Download or read book Macrophages and Related Cells written by Michael A. Horton and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . .
Download or read book Immunobiology of the Macrophage written by David Selwyn Nelson and published by . This book was released on 1976 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book's contributors-immunologists of diverse scientific and geographic backgrounds-have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making an ...
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Download or read book Biology of the Lymphokines written by Stanley Cohen and published by Academic Press. This book was released on 2013-09-17 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory properties of interferons and rationale developed for integrating interferons with the family of lymphokines are likewise deliberated. This publication is a good source for students and researchers conducting work on lymphokines.
Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disease Pathways written by Anastasia P. Nesterova and published by Elsevier. This book was released on 2019-10-18 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Download or read book Hemopoietic System written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the hemopoietic system, is the eighth volume of a set prepared under the sponsorship of the International Life Sciences In stitute (ILSI).
Download or read book Dendritic Cell and Macrophage Nomenclature and Classification written by Florent Ginhoux and published by Frontiers Media SA. This book was released on 2016-07-14 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mononuclear phagocyte system (MPS) comprises dendritic cells (DCs), monocytes and macrophages (MØs) that together play crucial roles in tissue immunity and homeostasis, but also contribute to a broad spectrum of pathologies. They are thus attractive therapeutic targets for immune therapy. However, the distinction between DCs, monocytes and MØ subpopulations has been a matter of controversy and the current nomenclature has been a confounding factor. DCs are remarkably heterogeneous and consist of multiple subsets traditionally defined by their expression of various surface markers. While markers are important to define various populations of the MPS, they do not specifically define the intrinsic nature of a cell population and do not always segregate a bona fide cell type of relative homogeneity. Markers are redundant, or simply define distinct activation states within one subset rather than independent subpopulations. One example are the steady-state CD11b+ DCs which are often not distinguished from monocytes, monocyte-derived cells, and macrophages due to their overlapping phenotype. Lastly, monocyte fate during inflammation results in cells bearing the phenotypic and functional features of both DCs and MØs significantly adding to the confusion. In fact, depending on the context of the study and the focus of the laboratory, a monocyte-derived cell will be either be called "monocyte-derived DCs" or "macrophages". Because the names we give to cells are often associated with a functional connotation, this is much more than simple semantics. The "name" we give to a population fundamentally changes the perception of its biology and can impact on research design and interpretation. Recent evidence in the ontogeny and transcriptional regulation of DCs and MØs, combined with the identification of DC- and MØ-specific markers has dramatically changed our understanding of their interrelationship in the steady state and inflammation. In steady state, DCs are constantly replaced by circulating blood precursors that arise from committed progenitors in the bone marrow. Similarly, some MØ populations are also constantly replaced by circulating blood monocytes. However, others tissue MØs are derived from embryonic precursors, are seeded before birth and maintain themselves in adults by self-renewal. In inflammation, such differentiation pathways are fundamentally changed and unique monocyte-derived inflammatory cells are generated. Current DC, monocyte and MØ nomenclature does not take into account these new developments and as a consequence is quite confusing. We believe that the field is in need of a fresh view on this topic as well as an upfront debate on DC and MØ nomenclature. Our aim is to bring expert junior and senior scientists to revisit this topic in light of these recent developments. This Research Topic will cover all aspects of DC, monocyte and MØ biology including development, transcriptional regulation, functional specializations, in lymphoid and non-lymphoid tissues, and in both human and mouse models. Given the central position of DCs, monocytes and MØs in tissue homeostasis, immunity and disease, this topic should be of interest to a large spectrum of the biomedical community.
Download or read book Macrophages Biology and Role in the Pathology of Diseases written by Subhra K. Biswas and published by Springer. This book was released on 2014-11-12 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.
Download or read book Avian Immunology written by Bernd Kaspers and published by Academic Press. This book was released on 2012-12-02 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research
Download or read book Skin and Arthropod Vectors written by Nathalie Boulanger and published by Academic Press. This book was released on 2018-01-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods. Offers the only compilation of research focusing on both the skin interface and arthropod vectors, with contributions from international experts Advances research in the effort toward generating more effective diagnostic tools and vaccines focusing on the skin interface Can also serve as supplemental material for dermatology lectures or specialized lectures on medical entomology and skin immunity
Download or read book Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine written by Miguel Angel Reina and published by Springer. This book was released on 2014-11-26 with total page 929 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first atlas to depict in high-resolution images the fine structure of the spinal canal, the nervous plexuses, and the peripheral nerves in relation to clinical practice. The Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine contains more than 1500 images of unsurpassed quality, most of which have never been published, including scanning electron microscopy images of neuronal ultrastructures, macroscopic sectional anatomy, and three-dimensional images reconstructed from patient imaging studies. Each chapter begins with a short introduction on the covered subject but then allows the images to embody the rest of the work; detailed text accompanies figures to guide readers through anatomy, providing evidence-based, clinically relevant information. Beyond clinically relevant anatomy, the book features regional anesthesia equipment (needles, catheters, surgical gloves) and overview of some cutting edge research instruments (e.g. scanning electron microscopy and transmission electron microscopy). Of interest to regional anesthesiologists, interventional pain physicians, and surgeons, this compendium is meant to complement texts that do not have this type of graphic material in the subjects of regional anesthesia, interventional pain management, and surgical techniques of the spine or peripheral nerves.
Download or read book Biology of Myelomonocytic Cells written by Anirban Ghosh and published by BoD – Books on Demand. This book was released on 2017-05-10 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.
Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammation 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.
