Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Download or read book NAFTA and Democracy in Mexico written by Pablo Calderón Martínez and published by Routledge. This book was released on 2018-09-05 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: After describing NAFTA as ‘the worst trade deal maybe ever signed anywhere’, Donald Trump’s election seemed to represent the final nail in the coffin for North American economic integration. Following a decade of stagnation, however, Trump’s victory presents a timely opportunity to reconsider North American integration and evaluate NAFTA’s democratic track record in Mexico. In this book, Pablo Calderón Martínez presents a detailed analysis of NAFTA’s influence as a political tool for democracy in Mexico. Extending beyond a mere economic or social exploration of the consequences of NAFTA, Calderón Martínez uses a three-tiered analysis based on causality mechanisms to explain how the interactions between internationalisation and democratisation unfolded in Mexico. Calderón Martínez’s analysis demonstrates that Mexico’s internationalisation project under the framework of NAFTA gave shape to, if not made, Mexico’s democratisation process. An original and timely resource for scholars and students interested in understanding how – in cases like Mexico where transitions to democracy are characterised by a finely poised balance of power – small influences from abroad can make significant long-lasting differences domestically.
Download or read book Beyond Development written by Miriam Lang and published by . This book was released on 2013 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The North American Mosaic written by Commission for Environmental Cooperation (Montréal, Québec). Secretariat and published by . This book was released on 2001 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The North American Mosaic has four overarching features. First, it is, to the extent feasible, based on comparable information on the status and trends of major indicators of the state of the environment in Canada,Mexico, and the United States. Second, the report confirms that these three countries together make up an incredibly complex, dynamic, and interconnected ecosystem in which humans play a dominant and decisive role. Third, the report raises important and sometimes disquieting questions concerning the sustainability of some current trends. Finally, the report is a reminder that our economic, social, and physical well-being are utterly dependent on the life-sustaining services provided by nature. This report emphasizes the importance of developing mutually compatible economic, social, and environmental goals and policies across the three-country region.
Download or read book Handbook of Regional and Urban Economics written by V. Henderson and published by Elsevier. This book was released on 2004-07-21 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new Handbook of Regional and Urban Economics: Cities and Geography reviews, synthesizes and extends the key developments in urban and regional economics and their strong connection to other recent developments in modern economics. Of particular interest is the development of the new economic geography and its incorporation along with innovations in industrial organization, endogenous growth, network theory and applied econometrics into urban and regional economics. The chapters cover theoretical developments concerning the forces of agglomeration, the nature of neighborhoods and human capital externalities, the foundations of systems of cities, the development of local political institutions, regional agglomerations and regional growth. Such massive progress in understanding the theory behind urban and regional phenomenon is consistent with on-going progress in the field since the late 1960’s. What is unprecedented are the developments on the empirical side: the development of a wide body of knowledge concerning the nature of urban externalities, city size distributions, urban sprawl, urban and regional trade, and regional convergence, as well as a body of knowledge on specific regions of the world—Europe, Asia and North America, both current and historical. The Handbook is a key reference piece for anyone wishing to understand the developments in the field.
Download or read book The Macroeconomics of Populism in Latin America written by Rudiger Dornbusch and published by University of Chicago Press. This book was released on 2007-12-01 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Again and again, Latin America has seen the populist scenario played to an unfortunate end. Upon gaining power, populist governments attempt to revive the economy through massive spending. After an initial recovery, inflation reemerges and the government responds with wage an price controls. Shortages, overvaluation, burgeoning deficits, and capital flight soon precipitate economic crisis, with a subsequent collapse of the populist regime. The lessons of this experience are especially valuable for countries in Eastern Europe, as they face major political and economic decisions. Economists and political scientists from the United States and Latin America detail in this volume how and why such programs go wrong and what leads policymakers to repeatedly adopt these policies despite a history of failure. Authors examine this pattern in Argentina, Brazil, Chile, Mexico, Nicaragua, and Peru—and show how Colombia managed to avoid it. Despite differences in how each country implemented its policies, the macroeconomic consequences were remarkably similar. Scholars of Latin America will find this work a valuable resource, offering a distinctive macroeconomic perspective on the continuing controversy over the dynamics of populism.
Download or read book The Oxford Handbook of Latin American Economics written by José Antonio Ocampo and published by Oxford University Press, USA. This book was released on 2011-07-28 with total page 959 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the key factors affecting the development of Latin American economies that examines long-term growth performance, macroeconomic issues, Latin American economies in the global context, technological and agricultural policies, and the evolution of labour markets, the education sector, and social security programmes.
Download or read book The Second Chinese Revolution written by E. Bregolat and published by Springer. This book was released on 2016-04-30 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Chinese Revolution explores some of the keys to understanding China, a country whose evolution already affects all of us. Beginning in 1978 - when China's GDP was only 6% of the USA's - the author takes us through the different aspects that have played a fundamental role in the country's change: China's eruption in world markets in the background of the West's economic crisis; its obsession with science and technology and its relentless march towards a 'knowledge society'; and a reassessment of the Tiananmen Square events of June 1989 and the ongoing debate on political reform. The book also includes a comparative analysis of the reforms in China and Russia in the last decades.
Download or read book Conditional Cash Transfer Programmes written by Simone Cecchini and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes experience with conditional cash transfer or "co-responsibility" (CCT) programmes in Latin America and the Caribbean, over a period lasting more than 15 years.
Download or read book Rural Women in Latin America written by Isis International and published by . This book was released on 1987 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Measuring Levels of Living in Latin America written by Oscar Altimir and published by . This book was released on 1986 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Extent of Poverty in Latin America written by Oscar Altimir and published by . This book was released on 1982 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work originated in a research project for the measurement and analysis of income distribution in the Latin American countries, undertaken jointly by the Economic Commission for Latin America and the World Bank. The present paper presents estimates of the extent of absolute poverty for ten Latin American countries and for the region as a whole in the 1970s, on the basis of available household surveys and population censuses. They are based on country-specific poverty lines representing minimum acceptable levels of private consumption, drawn according to a food-based method. Such poverty lines - ranging from 150 to 250 dollars of annual household consumption per capita - express a normative definition of the absolute dimensions of poverty, partly based on expert appraisals and partly reflecting the actual behavior of low income households facing the life style projected by Latin American development. According to these estimates, 40 percent of Latin American households were poor at the beginning of the 1970s, the incidence of poverty being 26 percent in urban areas and 60 percent in rural areas. Urban poverty extended to more than one-third of urban households in some countries (Brazil, Colombia, Honduras) while affecting between 20 and 30 percent in others (Peru, Mexico, Venezuela), about 15 percent in Costa Rica and Chile and less than 10 percent in Argentina and Uruguay. The extent of poverty in rural areas would not be less than 20 percent in any case and would reach more than 60 percent in some countries. The corresponding poverty gaps were also estimated; in terms of total household income, they may represent manageable proportions (around 2-3 percent) in the better-off countries, but are in the 4-8 percent range in the bigger countries of the region and reach as much as 12 percent in Peru and 17 percent in Honduras.
Download or read book Informe Sobre Desarrollo Humano 2012 written by United Nations and published by UN. This book was released on 2012-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investigaci n en sistemas de salud written by Instituto Nacional de Salud Pública (Mexico) and published by . This book was released on 2011 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Redistributive Effects of Government Programmes written by Alejandro Foxley and published by Elsevier. This book was released on 2013-10-22 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Redistributive Effects of Government Programmes: The Chilean Case examines the government redistributive policy in Chile over the period 1964 until 1973. The book looks into the incidence of taxation, government expenditure, and social security operations on different income groups. The text also notes the critical factors which limited vertical redistribution effects of fiscal policy. The role of asset redistribution in poverty-focused development strategies is also explained. This monograph will be useful to those interested in Chile and concerned with economic development in general.
Download or read book South South Cooperation in Education and Development written by Linda Chisholm and published by . This book was released on 2009 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Multinationals written by Christopher Tugendhat and published by . This book was released on 1984 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt:
