Download or read book Tuberculosis written by Thomas M. Shinnick and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis has plagued mankind since prehistoric times and is still an important source of morbidity and mortality, with particularly devastating effects in developing and tropical countries. Tuberculosis results from an infection with Myeo baeterium tubereu/osis, and the World Health Organization estimates that perhaps as much as one-third of the world's population or approximately 1. 9 billion persons are or have been infected with M. tubereu/osis. Each year, there are 8-10 million new cases of tuberculosis and about 3 million deaths due to it. Indeed, tuberculosis is the leading cause of death in adults due to a single infectious agent and accounts for ap proximately 26% of all preventable adult deaths in the world. In addition, tuberculosis is an enormous social and economic problem because approximately 95% of new cases occur in developing countries and because about 80% of tuberculosis cases affect persons of child-bearing age and du ring their most economically productive years (ages 15-59). Tuberculosis has also re-emerged as an important public health problem in many developed countries. For example, between 1985 and 1992, the number of tuberculosis cases reported to the United States Centers for Disease Control and Prevention increased by more than 20%. Similarly, Austria experienced a 5% increase in tuberculosis cases from 1987 to 1991, Ireland a 9% increase from 1988 to 1991, Denmark a 20% increase from 1987 to 1992, and Italy a 27% increase from 1988 to 1992.

Download or read book Mycobacterium tuberculosis written by Mauro Bendinelli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis once again occupies a special position in the areas of infec tious diseases and microbiology. This disease has been important to mankind since even before biblical times. Tuberculosis has been a major cause of morbidity and mortality in humans, especially in highly ur banized Europe, until a few decades ago. Indeed, this disease became a center of many novels, plays, and operas, since it appeared to be quite popular to have the heroine dying of "consumption. " Most importantly, tuberculosis also became the focus of attention for many investigations during the 19th and even the 20th centuries. Major advances were made in the areas of isolation and identification of M. tuberculosis and related microorganisms. The discovery, by Robert Koch, that tuberculosis was caused by an infectious agent revolutionized our thinking about dis eases. Koch's postulates were developed with tuberculosis in mind and became a focal point for many advances in microbiology and medicine. Studies with mycobacteria as a central focus have also led to revolu tionary new concepts about immunology in general. Koch himself showed that those exposed to M. tuberculosis develop a skin hypersen sitivity or allergy to the microorganism's antigens, an observation which was the starting point for many important developments. Indeed, imme diate-type hypersensitivity and atopic or IgE-mediated allergy were de fined in relation to the delayed-type cutaneous hypersensitivity evi denced with the tubercle bacillus.

Download or read book Mycobacterium Tuberculosis Molecular Infection Biology Pathogenesis Diagnostics and New Interventions written by Seyed Ehtesham Hasnain and published by Springer Nature. This book was released on 2019-11-30 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.

Download or read book Understanding Tuberculosis written by Pere-Joan Cardona and published by BoD – Books on Demand. This book was released on 2012-02-24 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis in an attempt to understand the extent to which the bacilli has adapted itself to the host and to its final target. On the other hand, there is a section in which other specialists discuss how to manipulate this immune response to obtain innovative prophylactic and therapeutic approaches to truncate the intimal co-evolution between Mycobacterium tuberculosis and the Homo sapiens.

Download or read book Focus on Tuberculosis Research written by Lucy T. Smithe and published by Nova Publishers. This book was released on 2005 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis, the disease that the World Health Organisation has recently declared a global emergency, was supposedly defeated by antibiotics half a century ago. It has returned in a highly contagious and fatal new form that cannot be treated with conventional drugs. Multidrug-resistant TB (MDR-TB), could cause some 10 million deaths over the next decade and is thriving in the overcrowded prisons of the former Soviet Union. The virtual collapse of the world's borders means that refugees, tourists, immigrants, business travellers, and others can spread the TB bacillus very efficiently. London, for example, has experienced a 100% increase in reported cases in the past 10 years. This new book covers all aspects of the disease: epidemiology, microbiology, diagnosis, treatment, control and prevention. Leading research is presented from centres around the world.

Download or read book Tuberculosis and the Tubercle Bacillus written by William R. Jacobs, Jr. and published by John Wiley & Sons. This book was released on 2017-09-01 with total page 1442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.

Download or read book Tuberculosis written by Wellman Ribón and published by BoD – Books on Demand. This book was released on 2015-07-08 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress obtained by mycobacteriology in recent years is undeniable with regards to preventing, detecting, and treating cases of tuberculosis, millennial disease that is still present as public health issue worldwide. We present here high-impact research and interest topics related to the application of new methodologies, especially molecular methods for rapid diagnostic such as rapid DST, application of high performance liquid chromatography, molecular epidemiology and molecular diagnostic testing on post mortem. Currently, the constant search for vaccines that prevent the disease is promising through research of the immune response generated by the host towards the bacterium, and the effectiveness that may be achieved from developed vaccines. Another high-impact factor is the one generated by considering tuberculosis as a social disease with an infectious component reflected in research about tuberculosis and human rights. Finally, we present important issues of the pathogen interaction with different hosts. The constant knowledge generation that expands the frontiers of understanding is a key factor for finding solutions and successful activities for public health.

