Download or read book Luminescent Tetradentate Platinum II Complexes Bearing Asymmetric Ligands with Mixed Oxygen Nitrogen and Carbon Donor Atoms written by 高敏盈 and published by . This book was released on 2017 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Luminescent Platinum ii Complexes Containing Dianionic Tetradentate Ligands Having Mixed Oxygen Nitrogen and Carbon Donor Atoms and Platinum ii Containing Phosphorescent Polymers written by Wai-Yip Tong and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Luminescent Platinum(II) Complexes Containing Dianionic Tetradentate Ligands Having Mixed Oxygen, Nitrogen and Carbon Donor Atoms and Platinum(II)-containing Phosphorescent Polymers: Synthesis, Photophysical Properties and Material Applications" by Wai-yip, Tong, 唐煒燁, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled LUMINESCENT PLATINUM(II) COMPLEXES CONTAINING DIANIONIC TETRADENTATE LIGANDS HAVING MIXED OXYGEN, NITROGEN AND CARBON DONOR ATOMS AND PLATINUM(II)-CONTAINING PHOSPHORESCENT POLYMERS: SYNTHESIS, PHOTOPHYSICAL PROPERTIES AND MATERIAL APPLICATIONS Submitted by TONG WAI YIP for the degree of Doctor of Philosophy at The University of Hong Kong in May 2014 Square planar platinum(II) complexes exhibit rich photophysical properties which are tunable through the structural variation of ligands and can be harnessed for applications in materials science. In this thesis, the great variety of spectroscopic properties of various square planar cyclometalated platinum(II) complexes supported by tetradentate (O DEGREESN DEGREESN DEGREESC and O DEGREESN DEGREESC DEGREESN) and tridentate (C DEGREESN DEGREESN) ligands containing dipyridyl moieties will be highlighted, along with their synthesis, characterization and potential application in organic light emitting diodes (OLEDs). Ind Platinum(II) complexes supported by tetradentate O DEGREESN DEGREESN DEGREESC or O DEGREESN DEGREESN DEGREESC types of ligands (O DEGREESN DEGREESN DEGREESC = 2-(4-(3,5-di-tert-butylphenyl)-6'-phenyl-2,2'- Ind bipyridin-6-yl)phenolate; O DEGREESN DEGREESN DEGREESC = 5,5-dialkyl-2-(6-phenylpyridin-2-yl) indeno[1,2-b]pyridin-9-olate) are emissive in solution at room temperature, with emission maxima tunable from 582 nm to 640 nm and quantum yields up to 0.28. Mechanochromism and the associated luminescence change in [Pt(dihexyl- Ind O DEGREESN DEGREESN DEGREESC)] (Complex 3.6) were found associated with the two different crystal packings revealed by powder X-ray diffraction (PXRD) studies. Fast vapochromic response of [Pt(3-O DEGREESN DEGREESN-2,6-difluoropyridine)] (Complex 3.3) on chloroform or dichloromethane vapours was found to be associated with structural changes in the solid state through PXRD studies. Robust and strongly emissive platinum(II) complexes supported by tetradentate O DEGREESN DEGREESC DEGREESN ligands featuring fused six-five-six membered metallacyclic ring (O DEGREESN DEGREESC DEGREESN = 2-(4-(3,5-di-tert-butylphenyl)-6-(9-(pyridin-2-yl) carbazol-2-yl)pyridin-2-yl)phenol) have been prepared. These platinum(II) complexes are among the most efficient yellow phosphors, with emission maxima ranging from 526 nm to 553 nm and luminescence quantum yields as high as -1 0.47-0.86. A yellow OLED with power efficiency (η ) up to 52 lm W is power demonstrated. In combination with the typical blue emitting iridium(III) 2' bis(4,6-difluorophenyl-pyridinato-N, C ) picolinate (FIrpic), white organic -1 light-emitting diodes (WOLEDs) displayed η up to 61 lm W and reduced power -2 efficiency roll-off at 1000 cd m . Random copolymers with photo-inert backbone poly[(N-vinylcarbazole)-co- ((R-C DEGREESN DEGREESN)Pt)] and poly[(2-(4-tert-butylphenyl)-5-(4-vinylphenyl)-1,3,4- oxadiazole)-co-((R-C DEGREESN DEGREESN)Pt)] (R-C DEGREESN DEGREESN = 3-(6-phenyl-4-(4-vinylphenyl) pyridine-2-yl)-isoquinoline or 3-(4-(4-(dec-9-enyloxy)phenyl)-6-phenylpyridin- 2-yl)isoquinoline) have been synthesized and characterized. Energy transfer between the charge transporting units and emissive (R-C DEGREESN DEGREESN)Pt units was revealed through ICP-MS inve

Download or read book Luminescent Platinum II Complexes Containing Dianionic Tetradentate Ligands Having Mixed Oxygen Nitrogen and Carbon Donor Atoms and Platinum II containing Phosphorescent Polymers written by 唐煒燁 and published by . This book was released on 2014 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Strongly Luminescent Tetradentate Platinum II and Palladium II Complexes written by 洪偉鴻 and published by . This book was released on 2017 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book DESIGN SYNTHESIS OF LUMINESC written by Suk-Hang Lam and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Design and Synthesis of Luminescent Platinum(II) and Gold(III) Complexes With Tridentate Pincer-type Ligands: From Computational Study to Experiments and Application Studies" by Suk-hang, Lam, 林淑恒, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DESIGN AND SYNTHESIS OF LUMINESCENT PLATINUM(II) AND GOLD(III) COMPLEXES WITH TRIDENTATE PINCER-TYPE LIGANDS - FROM COMPUTATIONAL STUDY TO EXPERIMENTS AND APPLICATION STUDIES Submitted by LAM Suk Hang for the degree of Doctor of Philosophy at The University of Hong Kong in June 2015 Square planar platinum(II) and gold(III) complexes possess unique spectroscopic and photophysical properties which enable them as promising candidates for many applications such as optoelectronic devices and biological sensors. The understanding of the intrinsic properties of these complexes is therefore essential to optimize their performance as well as provide guidance on the molecular design for specific applications. This thesis aims to provide useful insights for the molecular design strategies with the aid of computational studies to tune the electronic properties of these complexes and electroluminescence studies in the fabrication of organic light-emitting devices (OLEDs). Computational studies have been performed to inspect electronic structures and photophysical properties as well as their correlation with the nature of ancillary ligands in the platinum(II) complexes of 1,3-bis(N-alkylbenzimidazol-2′-yl)benzene, [Pt(bzimb)(C≡C-R)], 1,3-bis-hetero-azolylbenzenes, [Pt(N DEGREESC DEGREESN)(C≡C-R)], and pyridine-based N-heterocyclic carbene, [Pt(NHC)(C≡C-R)] . It was found that the emission of the arylalkynylplatinum(II) complexes with pyridine-based N-heterocyclic carbene ligand was originated from the triplet alkynyl-to-tridentate pincer ligand-to-ligand charge transfer excited state mixed with platinum-to-tridentate pincer metal-to-ligand charge transfer character, and the excited state energy was found to be red-shifted according to the increasing π electron-donating ability of the aryl group attached to the alkynyl ligand. On the other hand, the emission energies of the platinum(II) complexes of 1,3-bis(N-alkylbenzimidazol-2′-yl)benzene and 1,3-bis-hetero-azolylbenzenes were found to be dependent on the different electron-donating substituents on the pincer ligands. Calculations have also been performed on the representative alkynylplatinum(II) + + complexes [Pt(trpy)(C≡C-R)] (trpy = 2,2′ 6′,2′′-terpyridine), [Pt(bzimpy)(C≡C-R)] (bzimpy = 2,6-bis(N-alkylbenzimidazol-2′-yl)pyridine) and [Pt(bzimb)(C≡C-R)] as well as alkynylgold(III) complexes [Au(C DEGREESN DEGREESC)(C≡C-R)] (C DEGREESN DEGREESC = 2,6-diphenylpyridine), [Au{C(Np) DEGREESN DEGREESC(Np)}(C≡C-R)] (C(Np) DEGREESN DEGREESC(Np) = 2,6-di(2-naphthyl)pyridine) and [Au(N DEGREESN DEGREESN)(C≡C-R)] (N DEGREESN DEGREESN = 2,6-bis(1H-benzimidazol-2-yl)pyridine) in order to have a better understanding on their nature of the emissive origins as well as the radiative and nonradiative processes. In particular, factors governing the ordering of the triplet excited states and radiative decay rate constants of the emissive state ( ES) have been examined. Their potential energy profiles for the deactivation process from the ES via triplet metal-centered states have also been explored. This study revealed for the first time the potential energy profiles for the thermal deactivation pathway of square planar platinum(II) and gold(III) complexes. In addition to the computational

