Download or read book Les Conventions locales de gestion des ressources naturelles et de l environnement written by Laurent Granier and published by IUCN. This book was released on 2006 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxines et cancer written by GOUDEY-PERRIÈRE Françoise and published by Lavoisier. This book was released on 2006-11-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: De tout temps, l'homme a eu conscience de l'intérêt thérapeutique des toxines. Certaines toxines végétales depuis longtemps utilisées figurent encore dans la pharmacopée actuelle. Viennent s'y ajouter depuis peu des toxines microbiennes. Cependant le maniement des toxines natives ou à peine modifiées reste délicat tant est faible la marge entre les effets toxiques et l'efficacité thérapeutique. Comment, dans une perspective médicale, canaliser la puissance d'action et l'efficacité d'une toxine ? Connaître sa structure, comprendre son mécanisme d'action n'est pas suffisant : il faut aussi identifier sa cible privilégiée, autrement dit un récepteur cellulaire, faute de quoi l'entreprise apparemment chimérique d'un détournement de sa puissance et de sa spécificité reste aveugle. Ce cap est franchi, depuis un certain nombre d'années, et le développement des recherches sur les toxines axées sur la thérapeutique est devenu foisonnant. Voyez telle ou telle toxine protéique ternaire, avec ses trois domaines, de fixation sur un récepteur membranaire, de translocation qui lui permet de franchir la membrane cellulaire, et d'activité enzymatique qui va alors pouvoir s'exercer dans la cellule. Qu'on parvienne à dissocier chacun de ces trois domaines en leur conservant leurs propriétés, et des possibilités nouvelles d'utilisation thérapeutique vont s'ouvrir, presque à l'infini semble-t-il. Car chacun d'entre eux pourra être couplé à une molécule active bien ciblée, et leur efficacité sera même améliorée pour peu qu'on parvienne à conjuguer leur action. Qu'un récepteur, qu'une molécule, propres au métabolisme ou à la physiologie d'une cellule cancéreuse soient identifiés, et des toxines conjuguées à un ligand de ce récepteur, de cette molécule (ce peut être un anticorps) bloqueront les canaux ioniques ou exerceront leur effet cytolytique sur cette seule cellule, sans nuire aux cellules saines. Nous voilà dégagés de l'utopie, le contenu de cet ouvrage le prouve abondamment. Et même si la concrétisation des promesses reste délicate, le champ d'action est si vaste initialement qu'il ne saurait rester improductif : il ne l'est d'ailleurs déjà plus.
Download or read book Bulletin Bibliographique Des Ouvrages Publi s en France Sur Les Sciences M dicales Naturelles Et Physiques written by and published by . This book was released on 1835 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Discovery and Design Using Natural Products written by Jorddy Neves Cruz and published by Springer Nature. This book was released on 2023-08-28 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural optimization to enhance the pharmacological properties of biomolecules; are some of the main difficulties encountered in research with natural products and in the design/discovery of new medicines. Therefore, this book addresses the great scientific advances that provide practical solutions to using natural products to develop new drugs. We address topics related to the genesis of research projects that use natural products to design new drugs. We address the discovery of new species, initial processes for identification and extraction of compounds, isolation and identification of these structures, techniques, and advances in vitro and in vivo methods that support the discovery of new natural drugs, synthesis of new compounds from natural molecules, in silico optimization processes of potentially promising compounds.
Download or read book Natural Products and Drug Discovery written by Subhash C. Mandal and published by Elsevier. This book was released on 2018-02-16 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2002-03-01 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Natural Products (Part G)
Download or read book The New Natural History of Madagascar written by Steven M. Goodman and published by Princeton University Press. This book was released on 2022-11-15 with total page 2297 pages. Available in PDF, EPUB and Kindle. Book excerpt: A marvelously illustrated reference to the natural wonders of one of the most spectacular places on earth Separated from Africa’s mainland for tens of millions of years, Madagascar has evolved a breathtaking wealth of biodiversity, becoming home to thousands of species found nowhere else on the planet. The New Natural History of Madagascar provides the most comprehensive, up-to-date synthesis available of this island nation’s priceless biological treasures. Now fully revised and expanded, this beautifully illustrated compendium features contributions by more than 600 globally renowned experts who cover the history of scientific exploration in Madagascar, as well as the island’s geology and soils, climate, forest ecology, human ecology, marine and coastal ecosystems, plants, invertebrates, fishes, amphibians, reptiles, birds, and mammals. This invaluable two-volume reference also includes detailed discussions of conservation efforts in Madagascar that showcase several successful protected area programs that can serve as models for threatened ecosystems throughout the world. Provides the most comprehensive overview of Madagascar’s rich natural history Coedited by 18 different specialists Features hundreds of new contributions by world-class experts Includes hundreds of new illustrations Covers a broad array of topics, from geology and climate to animals, plants, and marine life Sheds light on newly discovered species and draws on the latest science An essential resource for anyone interested in Madagascar or tropical ecosystems in general, from biologists and conservationists to ecotourists and armchair naturalists
Download or read book Authors and Subjects written by and published by . This book was released on 1880 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Natural Products Chemistry of Botanical Medicines from Cameroonian Plants written by Xavier Siwe-Noundou and published by CRC Press. This book was released on 2021-09-28 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forms an important part of the series on Natural Products Chemistry of Global Plants, as Cameroon is a country with rich experience in the use of medicinal plants and with a wide diversity of botanical resources Addresses the current development of pharmacognostic research in Cameroon Provides readers with updated information on the chemistry and pharmacology of natural products with pharmaceutical potentials Covers an extensive range of chemical, botanical and pharmacological diversities
Download or read book Natural Products and Neuroprotection written by Cristina Angeloni and published by MDPI. This book was released on 2020-06-17 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.