Download or read book Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism written by Jean Pieters and published by Springer Science & Business Media. This book was released on 2013-12-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Download or read book Tuberculosis Host Pathogen Interactions written by Jeffrey D. Cirillo and published by Springer Nature. This book was released on 2019-09-10 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide.

Download or read book Tuberculose written by Encyclopaedia Universalis, and published by Encyclopaedia Universalis. This book was released on 2016-09-19 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le terme tuberculose englobe toutes les manifestations pathologiques susceptibles d'être provoquées dans l'organisme par un agent pathogène bactérien spécifique, le bacille de Koch (Mycobacterium tuberculosis). De toutes les localisations de cette affection, la tuberculose pulmonaire (cf...

Download or read book Mycobacterium tuberculosis et mycobact ries atypiques written by François Denis and published by Elsevier Masson. This book was released on 2004 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: La tuberculose connaît une certaine recrudescence. Elle demeure au niveau planétaire la première cause de mortalité due à un agent infectieux unique et les mycobactéries atypiques sont responsables d'infections préoccupantes. Malgré l'importance du problème posé par ces infections qui sont loin d'être éradiquées, très peu d'études en langue française sont publiées sur ce sujet. Alors que les connaissances sur les mycobactéries ont considérablement évolué ces dernières années, un ouvrage actualisé pour le XXIe siècle était indispensable. Celui-ci met un accent tout particulier sur le diagnostic bactériologique de ces infections à l'ère génomique puisque l'on dispose depuis peu du séquençage de différentes mycobactéries. Les nouveaux outils s'appliquent au diagnostic de M. tuberculosis et des mycobactéries atypiques, à l'étude des résistances aux antibiotiques et à l'épidémiologie moléculaire afin de pouvoir comparer et suivre la propagation des souches. Enfin, le problème du diagnostic, du contrôle et de la prévention des infections chez les enfants et les adultes est abordé sous différents aspects (au laboratoire, approches vaccinales, etc.) Cet ouvrage, qui fait appel aux meilleurs spécialistes du sujet, est lisible à plusieurs niveaux, tant par le généraliste que par le spécialiste, et, d'une manière générale, par toutes les personnes concernées par les mycobactérioses, maladies encore sous-estimées sur lesquelles les progrès récents apportent un nouvel éclairage.

Download or read book L infection bacillaire et la tuberculose chez l homme et chez les animaux written by Albert Calmette and published by . This book was released on 1922 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book L infection bacillaire et la tuberculose written by Albert Calmette and published by . This book was released on 1920 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberkelbakterien.

Download or read book Tuberculosis Bacteriology 2Ed written by C Collins and published by CRC Press. This book was released on 1997-06-12 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes current practice and future developments in the laboratory diagnosis of tuberculosis and other mycobacterial diseases.

Download or read book L infection bacillaire et la tuberculose chez l homme et chez les animaux written by Albert Calmette and published by . This book was released on 1928 with total page 1030 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book L Infection Bacillaire Et La Tuberculose written by Albert Calmette and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Albert Calmette, célèbre pour sa découverte du vaccin contre la tuberculose, examine dans ce livre les processus d'infection et de défense contre la tuberculose chez les humains et les animaux. Il utilise une approche expérimentale pour explorer les caractéristiques des bactéries et les moyens par lesquels le système immunitaire peut combattre l'infection. Ce livre est une lecture essentielle pour quiconque travaille dans les sciences de la santé. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Download or read book En garde tuberculose written by Louise Côté and published by Presses de l'Université Laval. This book was released on 2017-02-03T00:00:00-05:00 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toute action ou réaction face à une maladie est guidée par l'idée que nous nous en faisons, par notre façon de l'interpréter, de la penser. Cet ouvrage montre les liens entre, d'une part, les représentations sociales et médicales d'une maladie et, d'autre part, la nature des traitements proposés et les représentations de l'expérience du malade dans un contexte institutionnel de prise en charge. L'étude se concentre sur la tuberculose parce que, tout en étant moins spectaculaire que les épidémies de typhus ou de choléra, elle a néanmoins suscité une grande inquiétude dans la première moitié du XXe siècle, et ce partout en Occident. Comme le sida aujourd'hui, la tuberculose fut longtemps perçue comme un mal sournois et mortel, qui prospérait sous des conditions et dans un environnement particulier. Au Québec comme ailleurs, cette perception eut un impact certain sur les tuberculeux et sur leur expérience de la maladie.