Download or read book LIGHT EMITTING PLATINUM II written by Wei Lu and published by Open Dissertation Press. This book was released on 2017-01-28 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Light-emitting Platinum (II) and Gold (I) Complexes Containing Cyclometalated and Alkynyl Ligands" by Wei, Lu, 陸為, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled LIGHT-EMITTING PLATINUM(II) AND GOLD(I) COMPLEXES CONTAINING CYCLOMETALATED AND ALKYNYL LIGANDS Submitted by Lu Wei for the degree of Doctor of Philosophy at The University of Hong Kong in July 2003 The syntheses, characterizations, spectroscopic properties and applications of light-emitting platinum(II) and gold(I) complexes containing cyclometalated and alkynyl ligands are described and five systems are explored in detail. The tuning of the photoluminescent properties of tridentate cyclometalated platinum(II) complexes bearing σ-alkynyl auxiliaries, namely [(C DEGREESN DEGREESN)Pt(C≡C) R] [H(C DEGREESN DEGREESN) = 6-aryl- 2,2'-bipyridine; n = 1-4; R = aryl, alkyl or trimethylsilyl], through modifications of both the cyclometalating and acetylide ligands, is presented. These neutral Pt(II) materials exhibit enhanced stability during vacuum deposition. Organic light-emitting devices (OLEDs) based on these emitters display orange to red electrophosphorescence with low turn-on voltages ( 4 V), maximum luminance -2 -1 approaching 10,000 cd m and efficiencies up to 4.2 cd A . The crystal structures and photoluminescence of tethered trinuclear cyclometalated platinum(II) complexes, 3+ namely [{R(C DEGREESN DEGREESN)} Pt ( -dpmp)] (R denotes substituent(s) on the (C DEGREESN DEGREESN) 3 3 3 ligand, dpmp = bis(diphenylphosphinomethyl)phenylphosphine), were investigated and compared with their mono- and binuclear analogues to yield insight into the nature of their respective excited states. The emission energies were found to be dependent on the substituents on the cyclometalating ligands and the oligophosphine 8 8 ligands, and sensitive to d -d and π-π interactions. Intermolecular π-stacking interactions were found to affect the crystal packing, solid-state emission energy and vapochromic behavior of mono- and multinuclear dicyclometalated Pt(II) complexes, 1 1 namely [Pt(C DEGREESN DEGREESC)L ] [HC DEGREESN DEGREESCH = 2,6-diphenylpyridine; L = pyridine, isocyanide, 2 2 phosphine], [Pt (C DEGREESN DEGREESC) (-L )] [L = pyrazine, bidentate phosphine] and 2 2 [Pt (C DEGREESN DEGREESC) ( -dpmp)], and aromatic α-diimine Pt(II) complexes bearing 3 3 3 t t functionalized σ-alkynyl auxiliaries, namely [( Bu bpy)Pt(C≡CAr) ] ( Bu bpy = 4,4'- 2 2 2 bis-tert-butyl-2,2'-bipyridine, Ar = 4-pyridyl, 3-pyridyl, 2-pyridyl, 4-ethynylpyridyl, 2-thienyl and pentafluorophenyl). The weak non-covalent interactions observed in the solvated crystal structures, such as π-π, C-H---π(C≡C), C-H---N(py), C-H---F-C and Cl---Cl contacts, were invoked to rationalize the reversible VOC (volatile organic compound) sensing and signaling capabilities of these materials. The syntheses, crystal structures and spectroscopic properties of several π-conjugated carbon-rich scaffolds bearing [Au(PCy )] (Cy = cyclohexyl) termini are described. The ν of the 3 0-0 acetylenic (ππ*) emission for [(Cy P)Au(C≡C) Au(PCy )] (n = ∞) was estimated to 3 n 3 -1 1 occur at 11000 cm by extrapolation of the plot of ν versus 1/n. Prompt (ππ*) 0-0 fluorescence only was detected from the cross-conjugated species [TEE][Au(PCy )] 3 4 ([TEE]H = tetraethynylethene). A correlation between the solid-state emissions and crystal structures of the phosphorescent polymorphic complex [4-NO - C H C≡CAu(PCy )] and their related complexes was observed, and a rationale based 6 4 3 on excitonic coupling is proposed. DOI: 10.5353/th_b

Download or read book Luminescent Mixed Ligand Square Planar Platinum II Complexes Containing Dithiolate Or Dithiocarbamate Ligands written by Joanne McDonald Bevilacqua and published by . This book was released on 1994 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Luminescent Platinum II Complexes with Tridentate N donor Ligands as Building Blocks for Supramolecular assembled 1D Materials and Metallofoldamers written by 黃進熙 and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Platinum II Complexes with Dianionic Tetradentate Ligands as Green Red and Near Infrared Emitters written by 鄺俊霖 and published by . This book was released on 2019 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Luminescent Platinum ii Palladium ii and Gold iii Complexes Containing Isocyanide Alkynyl and N Heterocyclic Carbene Ligands written by Faan-Fung Hung and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Luminescent Platinum(II), Palladium(II) and Gold(III) Complexes Containing Isocyanide, Alkynyl and N-heterocyclic Carbene Ligands: Synthesis, Photophysical Properties and Material Applications" by Faan-fung, Hung, 孔繁峰, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Several cyclometalated Pt(II) isocyanide complexes containing C-deprotonated C DEGREESN DEGREESC ligands (C DEGREESN DEGREESC = 2,6-diphenylpyridine derivatives) were synthesized. These complexes display orange-red emissions with max at 582-619 nm and quantum yields of up to 26% in CH2Cl2 at room temperature. The incorporation of carbazole/fluorene/thiophene unit(s) to C DEGREESN DEGREESC ligands leads to minimized structural distortion of complexes in their excited states and thereby suppresses non-radiative decay pathways. The high thermal stability (Td >300 C) renders these complexes good candidates as phosphorescent dopants in organic light-emitting diodes (OLEDs). Red-emitting OLEDs with CIE coordinates of (0.650.01, 0.350.01) were fabricated by vacuum deposition, showing a maximum external efficiency of 12%. In addition, well-defined nano/microstructures were obtained from self-assembly of these complexes driven by π∙∙∙π, C-H∙∙∙π and C-H∙∙∙H-C interactions as observed in the crystal structures. Two series of organopalladium(II) alkynyl complexes containing a terpy (terpy = 2,2':6',2''-terpyridine) or C DEGREESN DEGREESC pincer carbene ligand (C DEGREESN DEGREESC = 2,6-bis(1-butylimidazol-2-ylidenyl)pyridine) were prepared. These complexes are non-emissive in solution at room temperature except that the one containing both C DEGREESN DEGREESC and pyrenylacetylide ligands shows phosphorescence (Φ = 0.3%) originating from intraligand state of the acetylide ligand. This could be attributed to the strong -donating N-heterocyclic carbene (NHC) in the pincer ligand that strongly destabilizes d-d state, the population of which provides an efficient non-radiative decay channel. To make comparison between Pd(II) and Pt(II) complexes with the two ligand systems, Pt(II) C DEGREESN DEGREESC alkynyl complexes were also prepared. They are emissive in solution and some display excimer emissions at high concentration (〖10〗 DEGREES(-4)-〖10〗 DEGREES(-3) mol 〖10dm〗 DEGREES(-3)). The X-ray crystal structures of [Pd(L)(CCPh)](〖PF〗_6) (L = terpy and C DEGREESN DEGREESC) revealed one-dimensional chain stacking of complex cations with alternating Pd(II)∙∙∙Pd(II) contacts of about 3.29-3.35 A and π-π interactions of about 3.4 A . Well-defined submicron/nanostructures were obtained from self-assembly of Pd(II) and Pt(II) alkynyl complexes driven by π-π interactions between aromatic moieties and/or metal∙∙∙metal interactions. DFT calculations on the optimized structures of [M(L)(CCPh)]+ (M = Pd(II) and Pt(II)) revealed the existence of metal∙∙∙metal closed-shell interactions. In addition, the complex containing the C DEGREESN DEGREESC ligand exhibits slightly enhanced metal∙∙∙metal interactions and larger "bonding" energy upon dimerization. Furthermore, spin-orbit coupling between singlet and triplet excited states is more effective which promotes rapid intersystem crossing. A new class of cyclometalated Au(III) complexes containing C-deprotonated C DEGREESN ligands (C DEGREESN = 2-phenylpyridine and its derivatives) and cis-chelating bis-NHC ligands was synthesized. These are the first examples of Au(III) complexes supported by cis-chelating bis-NHC ligands. They display emissions in solution under degassed condition at room temperature with &

Download or read book Luminescent Platinum ii Copper i Silver i and Zinc ii Complexes with Functional Pyridyl and Arylacetylide Ligands written by Yongyue Lin and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design and Synthesis of Luminescent Metal Polypyridyl Complexes of Platinum ii Ruthenium ii and Osmium ii for Chemosensing and Biological Studies written by Wing-Suen Tang and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Design and Synthesis of Luminescent Metal Polypyridyl Complexes of Platinum(II), Ruthenium(II) and Osmium(II) for Chemosensing and Biological Studies" by Wing-suen, Tang, 鄧詠璇, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DESIGN AND SYNTHESIS OF LUMINESCENT METAL POLYPYRIDYL COMPLEXES OF PLATINUM(II), RUTHENIUM(II) AND OSMIUM(II) FOR CHEMOSENSING AND BIOLOGICAL STUDIES Submitted by TANG WING SUEN for the degree of Doctor of Philosophy at The University of Hong Kong in November 2006 A series of platinum(II) terpyridyl alkynyl complexes derivatized with basic amino functionalities and crown ether pendants, [Pt(trpy)(C≡C-R)]X (R = - - -C H -N(CH ) -4, X = OTf; R = -C H -N(CH CH OCH ) -4, X = OTf; R = 6 4 3 2 6 4 2 2 3 2 - - -C H -NH-4, X = OTf; R = -C H -N(CH )-4, X = Cl; R = 6 4 2 6 4 3 2 - - -C H -N(CH CH OCH ) -4, X = Cl; R = -C H -NH -4, X = Cl; R = -B15C5, X 6 4 2 2 3 2 6 4 2 - - = OTf; R = -A15C5, X = OTf ) have been synthesized. The X-ray crystal structure of [Pt(trpy){C≡CC H -N(CH CH OCH )-4}](OTf) has been 6 4 2 2 3 2 determined. The lowest energy absorption of the complexes except [Pt(trpy)(C≡CB15C5)](OTf) were tentatively assigned to originate from a π(C≡C) → π*(trpy) ligand-to-ligand charge transfer (LLCT) transition mixed with some metal-to-ligand charge transfer (MLCT) contribution. The ion-binding and pH dependent properties have also been studied. Their photophysical and spectroscopic properties were shown to be dependent on pH and selected metal ions, and their colorimetric and luminescence chemosensing properties were described. Another series of platinum(II) terpyridyl alkynyl complexes, t - [Pt( Bu trpy)(C≡C-R)]X [R = -C H -NH -4, X = OTf; R = -C H -NCS-4, X = 3 6 4 2 6 4 - - - OTf; R =-C H -NHCOCH I-4, X = OTf; R = -UH-5 (UH = Uracil), X = Cl; 6 4 2 -UMe-5, X = OTf (UMe = 1,3-dimethyluracil)] have been successfully synthesized and characterized. The X-ray crystal structures of t t [Pt( Bu trpy)(C≡C-C H-NCS-4)](OTf), [Pt( Bu trpy)(C≡C-UH-5)]Cl and 3 6 4 3 [Pt( Bu trpy)(C≡C-UMe-5)](OTf) have been determined. Their photophysical and electrochemical behaviour, together with their protein labeling and DNA binding studies, have also been studied. The emission of the complexes in solution at room temperature has been tentatively assigned as originated from a dπ(Pt) → π*( Bu trpy) triplet MLCT excited state. The 77 K butyronitrile glass displayed dual luminescence which were assigned to originate from an intraligand (IL) phosphorescence of the terpyridine ligand and a dπ(Pt) → t 3 t π*( Bu trpy) MLCT phosphorescence. The [Pt( Bu trpy)(C≡C- 3 3 C H-NHCSNH-4)](OTf)-HSA and [Pt( Bu trpy)(C≡C-C H -NHCOCH S- 6 4 3 6 4 2 4)](OTf)-HSA (HSA = human serum albumin) bioconjugates were highly colored and exhibited luminescence in the visible region upon photoexcitation. A series of ruthenium(II) diimine complexes and an osmium(II) diimine complex containing extended π-conjugated ligands, [Ru(bpy) (pmra)](PF ) 2 6 2 [pmra = N-(2-pyridylmethylene)-2-fluorenamine], [Ru(bpy) (pmra)]Cl, 2 2 [Ru(bpy) (pmaa)]Cl [pmaa = N-(2-pyridylmethylene)-2-anthramine], 2 2 [Ru(bpy) (pmpa)]Cl [pmpa = N-(2-pyridylmethylene)-1-pyrenamine], 2 2 [Ru(bpy) (pmfa)]Cl [pmfa = N-(2-pyridylmethylene)-3-fluoranthenamine] 2 2 and [Os(bpy) (pmaa)](PF ), have been synthesized. The lowest energy 2 6 2 absorption bands of the ruthenium(II) complexes w

