Download or read book Leukemia and Related Disorders written by Elihu H. Estey and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia. It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice. In keeping with the Center’s groundbreaking research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment. It also addresses the important issues of supportive care and long-term complications of successful treatment. •Edited and written by experts at the Fred Hutchinson Cancer Research Center •Clinically focused and comprehensive coverage of treatment approaches •Allogeneic transplant addressed in detail •Separate chapters on supportive care and long-term complications

Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Download or read book Leukemia and Related Disorders written by Elihu H. Estey and published by Humana Press. This book was released on 2011-12-21 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia. It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice. In keeping with the Center’s groundbreaking research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment. It also addresses the important issues of supportive care and long-term complications of successful treatment. •Edited and written by experts at the Fred Hutchinson Cancer Research Center •Clinically focused and comprehensive coverage of treatment approaches •Allogeneic transplant addressed in detail •Separate chapters on supportive care and long-term complications

Download or read book Leukemias written by Stefan Faderl and published by John Wiley & Sons. This book was released on 2011-09-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Download or read book Acute Myeloid Leukemia written by Christoph Röllig and published by Springer Nature. This book was released on 2021-05-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults. The opening chapters present current knowledge of epidemiology, etiologic factors, and the pathogenesis and molecular development of AML. Detailed guidance is offered on laboratory and clinical diagnostic workup and disease classification, and the patient- and disease-related factors that determine prognosis and treatment allocation are identified. On the basis of these general considerations, initial treatments in patients considered fit for intensive treatment and in older and co-morbid patients are reviewed, and the available relapse treatment strategies, explained. For all clinical scenarios, the most recent data on the optimal use of newly approved agents in different AML subgroups are presented. Separate chapters address the treatment of acute promyelocytic leukemia, current practice of allogeneic stem cell transplantation, and special clinical situations. Finally, promising approaches in drug development, current standards and challenges in assessment of measurable residual disease, immune approaches, and ideas for innovative trial designs are considered.

Download or read book The Leukemias Etiology Pathophysiology and Treatment written by John W. Rebuck and published by Elsevier. This book was released on 2013-10-22 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leukemias: Etiology, Pathophysiology, and Treatment documents the proceedings of an International Symposium on The Leukemias: Etiology and Pathophysiology, held at Henry Ford Hospital, Detroit, Michigan, 8-10 March 1956. This volume gives the present complex position of leukemic etiology and pathophysiologic disturbance, a much needed knowledge of detailed leukocytic functions and comprehensive thought on the therapy of the leukemias. It also establishes a basis of comparison with the earlier works of Downey and Forkner in this field in the late thirties and thus makes it possible to see with some clarity the extent of progress made. The volume contains 39 papers organized into nine parts. The papers in Part I focus on the leukemic cell, its structure, and antigenicity. Part II presents studies on genetic and environmental factors in the transmission of leukemia. Part III examines the radiation biology of leukocytes. Part IV focuses on the leukemias and the malignant lymphomas while Part V deals with leukocytic physiology. Part VI covers the metabolism of amino and nucleic acids in the leukemias. Part VII takes up further biochemical considerations in the leukemias. Part VIII contains papers that examine nucleic acids as the target for chemotherapy. Part IX presents a round-table discussion on therapy.

Download or read book Neoplastic Diseases of the Blood written by Peter H. Wiernik and published by Springer Science & Business Media. This book was released on 2012-07-31 with total page 1410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. Coerage includes Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, and Lymphomas.

Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Download or read book Leukemia written by Uday R. Popat, MD, MRCP, FRCPath, FACP and published by Demos Medical Publishing. This book was released on 2011-08-29 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Emerging Cancer Therapeutics provides a comprehensive review for practitioners on the current status of leukemia treatment. Leukemia treatment has undergone major change over the course of the past few years and Leukemia addresses current best practices in the light of the most recent evidence. With contributions from experts across the US and Canada, Leukemia details the current management of different types of leukemia and reviews new therapies in development for various forms of acute leukemia, chronic leukemia, myelodysplastic syndrome, and myeloproliferative disorders. Coverage includes new developments in hematopoitic cell transplantation, leukemia pathology and management, immunotherapy and targeted therapies. It is a valuable tool for clinicians, nurses, researchers, medical students, residents, and fellows. Emerging Cancer Therapeutics Series Titles Features: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice

Download or read book Hematology written by Ronald Hoffman and published by . This book was released on 2005 with total page 2821 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Leukaemia Diagnosis written by Barbara J. Bain and published by John Wiley & Sons. This book was released on 2017-05-08 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: UP-TO-DATE PRACTICAL GUIDE TO LEUKAEMIA DIAGNOSIS Written by a renowned expert this practical guide had been fully revised and updated. The book covers recent advances in the fields of immunophenotyping, cytogenetics and molecular genetics. It illustrates how laboratory techniques are used for the diagnosis and classification of leukaemia and includes images of abnormal cells to aid diagnosis. This fifth edition: Incorporates the recommendations of the 2015 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Includes 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma Full colour diagrams and helpful tables clarify and summarise key points throughout Essential reading for every haematologist and haematopathologist.

Download or read book Chemotherapy for Leukemia written by Takanori Ueda and published by Springer. This book was released on 2017-04-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the latest progress in chemotherapy for leukemia and related diseases, including still-ongoing but promising studies. The effectiveness of treatment for chronic myeloid leukemia and acute promyelocytic leukemia has been dramatically improved in recent years. This improvement has been made possible with the development of molecular targeted agents such as bcr-abl tyrosine kinase inhibitors and all-trans retinoic acid. The antibody for the unique target of chemokine receptor 4 for adult T-cell leukemia/lymphoma, or FLT3 inhibitors (signaling inhibitors) has been applied to other leukemias. Also, chemotherapeutic agents including antimetabolite analogues such as clofarabine, and azacitidine (an epigenetic regulator) have undergone progressive development. Meanwhile, the novel concept of therapy targeting leukemic stem cells has been developed. The contributors discuss prospective results of basic and preclinical studies and clinical possibilities based on the effects for leukemic stem cells. This work facilitates a comprehensive understanding of modern treatment methodology for leukemia. The volume therefore will greatly benefit not only hematologists but also oncologists, all physicians who specialize in blood cancer, and pharmacologists who are involved in the development of therapeutic agents for leukemia.

Download or read book Leukemia written by Edward S. Henderson and published by . This book was released on 2002 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: An international roster of field-leading experts delivers the seventh edition of the definitive textbook, LEUKEMIA. This classic provides comprehensive guidance on all aspects of leukemia, from etiology and biology to clinical features and therapy. This edition now also provides the molecular basis of several leukemias. It reflects the most exciting period of research in the field in a quarter century, and features information on molecular biology and molecular genetics, as well as biological therapy.

Download or read book Leukemia written by Margarita Guenova and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukemias are a group of heterogeneous neoplastic disorders, that differ significantly in terms of morhological, immunophenotypic, cytogenetic and molecular features of malignant cells. These specific features reflect the differences in the spectrum of underlying biological alterations involved in malignant transformation, and/or variations in the level of hematopoietic stem cells hierarchy where the transforming events occur. The continuous and rather extensive influx of new information regarding the pathogenesis and treatment of leukemias requires a frequent updating of this topic. The primary objective of this book is to provide the specialists involved in the diagnosis and management of acute and chronic leukemias with a comprehensive and concise information on some important theoretical and practical issues of the biology and clinical presentation, the diagnosis, treatment and follow up of patients with leukemias.

Download or read book Leukemia and Lymphoma written by Theodore F. Zipf and published by Springer Science & Business Media. This book was released on 2002-10-21 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.

Download or read book Acute Myeloid Leukemia written by Juan M. Garza and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute myeloid leukemia (AML) is an aggressive bone marrow cancer associated with high morbidity and mortality and most commonly affects older patient populations. In this book, the clinical presentation of acute myeloid leukemia are presented. Other chapters present the differences in the outcomes of two subtypes of core binding factor (CBF) acute myeloid leukemia (AML); examine the occurrence of the Philadelphia chromosome in AML with core binding factor leukemia; and therapeutic options of older patients with AML.

Download or read book Adult Leukemias written by Peter H. Wiernik and published by PMPH-USA. This book was released on 2001 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: American Cancer Society Atlas of Clinical Oncology ACS Adult Leukemias Adult Leukemias summarizes advances in leukemia biology and treatment. It discusses the most successful treatments currently available and examines the remaining obstacles to a cure. Dr. Wiernik’s team at New York Medical College has done seminal work in ......