Download or read book Laser Ablation Inductively Coupled Plasma Mass Spectrometry LA ICP MS as a Biomonitoring Tool written by Brianne Duncan and published by . This book was released on 2019 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) this research analyzed human cadaver hair for gadolinium and mice hair samples for cadmium. This project combined fundamental bench science (analytical chemistry and animal studies), and insight into exposures to an emerging contaminant. This study demonstrated the feasibility of LA-ICP-MS to measure time resolved exposure profiles in hair samples, potentially opening up a transformative new exposure analysis method for investigators conducting both bench toxicology and human epidemiology studies. Consecutive autopsy cases that presented at the University of Washington's medical department, who had received a gadolinium-based contrasting agent (GBCA) to enhance magnetic resonance imaging procedures constituted the human population component of this research. Multiple hairs from numerous subjects were analyzed using LA-ICP-MS along with calibration gels (bovine-skin based) and a standard reference material glass disc with trace metals. Overall analytical method accuracy and precision was acceptable. There was moderate correlation between gadolinium dose and area under the curve as well as gadolinium peak position and GBCA injection day. Hair concentrations were also compared to the other tissue (brain, bone, and skin) concentrations using linear regression. This analysis showed good correlation between hair gadolinium concentrations and brain and skin gadolinium concentrations. These results suggest that hair may serve as a safe and effective biomonitoring tissue for patients who receive GBCA injections. A mouse animal model was used to evaluate LA-ICP-MS as a biomonitoring tool in assessing cadmium exposure. Hair samples from mice that were part of a mechanistic toxicology study at the University of Washington were opportunistically obtained for inclusion in this analytical methods-focused element of the research. The mice were dosed with cadmium-spiked water at three levels (0, 0.6, and 3 mg/L) for 14 weeks before they were sacrificed. Hairs from seven mice were analyzed using LA-ICP-MS. This research showed that there were increasing concentrations of cadmium in hair shafts with increasing doses of cadmium in drinking water among mice.

Download or read book Inductively Coupled Plasma Mass Spectrometry Handbook written by Simon M. Nelms and published by CRC Press. This book was released on 2005 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a level of detection of one part in 1015, inductively coupled plasma mass spectrometry (ICP-MS) is a highly sensitive tool in a huge range of analytical applications. Development of the technology continues rapidly, further opening up the scope for this invaluable analytical technique. Despite widespread interest and usage, little has been written to describe the analytical techniques and instrumentation in a format accessible to both new and experienced users of the technique. Inductively Coupled Plasma Mass Spectrometry Handbook provides a thorough description of ICP-MS instrumentation and techniques, giving the reader sufficient knowledge to approach the technique with confidence.

Download or read book Laser ablation ICPMS in the Earth Sciences written by Paul Joseph Sylvester and published by . This book was released on 2001 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM titled: "Short course volume 29, 2001 (to accompany Short course 40, 2008)".

Download or read book Laser ablation Inductively coupled plasma Mass Spectrometry LA ICP MS of Oils and Tars Trace Metal Ratios Made Easy written by A. D. Bradley and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Laser Ablation ICP MS in the Earth Sciences written by Paul Joseph Sylvester and published by . This book was released on 2008 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM titled: "Short course volume 29, 2001 (to accompany Short course 40, 2008)".

Download or read book Laser Ablation Inductively Coupled Plasma Mass Spectrometer LA ICP MS in Geosciences Further Improvement for Elemental Analysis written by Shitou Wu and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A quantitative reduction strategy consisting of Ratioing, Standardization, and Normalization (RSN) was proposed to process the LA-ICP-MS transient signal of NIST, MPI-DING, USGS and CGSG glass reference materials. The RSN strategy allows the quantitative reduction without knowing the concentration of internal standard prior to LA-ICP-MS analysis. The down-hole fractionations of the investigated glasses in initial 5-35s ablation period were insignificant and independent of the chosen internal standards under the given laser conditions. The analytical accuracy obtained from internal standardi...

