Download or read book Kratom and Other Mitragynines written by Robert B. Raffa and published by CRC Press. This book was released on 2014-10-29 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature’s only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds—those derived from the plant Mitragyna speciosa. This plant, known as Kratom in Thailand or Biak-Biak in Malaysia, has long been used locally as treatment for pain, fever reduction, diarrhea, and even depression. Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source presents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s "other opioid."

Download or read book Kratom and Other Mitragynines written by Robert B. Raffa and published by CRC Press. This book was released on 2014-10-29 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature's only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds-those derived from the plant Mitragyna speciosa. This plan

Download or read book Prescriptyion Opioid Analgesic Use Among Adults United States 1999 2012 written by Steven M. Frenk and published by . This book was released on 2015 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Plant Medicines Healing and Psychedelic Science written by Beatriz Caiuby Labate and published by Springer. This book was released on 2018-04-28 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about the intersections of three dimensions. The first is the way social scientists and historians treat the history of psychiatry and healing, especially as it intersects with psychedelics. The second encompasses a reflection on the substances themselves and their effects on bodies. The third addresses traditional healing, as it circles back to our understanding of drugs and psychiatry. The chapters explore how these dimensions are distinct, but deeply intertwined, themes that offer important insights into contemporary healing practices. The intended audience of the volume is large and diverse: neuroscientists, biologists, medical doctors, psychiatrists, psychologists; mental health professionals interested in the therapeutic application of psychedelic substances, or who work with substance abuse, depression, anxiety, and PTSD; patients and practitioners of complementary and alternative medicine; ethnobotanists and ethnopharmacologists; lawyers, criminologists, and other specialists in international law working on matters related to drug policy and human rights, as well as scholars of religious studies, anthropologists, sociologists, and historians; social scientists concerned both with the history of science, medicine, and technology, and concepts of health, illness, and healing. It has a potentially large international audience, especially considering the increasing interest in “psychedelic science” and the growing spread of the use of traditional psychoactives in the West.

Download or read book Novel Psychoactive Substances written by Paul I. Dargan and published by Academic Press. This book was released on 2013-08-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals. Includes chapters written by international experts in the field. Provides a comprehensive look at the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance. Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies. Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene including mephedrone and the synthetic cannabinoid receptors in ‘spice’ / ‘K2’.

Download or read book Drunk Flies and Stoned Dolphins written by One R. Pagan and published by BenBella Books. This book was released on 2021-11-16 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the cup of coffee that jumpstarts the day to dangerously addictive drugs, the recreational use of plants with psychoactive properties has a long history among humans. But, as with many things, it turns out that other animals got there first. From parrots to primates, consuming medicinal chemicals is an instinctive behavior that helps countless organisms fight infection and treat disease. But the similarities don't end there: Like us, many creatures also consume substances that have no apparent benefit . . . except for inducing intoxication. In fact, animals have been using drugs for recreational purposes since prehistoric times. We may even have animals to thank for the idea—legend says that coffee was discovered by observing the behavior of goats that had eaten it. In his previous book, Strange Survivors, author and biologist Oné R. Pagán introduced readers to some of the truly bizarre strategies animals use to survive in the cutthroat world of natural selection. Now, in Drunk Flies and Stoned Dolphins, he sheds light on the surprising cravings they indulge when it's time to unwind. In this book, you'll get an eye-opening glimpse into the mind-altering behavior of the non-human members of the animal kingdom, spanning insects to elephants—including the dolphin species that apparently likes to pass around an intoxicating pufferfish as if they were sharing a joint. Combining fascinating science with humor and enthusiasm, Pagán's latest is full of the kind of unforgettable stories and odd facts that you'll find yourself repeating to everyone you meet. From fruit fly happy hour to the evolutionary reasons behind nature's drugs, Drunk Flies and Stoned Dolphins takes you on a trip through the colorful world of animal intoxication—and along the way, explores what this science reveals about the surprising connections between all the world's creatures.

Download or read book Encyclopedia of Pain written by G.F. Gebhart and published by Springer. This book was released on 2013-11-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Pain includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. A thousand color figures enhance understanding of this too-little-understood topic. The book is available in print, in online only form, or in a print-online bundle.

Download or read book Novel Psychoactive Substances written by Ornella Corazza and published by Springer. This book was released on 2017-08-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: In light of the recent emergence of Novel Psychoactive Substances (NPS) on a global scale, this book provides a timely analysis of the social and economic impact of the NPS phenomenon, and of the global policy and regulatory responses to it. It presents the first comprehensive overview of the international regulation, policy and market structure of the NPS phenomenon, offering a guide to inform legislative discussions and demonstrating from a comparative perspective the different approaches used to address the rise of NPS to date. It covers topics such as organized crime, drug markets, clinical evidence on NPS, and different regulatory approaches also in less explored settings such as prisons and sport environments. Overall, this highly informative and well-structured repository of different experiences with NPS policy, law and regulation offers an essential primary source of evidence for anyone interested in the area of drug and NPS policy, health economics and p ublic health.

Download or read book Strange Survivors written by One R. Pagan and published by National Geographic Books. This book was released on 2018-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life is beautiful, ruthless, and very, very strange. In the evolutionary arms race that has raged on since life began, organisms have developed an endless variety of survival strategies. From sharp claws to brute strength, camouflage to venom—all these tools and abilities share one purpose: to keep their bearer alive long enough to reproduce, helping the species avoid extinction. Every living thing on this planet has developed a time-tested arsenal of weapons and defenses. Some of these weapons and defenses, however, are decidedly more unusual than others. In Strange Survivors, biologist Oné R. Pagán takes us on a tour of the improbable, the ingenious, and the just plain bizarre ways that creatures fight for life. Inside this funny, fascinating field guide to nature’s most colorful characters, you’ll meet killer snails, social bacteria, and an animal with toxic elbows. But Strange Survivors is more than a collection of curiosities—it is a love letter to science and an argument for the continuing relevance of this evolutionary battle as we face the threat of resistant bacteria and the need for novel medical therapies. Whether discussing blood-thinning bats and electric fish or pondering the power of cooperation, Pagán reveals the surprising lessons found in some of life’s natural oddities and how the tactics they employ to live might aid our own survival.

Download or read book The Alkaloids written by R. H. Manske and published by . This book was released on 1965-08-01 with total page 861 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Opioids and Their Receptors written by Mariana Spetea and published by MDPI. This book was released on 2020-12-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Download or read book Toxicology Cases for the Clinical and Forensic Laboratory written by Hema Ketha and published by Academic Press. This book was released on 2020-06-20 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both. Brings together expert cases encompassing analytical toxicology, clinical medicine and basic science in a consolidated format Presents unique and challenging cases in clinical laboratories contributed by experts in the field Consolidated format that make concepts in toxicology easy to learn and teach Key learning points highlighted with multiple choice questions

Download or read book Handbook of Novel Psychoactive Substances written by Ornella Corazza and published by Routledge. This book was released on 2018-10-10 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Novel Psychoactive Substances (NPS) provides a comprehensive overview of the challenges that clinicians face when dealing with NPS and discusses how the profile of patients and their socio-demographic characteristics frame the serious public health concern that NPS pose. It presents various clinical cases, as well as detailed accounts of symptoms, psychopathology, toxicity, and overall clinical management that NPS require. This handbook brings together a unique collection of chapters written by leading experts in the field, who have felt the need to share their knowledge and experience to improve the clinical practice on NPS and the wellbeing of their patients.

Download or read book Herbal Biomolecules in Healthcare Applications written by Subhash C. Mandal and published by Academic Press. This book was released on 2021-10-05 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful. Provides a study of different type of biomolecules from herbal extracts and their bioactivities as well as their application in the healthcare industry Contributions by global leaders and experts from academia, industry and regulatory agencies, who have been considered as pioneers in the application of herbal biomolecules in the diverse healthcare fields Includes updated literature review along with practical examples and research case studies

Download or read book Neurobiology of Addiction written by George F. Koob and published by Elsevier. This book was released on 2005-11-11 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Download or read book Pharmaceutical Botany written by Heber Wilkinson Youngken and published by . This book was released on 1914 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Naturally Occurring Benzodiazepines written by Ivan Izquierdo and published by CRC Press. This book was released on 1993-01-01 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of benzodiazepines (BZDs), including the widely-used drug Valium, which have been in wide circulation in clinical practice since the 1960s as sedatives, antidepressants, hypnotics and anticonvulsants. It reveals research results with naturally-occurring BZDs in plants and animals.