Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Download or read book Molecular Basis of Health and Disease written by Undurti N. Das and published by Springer Science & Business Media. This book was released on 2011-04-02 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Download or read book Lectures on the diseases of women written by Charles West and published by . This book was released on 1858 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Inflamed written by Rupa Marya and published by Farrar, Straus and Giroux. This book was released on 2021-08-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raj Patel, the New York Times bestselling author of The Value of Nothing, teams up with physician, activist, and co-founder of the Do No Harm Coalition Rupa Marya to reveal the links between health and structural injustices--and to offer a new deep medicine that can heal our bodies and our world. The Covid pandemic and the shocking racial disparities in its impact. The surge in inflammatory illnesses such as gastrointestinal disorders and asthma. Mass uprisings around the world in response to systemic racism and violence. Rising numbers of climate refugees. Our bodies, societies, and planet are inflamed. Boldly original, Inflamed takes us on a medical tour through the human body—our digestive, endocrine, circulatory, respiratory, reproductive, immune, and nervous systems. Unlike a traditional anatomy book, this groundbreaking work illuminates the hidden relationships between our biological systems and the profound injustices of our political and economic systems. Inflammation is connected to the food we eat, the air we breathe, and the diversity of the microbes living inside us, which regulate everything from our brain’s development to our immune system’s functioning. It’s connected to the number of traumatic events we experienced as children and to the traumas endured by our ancestors. It’s connected not only to access to health care but to the very models of health that physicians practice. Raj Patel, the renowned political economist and New York Times bestselling author of The Value of Nothing, teams up with the physician Rupa Marya to offer a radical new cure: the deep medicine of decolonization. Decolonizing heals what has been divided, reestablishing our relationships with the Earth and one another. Combining the latest scientific research and scholarship on globalization with the stories of Marya’s work with patients in marginalized communities, activist passion, and the wisdom of Indigenous groups, Inflamed points the way toward a deep medicine that has the potential to heal not only our bodies, but the world.

Download or read book The Complete Idiot s Guide to the Anti Inflammation Diet written by Dr. Christopher P. Cannon and published by Penguin. This book was released on 2006-12-05 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: New research shows that abnormal inflammation may be linked to a variety of diseases and conditions. In this book, you will find what diseases and conditions are caused by inflammation, which foods reduce inflammation and which foods contribute to inflammation, and how to tweak today's diets to make them anti-inflammatory. Over 60 million Americans suffer from cardiovascular disease and over 20 million Americans suffer from asthma - two conditions thought to be affected, if not caused, by inflammation. Many Newsweek articles have been dedicated to this topic, including 'Quieting a Body's Defenses' by Anne Underwood, in 2005. New York Times best-selling author Andrew Weil dedicated a portion of his new book, Healthy Aging, to a discussion of inflammation, its role in diseases, and the use of diet to control ageing.

Download or read book Lectures on the diseases of women v 1 1857 written by Charles West and published by . This book was released on 1857 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lipid Management written by Hussein Yassine and published by Springer. This book was released on 2015-03-03 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely, concise title provides an important update on clinical lipid management. Using information from recent clinical trials and in special populations, the book begins by offering an easy-to-read overview of LDL, HDL, and triglyceride metabolism and the genetics of lipid disorders. The link between inflammation and lipids, and how this relates to atherosclerosis development, is also addressed, as are the measures of subclinical atherosclerosis in patients with abnormal lipid levels. Lipid abnormalities in children, with a particular focus on vulnerable populations (with an emphasis on ethnicity and childhood obesity), are covered. The treatment goals and approaches for managing lipids in the clinic are thoroughly discussed, emphasizing the important role of statin use and addressing controversies of lipid management in special populations such as heart failure, end stage kidney disease and fatty liver disease. Of special note, an important update on how new HIV medications impact lipid levels is provided. In all, Lipid Management: From Basics to Clinic, is an invaluable, handy resource for understanding changes in lipids in different populations and for sharpening the clinical approach to managing complicated lipid cases.

Download or read book Lectures on the Morbid Anatomy Nature and Treatment of Acute and Chronic Diseases written by John Armstrong and published by . This book was released on 1834 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Inflamed Mind written by Edward Bullmore and published by Macmillan + ORM. This book was released on 2018-12-31 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge professor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

Download or read book The Anti Inflammation Diet and Recipe Book written by Jessica K. Black and published by Turner Publishing Company. This book was released on 2011-01-01 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, the connection between inflammation and heart disease, arthritis, and other chronic diseases has become established. Many food allergies inefficiently and overabundantly stimulate the immune system to react and cause inflammatory responses. Any inflammation in the body interferes with and slows down metabolism and the healing response. Chronic inflammation within our bodies erodes our wellness and paves the path for ill health. What is an anti-inflammatory diet? It eliminates many common allergenic foods that may promote inflammation in the body and reduces intake of pesticides, hormones, and antibiotic residues. The diet is full of whole foods, eliminates processed foods, sugars, and other man-made foods such as hydrogenated oils, and encourages ample vegetable intake for essential nutrients. The anti-inflammatory diet therefore promotes simpler and easier digestion and offers less insult on the body by reducing intake of toxins and other difficult to digest foods. If the blood and lymph are properly supplied and difficult to digest or assimilate foods are eliminated, cellular function, or in other words, metabolism, improves. Therefore the body is supported in such a way as to facilitate cellular regeneration and not cellular degeneration which may promote disease. The author, a naturopathic doctor, has helped many people on their way back to health with this anti-inflammatory diet. THE ANTI-INFLAMMATORY DIET AND RECIPE BOOK is the first book to give the complete program with specifics on how to eat and cook in order to prevent and counter inflammation. The purpose of the book is to act as a guide to help people learn to cook healthily. The first part of the book explains the benefits of the anti-inflammatory diet, gives the science. The second half of the book contains 108 recipes. Many of the recipes can be used as a template for even greater meals. The author offers many substitution suggestions and includes healthy tips with each of the recipes. Most of the recipes take very little time to fix. A week's sample menu for summer months and another for winter months is included as well as a substitutions chart, so that you can modify your favorite recipes to make them more healthy. This is a book for every healthy kitchen.

Download or read book Recent Developments in Anti Inflammatory Therapy written by Parteek Prasher and published by Academic Press. This book was released on 2023-02-17 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation therapy in clear and concise language, with insights from academia and industry. Sections cover key regulatory pathways that mediate acute and chronic inflammation and disease onset. Further chapters are devoted to advanced anti-inflammatory pharmaceuticals, including chemical moieties, pharmacophores, APIs, natural products, herbal therapies, molecular nanomedicine and advanced drug delivery vectors. Systematically planned chapters and illustrations enable potential readers to gain essential insights on the most recent advancements in the field. Arranged with systematic chapters covering a broad range of inflammatory diseases, discussions on past, current and future therapeutics and advanced anti-inflammatory pharmaceuticals, this book will be useful to a wide range of researchers, especially medicinal chemists, drug design experts, and biological and translational researchers working in the field of inflammation. - Identifies recent developments and current trends in anti-inflammation therapy - Discusses advanced chemotherapeutics, SAR analysis of novel pharmacophores and natural products - Outlines the pathophysiology of inflammatory pathways in the pathogenesis of disease onset, including strategies to counter these intricacies - Contains a blend of editors from both academia and industry

Download or read book Lectures on the Diseases of Women written by Charles West (M.D.) and published by . This book was released on 1864 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical Lectures on the Diseases of Women and Children Ninth thousand carefully revised and enlarged written by Gunning Samuel BEDFORD and published by . This book was released on 1876 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lectures on clinical medicine v 2 written by Armand Trousseau and published by . This book was released on 1873 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lectures on preternatural and complex parturition and lactation written by Edward William Murphy and published by . This book was released on 1852 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: