Download or read book The Malaria Project written by Karen M. Masterson and published by Penguin. This book was released on 2014-10-07 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.

Download or read book War and Disease written by Leo Barney Slater and published by Rutgers University Press. This book was released on 2009 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine - a natural cure - became hard to acquire. This historical study shows the roots and branches of an enormous drug development project during World War II.

Download or read book War and Disease written by Leo Slater and published by Rutgers University Press. This book was released on 2009-01-09 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of the leading killers in the world today. Though drugs against malaria have a long history, attempts to develop novel therapeutics spanned the twentieth century and continue today. In this historical study, Leo B. Slater shows the roots and branches of an enormous drug development project during World War II. Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine–a natural cure–became harder to acquire. A U.S. government-funded antimalarial program, initiated by the National Research Council, brought together diverse laboratories and specialists to provide the best drugs to the nation's military. This wartime research would deliver chloroquinine–long the drug of choice for prevention and treatment of malaria–and a host of other chemotherapeutic insights. A massive undertaking, the antimalarial program was to biomedical research what the Manhattan Project was to the physical sciences. A volume in the Critical Issues in Health and Medicine series, edited by Rima D. Apple and Janet Golden.

Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Download or read book Mosquito Soldiers written by Andrew McIlwaine Bell and published by LSU Press. This book was released on 2010-04 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the 620,000 soldiers who perished during the American Civil War, the overwhelming majority died not from gunshot wounds or saber cuts, but from disease. In this ground-breaking medical history, Andrew McIlwaine Bell explores the impact of two terrifying mosquito-borne maladies---malaria and yellow fever---on the major political and military events of the 1860s, revealing how deadly microorganisms carried by a tiny insect helped shape the course of the Civil War.

Download or read book The Mosquito War written by V. A. MacAlister and published by Macmillan. This book was released on 2004-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his debut novel, MacAlister combines crooked pharmaceutical companies, a CIA plot gone horribly awry, a terrorist weapon that comes in a small package, and a grief-stricken scientist determined to make America pay for its indifference to the suffering in Third World countries.

Download or read book Cold War Deadly Fevers written by Marcos Cueto and published by Woodrow Wilson Center Press. This book was released on 2007-05-04 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher description

Download or read book The War Against Malaria written by Cynthia O'Brien and published by Crabtree Classics. This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Malaria is an ancient disease caused by a parasite passed through the bites of infected mosquitoes. It is only now-through extensive scientific research-that malaria can be prevented, treated, and cured. This fascinating book examines the difficulties malaria still presents and how science is working on a "zero malaria plan" that will one day eradicate the disease entirely"--

Download or read book Malaria Control in War Areas 1942 43 written by and published by . This book was released on 1943 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Download or read book Battling Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 2006-07-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is an infectious disease common to several parts of the world, including Africa, northern South America, and Asia. During their service in the military, U.S. active members may be sent to any part of the world, including parts of the world where Malaria is an issue. In Liberia in 2003, for example, there was a 28 percent attack rate in Marines who spent a short time ashore, and half of the 80 Marines affected needed to be evacuated to Germany. This was not only costly to the U.S. military but dangerous as well. To fight against this disease, there exists a Malaria Vaccine program in the U.S. military. However, there exists a variety of potential vaccine targets for the most severe and important form of malaria; malaria from the species Plasmodium falciparum. Issues also arise with the fact that there are three possible stages to create vaccines against-preerythrocytic, blood, or transmission. The Department of Defense (DoD), through the commanding general of the U.S. Army Medical Research and Materiel Command (USAMRMC), requested that the Institute of Medicine (IOM) conduct a programmatic review of the military Plasmodium falciparum malaria vaccine research and development program. There was to be a focus on vaccine against the preerythrocytic and blood stages. The IOM formed a committee of 11 experts with collective expertise in malaria vaccine research, parasite immunology, malarial biology, clinical trials and regulatory affairs, industrial and public-sector vaccine development, biologic products research and development (vaccinology), military research and development programs, tropical medicine, and public health. The committee focused different tasks including determining whether the DoD malaria vaccine research and development program is scientifically sound and able to achieve the vaccine program objectives within specified timelines, recommending how to overcome significant, identified barriers, and identifying major strategic goals and timelines based on the material received and presentations made by the DoD's program representatives. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program presents the committee's findings, current malaria vaccines, and recommendations for the development of the U.S. Military vaccine research.

Download or read book Bugs in Armor written by Robert Bwire and published by iUniverse. This book was released on 2000-02-14 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: From military expeditions in antiquity to peacekeeping missions in the twentieth century, malaria has been the single most important medical problem confronting nonimmune troops in malarious regions. Its devastating effects were clearly visible during both world wars. During the Macedonian campaign in World War I, an exasperated French general could not counterattack as he desperately reported, "Regret that my army is in hospital with malaria." Malaria also popped up in Korea, Vietnam and during Operation Restore Hope in Somalia. Often malaria causes more casualties than enemy action. A 1772 Dutch force sent to quell rioting slaves in Surinam lost three-quarters of its troops to malaria, and only a handful to the rebels. Bugs in Armor takes the reader on a historical journey of military expeditions and their encounters with a relentless bugthe malaria parasite. It is also a story of how this confrontation fuelled research that gave the world a better understanding of the nature of malaria, its treatment and prevention.

Download or read book The Mosquito written by Timothy C. Winegard and published by Penguin. This book was released on 2019-08-06 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: **The instant New York Times bestseller.** *An international bestseller.* Finalist for the Lane Anderson Award Finalist for the RBC Taylor Award “Hugely impressive, a major work.”—NPR A pioneering and groundbreaking work of narrative nonfiction that offers a dramatic new perspective on the history of humankind, showing how through millennia, the mosquito has been the single most powerful force in determining humanity’s fate Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito. Across our planet since the dawn of humankind, this nefarious pest, roughly the size and weight of a grape seed, has been at the frontlines of history as the grim reaper, the harvester of human populations, and the ultimate agent of historical change. As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power. The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village. Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable. Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito’s reign through human history and her indelible impact on our modern world order.

Download or read book The Malaria Problem in Peace and War written by Frederick Ludwig Hoffman and published by . This book was released on 1918 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Fever Trail written by Mark Honigsbaum and published by Macmillan. This book was released on 2003-05 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Literally Italian for "bad air," malaria once plagued Rome, tropical trade routes and colonial ventures into India and South America and the disease has no known antidote aside from the therapeutic effects of the "miraculous" quinine. This first book from journalist Honigsbaum is a rousing history of the search for febrifuge or, more specifically, the rare red cinchona tree, the bark from which quinine is derived.

Download or read book New Wars and Old Plagues written by Katherine Hirschfeld and published by Springer Nature. This book was released on 2023-06-12 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access book uses Mary Kaldor’s concept of “New Wars” to explore how ethnic conflict reshaped the social and environmental landscape of the Southern Caucuses following the collapse of the Soviet Union. It relies on remote sensing data and qualitative historical research to explore how armed conflict between non-state actors generated the region’s largest epidemic of P. vivax malaria since the 1960s. This book is an important addition to the literature on the Karabakh conflict and conflict studies more broadly because the infectious disease outbreaks associated with warfare often kill more people than the armed conflicts themselves. Warfare itself has also changed dramatically since the collapse of the USSR, and the Karabakh conflict provides an excellent case study of the way “New Wars” transform the natural and social environment to facilitate outbreaks of preventable disease. This extended case study will be useful to researchers from a variety of academic disciplines, including medical anthropology, geography, conflict studies, disease ecology, global health and public health. It also reveals the fragility of twentieth century malaria control in temperate regions and will assist in predictive modeling for future outbreaks.

Download or read book Egypt s Other Wars written by Nancy Elizabeth Gallagher and published by Syracuse University Press. This book was released on 2021-10-29 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three devastating epidemics swept Egypt in the 1940’s killing more people than all the wars Egypt has fought in the twentieth century. Egypt’s Other Wars vividly reconstructs the nation’s struggle against malaria, relapsing fever, and cholera and explores the unique combination of forces that put public health at the top of the national political agenda. Egypt in the 1940’s as in the throes of a nationalist upheaval. Nationalists of all political ideologies attributed the sever epidemics that the country was experiencing to Egypt’s status as an underdeveloped and colonized nation. The epidemics were therefore viewed for the first time as not only a public health crisis but also a political problem that called for a political solution.