Download or read book Living Materials for the Deployment of Genetically Engineered Organisms written by Eleonore Claure Cecilia Tham and published by . This book was released on 2018 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary objective of this work is to establish an innovative and broad platform to engineer living materials and assemble them into functional devices. First, we assemble bacterial sensor communities into core-shell hydrogel structures to address the major challenge of biocontainment. Biosafety has become a major challenge for synthetic biology tools to transition from laboratory experiments to real applications and prevent potential negative impacts. Genetic and chemical containment strategies have been implemented to restrict the growth and replication of genetically modified organisms while no robust physical containment has been proposed. We developed a hydrogel-based encapsulation technique by leveraging a tough biocompatible shell and genetically recoded organisms to achieve unprecedented containment performance. Then, we implemented biocontainment into wearable hydrogel devices. We use stretchable, robust, and biocompatible hydrogel-elastomer hybrids to host genetically programed bacteria, thus creating a set of stretchable and wearable living materials and devices that possess unprecedented functions and capabilities. Lastly, we genetically encode the formation of biological polymers in E.coli to achieve the self-assembly of bacterial devices. Generating complex biomaterials often requires the coordinated and precise expression of several genes and light induction of biological material formation and patterning offer a powerful toolkit to achieve the necessary degree of precision and control. We leveraged a multichromatic optogenetic control in the bacterium Escherichia coli to express the principal structural component biological nanowires.
Download or read book Towards Engineering Living Functional Materials written by Tzu-Chieh Tang (Ph. D.) and published by . This book was released on 2021 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology has become one of the most rapidly evolving research fields, with impacts on all aspects of our daily life. Through applying engineering principles to programming biological systems, synthetic biology provides advanced techniques to program organisms to perform desired tasks, similar to machines created by humans. Today, it has enabled the development of alternative meat substitutes, biosensors for water contamination, and living fertilizers that promote plant growth. The grand challenge to bridge the concept-to-product gap is twofold: scalability and safe deployment. First, most model microorganisms cannot produce a macroscale matrix to sustain themselves as standalone devices. The field of engineered living materials (ELMs) aims to recapitulate the remarkable properties of natural biology to create novel, growable, multifunctional materials using genetically engineered organisms. Nevertheless, most relevant pioneering work was created using nano- to microscale biofilm, which has rather small yields and usually requires costly modification. Second, releasing genetically modified microorganisms (GMMs) into the field for food, water, or agricultural applications is often considered risky due to the uncertainty of wild-type organisms acquiring undesirable traits, such as antibiotic resistance, from the GMMs. A significant effort in addressing these unmet needs is called for. This Thesis starts with an introduction of genetic circuits and an in-depth review of the current trends in materials synthetic biology, which includes two major categories of ELMs: self-organizing functional materials and hybrid living materials. The following chapters describe the technologies developed to achieve high scalability and safe deployment of ELMs in these two categories and living devices suitable for real-world applications. Finally, a detailed outlook summarizes the challenges and prospects for materials synthetic biology and engineering living functional materials.
Download or read book Genetically Engineered Crops written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-01-28 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.
Download or read book Preparing for Future Products of Biotechnology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.
Download or read book Industrialization of Biology written by National Research Council and published by National Academies Press. This book was released on 2015-06-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.
Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Download or read book Animal Biotechnology written by National Research Council and published by National Academies Press. This book was released on 2002-12-29 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnologyâ€"key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effectsâ€"the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.
Download or read book Plant Biotechnology written by Agnès Ricroch and published by Springer Nature. This book was released on 2021-08-30 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in easy to follow language, the book presents cutting-edge agriculturally relevant plant biotechnologies and applications in a manner that is accessible to all. This book updates and introduces the scope and method of plant biotechnologies and molecular breeding within the context of environmental analysis and assessment, a diminishing supply of productive arable land, scarce water resources and climate change. New plant breeding techniques including CRISPR-cas system are now tools to meet these challenges both in developed countries and in developing countries. Ethical issues, intellectual property rights, regulation policies in various countries related to agricultural biotechnology are examined. The rapid developments in plant biotechnology are explained to a large audience with relevant examples. New varieties of crops can be adapted to new climatic conditions in order to reduce pest-associated losses and the adverse abiotic effects
Download or read book Safety of Genetically Engineered Foods written by National Research Council and published by National Academies Press. This book was released on 2004-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.
Download or read book Glossary of Biotechnology and Genetic Engineering written by Food and Agriculture Organization of the United Nations and published by Fao. This book was released on 1999 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date list of terms currently in use in biotechnology, genetic engineering and allied fields. The terms in the glossary have been selected from books, dictionaries, journals and abstracts. Terms are included that are important for FAO's intergovernmental activities, especially in the areas of plant and animal genetic resources, food quality and plant protection.