Download or read book Luminescent Cyclometalated Platinum ii Complexes written by Kit-Man Phyllis Siu and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Luminescent Cyclometalated Platinum(II) Complexes: Protein Binding Studies and Biological Applications" by Kit-man, Phyllis, Siu, 蕭潔敏, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4501498 Subjects: Platinum compounds - Synthesis Photoluminescence DNA-ligand interactions

Download or read book Luminescent Cyclometalated Platinum II Complexes with Isocyanide Ligands as Nucleic Acid Probes Topoisomerase Poisons and Anti Cancers Agents written by Jia Liu and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Luminescent Cyclometalated Platinum (II) Complexes With Isocyanide Ligands as Nucleic Acid Probes, Topoisomerase Poisons and Anti-cancers Agents" by Jia, Liu, 刘佳, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: LUMINESCENT CYCLOMETALATED PLATINUM (II) COMPLEXES WITH ISOCYANIDE LIGANDS AS NUCLEIC ACID PROBES, TOPOISOMERASE POISONS AND ANTI-CANCER AGENTS LIU JIA Ph.D. THESIS THE UNIVERSITY OF HONG KONG May 2011 Abstract of thesis entitled LUMINESCENT CYCLOMETALATED PLATINUM (II) COMPLEXES WITH ISOCYANIDE LIGANDS AS NUCLEIC ACID PROBES, TOPOISOMERASE POISONS AND ANTI-CANCER AGENTS Submitted by Liu Jia for the degree of Doctor of Philosophy at The University of Hong Kong in May 2011 Since the discovery of anti-cancer cisplatin and its derivatives, extensive studies have been conducted on the interaction between platinum(II) complexes and their proposed cellular target DNA. Besides DNA, other cellular targets which may improve cancer cell specificity are less explored. Recent studies have shown that poisoning of DNA topoisomerases (Topo) could be owing to DNA interaction by DNA intercalators. In this thesis work, a class of planar cyclometalated platinum(II) complexes were prepared and their activities on DNA and Topo were examined. A new class of highly cytotoxic luminescent platinum(II) complexes containing C DEGREESN DEGREESN (HC DEGREESN DEGREESN = 6- phenyl-2,2′-bipyridine) ligand were prepared and found to II act as DNA TopoI poisons and probes. [Pt (C DEGREESN DEGREESN)(C≡NR)]ClO 3-1c (R = tert-butyl) inhibited TopoI-mediated DNA relaxation with concentration down to 20 nM. The high potency of 3-1c towards TopoI was attributed to its stabilization of the transient TopoI-DNA cleavage complexes via π---π interactions. The superior photoluminescent properties of 3-1c were used for the in-gel detection of TopoI-DNA cleavage complexes. The detection limit of this method was determined to be approximately 1.8 U/L, which is similar to that of western blotting (1.2 U/L) and much lower than that of coomassie blue staining. 3-1c displayed a significantly high cytotoxicity against human carcinoma cell lines while relatively low toxicity toward normal human cells. The cell death pathway caused by 3-1c was attributed to its TopoI poisoning, which induces cell cycle arrest and apoptosis. Another series of platinum(II) complexes which contain bidentate C DEGREESN ligands II were prepared. [Pt (C DEGREESN)(C≡NR) ]OTf 4-1d (HC DEGREESN = 2-phenylpyridine, R = 2-naphthyl) is stable under physiological conditions and intercalates DNA preferentially at major groove. This complex inhibits TopoIIα-mediated DNA relaxation and kDNA decatenation, with a much higher potency than the known TopoIIα poison Vp-16. To confirm that the cytotoxicity of 4-1d is related to its TopoIIa poisoning, wild-type and TopoIIa-knockdown SUNE1 cell lines were established using siRNA method. Compared with the parental cells, 4-1d is 22-fold less cytotoxic towards the cells with reduced TopoIIa expression, suggesting that TopoIIa is a cellular target of 4-1d. Self-assembling properties of the cyclometalated platinum(II) complexes on phosphate backbones of oligonucleotides due to electrostatic interaction were studied. Due to the superior photophysical properties of the platinum(II) complexes, the subtle competition between self-assembling and hydrophobic intercalation of platinum(II) complexes with DNA can be used to monitor the changes

Download or read book Half Sandwich Platinum Group Metal Complexes Containing Tetradentate i N i donor Ligand Bearing Two Pyrazolyl pyridine Units Linked by an Aromatic Spacer written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Photoluminescent Organoplatinum II Complexes Containing N Heterocyclic Carbene Nhc Ligands written by Kai Li and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Photoluminescent Organoplatinum (II) Complexes Containing N-heterocyclic Carbene (NHC) Ligands" by Kai, Li, 李凯, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: The syntheses, structures, photophysical properties and applications of three types of photoluminescent organoplatinum(II) complexes containing N-heterocyclic carbene (NHC) ligands are described. The tetradentate dianionic bis(phenolate-NHC) type ligands provide a superior scaffold for constructing thermally stable and efficient deep-blue phosphorescent Pt(II) complexes with λmax of 440-460 nm and solid-state emission quantum yields of 30%. Highly efficient blue OLEDs with CIEx, y of (0.19, 0.21) were fabricated based on these emitters with maximum brightness, peak current efficiency and power efficiency of 9500 cd m DEGREES(-2), 24 cd A DEGREES(-1) and 17 lm W DEGREES(-1), respectively. Structural modification by extending the π-conjugation of the tetradentate bis(phenolate-NHC) ligand leads to strongly phosphorescent platinum(II) complexes with long-lived emissive electronic states that can be used as a luminescent sensor for oxygen. DFT/TDDFT calculations and time-resolved spectroscopic characterizations were performed to gain insight into the structure-photophysics correlation. The N-heterocyclic carbene (NHC) ligand was incorporated into Pt(II) complexes containing tridentate deprotonated 1,3-bis(2-pyridyl)benzene (N DEGREESC DEGREESN) type ligand. In addition to the [(N DEGREESC DEGREESN)Pt(NHC)]PF6 type complexes with (N DEGREESC DEGREESN) in η3-tridentate coordination mode, Pt(II) complexes with η2-bidentate (N DEGREESCN) ligands, namely [(N DEGREESCN)Pt(NHC)2]PF6, have been isolated and structurally characterized. The highly phosphorescent [(N DEGREESC DEGREESN)Pt(NHC)]PF6 complexes were used for solution-processed green OLEDs fabrication. The peak current efficiency of 12.5 cd A DEGREES(-1) and maximum brightness higher than 2000 cd m DEGREES(-2) were achieved. The presence of the pendent pyridyl motif causes quenching of emission of the [(N DEGREESCN)Pt(NHC)2]PF6 complexes in solution at room temperature. Turning on solid-state emission of [(N DEGREESCN)Pt(nBu2Im)2]PF6 in the presence of an acidic vapor revealed its potential as a luminescent chemosensor. A class of dicationic platinum(II) terpyridyl complexes containing NHC ligand, namely [Pt(tpy)(NHC)](PF6)2, has been synthesized and structurally characterized. Even in the presence of the strong σ-donating NHC ligand, these complexes are non- or weakly emissive in solution at room temperature. However, this class of complexes displays intense emissions in solid state (298 K and 77 K), in glassy solution (77 K butyronitrile) and in PMMA (2 wt.%, 298 K). The ligand (terpyridine) displacement reaction arising from CN attack onto the Pt(II) center has been observed for [Pt(tpy)(nBu2Im)](PF6)2 leading to its application as a chemodosimeter for selective cyanide sensing in aqueous solution. DOI

Download or read book Reactions of Trans platinum II Complexes Containing Nitrogen Donor Ligands with Thiols and Thioethers written by Kevin Cong The and published by . This book was released on 1997 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: