Download or read book Report written by United States. Congress. House and published by . This book was released on with total page 2170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Preclinical Development Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2008-03-21 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Download or read book The Federal Bureau of Investigation written by Max Lowenthal and published by . This book was released on 1950 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lt Col Carl E Welchner June 9 legislative Day May 13 1954 Ordered to be Printed written by and published by . This book was released on 1954 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Physiologically Based Pharmacokinetic Modeling written by Micaela Reddy and published by John Wiley & Sons. This book was released on 2005-06-14 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling.

Download or read book Aviation in the U S Army 1919 1939 written by Maurer Maurer and published by . This book was released on 1987 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The American Military on the Frontier written by Betsy C. Kysely and published by . This book was released on 1976 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Afghanistan Official Standard Names written by United States. Geographic Names Division and published by . This book was released on 1971 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modeling and Informatics in Drug Design written by Prasad V. Bharatam and published by . This book was released on 2007-10 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as an introduction to advanced research topics related to molecular modeling, chemoinformatics, bioinformatics, and pharmacoinformatics. It functions as a text for post-graduate level students as well as a reference for researchers. Both fundamentals and recent research applications are included in the book. Topics related to molecular modeling (QSAR, molecular docking, pharmacophore mapping, etc.), chemoinformatics, bioinformatics, and pharmacoinformatics are treated as new technologies; meaning there is an introduction and description of the advantages and disadvantages of these methodologies.

Download or read book Official Register of the Officers and Cadets written by United States Military Academy and published by . This book was released on 1930 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Gazetteer of North Korea written by Tei Scott and published by . This book was released on 1983 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Strategic Air Warfare written by Richard H. Kohn and published by Air Force History & Museums Program. This book was released on 1988 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of the American air forces to wage war independently and to carry the battle to the enemy's heartland has played a critical role in American air doctrine and military strategy since the 1930s. Generals LeMay, Johnson, Burchinal, and Catton explain their roles in flying and commanding bombing missions and campaigns during World War II, in creating the atomic force in the immediate postwar years, and in building the Strategic Air Command in the 1950s. The Cuban Missile Crisis and the Vietnam War are also discussed.