Download or read book Liver and Environmental Xenobiotics written by S.V.S. Rana and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made.

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Download or read book Industrial and Environmental Xenobiotics written by I. Gut and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book you are just going to read represents the greater part of the papers presented at the International Conference on Industrial and En vironmental Xenobiotics, held in Prague, 1980, and some contributions by those who could not come. The first aim of the meeting was to fol low the tradition set up by the first conference in 1977. Again, we in vited biochemists, pharmacologists, and toxicologists from both East and West, who were involved in the study of disposition, biotransforma tion, and toxicity of important kinds of industrial and environmental pollutants, to promote the exchange of ideas and opinions on priorities in this area of the study of human environment. The invited contributions offer an excellent survey of and pro found insight into specific areas of toxicology and disposition of metals and organic chemicals, and the series of papers on specific subjects bring fresh information on the biotransformation and mechanisms of toxic action of several industrially important solvents tmd monomers of plastics. Rather than from the Preface, the reader should seek guidance from the Index, which clearly shows the overlapping of this area of toxicology with the latest results in biochemistry. We gratefully acknowledge the understanding, care, and preciSion of the publisher that made this book possible. The Editors Contents Metals Metabolic Factors in the Distribution and Half Time of Mercury After Exposure to Different Mercurials 1. Magos. With 1 Figure . . . . . . . . . . . . . . . . . . .. . . . 1 . . . . . Biliary Excretion of Metals M. Cikrt. With 9 Figures. . . . . . . . . . . . . . . . . . . .. . . 17 . . . . .

Download or read book Plant Responses to Xenobiotics written by Anita Singh and published by Springer. This book was released on 2016-12-28 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is compilation of studies related with the xenobiotics i.e. chemical or other substance that is not normally found in the ecosystems and get accumulated at higher concentration in the biological system due to rampant industrialisation and urbanisation activities. This book has tried to give information on various issues to give comprehensive and concise knowledge of the recent advancement in the field of environmental xenobiotics and how it disturbs the plants metabolism. Other key features of the book are related to xenobiotic toxicity and detoxification mechanism, biochemical tools toward its remediation processes, molecular mechanism for xenobiotics detoxification and effect on metallomics. It also focuses on recent development in the field of waste water remediation concerned with the xenobiotics involvement. This book is different in such a way that it includes all the initial information along with the new researches. It includes the description of problem along with its solution. This volume describe the effects of xenobiotics at different levels i.e. biochemical, physiological and molecular, giving the details on signaling pathways to modify the responses of xenobiotics in plant system. Thus, it gives confirming crosstalk between xenobiotic effects and signalling pathways. This book includes description about both the organic contaminants such as pesticides, solvents and petroleum products as well as inorganic xenobiotics that include heavy metals, non-metals, metalloids, and simple soluble salts. Here the plant is main objective and that have to deal with these kinds of compounds either by avoiding accumulation of these compounds or by exhibiting several enzymatic reactions for detoxification including oxidation, reduction, and conjugation reactions. Affected plants exhibit several enzymatic and non-enzymatic antioxidant and other reactions for detoxification of ROS including oxidation, reduction, hydrolysis and conjugation reactions. The book focuses on different forms and sources of xenobiotics including organic and inorganic xenobiotics. The matter of this book will definitely increase the knowledge about the impacts of xenobiotics on plants system. There must be potentially broad readership who could find this fruitful for their study as well as for their research. As this book has balance between basic plant physiology and toxicity caused by the xenobiotics so it can be widely used in several disciplines. Overall, the book will bring deep knowledge in the field of xenobiotics toxicity in plants during recent years and it is definitely a compilation of interesting information which isn't fully covered elsewhere in the current market.

Download or read book Xenobiotics in the Soil Environment written by Muhammad Zaffar Hashmi and published by Springer. This book was released on 2017-02-15 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the vast variety of xenobiotics, such as pesticides, antibiotics, antibiotic resistance genes, agrochemicals and other pollutants, their interactions with the soil environment, and the currently available strategies and techniques for soil decontamination and bioremediation. Topics covered include: transport mechanisms of pollutants along the Himalayas; use of earthworms in biomonitoring; metagenomic strategies for assessing contaminated sites; xenobiotics in the food chain; phyto-chemical remediation; biodegradation by fungi; and the use of enzymes and potential microbes in biotransformation. Accordingly, the book offers a valuable guide for scientists in the fields of environmental ecology, soil and food sciences, agriculture, and applied microbiology.

Download or read book Polycyclic Aromatic Hydrocarbons written by and published by National Academies. This book was released on 1983-01-01 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Download or read book Fundamentals of Toxicologic Pathology written by Matthew A. Wallig and published by Academic Press. This book was released on 2009-11-23 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. 25% brand new information, fully revised throughout New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology New color photomicrographs detailing specific toxicant-induced diseases in animals Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Download or read book Fish Ecotoxicology written by Braunbeck and published by Birkhäuser. This book was released on 2013-03-07 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: In modern ecotoxicology, fish have become the major vertebrate model, and a tremendous body of information has been accumulated. This volume attempts to summarize our present knowledge in several fields of primary ecotoxicological interest ranging from the use of (ultra)structural modifications of selected cell systems as sources of biomarkers for environmental impact over novel approaches to monitoring the impact of xenobiotics with fish in vitro systems such as primary and permanent fish cell cultures, the importance of early life-stage tests with fish, the bioaccumulation of xenobiotics in fish, the origin of liver neoplastic lesions in small fish species, immunocytochemical approaches to monitoring effects in cytochrome P450-related biotransformation, the impact of heavy metals in soft water systems, the environmental toxicology of organotin compounds, oxidative stress in fish by environmental pollutants to effects by estrogenic substances in aquatic systems.

Download or read book Autoimmune Liver Disease written by James Neuberger and published by John Wiley & Sons. This book was released on 2020-04-13 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to autoimmune liver diseases through pathogenesis, diagnosis, and management In Autoimmune Liver Disease Management and Clinical Practice, practitioners will learn about the current state of autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver transplantation, and learned approaches to patient management and empowerment. Expert authors in the field have come together to provide a thorough examination of autoimmune liver disease to help support clinicians assisting patients. The text provides an in-depth look at topics including: ● The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management ● The use (and misuse) of autoantibodies in diagnosis and treatment ● The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as de novo autoimmune hepatitis ● Optimal approaches to managing patients and keeping care personalised With breadth, depth and current-day relevance, Autoimmune Liver Disease sheds light on recent developments in management of liver disease for practitioners, nurses, and health care professionals.

Download or read book Metabolism of Xenobiotics written by Johannes Hendrikus Dewaide and published by . This book was released on 1971 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toxicology and Human Environments written by Ernest Hodgson and published by Academic Press. This book was released on 2012-09-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.

Download or read book Contaminated Water Supplies at Camp Lejeune written by National Research Council and published by National Academies Press. This book was released on 2009-09-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.

Download or read book Mammalian Toxicology written by Mohamed Abou-Donia and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

Download or read book Handbook of Toxicologic Pathology written by Wanda M. Haschek and published by San Diego : Academic Press. This book was released on 2002 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.-

Download or read book Monitoring Human Tissues for Toxic Substances written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.