Download or read book Intracellular Signalling Proteins written by and published by Academic Press. This book was released on 2019-04-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more. - Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms - Targeted to a very wide audience of specialists, researchers and students - Contains timely chapters written by well-renowned authorities in their field - Includes a number of high quality illustrations, figures and tables

Download or read book Cell Signalling written by John T. Hancock and published by Oxford University Press. This book was released on 2017 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Cell Signalling' presents a carefully structured introduction to this subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems.

Download or read book Cell Signalling written by John Hancock and published by Oxford University Press, USA. This book was released on 2010-01-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signalling within and between cells is an essential part of many biological processes, from the development of the body to the activity of our immune system. Cell Signalling, Third Edition, presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms before examining how these components come together to create signalling pathways, which are so crucial to the survival of many living organisms. The text is enhanced by two-color artwork and 3-D protein models. A Companion Website provides resources for students and instructors.

Download or read book Landmark Papers in Pain written by Paul Farquhar-Smith and published by Oxford University Press. This book was released on 2018-08-10 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Medicine, a relatively new specialty, has proven increasingly relevant to medical practitioners in every field. The specialism of pain has emerged over the past 50 years, largely due to the persistence of experts and new medical evidence that points to its necessity. Today, it is a distinct and integral part of global medical practice. Landmark Papers in Pain offers a comprehensive inventory of over 80 key studies in pain medicine from the last 100 years. Each paper is accompanied by a concise commentary on the significance of the original findings written by an expert in pain. The reviews discuss how the paper influenced the development of the speciality, and how the findings have advanced our global comprehension of pain. Together, the selected papers and reviews chart the growth of an embryonic field into the modern speciality of pain medicine. Complied by leading specialists in the field, the papers included in this book are significant for any student, researcher, clinical practitioner, or medical historian interested in pain medicine. Organised into eight distinct topics and cross-referenced by topics and author of original paper, the book is comprehensive in its coverage and easy to use. A review of the contemporary and historical research that shaped the speciality of pain, Landmark Papers in Pain is essential reading for all medical practitioners with an interest in pain medicine.

Download or read book Landmark Papers in Nephrology written by John Feehally and published by Oxford University Press. This book was released on 2013-03-07 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book selects the most important scientific papers related to kidney disease and comments on their significance within the wider field. Fascinating reading for both nephrologists and medical historians, no doubt giving rise to further debate over the origins and progress of nephrology.

Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Download or read book Landmark Papers in Cell Biology written by Joseph G. Gall and published by CSHL Press. This book was released on 2001 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Contains 42 seminal papers illustrating advances in cell biology, along with brief commentaries that place the papers in historical and intellectual context. All papers are studies of eukaryotes, and are grouped according to themes of genome organization and replication, transcription, nuclear envelope and nuclear import, mitosis and cell cycle control, cell membrane and extracellular matrix, protein synthesis and membrane traffic, and cytoskeleton. Lacks a subject index. Gall teaches embryology at the Carnegie Institution. McIntosh teaches cell biology at the University of Colorado. Annotation c. Book News, Inc., Portland, OR (booknews.com).

Download or read book Landmark Experiments in Protein Science written by Pascal Leclair and published by CRC Press. This book was released on 2023-07-31 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are the workhorses of cells, performing most of the important functions which allow cells to use nutrients and grow, communicate among each other, and importantly, die if aberrant behavior is detected. How were proteins discovered? What is their role in cells? How do dysfunctional proteins give rise to cancers? Landmark Experiments in Protein Science explores the manner in which the inner workings of cells were elucidated, with a special emphasis on the role of proteins. Experiments are discussed in a manner as to understand what questions were being asked that prompted the experiments and what technical challenges were faced in the process; and results are presented and discussed using primary data and graphs. Key Features Describes landmark experiments in cell biology and biochemistry. Discusses the "How" and "Why" of historically important experiments. Includes primary, original data and graphs. Emphasizes biological techniques, that help understand how many of the experiments performed were possible. Documents, chronologically, how each result fed into the next experiments.

Download or read book Transactions written by Biochemical Society (Great Britain) and published by . This book was released on 1999 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Landmark Papers in Rheumatology written by Richard A. Watts and published by OUP Oxford. This book was released on 2015-06-25 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatic disease is a major cause of morbidity and disability in the Western world. There have been major developments in our understanding of the causes of rheumatic disease and in their treatment during the last half-century, and there are relatively few papers which can be regarded as truly 'landmark' in their construction and subsequent findings. Part of the Landmark Papers in series, this book provides a detailed review of the seminal papers that have paved the way for breakthroughs in the clinical management of the entire spectrum of rheumatic diseases.

Download or read book Cellular Signaling in Health and Disease written by Martin Beckerman and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Download or read book Landmark Papers in Neurology written by Martin R. Turner and published by OUP Oxford. This book was released on 2015-08-20 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current understanding of neurological disease has been evolving over the past 150 years. With the increasing and earlier sub-specialization of neurology trainees, and their variable exposure to higher academic study, there is little opportunity to put this development into a historical context as a whole. Understanding the 'evidence-base', or appreciating the lack of it in some cases, is an important part of training but this is rarely presented in a palatable, entertaining form. Part of the Landmark Papers in series, this book brings together the ten most important papers for each sub-speciality within neurology, covering the full range of major neurological conditions. Papers have been selected by leading international experts, who not only summarize what each paper showed, but place them into a wider context that makes a coherent story of how their sub-speciality has developed.

Download or read book 50 Landmark Papers every Pediatric Surgeon Should Know written by Mark Davenport and published by CRC Press. This book was released on 2023-11-29 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book identifies the 50 key scientific articles in the field of pediatric surgery. It provides a commentary to each carefully selected paper and explains why these papers are so important, thus providing every surgeon with the foundation stones of knowledge in this fast-moving area. The key advances in neonatal, pediatric, and fetal surgery – game-changers if you will – that have led to the significant improvements in clinical outcome and results are all included. The choice of papers provides an insight into the development of pediatric surgery and offers an important aid to understanding the subject for practicing pediatric surgeons and residents.

Download or read book Landmark Papers in Internal Medicine written by Harold C. Sox and published by ACP Press. This book was released on 2009 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: ACPs journal, Annals of Internal Medicine, is one of the most prestigious journals in medicine. This new book looks at the landmark papers published in Annals, as selected by leading experts from each subspecialty of internal medicine, and how they impacted (and continue to influence) medical science.

Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The ras Superfamily of GTPases written by Juan Carlos Lacal and published by CRC Press. This book was released on 1993-06-11 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.