Download or read book Laser Desorption Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Organic Compounds written by Ronald Edward Shomo and published by . This book was released on 1985 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ion Detection and Structural Mass Spectrometry by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Matrix Assisted Laser Desorption Ionization written by Touradj Solouki and published by . This book was released on 1994 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book FT ICR MS written by Bruce Asamoto and published by Wiley-VCH. This book was released on 1991 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asphaltenes Heavy Oils and Petroleomics written by Oliver C. Mullins and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: With substantial contributions from experienced industrial scientists and engineers, this work will have real application towards improving process efficiency and improvement in the trillion-dollar global petroleum industry. It presents an overview of the emerging field of petroleomics, which endeavors to understand the fundamental components of crude oil. Petroleomics promises to revolutionize petroleum science in much the same way that genomics transformed the study of medicine not long ago. Asphaltenes are a particular focus, with many chapters devoted to the analysis of their structure and properties.
Download or read book Laser Desorption Fourier Transform Ion Cyclotron Resonance LD FT ICR Mass Spectrometry for High Mass Ions written by Troy Dale Wood and published by . This book was released on 1993 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Theoretical Advances and Laser Desorption Applications in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Michael Alan May and published by . This book was released on 1994 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Matrix assisted Laser Desorption Fourier Transform Mass Spectrometry for Biological Compounds written by and published by . This book was released on 1990 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent development of matrix-assisted UV laser desorption (LD) mass spectrometry has made possible the ionization and detection of extremely large molecules (with molecular weights exceeding 100,000 Daltons). This technique has generated enormous interest in the biological community for the direct examination of large peptides and oligonucleotides. Although this matrix-assisted ionization method has been developed and used almost exclusively with time-of-flight (TOF) mass spectrometers, research is currently in progress to demonstrate this technique with trapped ion mass spectrometers, such as Fourier transform ion cyclotron resonance mass spectrometry (FTMS). The potential capabilities of FTMS for wide mass range, high resolution measurement, and ion trapping experiments suggest that this instrumental technique should be useful for the detailed structural characterization of large ions generated by the matrix-assisted technique. We have recently demonstrated that matrix-assisted ultraviolet laser desorption can be successfully used with FTMS for the ionization of small peptides. The objective of this report is to summarize the application and current limitations of matrix-assisted laser desorption FTMS for the characterization of peptides and oligonucleotides at the isomeric level. 4 refs., 3 figs., 2 tabs.
Download or read book Fundamentals and Applications of Fourier Transform Mass Spectrometry written by Philippe Schmitt-Kopplin and published by Elsevier. This book was released on 2019-08-11 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis
Download or read book Proteomic Profiling and Analytical Chemistry written by Pawel Ciborowski and published by Elsevier. This book was released on 2016-03-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers Helps in designing and executing proteomic experiments with sound analytics
Download or read book Experimental Mass Spectrometry written by David H. Russell and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry underwent dramatic changes during the decade of the 1980s. Fast atom bombardment (F AB) ionization, developed by Barber and coworkers, made it possible for all mass spectrometry laboratories to analyze polar, highly functionalized organic molecules, and in some cases ionic, inorganic, and organometallic compounds. The emphasis of much of this work was on molecular weight determination. Parallel with the development of ionization methods (molecular weight mass spectrometry) for polar biological molecules, the increased mass range of sector and quadrupole mass spectrometers and the development of new instruments for tandem mass spectrometry fostered a new era in structural mass spectrometry. It was during this same period that new instrument technologies, such as Fourier transform ion cyclotron resonance, radio frequency quadrupole ion trap, and new types of time-of-flight mass spectrometers, began to emerge as useful analytical instruments. In addi tion, laser methods useful for both sample ionization and activation became commonplace in almost every analytical mass spectrometry laboratory. In the last 5 years, there has been explosive growth in the area of biological mass spectrometry. Such ionization methods as electrospray and matrix-assisted laser desorption ionization (MALDI) have opened new frontiers for both molecular weight and structural mass spectrometry, with mass spectrometry being used for analysis at the picomole and even femto mole levels. In ideal cases, subfemtomole sample levels can be successfully analyzed. Sample-handling methods are now the limiting factor in analyz ing trace amounts of biological samples.