Download or read book Inductively Coupled Plasma Spectrometry and its Applications written by Steve J. Hill and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Inductively Coupled Plasma Spectrometry andits Applications was written as a handbook for users who wanted abetter understanding of the theory augmented by a practical insightof how best to approach a range of applications, and to provide auseful starting point for users trying an approach or technique newto them. These objectives have been retained in the second editionbut a slight shift in emphasis gives the volume an overallperspective that is more forward looking. Structured into 11 chapters, the current edition is a thoroughrevision of the original, covering the principles of inductivelycoupled plasmas, instrumentation, methodology and applicationswithin environmental analysis, earth science, food science andclinical medicine. Each chapter, written by internationallyrecognised leaders in their specific subject areas, provides enoughdetail to be useful to both the new and experienced users. Fullaccount is taken of recent developments, such as high resolutioninstruments, novel detection systems and electrospraytechniques. Written for all analytical scientists but particularly thoseinvolved in atomic spectroscopy and in environmental, geochemical,clinical or food analysis, this timely and informative book will bean essential reference in their use of inductively coupled plasmasto achieve their own scientific goals.

Download or read book Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Raman Spectroscopy Imaging of Biological Tissues written by Emma Lee Gorishek and published by . This book was released on 2016 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laser Ablation Inductively coupled plasma mass spectrometry (LA-ICP-MS) and Raman spectroscopy are both powerful imaging techniques. Their applications are numerous and extremely potential in the field of biology. In order to improve upon LA-ICP-MS an in-house built cold cell was developed and its effectiveness studied by imaging Brassica napus seeds. To further apply LA-ICP-MS and Raman imaging to the field of entomology a prong gilled mayfly (Ephemeroptera: Leptophlebiidae) from the Róbalo River, located on Navarino Island in Chile, was studied. Analysis of both samples showcased LA-ICP-MS and Raman spectroscopy as effective instruments for imaging trace elements and larger molecules in biological samples respectively.

Download or read book Inductively Coupled Plasma Mass Spectrometry written by Akbar Montaser and published by John Wiley & Sons. This book was released on 1998-04-22 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alles über ICP-MS in einem Band! Renommierte Autoren informieren Sie über Theorie, Anwendung und instrumentelle Ausrüstung von A bis Z. Grundlagen werden ebenso behandelt wie neueste Entwicklungen, etwa bei Probenpräparation und Einsatz von Hochfrequenzgeneratoren. Enthält eine Fülle bisher unveröffentlichten Materials!

Download or read book Inductively Coupled Plasma Mass Spectrometry written by Howard E. Taylor and published by Academic Press. This book was released on 2001 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: It also includes information on processing and interpreting results to obtain high-quality data.".

Download or read book The Use of Laser Ablation Inductively Coupled Plasma Mass Spectrometry LA ICP MS for the Discrimination of Glass Fragments in Forensic Casework written by David William Szymanski and published by . This book was released on 2004 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Analysis of Solids by Laser Ablation Inductively Coupled Plasma Mass Spectrometry written by David Brian Aeschliman and published by . This book was released on 2003 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation manuscript concentrates on methods to improve the utility of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) as a rapid and accurate technique for quantitative analysis, forensic matching, and source attribution of solid samples. A solution calibration method for LA-ICP-MS is described that does not require matrix-matched solid standards or prior knowledge of sample composition. Desolvated particles from a microconcentric nebulizer and particles ablated from a localized position on a solid sample are mixed and introduced simultaneously to the ICP-MS. The transport of sample particulates from the ablation cell is measured online with piezoelectric microbalance to provide signal normalization. The relative accuracy of the quantitative analysis of NIST 612 glass and NIST 1264a steel is 3% and 12%, respectively, except for the elements Pb and Bi in steel. LA-ICP-MS is also used with principal components analysis (PCA) to simplify routine comparisons of forensic materials without time-consuming and destructive sample dissolution. The relative concentrations of trace elements in a solid sample are examined to provide a "fingerprint" composition that can be used for definitive identification and source matching of the material. Residue samples are matched to bulk materials using PCA. Variation of laser focus and PCA are also used to diagnose the presence and severity of elemental fractionation, which remains the most significant limitation for accurate quantitative analyses by LA-ICP-MS. High-speed photographs and video of an ICP are used to examine the validity of solution calibration for LA-ICP-MS and to study the trajectories, lifetimes, and emission behavior of particles traversing the plasma under a variety of conditions. No red emission clouds from YO are visible in the ICP when a 20-[mu]L min−1 nebulizer is used to spray a 2000 ppm aqueous yttrium solution, suggesting that the wet droplets from this nebulizer desolvate almost completely before entering the ICP. These desolvated particles appear to atomize and ionize like the small dry particulates from laser ablation. However, some large ablated particulates are observed to fly through the plasma intact, possibly contributing to elemental fractionation. Nevertheless, accurate calibration results using solution standards can be obtained for elements not affected by fractionation.

