phylogenetic analyses conducted within our lab identified the RABL2 orthologues in all ciliated organisms and an absence of the orthologues in non-ciliated species suggesting it is associated with cilia development. RAB-like proteins are small GTPases within an uncharacterised clade of the RAS superfamily. Based on this we predicted they are able to switch between inactive and active states and are likely involved in protein delivery. We predicted in the active GTP-bound RABL2 would bind to a specific set of effector proteins and deliver them to the growing sperm tail that is the affected organelle in the Rabl2Mot/Mot animals. The Mot1 mutation disrupted effector proteins delivery and as such the Rabl2Mot/Mot males were sterile due to reduced levels of effector proteins in sperms. Further, RABL2 binds to intra-flagella transport (IFT) complex B component proteins which are important in cilia/flagella formation. In addition to the fertility phenotype, the Rabl2Mot/Mot animals develop juvenile onset steatosis and adult onset obesity. The weight gain in the Rabl2Mot/Mot animals is a result of increase in adiposity. Although Rabl2Mot/Mot animals have a normal food intake and are sensitive to exogenous leptin, they have insulin resistant, glucose intolerant and are less active than Rabl2WT/WT. Further investigations suggest that metabolic dysfunction is the consequence of primary hepatic dysfunction; specifically Rabl2Mot/Mot animals develop juvenile liver steatosis. They show an increase in pro-lipogenic genes expression and a reduced ability for fatty acid [beta] oxidation which subsequently lead to lipid accumulation. The identified RABL2 putative effector proteins in liver showed enrichment in mitochondrial and peroxisomal proteins indicating RABL2 association in fatty acid metabolism. I hypothesise that RABL2 is involved in the organelle movement associated with microtubules within hepatocytes or it delivers effector proteins required for metabolism to organelles. Furthermore, Rabl2Mot/Mot animals develop age-dependent lung pathology from seven months. Rabl2Mot/Mot lungs were characterised with eosinophilic exudate lining the distal alveolar regions and emphysema. With increasing age, immune infiltrates became prominent. The progressive nature of this phenotype resembles the clinical features in primary ciliary dyskinesia. The data presented in this thesis demonstrates the role of RABL2 in male fertility, fatty acids metabolism and lung function. The co-pathologies presentation in the Rabl2Mot/Mot animals suggested RABL2 is essential for post-natal physiological development. The similar fertility and obesity phenotype in the Rabl2Mot/KO animals have confirmed the Mot1 phenotype is caused by the D73G mutation in Rabl2. 1. McLachlan RI, Mallidis C, Ma K, Bhasin S, de Kretser DM (1998) Genetic disorders and spermatogenesis. Reprod Fertil Dev 10: 97-104.2. Kennedy CL, O'Connor AE, Sanchez-Partida LG, Holland MK, Goodnow CC, et al. (2005) A repository of ENU mutant mouse lines and their potential for male fertility research. Mol Hum Reprod 11: 871-880.3. Qin H, Wang Z, Diener D, Rosenbaum J (2007) Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control. Curr Biol 17: 193-202.4. Silva DA, Huang X, Behal RH, Cole DG, Qin H (2011) The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in Chlamydomonas reinhardtii. Cytoskeleton (Hoboken).

Download or read book Polyunsaturated Fatty Acid Metabolism written by Graham C. Burdge and published by Elsevier. This book was released on 2018-05-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. - Provides a comprehensive view of polyunsaturated fatty acid metabolism - Describes underlying metabolism on lipids that include polyunsaturated fatty acids - Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism

Download or read book Male Fertility and Its Regulation written by Thomas Lobl and published by Springer. This book was released on 1985-01-31 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the 'Symposium on Male Fertility and its Regulation' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No.1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man uscripts from leaders in specific areas were solicited to provide additional range to the topics covered.

Download or read book Male Reproductive Function and Semen written by T. Mann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: To present a coherent and meaningful survey of scientific research endeavour in an area that has expanded as fast as physiology and biochemistry of reproduction in the male is no mean task these days. No less prodigious than the growth of knowledge of male reproductive function has been the rate at which the outpouring of publications on this subject has continued since the appearance of 'The Biochemistry of Semen and of the Male Reproductive Tract' in 1964. Since cyclopaedic treatment of this vast literature did not appeal to us, we have made no attempt either to rehash the material contained in that book or to enlarge the bibliography beyond the nearly 3500 references included in the present treatise. At the same time, whilst writing, we felt strongly that to advance, it is necessary to understand the past, and for this reason we have not hesitated to refer (especially in the introductory chapter) to a number of those fundamental early discoveries in which today's knowledge is deeply and firmly rooted.

Download or read book Lipid Biochemistry written by Michael I. Gurr and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition of this successful and popular book in 1970, the subject of lipid biochemistry has evolved greatly and this fifth up-to-date and comprehensive edition includes much new and exciting information. Lipid Biochemistry, fifth edition has been largely re-written in a user-friendly way, with chapters containing special interest topic boxes, summary points and lists of suggested reading, further enhancing the accessibility and readability of this excellent text. Contents include abbreviations and definitions used in the study of lipids, routine analytical methods, fatty acid structure and metabolism, dietary lipids and lipids as energy stores, lipid transport, lipids in cellular structures and the metabolism of structural lipids. The book provides a most comprehensive treatment of the subject, making it essential reading for all those working with or studying lipids. Upper level students of biochemistry, biology, clinical subjects, nutrition and food science will find the contents of this book invaluable as a study aid, as will postgraduates specializing in the topics covered in the book. Professionals working in research in academia and industry, including personnel involved in food and nutrition research, new product formulation, special diet formulation (including nutraceuticals and functional foods) and other clinical aspects will find a vast wealth of information within the book's pages. Michael Gurr was a Visiting Professor in Human Nutrition at the University of Reading, UK and at Oxford Brookes University, UK. John Harwood is a Professor of Biochemistry at the School of Biosciences, Cardiff University, UK. Keith Frayn is a Professor of Human Metabolism at the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK.

Download or read book Sex Determination in Plants written by CC Ainsworth and published by Garland Science. This book was released on 2004-08-02 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indispensable for all plant biologists, this is a fascinating and thorough examination of those factors which affect the sex determination of plant species, describing all of the main classes of plant with unisexual flowers hermaphrodite, monoecious and

Download or read book Fertility Preservation in Male Cancer Patients written by John P. Mulhall and published by Cambridge University Press. This book was released on 2013-02-21 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by international authorities, this book is aimed at clinicians dealing with male patients rendered infertile by cancer therapy.

Download or read book Male Infertility Understanding Causes and Treatment written by RAJENDER SINGH and published by Springer. This book was released on 2017-06-17 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest research on male infertility. The topics discussed range from understanding the genetic basis of infertility, to its causes and treatment. Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. Given the complex etiology of infertility, the book includes a number of chapters defining the known and probable causes of male infertility. Providing detailed information suitable for patients and clinicians alike, it also features a separate section on treatment, the ultimate goal.