Download or read book Magnetic Resonance Imaging of Stem Cell Applications written by Xiaoming Yang and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell-based regenerative therapy has become a frontier in modern medicine. For the success of both basic research and clinical application of stem cell technology, it is essential to have noninvasive methods to monitor the delivery of transplanted stem cells, track migration/homing of stem cells to the targets, and assess survival and function of the transplanted stem cells at the targets. Magnetic resonance imaging (MRI) represents a promising technology fitting in this necessity. So far, scientists from various disciplines around the world have done outstanding works in developing different MR techniques for in vivo imaging of stem cells, so-called cellular MRI. The aim of this book is to facilitate such translation of advanced cellular MRI techniques from laboratory benches to pre-clinical animal studies, and, ultimately, to clinical practice. The authors are from several continents around the world, with their expertise in the fields of stem cell science, biomedical engineering, medicine, pathology, medical imaging, and interventional radiology. We hope this book will provoke common interests, brainstorming and cooperation among professionals in both stem cell science and medical imaging, and bring regenerative medicine one step closer to benefiting the patients.

Download or read book Magnetic Resonance Imaging of Stem Cell Applications written by Xiaoming Yang and published by . This book was released on 2015 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell-based regenerative therapy has become a frontier in modern medicine. For the success of both basic research and clinical application of stem cell technology, it is essential to have noninvasive methods to monitor the delivery of transplanted stem cells, track migration/homing of stem cells to the targets, and assess survival and function of the transplanted stem cells at the targets. Magnetic resonance imaging (MRI) represents a promising technology fitting in this necessity. So far, scientists from various disciplines around the world have done outstanding works in developing differ.

Download or read book Imaging in Stem Cell Transplant and Cell based Therapy written by Tarun Pandey and published by Springer. This book was released on 2017-05-29 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a review of imaging techniques and applications in stem cell transplantation and other cell-based therapies. The basis of different molecular imaging techniques is explained in detail, as is the current state of interventional radiology techniques. While the whole is a comprehensive discussion, each chapter is self-sufficient enough so that each can be reviewed independently. The contributors represent years of international and cross-disciplinary expertise and perspective and are all well known in their fields. comprehensive information on the role of clinical and molecular imaging in stem cell therapy from this book reviewed in detail. Essential reading for radiologists and physicians who are interested in developing a basic understanding of stem cell imaging and applications of stem cells and cell based therapies. However, it will also be of interest to clinical scientists and researchers alike, including those involved in stem cell labeling, tracking & imaging, cancer therapy, angiogenesis and cardiac regeneration.

Download or read book Magnetic Resonance Imaging in Tissue Engineering written by Mrignayani Kotecha and published by John Wiley & Sons. This book was released on 2017-02-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging in Tissue Engineering provides a unique overview of the field of non-invasive MRI assessment of tissue engineering and regenerative medicine Establish a dialogue between the tissue-engineering scientists and imaging experts and serves as a guide for tissue engineers and biomaterial developers alike Provides comprehensive details of magnetic resonance imaging (MRI) techniques used to assess a variety of engineered and regenerating tissues and organs Covers cell-based therapies, engineered cartilage, bone, meniscus, tendon, ligaments, cardiovascular, liver and bladder tissue engineering and regeneration assessed by MRI Includes a chapter on oxygen imaging method that predominantly is used for assessing hypoxia in solid tumors for improving radiation therapy but has the ability to provide information on design strategies and cellular viability in tissue engineering regenerative medicine

Download or read book Application of Stem Cell Therapy and Magnetic Resonance Imaging in Experimental Models of Cardiovascular Diseases written by K. K. Cheung and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging written by Dara L. Kraitchman and published by CRC Press. This book was released on 2011-11-18 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy. The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters, leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems. Through clear descriptions and color images, this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field, the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.

Download or read book Application of Stem Cell Therapy and Magnetic Resonance Imaging in Experimental Models of Cardiovascular Diseases written by King Kenneth Cheung and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular and Cellular MR Imaging written by Michel M.J. Modo and published by CRC Press. This book was released on 2007-03-28 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and

Download or read book Progress in Stem Cell Applications written by Allen V. Faraday and published by Nova Publishers. This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to recent research in stem cell applications. Stem cells are the foundation cells for every organ, tissue and cell in the body. They are like a blank microchip that can ultimately be programmed to perform any number of specialised tasks. Stem cells are undifferentiated, "blank" cells that do not yet have a specific function. Under proper conditions, stem cells begin to develop into specialised tissues and organs. Additionally, stem cells are self-sustaining and can replicate themselves for long periods of time. These unique characteristics make stem cells very promising for supplying cells to treat debilitating diseases like Alzheimer's disease, cancer, Parkinson's disease, type-1 diabetes, spinal cord injury, stroke, burns, heart disease, osteoarthritis and rheumatoid arthritis.

