Download or read book Key Developments in the Telomerase Revolution written by Applied Research Applied Research Press and published by . This book was released on 2015-11-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews key developments in the medical applications of telomerase biochemistry and includes 22 open access research papers by various authors. Topics include: Insights into the evolution of mammalian telomerase: Platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes; Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation; A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome; siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells; Effect of a qigong intervention program on telomerase activity and psychological stress in abused Chinese women: a randomized, wait-list controlled trial; Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: possible extra-telomerase role of BIBR 1532; Telomerase immunity from bench to bedside: round one; Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility; Epstein-Barr virus and telomerase: from cell immortalization to therapy; Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential; Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer; PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway; miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3zeta; Targeting DNA-PKcs and telomerase in brain tumour cells; Inhibition of telomerase activity by HDV ribozyme in cancers; Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma; Telomere length and telomerase activity in non-small cell lung cancer prognosis: clinical usefulness of a specific telomere status; Telomerase and breast cancer; Complex roles for telomeres and telomerase in breast carcinogenesis; Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk ofcardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study; Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs); The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation.

Download or read book The Telomerase Revolution written by Michael Fossel and published by National Geographic Books. This book was released on 2017-07-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body's trillions of cells. But some of our cells don't age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

Download or read book The Telomerase Revolution written by Michael Fossel and published by . This book was released on 2017-07 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Telomerase Revolution written by Michael Fossel and published by . This book was released on 2016-03-09 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Named one of Wall Street Journal's Best Books for Science Lovers Science is on the cusp of a revolutionary breakthrough. We understand more about aging - and how to prevent it - than ever before. Now life - extension has moved from science fiction to real possibility. Dr. Michael Fossel has been at the forefront of aging research for decades. In The Telomerase Revolution, he takes us on a scientific journey, with startling insights into the nature of human aging. Scientists now know that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres - the tips of the chromosomes - shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. Human aging is the result of the aging of the body's trillions of cells. However the enzyme telomerase re - lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase is starting to be used as a powerful therapeutic tool, with the potential to dramatically extend life spans. It offers promise for treating Alzheimer's and many other diseases of aging. 'A fascinating story that pulls together at last a single coherent theory of how and why growing old leads to so many different forms of illness. It also offers a tantalizing promise that we might soon know not only how to cure and prevent age - related diseases, but how to reset the aging process itself. Michael Fossel is a radical optimist.' - Matt Ridley, author of Genome and The Rational Optimist.

Download or read book The Telomere Effect written by Dr. Elizabeth Blackburn and published by Grand Central Publishing. This book was released on 2017-01-03 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

Download or read book The Telomerase Revolution Dyslexic Edition written by Michael Fossel and published by . This book was released on 2016 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Telomerase Revolution written by Michael Fossel and published by BenBella Books, Inc.. This book was released on 2015-10-06 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body's trillions of cells. But some of our cells don't age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.

Download or read book The Official Anti Aging Revolution Volume 1 of 5 EasyRead Super Large 24pt Edition written by and published by ReadHowYouWant.com. This book was released on with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Official Anti Aging Revolution Volume 1 of 3 EasyRead Large Bold Edition written by and published by ReadHowYouWant.com. This book was released on with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Official Anti Aging Revolution Volume 1 of 2 EasyRead Edition written by and published by ReadHowYouWant.com. This book was released on with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Official Anti Aging Revolution Volume 1 of 4 EasyRead Super Large 20pt Edition written by and published by ReadHowYouWant.com. This book was released on with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Today s Curiosity is Tomorrow s Cure written by Steve Caplan and published by CRC Press. This book was released on 2021-11-09 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic curiosity-driven biomedical science has delivered many of today’s most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today’s classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Download or read book Reversing Human Aging written by Michael Fossel and published by Quill. This book was released on 1997-06-30 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking book about the medical advances that will definitively prevent aging. In a startling glimpse of our possible future, we see how we may live for two to three hundred years longer, how age-related diseases will be eradicated, and how the aging press will be prevented if not reversed. Illus.

Download or read book Telomere Timebombs written by Ed Park and published by . This book was released on 2013-08 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomere Timebombs: Defusing the Terror of Aging showcases a revolutionary new way to think about aging and health. Dr. Ed Park's entertaining and insightful new book introduces readers to Telomeres - repetitive DNA sequences that play a vital role in aging. Telomeres, if kept intact, can afford a lifetime of better sleep, healthier skin, better mood, better exercise recovery time, and even an improved sex life. Life-changing Information For millions, the fear of growing old is in itself enough to force out grey hairs and wrinkles. However, this compelling book presents a wholly-refreshing way to embrace aging and total health. While life-changing, Dr. Park's wisdom is far from complicated. In fact, using entertaining analogies ranging from queen bees to automobile repair, the book is poised to resonate with young and old around the world. Synopsis This fresh, fascinating and often funny book teaches you why we get old and sick and describes the journeys back to health and youth experienced after taking Telomerase Activation Medicine. It outlines a future in which Telomerase Activation Medicine has changed all your expectations about getting old. Dr. Park explains how it works: "Telomeres, or 'end bodies' are the caps that protect our chromosomes like the plastic tips on shoelaces. Each time a cell divides into two daughters, the daughters are left with shorter telomeres. These telomeres caps shorten like burning fuses on the end of a firecracker. When those 'fuses' become too short, the chromosomes are damaged and the cell either stops functioning properly or dies," he says. Continuing, "There is a cure for this erosion called the Telomerase Enzyme, and it is built into every single stem cell in your body. Stem cells are like queen bees that need produce many thousands of worker drones, so a stem cell always needs to add back telomere length to prevent premature damage and death." By keeping the Telomere length as long as possible, the individual can enjoy prolonged vitality, youthfulness and overall health. This is achieved through an ingestible supplement called TA-65, a molecule discovered by scientists to be a Telomerase activator. As one of the first twenty people in the world to trial it and, after noticing astonishing results, Dr. Park became the first medical doctor licensed to prescribe TA-65. Since then, hundreds of physicians and tens of thousands of patients have jumped on board with amazing results and no adverse effects. A Grand Unified Theory of Aging and Disease Dr. Park has developed a simple and intuitive new model of aging based on Telomere erosion and Stem Cell biology that will shift and unify much of the research and efforts currently in vogue. With his renowned knack for presenting his concepts in an engaging and easy-to-understand way, Dr. Park likens it to the on-going upkeep of an automobile. "Why not think of it as car maintenance? You are just changing your oil and replacing old parts. There is a man in New York who has maintained his Volvo for 3 million miles. Is the Volvo Corporation going to strike him down with a lightning bolt? No They love him ," he adds. Those wanting to find out how to embark on their own personal journey back to youthful health by using Telomere Activation Medicine are urged to purchase this book.

Download or read book Full Catastrophe Living Revised Edition written by Jon Kabat-Zinn and published by Bantam. This book was released on 2013-09-24 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: The landmark work on mindfulness, meditation, and healing, now revised and updated after twenty-five years Stress. It can sap our energy, undermine our health if we let it, even shorten our lives. It makes us more vulnerable to anxiety and depression, disconnection and disease. Based on Jon Kabat-Zinn’s renowned mindfulness-based stress reduction program, this classic, groundbreaking work—which gave rise to a whole new field in medicine and psychology—shows you how to use medically proven mind-body approaches derived from meditation and yoga to counteract stress, establish greater balance of body and mind, and stimulate well-being and healing. By engaging in these mindfulness practices and integrating them into your life from moment to moment and from day to day, you can learn to manage chronic pain, promote optimal healing, reduce anxiety and feelings of panic, and improve the overall quality of your life, relationships, and social networks. This second edition features results from recent studies on the science of mindfulness, a new Introduction, up-to-date statistics, and an extensive updated reading list. Full Catastrophe Living is a book for the young and the old, the well and the ill, and anyone trying to live a healthier and saner life in our fast-paced world. Praise for Full Catastrophe Living “To say that this wise, deep book is helpful to those who face the challenges of human crisis would be a vast understatement. It is essential, unique, and, above all, fundamentally healing.”—Donald M. Berwick, M.D., president emeritus and senior fellow, Institute for Healthcare Improvement “One of the great classics of mind/body medicine.”—Rachel Naomi Remen, M.D., author of Kitchen Table Wisdom “A book for everyone . . . Jon Kabat-Zinn has done more than any other person on the planet to spread the power of mindfulness to the lives of ordinary people and major societal institutions.”—Richard J. Davidson, founder and chair, Center for Investigating Healthy Minds, University of Wisconsin–Madison “This is the ultimate owner’s manual for our lives. What a gift!”—Amy Gross, former editor in chief, O: The Oprah Magazine “I first read Full Catastrophe Living in my early twenties and it changed my life.”—Chade-Meng Tan, Jolly Good Fellow of Google and author of Search Inside Yourself “Jon Kabat-Zinn’s classic work on the practice of mindfulness to alleviate stress and human suffering stands the test of time, a most useful resource and practical guide. I recommend this new edition enthusiastically to doctors, patients, and anyone interested in learning to use the power of focused awareness to meet life’s challenges, whether great or small.”—Andrew Weil, M.D., author of Spontaneous Happiness and 8 Weeks to Optimum Health “How wonderful to have a new and updated version of this classic book that invited so many of us down a path that transformed our minds and awakened us to the beauty of each moment, day-by-day, through our lives. This second edition, building on the first, is sure to become a treasured sourcebook and traveling companion for new generations who seek the wisdom to live full and fulfilling lives.”—Diana Chapman Walsh, Ph.D., president emerita of Wellesley College

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2000 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 1999 with total page 1780 pages. Available in PDF, EPUB and Kindle. Book excerpt: