Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Download or read book HIV AIDS Associated Viral Oncogenesis written by Craig Meyers and published by Springer. This book was released on 2018-12-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.

Download or read book Inpatient Dermatology written by Misha Rosenbach and published by Springer. This book was released on 2018-11-03 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​ Inpatient Dermatology is a concise and portable resource that synthesizes the most essential material to help physicians with recognition, differential diagnosis, work-up, and treatment of dermatologic issues in the hospitalized patient. Complete with hundreds of clinical and pathologic images, this volume is both an inpatient dermatology atlas and a practical guide to day-one, initial work-up, and management plan for common and rare skin diseases that occur in the inpatient setting. Each chapter is a bulleted, easy-to-read reference that focuses on one specific inpatient dermatologic condition, with carefully curated clinical photographs and corresponding histopathologic images to aid readers in developing clinical-pathologic correlation for the dermatologic diseases encountered in the hospital. Before each subsection the editors share diagnostic pearls, explaining their approach to these challenging conditions. This book is structured to be useful to physicians, residents, and medical students. It spans dermatology, emergency medicine, internal medicine, infectious disease, and rheumatology. Inpatient Dermatology is the go-to guide for hospital-based skin diseases, making even the most complex inpatient dermatologic issues approachable and understandable for any clinician.

Download or read book Kaposi Sarcoma Herpesvirus New Perspectives written by Chris Boshoff and published by Springer. This book was released on 2006-10-13 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: will follow

Download or read book Human Retrovirus Protocols written by Tuofu Zhu and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge collection of basic and state-of-the-art methods optimized for investigating the molecular biology of this class of retrovirus. These readily reproducible techniques range from methods for the isolation and detection of human retroviruses to cutting-edge methods for exploring the interplay between the viruses and the host. Here, the researcher will find up-to-date techniques for the isolation and propagation of HIV, HTLV, and foamy virus from a variety of sources. There are also assays for determining the cell tropism of HIV-1, the coreceptor usage of HIV-1, and human gene expression with HIV-1 infection by microarrays, as well as for phenotyping HIV-1 infected monocytes and examining their fitness. Highlights include the detection and quantification of HIV-1 in resting CD4+, a new cloning system for making recombinent virus, cDNA microarrays, and the determination of genetic polymorphisms in two recently identified HIV-1 co-factors that are critical for HIV-1 infection.

Download or read book Human Oncogenic Viruses written by Jing-hsiung James Ou and published by World Scientific. This book was released on 2010 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, EpsteinOCoBarr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers. Sample Chapter(s). Foreword (38 KB). Chapter 1: Oncogenic Viruses, Cellular Transformation and Human Cancers (211 KB). Contents: Oncogenic Viruses, Cellular Transformation and Human Cancers (Y-Y Zheng & J-H J Ou); Hepatitis B Virus and Hepatocellular Carcinogenesis (T S B Yen); Molecular Mechanism of Hepatitis C Virus Carcinogenesis (K Machida et al.); Human Papillomaviruses and Associated Malignancies (C L Nguyen et al.); Epstein-Barr Virus and Its Oncogenesis (H-P Li et al.); Human Kaposi's Sarcoma-associated Herpesvirus: Molecular Biology and Oncogenesis (P J Dillon & B Damania); Human T-Cell Leukemia Virus 1 and Cellular Transformation (Y-H Chi & K-T Jeang). Readership: Graduate students and postdoctoral fellows in infectious diseases, microbiology/virology, oncology/cancer research, and cell/molecular/structural biology; medical students, physicians and non-experts who are interested in understanding the relationship between oncogenic viruses and the cancers they cause

Download or read book European Handbook of Dermatological Treatments written by Andreas D. Katsambas and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermatology is a specialty in the field of medicine which constantly changes at a vast rate. Alongside technology, new drugs, methods and treatments are continuously developed for the treatment of all common skin diseases. The first edition of the European Handbook of Dermatological Treatments received an overwhelming response from dermatovenereologists all over Europe. Its easy-to-read format, which is also used for this 2nd edition, is aimed at helping the physician to obtain comprehensive information at a glance. The three main sections listed alphabetically define the different diseases, the drugs available and the various methods of treatment used in dermatological practice. Each chapter begins with a brief section of the aetiology and pathogenesis of the skin disease, and leads into the description of the clinical characteristics, the diagnosis and the differential diagnosis. Followed by a detailed discussion on treatment methods, alternative methods are covered as well. Each section ends with a reference list for further reading. This new edition provides an excellent update including the newest developments of drugs, methods and treatments in dermatological practice, maintaining the clear structure and well-proven format. It is a very comprehensive and practical guide and should not be missed by those treating patients with skin diseases.

Download or read book Herpesvirus Latency written by Benedikt B. Kaufer and published by Frontiers Media SA. This book was released on 2020-09-14 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Virology E Book written by Stephen N J Korsman and published by Elsevier Health Sciences. This book was released on 2012-08-17 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a concise, highly accessible introduction to medical virology, incorporating essential basic principles as well as a systematic review of viruses and viral diseases. It pays particular attention to developments in anti-viral therapy that are becoming increasingly effective in modern medicine. It is an ideal textbook for the information-overloaded student and an invaluable everyday companion for the busy professional who needs a good understanding of the current state of medical virology. In keeping with the highly successful format of other Illustrated Colour Texts, it presents the subject as a series of succinct 2 page 'learning units', using a superb collection of clear illustrations and clinical photographs, concise yet comprehensive text and key point boxes to aid quick access to information and examination preparation. So whether you are a medical student, junior doctor, medical scientist, trainee in infectious diseases or student on another allied medical course, this book is here to make your life easier! It will also provide a very solid foundation for any who plan to delve deeper into this fascinating field. - Part of the popular Illustrated Colour Text series - Information presented in double page spreads for easy learning - Highly illustrated with both full colour graphics and clinical photographs - Each spread includes a key point box for exam preparation

Download or read book Absolute Dermatology Review written by Hugh Morris Gloster, Jr. and published by Springer. This book was released on 2015-05-28 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​Each dermatologist that was board certified after 1992 is required by the American Board of Dermatology to take a recertification exam every ten years. One of the major components of the exam is to be able to identify clinical photographs of approximately 200 skin diseases, and while there are other components to the test, they vary according to subspecialty. However, everyone is required to identify the images, so several months before the exam, the American Board of Dermatology releases a list of the skin diseases that will be tested, but does not provide the images or reveal which ones will appear. Review of Clinical Conditions for the Dermatology Recertification Examination provides a thorough, concise review of clinical images of the specific conditions that the reader will be required to recognize during the American Board of Dermatology recertification test. In addition, concise key clinical features for each image will be provided that will assist the reader in recognizing the clinical images on the examination, enabling them a more efficient way to study for the test without having to look up images online or in a large text book. Written by a board certified dermatologic surgeon who recently took the recertification exam, this book proves indispensable to dermatologists taking the exam or residents who want a quick reference of the clinical appearances of the main conditions generally encountered by a dermatologist.​ ​​

Download or read book Managing Skin Cancer written by Eggert Stockfleth and published by Springer Science & Business Media. This book was released on 2010-02-26 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin cancer is the most common malignant neoplasm and its incidence is rising worldwide. The epidemic increase in such tumors calls for efficient management by the application of appropriate guidelines for therapy and prevention. Clinicians managing these patients need to keep up to date with the latest advances, allowing them to provide optimal treatment. This practical guide offers the reader a comprehensive overview of the options for the diagnosis, treatment, and prevention of cutaneous cancer. It covers all common skin cancers and also rarer lesions. Employing an "evidence-based medicine" approach, this truly international work presents a well-illustrated text in a reader-friendly format with step-by-step guidelines and visual flowcharts. Dermatologists, oncologists, and all other interested physicians will find this book an extraordinarily valuable resource for the clinical management of cutaneous cancer in their daily practice.

