Download or read book Lyme Disease Recent Advances and Perspectives written by Tanja Petnicki-Ocwieja and published by Frontiers Media SA. This book was released on 2015-08-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging. These studies have furthered our understanding of inflammatory processes during long-term infection and provided some surprising insights, such as the continued presence of bacterial products after clearance. The field of Lyme disease has long debated the etiology of long-term inflammation and recent studies in the murine host have shed light on relevant cell types and inflammatory mediators that participate in the pathology of Lyme arthritis. Live imaging and bioluminescent studies have allowed for a novel view of the bacterial life cycle, including the tick mid-gut, tick-to-mammal transmission and dissemination throughout a mouse. A number of tick and bacterial proteins have been shown to participate in the completion of the enzootic cycle. Novel mechanisms of gene regulation are continuously being identified. However, B. burgdorferi lacks many traditional virulence factors, such as toxins or specialized secretion systems. Many genes in the B. burgdorferi genome have no known homolog in other bacteria. Therefore, studies focusing on host-pathogen interactions have therefore been limited by an incomplete understanding of the repertoire of bacterial virulence factors. Questions such as how the pathogen causes disease, colonizes the tick and evades host immune-surveillance have been difficult to address. Genetic studies involving single gene deletions have identified a number of important bacterial proteins, but a large-scale genomics approach to identify virulence factors has not been attempted until recently. The generation of a site-directed mutagenesis library is an important step towards a detailed analysis of the B. burgdorferi genome and pathogenome. Using this library, high-throughput genomic studies, utilizing techniques such as massively parallel sequencing have been promising and could be used to identify novel virulence determinants of disease in the mammalian host or persistence in the tick vector. Continued research on this unique pathogen and its specific interaction with host and vector may have far reaching consequences and provide insights for diverse disciplines including ecology, infectious disease, and immunology. Here, several reviews will discuss the most recent advances and future studies to be undertaken in the field of B. burgdorferi biology.
Download or read book Critical Needs and Gaps in Understanding Prevention Amelioration and Resolution of Lyme and Other Tick Borne Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single tick bite can have debilitating consequences. Lyme disease is the most common disease carried by ticks in the United States, and the number of those afflicted is growing steadily. If left untreated, the diseases carried by ticks-known as tick-borne diseases-can cause severe pain, fatigue, neurological problems, and other serious health problems. The Institute of Medicine held a workshop October 11-12, 2010, to examine the state of the science in Lyme disease and other tick-borne diseases.
Download or read book Conquering Lyme Disease written by Brian A. Fallon and published by Columbia University Press. This book was released on 2017-12-12 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lyme disease is the most common tick-borne illness in the United States, with more than 300,000 cases diagnosed each year. However, doctors are deeply divided on how to diagnose and treat it, giving rise to the controversy known as the “Lyme Wars.” Firmly entrenched camps have emerged, causing physicians, patient communities, and insurance providers to be pitted against one another in a struggle to define Lyme disease and its clinical challenges. Health care providers may not be aware of its diverse manifestations or the limitations of diagnostic tests. Meanwhile, patients have felt dismissed by their doctors and confused by the conflicting opinions and dubious self-help information found online. In this authoritative book, the Columbia University Medical Center physicians Brian A. Fallon and Jennifer Sotsky explain that, despite the vexing “Lyme Wars,” there is cause for both doctors and patients to be optimistic. The past decade’s advances in precision medicine and biotechnology are reshaping our understanding of Lyme disease and accelerating the discovery of new tools to diagnose and treat it, such that the great divide previously separating medical communities is now being bridged. Drawing on both extensive clinical experience and cutting-edge research, Fallon, Sotsky, and their colleagues present these paradigm-shifting breakthroughs in language accessible to both sides. They clearly explain the immunologic, infectious, and neurologic basis of chronic symptoms, the cognitive and psychological impact of the disease, as well as current and emerging diagnostic tests, treatments, and prevention strategies. Written for the educated patient and health care provider seeking to learn more, Conquering Lyme Disease gives an up-to-the-minute overview of the science that is transforming the way we address this complex illness. It argues forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully and may soon even be reversed.