Download or read book Multiphoton Ionization of Laser Desorbed Neutral Molecules in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer written by Jeffrey A. Zimmerman and published by . This book was released on 1990 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resonant multiphoton ionization of laser desorbed non-volatile samples has been achieved in a Fourier transform ion cyclotron resonance mass spectrometer (FTICR). The detection of iron at the 100 parts-per-million doping level in an indium phosphide compound semiconductor sample and the production of molecular ions for a hexapeptide have been observed in a modified FTICR analyzer cell. A unique three laser experiment has been devised in which infrared muliphoton dissociation of laser desorbed dipeptide ions, formed by resonant multiphoton ionization of laser desorbed neutrals, is performed. Multiphoton ionization (MPI), Laser desorption, Semiconductor materials, Trace analysis, Peptide sequencing, Fourier transform ion cyclotron resonance mass spectrometry. (JG).
Download or read book Novel Ionization Methods for Characterization of Natural Organic Matter by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by David Christopher Podgorski and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: Natural organic matter (NOM) exists as a highly functionalized, polydisperse and complex mixture of organic compounds derived from decaying plan and animal detritus. NOM has been characterized by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for approximately the past 10 years. Over that time advancements in transfer optics and ICR cell technology have resulted in improvements in sensitivity, dynamic range, mass accuracy, and signal-to-noise; however, ionization techniques for NOM characterization have not improved significantly. Typically, NOM is ionized by negative ion electrospray (ESI). ESI is amenable to NOM characterization because the majority of NOM is highly polar; however, important fractions of NOM are not ionizable by ESI and are therefore remain uncharacterized at the molecular level. The work presented is devoted to novel ionization methods for two of the most under characterized fractions of NOM by FT-ICR MS. Dissolved organic nitrogen (DON) may be selectively ionized by positive ion atmospheric pressure photoionization. Typically, DON is not characterized by FT-ICR MS because ESI does not efficiently ionize DON relative to the C, H, and O component of NOM. Black carbon, including biochar may be ionized by desorption atmospheric pressure photoionization. Biochar has defied molecular level characterization by FT-ICR MS because, as temperature of thermal degradation increases, the solubility of char in common solvents decreases. Chapter 1 is a brief introduction to natural organic matter including a short overview of two major components of DOM that remain largely uncharacterized at the molecular level, dissolved organic nitrogen and black carbon. Chapter 2 is a brief introduction to FT-ICR MS principles and establishes why FT-ICR MS is necessary for characterization of complex mixtures such as DOM. In Chapter 3, positive ion APPI is established as a selective ionization method for DON. DON has an important role in biogeochemistry; however, it remains largely uncharacterized by FT-ICR MS due to inefficient ionization relative to dissolved organic carbon (DOC). Positive ion APPI dramatically increases S/N of DON ions compared with negative ion ESI. Extensive molecular characterization of DON may now be conducted, including tandem mass spectrometry to reveal structural information about DON ions of a single m/z. Chapter 4 and 5 are applications of positive ion FT-ICR MS for characterization of wastewater-derived DON before and after treatment by advanced oxidation processes and algal remediation, and characterization of DON treated by microbes. An important factor in the bioavailability of organic nitrogen is composition. Large, aromatic compounds that are not available to algae for uptake in the untreated sample are degraded to more labile compounds that are bioavailable. Furthermore, labile DON may be used by microbes and converted to refractory compounds. Chapter 6 focuses on biochar, an important natural product for the agricultural and fuel industries. Black carbon also represents a significant long-term sink for atmospheric carbon. Characterization of biochar is important for understanding how it interacts in the environment. Many questions are yet to be answered about how char is degraded after initial formation. To date, only the water-soluble fraction of char is characterized at the molecular level by FT-ICR MS. As the temperature of char formation increases, chars become insoluble in common solvents. In Chapter 5, the implementation of desorption atmospheric pressure photoionization (DAPPI) to characterize intact chars is described. DAPPI is an ambient ionization method that does not require sample preparation or separation. The elemental composition of a parent oak, oak combusted at 250 °C, and oak 400 °C are determined by DAPPI coupled to FT-ICR MS. The data show the parent material is mostly composed of lignin- and cellulose-like compounds. As the oak is thermally degraded, the compounds become more aromatic. At 400 °C the oak has lost all of its original identifiable components and is composed of mostly aromatic compounds.
Download or read book Statistical Analysis of Matrix assisted Laser Desorption ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Data with Applications to Cancer Biomarker Detection written by Donald Anthony Barkauskas and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrospray and MALDI Mass Spectrometry written by Richard B. Cole and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.
Download or read book Fourier Transform Ion Cyclotron Resonance Mass Spectrometry FT ICR MS to Study the Sources and Mobilization of Dissolved Organic Matter in Forested Catchments written by Maria Paula da Silva and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fundamental Studies of Electrospray Ionization and Matrix assisted Laser Desorption ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Markus Knobeler and published by . This book was released on 1996 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book State selected Chemistry Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Cindy Gayle Beggs and published by . This book was released on 1990 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
