Download or read book Life Span Extension written by Christian Sell and published by Springer Science & Business Media. This book was released on 2009-07-27 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice. Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.
Download or read book Life Extension written by Durk Pearson and published by New York : Warner Books. This book was released on 1983 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses various aspects of aging and includes suggestions on how to slow the aging process and improve your health.
Download or read book Lifespan written by David A. Sinclair and published by Atria Books. This book was released on 2019-09-10 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Download or read book Life Span Extension written by Fréderic C. Ludwig and published by . This book was released on 1991 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coping with Methuselah written by Henry Aaron and published by Rowman & Littlefield. This book was released on 2004-01-20 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many medical authorities predict that average life expectancy could well exceed 100 years by mid century and rise even higher soon thereafter. This astonishing prospect, brought on by the revolution in molecular biology and information technology, confronts policymakers and public health officials with a host of new questions. How will increased longevity affect local and global demographic trends, government taxation and spending, health care, the workplace, Social Security, Medicare, and Medicaid? What ethical and quality-of-life issues are raised by these new breakthroughs? In Coping with Methuselah, a group of practicing scientists and public policy experts come together to address the problems, challenges, and opportunities posed by a longer life span. This book will generate discussion in political, social, and medical circles and help prepare us for the extraordinary possibilities that the future may hold.
Download or read book The Life Extension Revolution written by Philip Lee Miller, M.D. and published by Bantam. This book was released on 2007-12-18 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time the lay public can benefit from the anti-aging secrets discovered by the Life Extension Foundation, the world’s largest, most respected organization dedicated to anti-aging research. Working with the Life Extension Foundation, renowned anti-aging physician Philip Lee Miller shows you how to retain your physical health and vigor, mental clarity, and youthful appearance–for life. This groundbreaking book translates cutting-edge anti-aging advances into a practical, easy-to-use program that will maximize your chances of living not only a long life–but a healthy, vibrant life. Drawing on his own clinical experience as well as the latest research from the Life Extension Foundation, Dr. Miller demystifies the aging process and provides you with: •Detailed strategies integrating the most advanced mainstream therapies with nutrients, hormones, and holistic approaches from around the world •A comprehensive plan to protect yourself from cancer, heart disease, arthritis, and Alzheimer’s disease at the cellular level by controlling inflammation and oxidation–two degenerative processes that cause us to age prematurely •A guide to individualizing this lifesaving program, including the Longevity Diet for maximum vitality and effortless weight loss and a unique supplement regimen–plus how to use medical tests to monitor your progress •An inspiring vision of the future of life extension science and what your future will be like without disease, premature death and aging–with novel strategies to help you get there This far-reaching anti-aging program will change your life forever. Like many of Dr. Miller’s patients, your physical and mental health will actually soar as you age chronologically. Your new longer, healthier life begins now as you embark on The Life Extension Revolution.
Download or read book Extra Life written by Steven Johnson and published by Penguin. This book was released on 2021-05-11 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Offers a useful reminder of the role of modern science in fundamentally transforming all of our lives.” —President Barack Obama (on Twitter) “An important book.” —Steven Pinker, The New York Times Book Review The surprising and important story of how humans gained what amounts to an extra life, from the bestselling author of How We Got to Now and Where Good Ideas Come From In 1920, at the end of the last major pandemic, global life expectancy was just over forty years. Today, in many parts of the world, human beings can expect to live more than eighty years. As a species we have doubled our life expectancy in just one century. There are few measures of human progress more astonishing than this increased longevity. Extra Life is Steven Johnson’s attempt to understand where that progress came from, telling the epic story of one of humanity’s greatest achievements. How many of those extra years came from vaccines, or the decrease in famines, or seatbelts? What are the forces that now keep us alive longer? Behind each breakthrough lies an inspiring story of cooperative innovation, of brilliant thinkers bolstered by strong systems of public support and collaborative networks, and of dedicated activists fighting for meaningful reform. But for all its focus on positive change, this book is also a reminder that meaningful gaps in life expectancy still exist, and that new threats loom on the horizon, as the COVID-19 pandemic has made clear. How do we avoid decreases in life expectancy as our public health systems face unprecedented challenges? What current technologies or interventions that could reduce the impact of future crises are we somehow ignoring? A study in how meaningful change happens in society, Extra Life celebrates the enduring power of common goals and public resources, and the heroes of public health and medicine too often ignored in popular accounts of our history. This is the sweeping story of a revolution with immense public and personal consequences: the doubling of the human life span.
Download or read book Longevity written by James R. Carey and published by Princeton University Press. This book was released on 2003-03-02 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite our deep interest in mortality, little is known about why some individuals live to middle age and others to extreme old age. Life span, mortality, and aging present some of the most profound mysteries in biology. In Longevity, James Carey draws on unprecedented data to develop a biological and demographic framework for identifying the key factors that govern aging, life span, and mortality in humans and other animals. Carey presents the results of a monumental, twelve-year, National Institute on Aging-funded research project on the determinants of longevity using data from the life tables of five million Mediterranean fruit flies, the most comprehensive set of life table studies ever on the mortality dynamics of a single species. He interprets the fruit fly data within the context of human aging and the aging process in general to identify the determinants of mortality. Three key themes emerge: the absence of species-specific life span limits, the context-specific nature of the mortality rate, and biodemographic linkages between longevity and reproduction. A powerful foundation for the emerging field of biodemography and a rich framework for considering the future of human life span, Longevity will be an indispensable resource for readers from a range of fields including population biology, demography, gerontology, ecology, evolutionary biology, and medical research.
Download or read book The Future of Aging written by and published by Springer Science & Business Media. This book was released on 2010-07-28 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt: Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.
Download or read book Fantastic Voyage written by Ray Kurzweil and published by Rodale. This book was released on 2005-09-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading scientist and an expert on human longevity explain how new discoveries in the fields of genomics, biotechnology, and nanotechnology could radically extend the human life expectancy and enhance physical and mental abilities, and introduce a cutting-edge program designed to enhance the immune system and slow the aging process on a cellular level. Reprint.
Download or read book Ending Aging written by Aubrey de Grey and published by Macmillan + ORM. This book was released on 2007-09-04 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
Download or read book Between Zeus and the Salmon written by Caleb E. Finch and published by . This book was released on 1997-10-29 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.
Download or read book The Science and Technology of Growing Young written by Sergey Young and published by BenBella Books. This book was released on 2021-08-24 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wall Street Journal, USA Today, and Publishers Weekly bestseller The prospect of living to 200 years old isn’t science fiction anymore. A leader in the emerging field of longevity offers his perspective on what cutting-edge breakthroughs are on the horizon, as well as the practical steps we can take now to live healthily to 100 and beyond. In The Science and Technology of Growing Young, industry investor and insider Sergey Young demystifies the longevity landscape, cutting through the hype and showing readers what they can do now to live better for longer, and offering a look into the exciting possibilities that await us. By viewing aging as a condition that can be cured, we can dramatically revolutionize the field of longevity and make it accessible for everyone. Join Sergey as he gathers insights from world-leading health entrepreneurs, scientists, doctors, and inventors, providing a comprehensive look into the future of longevity in two horizons: • The Near Horizon of Longevity identifies the technological developments that will allow us to live to 150—some of which are already in use—from AI-based diagnostics to gene editing and organ regeneration. • The Far Horizon of Longevity offers a tour of the future of age reversal, and the exciting technologies that will allow us to live healthily to 200, from Internet of Bodies to digital avatars to AI-brain integration. In a bonus chapter, Sergey also showcases 10 longevity choices that we already know and can easily implement to live to 100, distilling the science behind diet, exercise, sleep, mental health, and our environments into attainable habits and lifestyle hacks that anyone can adopt to vastly improve their lives and workplaces. Combining practical advice with an incredible overview of the brave new world to come, The Science and Technology of Growing Young redefines what it means to be human and to grow young.
Download or read book Exceptional Longevity written by Bernard Jeune and published by . This book was released on 1995 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: States that the number of genuine long-livers is exploding and a substantial proportion of new-borns in developed countries may survive to celebrate their 100th birthday. This book examines the storied realms of exceptional longevity.
Download or read book Extension of Healthy Life Span of Dialysis Patients in the Era of a 100 Year Life written by Masaaki Inaba and published by Mdpi AG. This book was released on 2021-12-20 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malnutrition is becoming a more prominent health problem, with an increasing number of elderly CKD patients being put on dialysis. In addition, the presence of inflammation, sarcopenia/frailty, diabetes, and CVD is a definite and independent risk factor associated with higher mortality in this population. Although the restriction of protein intake has been recommended to protect eGFR decline, hyperphosphatemia, and hyperkalemia in CKD patients, it might accelerate the loss of skeletal muscle and adipose mass, leading to a poor prognosis. Therefore, flexible responses are considered regarding whether protein restriction should be continued or loosened in pre-dialysis CKD patients. In undernourished elderly patients undergoing hemodialysis, sufficient calorie/protein intake is necessary to counteract the development of sarcopenia/frailty. It is expected that the application of new drugs including phosphate binders and potassium chelators may achieve both a high enough intake and balanced levels of phosphate and potassium. Furthermore, the improvement of deficient micronutrients and poor appetite is also necessary. Comprehensive care is essential for the wellbeing of elderly patients undergoing hemodialysis. The topicof this Special Issue is "Extension of Healthy Life Span of Dialysis Patients in the Era of a 100-Year Life".
Download or read book Merchants of Immortality written by Stephen S. Hall and published by Houghton Mifflin Harcourt. This book was released on 2003 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of contents
Download or read book Human Longevity Individual Life Duration and the Growth of the Oldest Old Population written by Jean-Marie Robine and published by Springer. This book was released on 2009-09-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Old-age survival has considerably improved in the second half of the twentieth century. Why has such a substantial extension of human lifespan occurred? How long can we live? In this book, these fundamental questions are explored by experts from diverse fields. They report on recent cutting-edge studies about essential issues of human longevity and social factors of long survival in old age.