Download or read book Improving Nature written by Michael J. Reiss and published by Cambridge University Press. This book was released on 2001-05-21 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Little more than a decade ago the term "genetic engineering" was hardly known outside research laboratories. Today it regularly makes headlines. Those in favor of genetic engineering--and those against it--tell us that it has the potential to change our lives perhaps more than any other scientific or technological advance. But what are the likely consequences of genetic engineering? Is it ethically acceptable? Should we be trying to improve on nature? In Improving Nature?, the authors, a biologist and a moral philosopher, examine the implications of genetic engineering in every aspect of our lives. The underlying science is clearly explained and the moral and ethical considerations are fully disussed, resulting in a wide-ranging, balanced overview of a controversial subject. Michael Jonathan Reiss, a biologist, is Professor of Science Education and Head of Science & Technology, University of London Institute of Education. He is the author of Understanding Science Lessons (Open University Press, 2000). Roger Straughan is Reader in Education at the University of Reading. He is the author of Beliefs, Behaviour and Education (Cassell Academic, 1989). Previous paperback edition (1996) 0-521-63754-6
Download or read book Impacts of Applied Genetics written by and published by . This book was released on 1981 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Palgrave Dictionary of Transnational History written by A. Iriye and published by Springer. This book was released on 2016-04-30 with total page 1267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by many of the world's foremost scholars of transnational history, this Dictionary challenges readers to look at the contemporary world in a new light. Contains over 400 entries on transnational subjects such as food, migration and religion, as well as traditional topics such as nationalism and war.
Download or read book Being Material written by Marie-Pier Boucher and published by MIT Press. This book was released on 2019-10-22 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explorations of the many ways of being material in the digital age. In his oracular 1995 book Being Digital, Nicholas Negroponte predicted that social relations, media, and commerce would move from the realm of “atoms to bits”—that human affairs would be increasingly untethered from the material world. And yet in 2019, an age dominated by the digital, we have not quite left the material world behind. In Being Material, artists and technologists explore the relationship of the digital to the material, demonstrating that processes that seem wholly immaterial function within material constraints. Digital technologies themselves, they remind us, are material things—constituted by atoms of gold, silver, silicon, copper, tin, tungsten, and more. The contributors explore five modes of being material: programmable, wearable, livable, invisible, and audible. Their contributions take the form of reports, manifestos, philosophical essays, and artist portfolios, among other configurations. The book's cover merges the possibilities of paper with those of the digital, featuring a bookmark-like card that, when “seen” by a smartphone, generates graphic arrangements that unlock films, music, and other dynamic content on the book's website. At once artist's book, digitally activated object, and collection of scholarship, this book both demonstrates and chronicles the many ways of being material. Contributors Christina Agapakis, Azra Akšamija, Sandy Alexandre, Dewa Alit, George Barbastathis, Maya Beiser, Marie-Pier Boucher, Benjamin H. Bratton, Hussein Chalayan, Jim Cybulski, Tal Danino, Deborah G. Douglas, Arnold Dreyblatt, M. Amah Edoh, Michelle Tolini Finamore, Team Foldscope and Global Foldscope community, Ben Fry, Victor Gama, Stefan Helmreich, Hyphen-Labs, Leila Kinney, Rebecca Konte, Winona LaDuke, Brendan Landis, Grace Leslie, Bill Maurer, Lucy McRae, Tom Özden-Schilling, Trevor Paglen, Lisa Parks, Nadya Peek, Claire Pentecost, Manu Prakash,Casey Reas, Paweł Romańczuk, Natasha D. Schüll, Nick Shapiro, Skylar Tibbits, Rebecca Uchill, Evan Ziporyn Book Design: E Roon Kang Electronics, interactions, and product designer: Marcelo Coelho
Download or read book Intellectual Property and Traditional Knowledge in the Global Economy written by Teshager W. Dagne and published by Routledge. This book was released on 2014-09-04 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arising from recent developments at the international level, many developing countries, indigenous peoples and local communities are considering using geographical indications (GIs) to protect traditional knowledge, and to promote trade and overall economic development. Despite the considerable enthusiasm over GIs in diverse quarters, there is an appreciable lack of research on how far and in what context GIs can be used as a protection model for traditional knowledge-based resources. This book critically examines the potential uses of geographical indications as models for protecting traditional knowledge-based products and resources in national and international intellectual property legal frameworks. By analysing the reception towards GIs from developing countries and advocates of development in the various legal and non-legal regimes (including the World Trade Organization, World Intellectual Property Organization, and the Convention on Biological Diversity and the Food and Agricultural Organization), the book evaluates the development potential of GIs in relation to ensuing changes in international intellectual property law in accommodating traditional knowledge. Teshager W. Dagne argues for a degree of balance in the approach to the implementation of global intellectual property rights in a manner that gives developing countries an opportunity to protect traditional knowledge-based products. The book will be of great interest and use to scholars and students of intellectual property law, public international law, traditional knowledge, and global governance.
Download or read book Engineering Trouble written by Rachel A. Schurman and published by Univ of California Press. This book was released on 2003-10-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Talk of genetically engineered organisms (GEOs) has moved from the hushed corridors of life science corporations to the front pages of major newspapers. This book examines these issues from the diverse perspectives of sociology, geography, law environmental studies and political science.
Download or read book The Baculoviruses written by Lois K. Miller and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has witnessed an explosion of information on the molecular biology of insect viruses and a frenzy of activity in applying this information to medicine and agriculture. Genetically engineered baculoviruses are presently being tested for commercial use as pesticides, and the study of such viruses is also revealing remarkable insights into basic cellular processes such as apoptosis. This comprehensive volume provides readers with knowledge of basic and applied baculovirology so that current literature in the field can be appreciated.