Download or read book Lyme Disease Perspectives on Disease Illness written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Deep Places written by Ross Douthat and published by Convergent Books. This book was released on 2021-10-26 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES EDITORS’ CHOICE • In this vulnerable, insightful memoir, the New York Times columnist tells the story of his five-year struggle with a disease that officially doesn’t exist, exploring the limits of modern medicine, the stories that we unexpectedly fall into, and the secrets that only suffering reveals. “A powerful memoir about our fragile hopes in the face of chronic illness.”—Kate Bowler, bestselling author of Everything Happens for a Reason In the summer of 2015, Ross Douthat was moving his family, with two young daughters and a pregnant wife, from Washington, D.C., to a sprawling farmhouse in a picturesque Connecticut town when he acquired a mysterious and devastating sickness. It left him sleepless, crippled, wracked with pain--a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which according to CDC definitions does not actually exist: the chronic form of Lyme disease, a hotly contested condition that devastates the lives of tens of thousands of people but has no official recognition--and no medically approved cure. From a rural dream house that now felt like a prison, Douthat's search for help takes him off the map of official medicine, into territory where cranks and conspiracies abound and patients are forced to take control of their own treatment and experiment on themselves. Slowly, against his instincts and assumptions, he realizes that many of the cranks and weirdos are right, that many supposed "hypochondriacs" are victims of an indifferent medical establishment, and that all kinds of unexpected experiences and revelations lurk beneath the surface of normal existence, in the places underneath. The Deep Places is a story about what happens when you are terribly sick and realize that even the doctors who are willing to treat you can only do so much. Along the way, Douthat describes his struggle back toward health with wit and candor, portraying sickness as the most terrible of gifts. It teaches you to appreciate the grace of ordinary life by taking that life away from you. It reveals the deep strangeness of the world, the possibility that the reasonable people might be wrong, and the necessity of figuring out things for yourself. And it proves, day by dreadful day, that you are stronger than you ever imagined, and that even in the depths there is always hope.
Download or read book Lyme written by Mary Beth Pfeiffer and published by Island Press. This book was released on 2018-04-17 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Superbly written and researched." --Booklist "Builds a strong case." --Kirkus Lyme disease is spreading rapidly around the globe as ticks move into places they could not survive before. Mary Beth Pfeiffer argues it is the first epidemic to emerge in the era of climate change, infecting millions around the globe. She tells the heart-rending stories of its victims, families whose lives have been destroyed by a single, often unseen, tick bite. Pfeiffer also warns of the emergence of other tick-borne illnesses that make Lyme more difficult to treat and pose their own grave risks. Lyme is an impeccably researched account of an enigmatic disease, making a powerful case for action to fight ticks, heal patients, and recognize humanity's role in a modern scourge.
Download or read book Bull s eye written by Jonathan A. Edlow and published by Yale University Press. This book was released on 2004-01-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides information on the history of Lyme disease focusing on the scientific processes involved in its discovery.
Download or read book Global Health Impacts of Vector Borne Diseases written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-10-21 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.
Download or read book Divided Bodies written by Abigail A. Dumes and published by Duke University Press. This book was released on 2020-08-24 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many doctors claim that Lyme disease—a tick-borne bacterial infection—is easily diagnosed and treated, other doctors and the patients they care for argue that it can persist beyond standard antibiotic treatment in the form of chronic Lyme disease. In Divided Bodies, Abigail A. Dumes offers an ethnographic exploration of the Lyme disease controversy that sheds light on the relationship between contested illness and evidence-based medicine in the United States. Drawing on fieldwork among Lyme patients, doctors, and scientists, Dumes formulates the notion of divided bodies: she argues that contested illnesses are disorders characterized by the division of bodies of thought in which the patient's experience is often in conflict with how it is perceived. Dumes also shows how evidence-based medicine has paradoxically amplified differences in practice and opinion by providing a platform of legitimacy on which interested parties—patients, doctors, scientists, politicians—can make claims to medical truth.
Download or read book Lyme Disease written by Richard Ostfeld and published by OUP USA. This book was released on 2011 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of research on the ecology of Lyme disease in North America describes how humans get sick, why some years and places are so risky and others not, and offers a new understanding that embraces the complexity of species and their interactions.
Download or read book Aspects of Lyme Borreliosis written by G. Schierz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aspects of Lyme Borreliosis is a comprehensive scientific presentation of virtually all aspects of lyme borreliosis. It starts with a concise history of lyme borreliosis and its causative agent, Borrelia burgdorferi. The morphological and biological characteristics of B. burgdorferi are presented, followed by outlines on the ecology and histopathology of LB.The various aspects of the clinical manifestations of LB are systematically dealt with, starting with a clinical overview. A special chapter covers the microbiological diagnosis. After a presentation on the susceptibility of B. burgdorferi in vitro and in animals against a great variety of antibiotics, a thorough discussion on the treatment of LB including criticalremarks follows. The book closes with a chapter on the epidemiology of LB.
Download or read book Why Can t I Get Better written by Richard I. Horowitz and published by Macmillan. This book was released on 2013-11-12 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: "When Dr. Richard Horowitz moved to the Hudson Valley over a decade ago to start his own medical practice, he didn't know that he would be jumping into the center of one of the fiercest, most heated medical disputes being waged today. The ongoing debate over Lyme disease as a chronic illness has made it difficult for sufferers to find care, as doctors are in many cases unable or unwilling to diagnose it. This is how once-treatable infections can become chronic, causing disabling conditions that may never be cured. In a field where the number of cases is growing each year and answers remain elusive, Horowitz has made extraordinary progress. His plan represents a paradigm shift, without which, he argues, the suffering will continue. In this book, Horowitz breaks new ground with a 16 Point Differential Diagnostic Map, the basis for his Lyme treatment plan, and an overarching approach to treating all chronic illness. He introduces MSIDS, or Multi-Systemic Infectious Disease Syndrome, a new lens on chronic illness that may prove to be an important missing link. And he covers in detail Lyme's leading symptoms and co-infections, including immune dysfunction, sleep disorders, chronic pain and neurodegenerative disorders. This book is an all-in-one source for patients of Lyme and other chronic illnesses to identify their own symptoms and work with their doctors for the best possible treatment outcome"--
Download or read book Lyme Disease and Relapsing Fever Spirochetes written by Justin D. Radolf and published by . This book was released on 2021 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Behavioral Neurogenetics written by John F. Cryan and published by Springer Science & Business Media. This book was released on 2012-05-04 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
Download or read book Ecology and Prevention of Lyme Borreliosis written by Marieta A. H. Braks and published by Brill Wageningen Academic. This book was released on 2016-11-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can nature be protected and biodiversity be preserved while the threats of zoonotic diseases are minimised? Expanding nature areas and creating ecological networks across Europe is not only beneficial for wildlife, but also for the pathogens they carry. A prominent case is Lyme borreliosis, which has risen from relative obscurity to become a major public health problem in Europe. The Dutch research program 'Shooting the messenger' took a 'One Health' approach aiming at the development of sustainable measures for the prevention of Lyme borreliosis. An interdisciplinary network of researchers, public health experts, and nature managers gained and shared knowledge in the ecological processes of ticks, Lyme spirochaetes and their vertebrate hosts as well as in the human epidemiology of tick bites and Lyme borreliosis. These new insights, together with new intervention methods and strategies, are described in this book.
Download or read book Treatment of Chronic Lyme Disease written by Waisbren Sr. and published by Biomed Publishing Group. This book was released on 2011-10 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book documents the experiences and opinions of a doctor in the management of chronic Lyme disease. It also contains eleven opinionated essays about this challenging disease.
Download or read book Insights Into Lyme Disease Treatment written by Connie Strasheim and published by BioMed Publishing Group. This book was released on 2009 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health care journalist Connie Strasheim has conducted intensive interviews with thirteen of the world's most competent Lyme disease healers, asking them thoughtful, important questions, and then spent months compiling their information into organized, user-friendly chapters that contain the core principles upon which they base their medical treatment of chronic Lyme disease. --publisher.