Download or read book Calibration of Laser Ablation Inductively Coupled Plasma Mass Spectrometry Using Dried Solution Aerosols for the Quantitative Analysis of Solids written by James Joseph Leach and published by . This book was released on 1998 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis concerns itself with the use of inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of solid samples. The instrumentation and attributes of ICP-MS are presented. The theoretical and practical considerations of laser ablation as a solid sampling source are reviewed. The feasibility of quantitative analysis of solids by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is assessed. A formula is presented which illustrates that solution standards can be used for the calibration of solids.

Download or read book Plasma Source Mass Spectrometry written by J Grenville Holland and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atomic spectrometry has exciting new bio-analytical horizons open to it, principally through the developments in the capabilities of ICP-MS coupled with the inventiveness of experimentalists. This is reflected in the use of the technique for ion-, capillary electrophoresis-, liquid- and gas-chromatographic separation in biological applications, as reported in this book. Traditional (environmental, semiconductor, geological and clinical) applications are also well represented. In addition, recent and future developments in sample introduction devices, multicollector sector, reaction cells and collision cells instruments, as well as co-existence, divergence and potential convergence of atomic and biomolecular mass spectrometries are discussed. Reflecting the current state of practical ICP-MS and drawing together the latest developments in the field, Plasma Source Mass Spectrometry: Current Trends and Future Developments is ideal for university researchers and laboratory practitioners. It will be of interest to all those involved in the development and application of this technique.

Download or read book New Quantitative Approach in Trace Elemental Analysis of Single Fluid Inclusions written by A. M. Ghazi and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Evaluation of Inductively Couple Plasma time of Flight Mass Spectrometry for Laser Ablation Analyses written by D. P. Baldwin and published by . This book was released on 2003 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this trip to LECO Corporation was to test the non-matrix matched calibration method and the principal component analysis (PCA) method on a laser ablation-inductively coupled plasma-time of flight mass spectrometry (LA-ICP-TOFMS) system. An LA-ICP-TOFMS system allows for multielement single-shot analysis as well as spatial analysis on small samples, because the TOFMS acquires an entire mass spectrum for all ions extracted simultaneously from the ICP. The TOFMS system differs from the double-focusing mass spectrometer, on which the above methods were developed, by having lower sensitivity and lower mass resolution.

Download or read book Laser Ablation inductively Coupled Plasma mass Spectrometry written by and published by . This book was released on 2011 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation provides a general introduction to Inductively coupled plasma-mass spectrometry (ICP-MS) and laser ablation (LA) sampling, with an examination of analytical challenges in the employment of this technique. It discusses the origin of metal oxide ions (MO+) in LA-ICP-MS, as well as the effect of introducing helium and nitrogen to the aerosol gas flow on the formation of these polyatomic interferences. It extends the study of polyatomic ions in LA-ICP-MS to metal argide (MAr+) species, an additional source of possible significant interferences in the spectrum. It describes the application of fs-LA-ICP-MS to the determination of uranium isotope ratios in particulate samples.