Download or read book Lyme Disease Perspectives on Disease Illness written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lyme Disease Recent Advances and Perspectives written by Tanja Petnicki-Ocwieja and published by Frontiers Media SA. This book was released on 2015-08-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging. These studies have furthered our understanding of inflammatory processes during long-term infection and provided some surprising insights, such as the continued presence of bacterial products after clearance. The field of Lyme disease has long debated the etiology of long-term inflammation and recent studies in the murine host have shed light on relevant cell types and inflammatory mediators that participate in the pathology of Lyme arthritis. Live imaging and bioluminescent studies have allowed for a novel view of the bacterial life cycle, including the tick mid-gut, tick-to-mammal transmission and dissemination throughout a mouse. A number of tick and bacterial proteins have been shown to participate in the completion of the enzootic cycle. Novel mechanisms of gene regulation are continuously being identified. However, B. burgdorferi lacks many traditional virulence factors, such as toxins or specialized secretion systems. Many genes in the B. burgdorferi genome have no known homolog in other bacteria. Therefore, studies focusing on host-pathogen interactions have therefore been limited by an incomplete understanding of the repertoire of bacterial virulence factors. Questions such as how the pathogen causes disease, colonizes the tick and evades host immune-surveillance have been difficult to address. Genetic studies involving single gene deletions have identified a number of important bacterial proteins, but a large-scale genomics approach to identify virulence factors has not been attempted until recently. The generation of a site-directed mutagenesis library is an important step towards a detailed analysis of the B. burgdorferi genome and pathogenome. Using this library, high-throughput genomic studies, utilizing techniques such as massively parallel sequencing have been promising and could be used to identify novel virulence determinants of disease in the mammalian host or persistence in the tick vector. Continued research on this unique pathogen and its specific interaction with host and vector may have far reaching consequences and provide insights for diverse disciplines including ecology, infectious disease, and immunology. Here, several reviews will discuss the most recent advances and future studies to be undertaken in the field of B. burgdorferi biology.
Download or read book Lyme Disease written by Judy Monroe and published by Capstone. This book was released on 2001 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains what Lyme disease is, what its symptoms are, and how it is spread. Also describes ways to avoid Lyme disease, as well as ways to treat it.
Download or read book Lyme Disease written by Mary E. Williams and published by Greenhaven Publishing LLC. This book was released on 2011-12-15 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: If left untreated Lyme Disease can spread to joints, heart, and nervous system. This guidebook provides essential information on Lyme Disease, but also serves as a historical survey, by providing information on the controversies surrounding its causes, and first-person narratives by people coping with Lyme Disease. Patients, family members, or caregivers explain the condition from their own experience. The symptoms, causes, treatments, and potential cures are explained in detail. Essential to anyone trying to learn about diseases and conditions, the alternative treatments are explored. Each essay is carefully edited and presented with an introduction, so that they are accessible for student researchers and readers.
Download or read book Conquering Lyme Disease written by Brian A. Fallon and published by Columbia University Press. This book was released on 2017-12-12 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lyme disease is the most common tick-borne illness in the United States, with more than 300,000 cases diagnosed each year. However, doctors are deeply divided on how to diagnose and treat it, giving rise to the controversy known as the “Lyme Wars.” Firmly entrenched camps have emerged, causing physicians, patient communities, and insurance providers to be pitted against one another in a struggle to define Lyme disease and its clinical challenges. Health care providers may not be aware of its diverse manifestations or the limitations of diagnostic tests. Meanwhile, patients have felt dismissed by their doctors and confused by the conflicting opinions and dubious self-help information found online. In this authoritative book, the Columbia University Medical Center physicians Brian A. Fallon and Jennifer Sotsky explain that, despite the vexing “Lyme Wars,” there is cause for both doctors and patients to be optimistic. The past decade’s advances in precision medicine and biotechnology are reshaping our understanding of Lyme disease and accelerating the discovery of new tools to diagnose and treat it, such that the great divide previously separating medical communities is now being bridged. Drawing on both extensive clinical experience and cutting-edge research, Fallon, Sotsky, and their colleagues present these paradigm-shifting breakthroughs in language accessible to both sides. They clearly explain the immunologic, infectious, and neurologic basis of chronic symptoms, the cognitive and psychological impact of the disease, as well as current and emerging diagnostic tests, treatments, and prevention strategies. Written for the educated patient and health care provider seeking to learn more, Conquering Lyme Disease gives an up-to-the-minute overview of the science that is transforming the way we address this complex illness. It argues forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully and may soon even be reversed.
