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Book Biology of the Mammary Gland

    Biology of the Mammary Gland

    Book Details:
  • Author : John A. Mol
  • Publisher : Springer Science & Business Media
  • Release : 2006-04-11
  • ISBN : 0306468328
  • Pages : 309 pages

Download or read book Biology of the Mammary Gland written by John A. Mol and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.

Book In Vitro Hormonal Regulation of Epidermal Growth Factor and Glucocorticoid Receptors in a Rat Mammary Tumor Clonal Line

Download or read book In Vitro Hormonal Regulation of Epidermal Growth Factor and Glucocorticoid Receptors in a Rat Mammary Tumor Clonal Line written by Ladan Basiripour and published by . This book was released on 1986 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Control of Growth Factors and Prevention of Cancer

Download or read book Control of Growth Factors and Prevention of Cancer written by Michael B. Sporn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now apparent that several fields of investigation are converging upon each other as the goal of finding a practical way to prevent cancer is pursued. The present monograph represents the efforts of an interdisciplinary ESO Task Force that was convened to assess interactions of peptide growth factors and steroid-like molecules in the prevention of cancer. Each of the participants in the Task Force represents a differentscientific discipline, and the monogrph is intended to be a synthesis of their different approaches to the common problem of cancer prevention. It is hoped that the reader will find this monograph to be of use in the evaluation of both preclinical and clinical approaches to the major issues that face us in chemoprevention. It is clear that prevention of cancer is an idea whose time has come, and the problem now is to implement the most effective approaches toward achieving the desired goals.

Book Intercellular Signalling in the Mammary Gland

Download or read book Intercellular Signalling in the Mammary Gland written by C.H. Knight and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.

Book Requirement of Proto oncogene C myc in Epidermal Growth Factor Stimulated Proliferation of Mammary Epithelial Cells

Download or read book Requirement of Proto oncogene C myc in Epidermal Growth Factor Stimulated Proliferation of Mammary Epithelial Cells written by Sharyl Jeanne Nass and published by . This book was released on 1991 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Hormone Growth Factor and Fatty Acid Effects on Differentiation of Mouse Mammary Epithelial Cells in Collagen Gel Culture

Download or read book Hormone Growth Factor and Fatty Acid Effects on Differentiation of Mouse Mammary Epithelial Cells in Collagen Gel Culture written by Brett Kingsley Young and published by . This book was released on 1987 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Hormonal Regulation of Mammary Gland Development and Breast Cancer

Download or read book Hormonal Regulation of Mammary Gland Development and Breast Cancer written by and published by . This book was released on 2003 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the principal objectives of our laboratory is to understand the mechanisms by which hormones and growth factors regulate normal mammary gland development and how these same regulatory pathways become altered in breast cancer. Specific emphasis has been placed upon studying the mechanisms by which the lactogenic hormones, prolactin, hydrocortisone and insulin, regulate milk protein gene expression. The CCAAT/enhancer binding protein B (c/EBPB), Yin Yang-i (YY- 1), signal transducers and activators of transcription S (STATS), and the glucocorticoid receptor (OR) all have been shown to mediate the hormonal and developmental regulation of B-casein gene expression. However, the mechanism by which these transcription factors as well as coactivator proteins coordinately function to promote normal mammary gland development and breast cancer remains undefined. To understand the role of C/EBPj3, STATS, OR and comodulatory factors in hormonally-regulated chromatin remodeling at the 3-casein promoter and enhancer, we have initiated chromatin immunoprecipitation assays in HCl 1 cells and in the mammary gland and liver from lactating mice. In addition, we have analyzed mammary gland development in several specific mouse knockouts. The examination of mammary transplants from OR* and CBP mice suggested that MR may compensate for the loss of OR in mammary gland development during pregnancy, lactation and involution, and that haploinsufficiency of CBP does not appear to affect mammary gland development.

Book The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells

Download or read book The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells written by Jennifer J. Gavinski and published by . This book was released on 2008 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Hormonal Control of Gene Expression in Mouse Mammary Epithelial Cells

Download or read book Hormonal Control of Gene Expression in Mouse Mammary Epithelial Cells written by Paul Brennan-Benson and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Regulation of Mammary Lactogenic Differentiation by Singleminded 2s

Download or read book Regulation of Mammary Lactogenic Differentiation by Singleminded 2s written by Elizabeth Wellberg and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Sim2s is a basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) transcription factor. In Drosophila, the Sim2 homolog, sim, is necessary for cell fate determination during central nervous system (CNS) development. In mammals, both Sim2 isoforms are involved in development of various tissues, including muscle, cartilage, and mammary gland. Loss-of-function studies revealed a role for Sim2s in specifying epithelial cell fate during mammary development and inhibiting growth and invasion of aggressive breast cancer cells. This study determined the role of Sim2s in mammary epithelial cell differentiation. Our hypothesis is that Sim2s is sufficient to promote lactogenic differentiation in vivo, characterized by expression of lactation-specific genes. Two models were used to test this hypothesis: (1) a transgenic mouse, expressing Sim2s under control of the MMTV-LTR, and (2) the mouse mammary epithelial cell line HC11. Together, these models allow analysis of the effect of Sim2s on global mammary gland differentiation and the mechanism through which it accomplishes this in a relatively homogenous population of cells. We determined that precocious expression of Sim2s in vivo is associated with upregulation of a subset of milk protein genes in nulliparous females. During early pregnancy, Sim2s regulation of lactogenic differentiation extended to a larger group of genes. Following pup removal, Sim2s appears to promote survival of alveolar epithelial cells. In vitro, Sim2s expression is necessary for maximal Csn2 expression, as determined by loss-of-function studies. Overexpression of Sim2s is sufficient to enhance prolactin-mediated Csn2 expression. Chromatin immunoprecipitation assays performed in HC11 cells revealed enhanced recruitment of Stat5a and RNA Polymerase II (RNAPII) to the regulatory region of Csn2 in the presence of Sim2s. In addition, Sim2s and RNAPII were found in a complex that was localized to both the promoter and coding region of the Csn2 gene. These studies support the idea that Sim2s is upregulated in a developmental stage-specific manner in the mouse mammary gland to promote the survival and differentiation of alveolar epithelial cells expressing high levels of milk protein genes. Further, Sim2s may regulate the function of a specific subset of alveolar cells by targeting the RNAPII holoenzyme complex to genes expressed during lactogenic differentiation.