Download or read book Macrophages Biology and Tissue Inflammation in Health and Disease written by Stuart Goodman and published by Academic Press. This book was released on 2024-07-10 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats. Outlines the important role of macrophages as regulators and orchestrators of inflammation and repair in health and disease Contains chapters by leading authors on the basic and translational aspects of macrophage biology in maintaining tissue homeostasis Deals with internal and external treats

Download or read book Macrophages Biology and Role in the Pathology of Diseases written by Subhra K. Biswas and published by Springer. This book was released on 2014-11-12 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Macrophage Activation written by Khalid Hussain Bhat and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.

Download or read book Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis written by Tarcio Teodoro Braga and published by Frontiers Media SA. This book was released on 2017-10-13 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive species, which in turn, influence the behavior of other cells. Furthermore, macrophages and interacting cells are also susceptible to metabolic changes that ultimately will define the outcome macrophage signaling and its effect in the tissue. Here, we present a concise series of discussions on the role of macrophages, its response to the microenvironment and effects on other cells during tissue injury and repair. Triggering of inflammasome in macrophage activation and function is of special interest in this issue. We will emphasize the role of different macrophage subpopulations and the plasticity of these cells during fibrotic process in different models of diseases.

Download or read book One No one One Hundred Thousand The Multifaceted Role of Macrophages in Health and Disease Part A written by and published by Academic Press. This book was released on 2022-04-20 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A, provides in-depth reviews on the last progresses on the role of macrophages in health and diseases with a special focus on the role of macrophages in SARS-COV2, breast cancer, liver and salivary glands. Provides accurate reviews from selected experts on the topic of macrophages in different tissues such as lung, uterus, breast and liver Each chapter of the volume provides useful graphic material for ease of reading of the audience Provides the latest insights and future perspectives on macrophage heterogeneity in different diseases

Download or read book Macrophages in inflammation and its resolution written by Heiko Mühl and published by Frontiers E-books. This book was released on with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when they migrate to distant sites and differentiate to specialized cells, like foam cells, osteoclasts, adipose tissue- and tumor -associated macrophages and other macrophage-derived cell types. These processes are affected by the inflammation-resolution axis and can result in health threats, such as atherosclerosis, bone loss, obesity, fibrosis and cancer. This Research Topic issue will cover a wide range of topics in macrophage biology: 1. Macrophages in immune responses to pathogens 2. Macrophages in the termination of acute and acquired immunity. 3. The role of macrophages and their descendents in inflammation-associated pathologies. 4. Macrophage polarization and differentiation. Particular focus will be given to the modulation of macrophage phenotype and function following their encounter with apoptotic cells and the signaling cascades that govern these changes.

Download or read book Macrophages in the Human Body written by Niels Olson Saraiva Camara and published by Academic Press. This book was released on 2022-06-08 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential. Covers translational aspects where there is research support to indicate potential therapeutic potential Aims at presenting a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics Introduces Macrophages generally and dive into the organ/tissue/specific representations covering their phenotype, function, and metabolic characteristics Brings updated aspects of macrophages biology

Download or read book One No One One Hundred Thousand The Multifaceted Role of Macrophages in Health and Disease Part B written by and published by Academic Press. This book was released on 2022-05-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B, Volume 369 provides in-depth reviews on the last progresses on the role of macrophages in health and diseases, with a special focus on the role of macrophages during development. New chapters cover The role of salivary gland macrophages in infection, disease and repair, Reprogramming or replacing brain macrophages to treat neurodegenerative disease, Targeting macrophages for cancer immunotherapy, Heart Macrophages at steady-state and disease: simple bystanders or active players?, Macrophages in the liver, and Developmental programming of macrophages. Provides accurate reviews from selected experts on the topic of macrophages in different tissues such as gut, kidney and heart Presents useful graphic material for ease of reading and learning for users Covers the latest insights and future perspectives on macrophage heterogeneity in different diseases

Download or read book Tissue Resident Macrophages written by Elvira Mass and published by Springer Nature. This book was released on 2023-08-28 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book M1 M2 Macrophages The Arginine Fork in the Road to Health and Disease written by Charles Dudley Mills and published by Frontiers Media SA. This book was released on 2015-03-23 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.

Download or read book Biology of the Lymphokines written by Stanley Cohen and published by Academic Press. This book was released on 2013-09-17 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory properties of interferons and rationale developed for integrating interferons with the family of lymphokines are likewise deliberated. This publication is a good source for students and researchers conducting work on lymphokines.

Download or read book Molecular Basis of Health and Disease written by Undurti N. Das and published by Springer Science & Business Media. This book was released on 2011-04-02 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

Download or read book Human Monocytes written by Marek Zembala and published by . This book was released on 1989 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.

Download or read book Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages comprehend a heterogeneous mononuclear phagocytic population with wide range phenotypes and roles in homeostasis maintenance and diseases, such as infections, autoimmunity and cancer. Technology improvements enable researchers to track different macrophage populations in different tissues and situations and hypothesize on their role in promoting inflammation or stimulating tissue repair. Through innate immune recognition system macrophages can launch several effector artilleries that culminate in the production of various types of inflammatory mediators as cytokines, chemokines, lipid mediators and oxygen reactive species, which in turn, influence the behavior of other cells. Furthermore, macrophages and interacting cells are also susceptible to metabolic changes that ultimately will define the outcome macrophage signaling and its effect in the tissue. Here, we present a concise series of discussions on the role of macrophages, its response to the microenvironment and effects on other cells during tissue injury and repair. Triggering of inflammasome in macrophage activation and function is of special interest in this issue. We will emphasize the role of different macrophage subpopulations and the plasticity of these cells during fibrotic process in different models of diseases.

Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.