Download or read book Lyme Disease written by Karen Angotti and published by Anarek Publications. This book was released on 1993 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the incredible, compelling drama of one family's struggle with a terrifying difficult-to-diagnose illness. As they consult doctor after doctor while their ten-year-old son develops more & more bewildering symptoms, they discover that there is a disease that can baffle doctors & escape detection by many of their intricate tests. LYME DISEASE, the fastest growing infectious disease behind AIDS according to the CDC, can make the medical technology of the twentieth century look like something from the Dark Ages. Like a phantom, it pilfers & destroys leaving no discernible trace of its presence. The greatest tragedy is that unlike many other diseases which are difficult to diagnose, Lyme disease is treatable, especially in its earliest stage. This book gives pertinent information on preventing Lyme disease, lists early & late symptoms, describes the unreliability of currently available Lyme testing, discusses illnesses that Lyme disease can imitate, explores the controversy regarding long-term antibiotic therapy, gives suggestions for dealing with a chronic medical problem & directs you to organizations that can help you find a physician & learn even more. This family's frightening experience could provide invaluable information for your family's health & well-being.
Download or read book Bull s eye written by Jonathan A. Edlow and published by Yale University Press. This book was released on 2004-01-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides information on the history of Lyme disease focusing on the scientific processes involved in its discovery.
Download or read book Lyme Disease 2nd Edition written by John J Halperin and published by CABI. This book was released on 2018-08-20 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects. This new edition includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others). Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis. Discusses the controversies about 'chronic Lyme disease', post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection. As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease.
Download or read book Lyme Disease written by Alan G. Barbour and published by JHU Press. This book was released on 2015-04-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: A world-renowned Lyme disease expert explains everything you need to know if you live, work, or play in areas with the ticks that carry disease. Once restricted to small forested areas in the northeast and north-central United States, Lyme disease is now a common infection in North America and Europe. The Centers for Disease Control and Prevention estimate that more than 300,000 new cases occur each year in the United States. Misunderstandings over symptoms and treatment increase the public's concerns about the disease—which, if not properly treated, can become chronic and debilitating. An expert on tick-borne diseases, Alan G. Barbour explains the course of illness that results from infection, diagnosis and treatment options, and steps that can be taken to avoid a tick bite in the first place. The ticks that transmit Lyme disease may also transmit other disease-causing pathogens, and these other infections are considered as well. Drawing on real case histories of individuals with Lyme disease—or illnesses that may be mistaken for Lyme disease—Barbour explains: The biology of the spirochete, Borrelia burgdorferi, that causes Lyme disease The role of animals such as mice that carry the infection The life cycle of the ticks that transmit the infection The importance of deer in perpetuating the cycle The basics of diagnostic laboratory tests and how test results are interpreted How antibiotics are used in treating Lyme disease Infected ticks are abundant in the woods, in walking trails, and in the shrubs and tall grass where suburban lawns meet wooded areas. Barbour stresses preventing disease through community-wide ecology projects and individual and household protection. While it may be difficult to escape infection, understanding the danger, the symptoms, and the treatment goes a long way toward preventing long-term health consequences. Featuring a list of reliable web sites and a glossary of terms, Lyme Disease is an invaluable resource for everyone who is at risk of the disease or is involved in preventing and treating it.
Download or read book Lyme Disease written by Raymond J. Lampke and published by Greenhaven Publishing LLC. This book was released on 2018-07-15 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lyme disease is not often discussed, which means the general public knows little about it. Many people are aware that it can be passed from ticks to humans, but questions remain. What are the symptoms? Is it contagious? Can it be treated? What are the best prevention methods? These questions and more are answered in this engaging book, with text that is enhanced with full-color photographs, annotated quotes, and informative sidebars. By fully informing themselves about this disease, readers will know the steps to take if they encounter it as well as how to support a loved one who contracts Lyme disease.
Download or read book The Deep Places written by Ross Douthat and published by National Geographic Books. This book was released on 2021-10-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES EDITORS’ CHOICE • In this vulnerable, insightful memoir, the New York Times columnist tells the story of his five-year struggle with a disease that officially doesn’t exist, exploring the limits of modern medicine, the stories that we unexpectedly fall into, and the secrets that only suffering reveals. “A powerful memoir about our fragile hopes in the face of chronic illness.”—Kate Bowler, bestselling author of Everything Happens for a Reason In the summer of 2015, Ross Douthat was moving his family, with two young daughters and a pregnant wife, from Washington, D.C., to a sprawling farmhouse in a picturesque Connecticut town when he acquired a mysterious and devastating sickness. It left him sleepless, crippled, wracked with pain--a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which according to CDC definitions does not actually exist: the chronic form of Lyme disease, a hotly contested condition that devastates the lives of tens of thousands of people but has no official recognition--and no medically approved cure. From a rural dream house that now felt like a prison, Douthat's search for help takes him off the map of official medicine, into territory where cranks and conspiracies abound and patients are forced to take control of their own treatment and experiment on themselves. Slowly, against his instincts and assumptions, he realizes that many of the cranks and weirdos are right, that many supposed "hypochondriacs" are victims of an indifferent medical establishment, and that all kinds of unexpected experiences and revelations lurk beneath the surface of normal existence, in the places underneath. The Deep Places is a story about what happens when you are terribly sick and realize that even the doctors who are willing to treat you can only do so much. Along the way, Douthat describes his struggle back toward health with wit and candor, portraying sickness as the most terrible of gifts. It teaches you to appreciate the grace of ordinary life by taking that life away from you. It reveals the deep strangeness of the world, the possibility that the reasonable people might be wrong, and the necessity of figuring out things for yourself. And it proves, day by dreadful day, that you are stronger than you ever imagined, and that even in the depths there is always hope.