Download or read book Peroxisome Proliferation and Its Role in Carcinogenesis written by and published by World Health Organization. This book was released on 1995 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art consensus report on what is known about peroxisome proliferation, the mechanisms involved, and their relevance to carcinogenesis. Peroxisomes are single, membrane-limited, cytoplasmic organelles that are found in cells of animals, plants, fungi, and protozoa. Peroxisome proliferators include certain hypolipidaemic drugs, phthalate ester plasticizers, industrial solvents, herbicides, food flavours, leukotriene D4 antagonists, and hormones. Numerous studies in rats and mice have demonstrated the hepatocarcinogenic effects of peroxisome proliferators, and these compounds have been unequivocally established as carcinogens. Since humans are exposed to peroxisome proliferators to a significant extent, assessment of the adverse biological effects of this group of compounds, and particularly their potential carcinogenicity, has become an important issue. The report has two parts. The first records the consensus reached by a group of eleven experts, including several of the leading investigators in this field. Questions addressed include the mechanisms by which peroxisome proliferators exert their carcinogenic effects in rodents, the relevance of animal studies to the evaluation of carcinogenic risk in humans, and the potential use of peroxisome proliferation as a biological marker for liver cancer. The report concludes that compounds inducing peroxisome proliferation in rats and mice have little, if any, effect on human liver. The report also issues advice on the interpretation of peroxisome proliferation, demonstrated in animal studies, when evaluating the carcinogenic risk to humans. The second part consists of three background papers presented by members of the working group.

Download or read book Human Herpesviruses written by Yasushi Kawaguchi and published by Springer. This book was released on 2018-06-12 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.

Download or read book Principles and Practice of Clinical Virology written by Arie J. Zuckerman and published by John Wiley & Sons. This book was released on 2004-08-13 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: The knowledge and practice of clinical virology continues to expand. This new fifth edition has thirty-six comprehensive chapters, each of which has been extensively revised or rewritten, with the addition of new colour plates. This updated version takes into account knowledge accumulated in molecular biology with its applications for laboratory diagnosis, immunisation and antiviral chemotherapy. Each chapter highlights the clinical features and epidemiological patterns of infection. Similarly, in response to the global concern of the threat posed by new viruses, a new chapter on Emerging Infections is included. There is also new material on Hospital Acquired Infections, including some advice relating to SARS, that will be of benefit to those dealing with the day-to-day management of patients in hospital.

Download or read book Pigmented Ethnic Skin and Imported Dermatoses written by Constantin E. Orfanos and published by Springer. This book was released on 2018-08-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast majority of the global population has pigmented non-Caucasian skin; accordingly, this book focuses on the diagnosis and management of skin diseases in dark-skinned populations, paying particular attention to different reactive profiles, the frequency and the clinical pictures of diseases in pigmented ethnic skin that arise in hot climate zones. Supplemented by a wealth of high-quality, full-color images, this comprehensive work covers the full range of dermatological entities and issues characteristic of the tropical and subtropical regions of the globe, including those that are now emerging in developed countries as a result of intensified travel, globalized business, and migration. Each disorder is described by respected experts on subtropical and tropical countries, and each chapter is clearly structured, examining the incidence, pathogenesis, clinical presentation, management and course. The book illustrates the clinical features and includes major schedules for the diagnosis and management of skin diseases presented in darkly pigmented to black skin. As such, it offers an invaluable tool for all dermatologists in developing and developed countries, especially those who are used to dealing with skin lesions mainly in white Caucasian skin. While enabling physicians to provide proper advice, medical services and support, Pigmented Ethnic Skin and Imported Dermatoses also represents a guide for a broader range of professionals working for governmental institutions, health and refugee agencies.

Download or read book Immunobiology of Proteins and Peptides VI written by M.Zouhair Atassi and published by Springer. This book was released on 1992-01-31 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles in this volume represent papers delivered by invited speakers at the 6th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss t heir significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptide reagents which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has in fact since occurred and many applications of these pep tides are now being realized.