Download or read book Making Science Fun A Tribute to Our Colleague and Friend Prof Antonius G Rolink 1953 2017 written by Hermann Eibel and published by Frontiers Media SA. This book was released on 2019-01-22 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic honors the memory of Prof. Antonius “Ton” G. Rolink (April 19, 1953–August 06, 2017), our colleague, mentor and friend in immunology. It is now over a year since Ton left us. This article collection, authored by many of Ton’s friends and colleagues, reflects the huge contribution to cellular and molecular immunology that work emanating directly from Ton’s own hands and laboratory have made to the understanding of lymphocyte development. Ton’s hard work, expertise, generosity, passion for science and infectious humor were legendary and for all of those lucky enough to have been his colleague, he ensured that science was fun. We take this opportunity of thanking all contributors for submitting their manuscripts; we are sure that Ton would have enjoyed reading and making his own insightful comments on them. In the form of original research and review articles, these papers cover many of Ton’s scientific interests in different aspects of lymphocyte development in mouse and man. In the first section, Development of hematopoietic cells and lymphocytes, Klein et al. describe the accumulation of multipotent hematopoietic progenitors in peripheral lymphoid organs of IL-7xFlt3L double transgenic mice and Pang et al. the role of the transcription factor PU.1 on the development of Common Lymphoid Progenitors. In Early B cell development, Winkler and Mårtensson review the role of the Pre-B cell receptor in B cell development and papers by Hobeika et al. and Brennecke et al. describe models of inducible B cell development. For B cell selection, survival and tolerance, Smulski and Eibel review the role of BAFF and Kowalczyk-Quintans et al. analyse the role of membrane-bound BAFF. The impact of BIM on B cell homeostasis is discussed by Liu et al. The role of the MEK-ERK pathway in B cell tolerance is discussed by Greaves et al. and the transcriptional regulation of germinal center development is reviewed by Song and Matthias. For Hematological diseases, Ghia reviews how studies of B cell development help the understanding of Leukemia development, Kim and Schaniel review how iPS technology helps the understanding of hematological diseases and Hellmann et al. describe development of new therapeutic antibody drug conjugates. Finally, in T cell development, homeostasis and graft vs. host disease, Heiler et al. describe the therapeutic effects of IL-2/anti-IL-2 immune complexes in GvHD, Calvo-Asensio et al. describe the DNA damage response of thymocyte progenitors and Mori and Pieters review the role of Coronin 1 in T cell survival.
Download or read book Making Science Fun A Tribute to Our Colleague and Friend Prof Antonius G Rolink 1953 2017 written by and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic honors the memory of Prof. Antonius "Ton" G. Rolink (April 19, 1953-August 06, 2017), our colleague, mentor and friend in immunology. It is now over a year since Ton left us. This article collection, authored by many of Ton's friends and colleagues, reflects the huge contribution to cellular and molecular immunology that work emanating directly from Ton's own hands and laboratory have made to the understanding of lymphocyte development. Ton's hard work, expertise, generosity, passion for science and infectious humor were legendary and for all of those lucky enough to have been his colleague, he ensured that science was fun. We take this opportunity of thanking all contributors for submitting their manuscripts; we are sure that Ton would have enjoyed reading and making his own insightful comments on them. In the form of original research and review articles, these papers cover many of Ton's scientific interests in different aspects of lymphocyte development in mouse and man. In the first section, Development of hematopoietic cells and lymphocytes, Klein et al. describe the accumulation of multipotent hematopoietic progenitors in peripheral lymphoid organs of IL-7xFlt3L double transgenic mice and Pang et al. the role of the transcription factor PU.1 on the development of Common Lymphoid Progenitors. In Early B cell development, Winkler and Mårtensson review the role of the Pre-B cell receptor in B cell development and papers by Hobeika et al. and Brennecke et al. describe models of inducible B cell development. For B cell selection, survival and tolerance, Smulski and Eibel review the role of BAFF and Kowalczyk-Quintans et al. analyse the role of membrane-bound BAFF. The impact of BIM on B cell homeostasis is discussed by Liu et al. The role of the MEK-ERK pathway in B cell tolerance is discussed by Greaves et al. and the transcriptional regulation of germinal center development is reviewed by Song and Matthias. For Hematological diseases, Ghia reviews how studies of B cell development help the understanding of Leukemia development, Kim and Schaniel review how iPS technology helps the understanding of hematological diseases and Hellmann et al. describe development of new therapeutic antibody drug conjugates. Finally, in T cell development, homeostasis and graft vs. host disease, Heiler et al. describe the therapeutic effects of IL-2/anti-IL-2 immune complexes in GvHD, Calvo-Asensio et al. describe the DNA damage response of thymocyte progenitors and Mori and Pieters review the role of Coronin 1 in T cell survival.
Download or read book Genomic Surveillance and Pandemic Preparedness written by Rajesh Pandey and published by Elsevier. This book was released on 2023-06-29 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inference—moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness. Highlights different aspects of genomic surveillance, from theory to implementation to inferences Covers a broad range of infectious diseases, with emphasis on recent COVID-19 studies Shares methods and approaches for sequencing-based pathogen detection, diagnostics, and surveillance Facilitates international collaboration in drug and vaccine development
Download or read book Fresh from the Farm 6pk written by Rigby and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kumba Africa written by Sampson Ejike Odum and published by iUniverse. This book was released on 2020-11-03 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘KUMBA AFRICA’, is a compilation of African Short Stories written as fiction by Sampson Ejike Odum, nostalgically taking our memory back several thousands of years ago in Africa, reminding us about our past heritage. It digs deep into the traditional life style of the Africans of old, their beliefs, their leadership, their courage, their culture, their wars, their defeat and their victories long before the emergence of the white man on the soil of Africa. As a talented writer of rich resource and superior creativity, armed with in-depth knowledge of different cultures and traditions in Africa, the Author throws light on the rich cultural heritage of the people of Africa when civilization was yet unknown to the people. The book reminds the readers that the Africans of old kept their pride and still enjoyed their own lives. They celebrated victories when wars were won, enjoyed their New yam festivals and villages engaged themselves in seasonal wrestling contest etc; Early morning during harmattan season, they gathered firewood and made fire inside their small huts to hit up their bodies from the chilling cold of the harmattan. That was the Africa of old we will always remember. In Africa today, the story have changed. The people now enjoy civilized cultures made possible by the influence of the white man through his scientific and technological process. Yet there are some uncivilized places in Africa whose people haven’t tested or felt the impact of civilization. These people still maintain their ancient traditions and culture. In everything, we believe that days when people paraded barefooted in Africa to the swarmp to tap palm wine and fetch firewood from there farms are almost fading away. The huts are now gradually been replaced with houses built of blocks and beautiful roofs. Thanks to modern civilization. Donkeys and camels are no longer used for carrying heavy loads for merchants. They are now been replaced by heavy trucks and lorries. African traditional methods of healing are now been substituted by hospitals. In all these, I will always love and remember Africa, the home of my birth and must respect her cultures and traditions as an AFRICAN AUTHOR.
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation XI written by Sudhir Gupta and published by Springer. This book was released on 2007-05-21 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Download or read book Affective Health and Masculinities in South Africa written by Hans Reihling and published by Routledge. This book was released on 2020 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Affective Health and Masculinities in South Africa explores how different masculinities modulate substance use, interpersonal violence, suicidality, and AIDS as well as recovery cross-culturally. With a focus on three male protagonists living in very distinct urban areas of Cape Town, this comparative ethnography shows that men's struggles to become invulnerable increase vulnerability. Through an analysis of masculinities as social assemblages, the study shows how affective health problems are tied to modern individualism rather than African 'tradition' that has become a clichâe in Eurocentric gender studies. Affective health is conceptualized as a balancing act between autonomy and connectivity that after colonialism and apartheid has become compromised through the imperative of self-reliance. This book provides a rare perspective on young men's vulnerability in everyday life that may affect the reader and spark discussion about how masculinities in relationships shape physical and psychological health. Moreover, it shows how men change in the face of distress in ways that may look different than global health and gender transformative approaches envision. Thick descriptions of actual events over the life course make the study accessible to both graduate and undergraduate students in the social sciences. Contributing to current debates on mental health and masculinity, the volume will be of interest to scholars from a number of disciplines including anthropology, gender studies, African studies, psychology and global health"--
Download or read book Truth Is a Woman written by Loren Jakobov and published by Createspace Independent Publishing Platform. This book was released on 2017-09-12 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Truth Is A Woman is a poetry collection by Loren Jakobov written in response to her friends tragic death in 2015 as a victim of rape and murder. The poems discuss the World from the eyes of a woman, the pain and the beauty that lies therein.
Download or read book Elmer Again written by David McKee and published by . This book was released on 1991 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elmer, the patchwork elephant, plays an amusing trick on his grey elephant friends.
Download or read book The Life of William Cavendish written by Margaret Cavendish Duchess of Newcastle and published by . This book was released on 1907 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Feminism and Social Change written by Heidi Gottfried and published by University of Illinois Press. This book was released on 1996 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Fresh, original, and brings together in one place a set of authors who are very important to the field." -- Mary Margaret Fonow, coeditor of Beyond Methodology: Feminist Scholarship as Lived Research "Finally, a collection dedicated to demonstrating precisely what it means to do feminist research " -- Madonna Harrington Meyer, University of Illinois at Urbana-Champaign How likely is feminist research to promote change in society? Are some research methods more successful at bringing about change than others? Contributors to this volume discuss principles of feminist inquiry, providing examples from their own experience and evaluating research practices for their potential to promote social change. The twelve chapters cover methodologies including ethnographic study, in-depth interviewing, naming, and going public. Also explored are consultative relationships between academic researchers and activist organizations, participatory and advocacy research processes, and coalition building.
Download or read book Love in Case of Emergency written by Daniela Krien and published by HarperCollins. This book was released on 2021-04-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Fans of Sarah Dunn, Elisabeth Egan, and Isabel Gillies will relate to the multifaceted lives of Krien’s characters, brilliantly rendered in her vivid voice." -- Booklist Writing with the wry realism of Sally Rooney, one of Germany’ most promising literary talents demonstrates her incisive understanding of the complexities of relationships and the depths of the human heart in this witty and compulsively readable novel about five very different women whose lives intersect. What happens when women fulfill their roles as wives, mothers, friends, lovers, sisters, and daughters? What comes next? Award-winning author Daniela Krien explores these questions in this powerful novel of friendship, love, loss, and everything in between. Krien explores the hopes, ambitions, challenges, and disappointments that shape modern women’s lives, offering intimate insights on motherhood and childlessness, bereavement, infidelity, and divorce. At the heart of the novel are five very different women who find themselves hurtling towards a new way of living without knowing quite how they got there. A fresh take on women’s lives, Love in Case of Emergency is a punchy yet sensitive novel that takes the notion of aspiring to find happiness and connection to new and exhilarating heights. Translated from the German by Jamie Bulloch