Download or read book Cure Unknown written by Pamela Weintraub and published by Macmillan. This book was released on 2008 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an investigation into the science, history, and politics of Lyme disease as observed by a journalist whose entire family contracted the illness traces its significant rise and the atypical presentations that have made its diagnosis and treatment difficult. It is a narrative investigation into the science, history, medical politics, and patient experience of Lyme disease told by a science journalist whose entire family contracted the disease. It paints a picture of the intense controversy and crippling uncertainty surrounding Lyme disease and sheds light on one of the angriest medical disputes raging today. The author also reveals her personal odyssey through the land of Lyme after she, her husband and their two sons became seriously ill with the disease beginning in the 1990s. From the microbe causing the infection and the definition of the disease, to the length and type of treatment and the kind of practitioner needed, Lyme is a hotbed of contention. With a CDC estimated 200,000 plus new cases of Lyme disease a year, it has surpassed both AIDS and TB as the fastest-spreading infectious disease in the U.S. Yet alarmingly, in many cases, because the disease often eludes blood tests and not all patients exhibit the classic "bulls-eye" rash and swollen joints, doctors are unable or unwilling to diagnose Lyme. When that happens, once treatable infections become chronic, inexorably disseminating to cause disabling conditions that may never be cured. The book reveals why the Lyme epidemic has been allowed to explode, why patients are dismissed, and what can be done to raise awareness in the medical community and find a cure. A comprehensive book written about the past, present and future of Lyme disease, it exposes the ticking clock of a raging epidemic
Download or read book Lyme written by Mary Beth Pfeiffer and published by Island Press. This book was released on 2018-04-17 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Superbly written and researched." --Booklist "Builds a strong case." --Kirkus Lyme disease is spreading rapidly around the globe as ticks move into places they could not survive before. Mary Beth Pfeiffer argues it is the first epidemic to emerge in the era of climate change, infecting millions around the globe. She tells the heart-rending stories of its victims, families whose lives have been destroyed by a single, often unseen, tick bite. Pfeiffer also warns of the emergence of other tick-borne illnesses that make Lyme more difficult to treat and pose their own grave risks. Lyme is an impeccably researched account of an enigmatic disease, making a powerful case for action to fight ticks, heal patients, and recognize humanity's role in a modern scourge.
Download or read book Lyme Disease and the Expanded Spectrum of Blacklegged Tick Borne Infections An Issue of Infectious Disease Clinics of North America E Book written by Robert P. Smith and published by Elsevier Health Sciences. This book was released on 2022-09-20 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Infectious Disease Clinics of North America, guest editor Dr. Robert P. Smith brings his considerable expertise to the topic of Lyme Disease and the Expanding Spectrum of Associated Tick-Borne Illness. With a primary focus on Lyme disease and its complications, the thorough reviews in this issue will also discuss the epidemiology, clinical presentations, diagnosis, treatment and outcomes of other infections transmitted by the black-legged tick in North America. The complexity of the public narrative of these diseases will also be addressed with an eye toward providing the clinician with a context for response. - Contains 14 practice-oriented topics including early Lyme disease: erythema migrans and Its mimics; Lyme arthritis; neurologic Lyme disease: four common fallacies and three diagnostic requirements; persistent symptoms in patients with treated Lyme disease; ID specialists approach to consultation in patients referred for refractory illness attributed to tick-borne disease; and more. - Provides in-depth clinical reviews on Lyme disease and the expanding spectrum of associated tick-borne illness, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Red Book written by Larry K. Pickering and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed by the AAP (American Academy of Pediatrics) Committee on Infectious Diseases in conjunction with the CDC (Centers for disease control), the FDA (Food and drug administration), and other leading institutions with contributions from hundreds of physicians nationwide, the newly revised and updated 2012 Red Book continues the tradition of excellence with the latest findings and clinical recommendations on the manifestations, etiology, epidemiology, diagnosis, and treatment of more than 200 childhood conditions. [Ed.].
Download or read book Rickettsial Diseases written by Didier Raoult and published by CRC Press. This book was released on 2007-04-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho
Download or read book On the Island of My Bed written by Carmen Alfonso and published by Troubador Publishing Ltd. This book was released on 2006-11-01 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of poetry based on the author's experiences of living with Lyme Disease. This work highlights Lyme Disease. It is a personal account of what it is like to live with Lyme Disease.