Download or read book Biologically Active Natural Products from Asia and Africa A Selection of Topics written by Anna Capasso and published by Bentham Science Publishers. This book was released on 2021-01-15 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both Asia and Africa are home to many plants that can be used for the treatment of many diseases and their medicinal properties are gaining interest in western societies. Medicinal plants from Asia and Africa are used for their healing abilities and also have a symbolic meaning in communities. The importance of traditional autochthonous plant remedies plays a crucial role in the health of millions of people of these two continents. Even today, traditional medicine represents the dominant medical system for millions of people showing a significant impact on health care practices. Therefore, traditional operators still represent a vital part of regional healthcare systems. For this reason, pharmaceutical industries consider traditional medicine as a source for the identification of bioactive compounds that can be used in the preparation of synthetic drugs. Biologically Active Natural Products from Asia and Africa: A Selection of Topics guides the reader to information about new natural products from these regions and the different ways to use them to treat or alleviate many of the most common diseases. The volume presents nine topics covering a number of facets of natural product medicine including: - pharmaceutical analysis of anti-diabetic herbal medicines from Bangladesh and local retailers - caffeine intake and the risk of female infertility - pharmaceutical analysis of Urena sinuata (bur mallow) - anti-CHIKV activities of diterpenes and their derivatives - anti-inflammatory nanogel for the treatment of psoriasis - antlithiatic properties of Moroccan medicinal plants - ethnobotanic, phytochemical and biological activities of Aristolochia longa L. (pipevine) - wound healing potential of combined extracts of stem bark and leaves of sphenocentrum jollyanum (an African shrub) This is a handy reference for specialists and R&D experts in pharmaceutical chemistry who wish to be informed about current knowledge on developing natural remedies in Asia and Africa.
Download or read book Herbs and Natural Supplements Volume 2 written by Lesley Braun and published by Elsevier Health Sciences. This book was released on 2015-03-30 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbs and Natural Supplements, 4th Edition: An evidence-based guide is an authoritative, evidence-based reference. This two-volume resource is essential to the safe and effective use of herbal, nutritional and food supplements. The second volume provides current, evidence-based monographs on the 132 most popular herbs, nutrients and food supplements. Organised alphabetically, each monograph includes daily intake, main actions and indications, adverse reactions, contraindications and precautions, safety in pregnancy and more. Recommended by the Pharmacy Board of Australia as an evidence-based reference works (print) that pharmacists are meant to have access to when dispensing Contributed content from naturopaths, GPs, pharmacists, and herbalists Useful in a clinical setting as well as a reference book. It provides up-to-date evidence on the latest research impacting on herbal and natural medicine by top leaders in Australia within the fields of Pharmacy, Herbal Medicine and Natural Medicine
Download or read book Plant Natural Products for Human Health written by Chun-Tao Che and published by MDPI. This book was released on 2019-03-21 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs. This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.
Download or read book The Bradley Bibliography written by Alfred Rehder and published by . This book was released on 1915 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Naming and Mapping the Gods in the Ancient Mediterranean written by Thomas Galoppin and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-12-31 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ancient religions are definitely complex systems of gods, which resist our understanding. Divine names provide fundamental keys to gain access to the multiples ways gods were conceived, characterized, and organized. Among the names given to the gods many of them refer to spaces: cities, landscapes, sanctuaries, houses, cosmic elements. They reflect mental maps which need to be explored in order to gain new knowledge on both the structure of the pantheons and the human agency in the cultic dimension. By considering the intersection between naming and mapping, this book opens up new perspectives on how tradition and innovation, appropriation and creation play a role in the making of polytheistic and monotheistic religions. Far from being confined to sanctuaries, in fact, gods dwell in human environments in multiple ways. They move into imaginary spaces and explore the cosmos. By proposing a new and interdiciplinary angle of approach, which involves texts, images, spatial and archeaeological data, this book sheds light on ritual practices and representations of gods in the whole Mediterranean, from Italy to Mesopotamia, from Greece to North Africa and Egypt. Names and spaces enable to better define, differentiate, and connect gods.
Download or read book Elsevier s Dictionary of Vitamins and Pharmacochemistry written by Henry Philippsborn and published by Elsevier. This book was released on 2006-12-04 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dictionary will contain terms covering the following fields and subfields: Vitamin Technology: Vitamin biochemistry / Physiology; Origin of vitamins: natural, synthetic; Fat-soluble vitamins; Water-soluble vitamins; Vitamins as antioxidants; Vitamin deficiencies / Hypervitaminosis - Enzymes/Proteins: Biotechnology as applied biological science aimed at industrial exploitation - Hormones: Biochemistry; Physiology - Pharmaceutical Chemistry / Pharmaceutical Technology / Pharmaceutical Processes: Conception of the active principles; Structural analysis; Antibiotics and their way of action; Biochemistry; The Drug / The Medicament: Definition, origin, way of action; Biochemistry - Medical Aspects in the languages English, German, French and Portuguese. *An important resource for pharmacologists, pharmaceutists and medical doctors *Includes definitions in several prominent languages (English, German, French, Portuguese) *Covers subfields of Vitamin Technology, Enzymes/Proteins, Hormones, Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Processes, and more