Download or read book The Development and Application of Nanoparticles for Cell Tracking and Multimodal Imaging written by Jeanne Elizabeth Lemaster and published by . This book was released on 2019 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell therapy is an emerging tool to treat a variety of conditions from cancer to musculoskeletal disorders to cardiac disease. Current FDA-approved stem cell therapies utilize cells from peripheral blood or bone marrow to treat patients who have disorders of the hematopoietic system; however clinical trials for utilizing stem cells to treat muscular skeletal disorders and cardiac disease are underway. Because stem cells self-renew and differentiate in multiple lineage pathways, the general theory behind stem cell therapy is that damaged tissue can be repaired or regenerated and that trophic activity of stem cells can modulate other immune cells. While stem cell therapy has the potential to treat a variety of conditions due to its regenerative and proliferative activity, more study is needed to address ideal injection time, method of injection, distribution, and retention concerns. Imaging stem cells addresses these concerns and can provide more information overall about the fate of stem cells. Contrast agents are needed to increase the contrast and specificity of imaging stem cells. Nanoparticle-based contrast agents are important tools for imaging because they offer high contrast and stable signal. Chapter 1 of this thesis provides a background on cell therapy and various imaging modalities. Chapter 2 details the design and synthesis of gadolinium-doped synthetic melanin nanoparticles which were used to label stem cells for photoacoustics and magnetic resonance imaging (MRI). Chapter 3 explores the mechanism of ultraviolet (UV)-induced synthetic melanin nanoparticle generation. Chapter 4 describes the design, synthesis, and application of an iron oxide PLGA-based nanoparticle used for ultrasound, photoacoustics, and magnetic particle imaging (MPI). Finally, Chapter 5 describes the synthesis and application of a nanoparticle for cancer treatment that shows an increase in photoacoustic intensity as drug is released. This nanoparticle was then used to treat tumors in mice and luminescence was used to monitor treatment response. Chapter 6 concludes with a perspective on the future of imaging cell therapy with possible directions.

Download or read book In Vivo Cellular and Molecular Imaging written by Eric T. Ahrens and published by Gulf Professional Publishing. This book was released on 2005-11-09 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent times there has been an explosive expansion of new imaging methodologies that are capable of visualizing specific populations of cells and molecular events in vivo. Vital imaging enhances our ability to study animal models of human development and disease, such as cancers, cardiovascular disease, diabetes, and Alzheimer's. Furthermore, non-invasive imaging may ultimately be useful for monitoring new generations of clinical molecular and cellular therapeutics, such as those utilizing viral vectors and stem cells. These new capabilities have been facilitated by the development of new imaging probes or reagents that target specific cell types, are chemically responsive to physiology, or are responsive to the presence of specific molecules, such as nucleic acids or enzymes. This volume provides an introduction to some of the most exciting methods and applications of emerging non-invasive imaging technologies using magnetic resonance imaging (MRI), positron emission tomography (PET), and various biophotonic approaches. Highlighted, are recent developments in reagent design that impart unique abilities to these imaging modalities to elucidate biological processes in vivo. * Includes 9 chapters by expert researchers in the field of imaging * Introduces new methods and applications of non-invasive imaging technologies * Covers ermerging topics in imaging such as in vivo cell cancer cells, imaging of autoimmune diseases, and maganetic resonance imaging

Download or read book In Vivo Imaging Of Transplanted Human Hepatic Stem Cells Negative Contrast Labeling And 7t Micro MRI Tracking written by and published by . This book was released on 2004 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell therapies have great potential as alternative options to whole organ transplantations in treating dysfunction or failure, and alleviating the chronic shortage of donor availability of organs such as the liver. In these therapies, adherent stem cells are transplanted to replace and repopulate diseased tissues, hence allowing the failing organs to regain their functional effectiveness. Given that clinical trials are ongoing or are about to occur with many different categories of stem cells, there is a need for in vivo stem cell imaging to monitor cell motility after inoculation, and to follow the location and expansion of the stem cells thereafter. Specifically, some topics being addressed comprise cell transplantation procedures, cell migration dynamics, and possibilities for creating tissue-cell-vacuums to permit engraftment and expansion of the transplanted cells. In this way, the efficacy of stem cell therapy may be evaluated and realized. The goals of the current study are to develop effective procedures for labeling stem cells with contrast agents for magnetic resonance imaging (MRI), and to investigate the MRI detectability of labeled cells. The model systems are human hepatic stem cells that are isolated by fractionation or immunoselection technologies from human fetal livers. In brief, there are two subpopulations of human hepatic stem cells, both of which are positive for Epithelial Cell Adhesion molecule (EpCAM) as well as for other antigens (Moss, Wauthier et al. 2004). The uptake, retention and physiological effects of magnetic labels are examined with in vitro experiments. Subsequently, the human hepatic stem cells are transplanted into immunocompromised SCID/nod mice to monitor in vivo MRI cell signals. To facilitate time-lapse investigations, several animals are inoculated simultaneously but independently imaged in order to quantify signal intensities, durations, and spatial distributions of cells within resident mice livers.

Download or read book Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and published by CRC Press. This book was released on 2016-10-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

Download or read book Stem Cell Induced Restoration of Myocardium SCIRM written by Robert Phillip Gallegos and published by . This book was released on 2007 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Imaging in Cellular and Tissue Engineering written by Hanry Yu and published by CRC Press. This book was released on 2013-05-16 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details on specific imaging modalities for different cellular and tissue engineering applications are scattered throughout articles and chapters in the literature. Gathering this information into a single reference, Imaging in Cellular and Tissue Engineering presents both the fundamentals and state of the art in imaging methods, approaches, and applications in regenerative medicine. The book underscores the broadening scope of imaging applications in cellular and tissue engineering. It covers a wide range of optical and biological applications, including the repair or replacement of whole tissues (such as bone, cartilage, blood vessels, and bladder) and more novel artificially created support systems (such as artificial pancreas and bioartificial liver). Each chapter describes a particular application, relevant optical instrumentation, physical principles governing the imaging method, and strengths and weaknesses of the technique. The book also presents current and emerging data processing procedures. As the field of tissue engineering moves from creating simpler outer body parts to more sophisticated internal organs, researchers need to evaluate and control how well the tissues are engineered and integrated into the living body. Suitable for both experts and newcomers in bioengineering and biomedical imaging, this book shows researchers how to apply imaging techniques to next-generation engineered cells and tissues. It helps them assess the suitability of specific imaging modalities for applications with various functional requirements.

Download or read book Fluorine Magnetic Resonance Imaging written by Eric T. Ahrens and published by CRC Press. This book was released on 2024-10-11 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-based biomarkers that report on specific cell phenotypes in the body are highly valued for disease detection and monitoring cytotherapies. Towards this need, there is sustained scientific interest in fluorine-19 (19F) magnetic resonance imaging (MRI) for in vivo molecular–cellular imaging applications. The attraction of 19F tracer MRI is its ability to produce pure ‘hot-spot’ images, an absence of false-positive signals, robust quantification, and tracer safety. For molecular–cellular applications, fluorine MRI does not require a pre-scan prior to tracer administration, thus offering several advantages over metal–ion-based proton (1H) contrast-agent approaches. Key applications of 19F MRI include cell tracking, inflammation detection, and biosensing. Fluorinated imaging tracers can also serve as therapeutic agents or drug-delivery vehicles. Over the past decade, the field of 19F MRI has seen remarkable innovation in tracer designs and detection methods as well as the realization of its clinical potential. This book is an interdisciplinary compendium detailing cutting-edge science and biomedical research in the emerging field of 19F MRI and includes technical issues, such as pulse sequence considerations and limits of detection of the techniques; synthesis of novel 19F MRI tracer agents; inflammation, cancer, and stroke imaging; regenerative brain repair; theranostic nanomedicine; and clinical perspectives. The book will appeal to investigators involved in MRI physics, biomedicine, immunology, pharmacology, and probe chemistry as well as general readers.

Download or read book Stem Cells and Biomaterials for Regenerative Medicine written by Marek J. Los and published by Academic Press. This book was released on 2018-11-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials