Download or read book Lead Compounds from Medicinal Plants for the Treatment of Cancer written by Christophe Wiart and published by Academic Press. This book was released on 2012-10-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kelley/DNA Repair in Cancer Therapy, 2012, 978-0-12-384999-1.
Download or read book Phytochemicals as Lead Compounds for New Drug Discovery written by Chukwuebuka Egbuna and published by Elsevier. This book was released on 2019-09-07 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. - Presents fundamental concepts and factors affecting choice for plant-based products - Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward - Highlights recent advances in computational-based drug discovery - Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance
Download or read book Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases written by Christophe Wiart and published by Academic Press. This book was released on 2013-12-16 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. - Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research - Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area - Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease - Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration
Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles
Download or read book Lead written by José S. Casas and published by Elsevier. This book was released on 2011-10-13 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead covers the salient aspects of the chemistry of lead, its environmental impact, and its effects on health. The technical, economic and social importance of Lead, at the present time, is beyond all doubt. However, over the last few decades little attention has been given to its behaviour (the properties and applications of its compounds, the environmental distribution of these derivatives, and their impacts on living creatures), this book addresses that gap. It includes coverage of historical aspects, lead mining and production, metal properties, common lead compounds, uses of lead and its derivatives, coordination chemistry, organometallic chemistry, environmental chemistry, toxicity mechanisms, and treatment strategies for lead poisoning. Finally, describing analytical procedures for the determination of lead in chemical, biological and environmental samples. - Written by a team of university teachers and researchers with extensive experience in the fields of the chemistry, analytical determination and environmental and health impact of lead and other heavy metals - For readers interested in the chemistry and biochemistry of lead and its effects on ecosystems - Provides comprehensive knowledge about lead toxicity and preventive measures against lead poisoning
Download or read book Bioactive Compounds from Natural Sources Second Edition written by Corrado Tringali and published by CRC Press. This book was released on 2011-09-27 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.
Download or read book Non ionizing Radiation written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lead Generation Approaches in Drug Discovery written by Zoran Rankovic and published by John Wiley & Sons. This book was released on 2010-04-07 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Download or read book Lead Optimization for Medicinal Chemists written by Florencio Zaragoza Dörwald and published by John Wiley & Sons. This book was released on 2013-02-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.
Download or read book Lead written by Kristi Lew and published by The Rosen Publishing Group, Inc. This book was released on 2008-08-15 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ancient Romans used the metal lead (Pb) to make pewter plates and pipes to carry water. Scientists now know that lead is quite poisonous to humans. It is a cumulative poison, and its built-up effects can lead to damage in the brain, liver, and kidneys. Lead has no useful biological function and should not be eaten or otherwise taken into the body. Students will learn about the physical and chemical properties of lead, its atomic structure, and its place on the periodic table. Readers will also learn about the various industrial applications of lead, including its use as a shield for X-rays and radiation produced in nuclear reactors and for absorbing vibration and sound. In compounds, lead is used in making lead-acid storage batteries, fine crystal, solder in circuit boards, and vulcanized rubber.
Download or read book The Organic Compounds of Lead written by Hymin Shapiro and published by Wiley-Interscience. This book was released on 1968 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioactive Compounds from Natural Sources written by Corrado Tringali and published by CRC Press. This book was released on 2011-09-27 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified-natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products
Download or read book Pb Organolead Compounds written by Friedo Huber and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery in 1922 of the exceptional effectiveness of tetraethyllead in suppressing knock in the combustion of gasoline in engines and its introduction as a gasoline additive in 1923 stimulated an enormous number of studies on procedures for its synthesis and industrial production, on its behavior and uses, and also on the toxicology of this compound and on its environmental impact resulting from large scale lead distribution. The results of these investigations are collected in more than 3000 papers and patents. The quantity of information on this prominent compound fills the second volume of the series on organo lead compounds. Complete literature coverage was strived for but not all of the voluminous patent data have been considered. Certain publications on production of tetraethyllead or on use as a gasoline additive that are not reported in Chemical Abstracts (C.A.) may not have been found; similarly, publications that could not be clearly identified as relevant to the subject might be missing. Publications concerning the fate of inorganic lead compounds that are products of the combustion of leaded gasoline as weil as the vast amount of related papers on analytical and toxicological studies and on health and environmental aspects have been deliberately omitted. The literature is covered through 1988; C.A. has been evaluated through volume 110 of 1989.
Download or read book Lead Compounds from Medicinal Plants for the Treatment of Cancer written by Christophe Wiart and published by Academic Press. This book was released on 2012-11-23 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent today's most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development. - Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discovery - Contains primary source references and hundreds of the most relevant citations from the current literature for additional research - Offers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery.
Download or read book Lead Toxicity written by Sarah E. Royce and published by . This book was released on 2000 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evaluation of the Potential Carcinogenicity of Lead and Lead Compounds written by and published by . This book was released on 1989 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
