Download or read book The Unfolded Protein Response written by Roberto Pérez Torrado and published by . This book was released on 2022 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Molecular and Cellular Interactions Between the Host and Herpesviruses written by and published by Frontiers Media SA. This book was released on 2021-11-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Download or read book Human Cytomegalovirus written by Thomas E. Shenk and published by Springer Science & Business Media. This book was released on 2008-05-09 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.

Download or read book Targeting Signaling Pathways in Solid Tumors Part B written by and published by Elsevier. This book was released on 2024-05-24 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targetting Signaling Pathways in Solid tumour Part B, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

Download or read book Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease written by A. Graham Pockley and published by Springer Science & Business Media. This book was released on 2009-11-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.

Download or read book The Unfolded Protein Response in Virus Infections written by and published by . This book was released on 2015 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Physical Virology written by Urs F. Greber and published by Springer. This book was released on 2019-07-17 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference. Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution. The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.

Download or read book Hematology written by Charles Lawrie and published by BoD – Books on Demand. This book was released on 2012-03-02 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematology encompasses the physiology and pathology of blood and of the blood-forming organs. In common with other areas of medicine, the pace of change in hematology has been breathtaking over recent years. There are now many treatment options available to the modern hematologist and, happily, a greatly improved outlook for the vast majority of patients with blood disorders and malignancies. Improvements in the clinic reflect, and in many respects are driven by, advances in our scientific understanding of hematological processes under both normal and disease conditions. Hematology - Science and Practice consists of a selection of essays which aim to inform both specialist and non-specialist readers about some of the latest advances in hematology, in both laboratory and clinic.

Download or read book Latency Strategies of Herpesviruses written by Janos Minarovits and published by Springer Science & Business Media. This book was released on 2006-12-13 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of the latency strategies developed during the estimated 200,000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.

Download or read book Human Viruses Diseases Treatments and Vaccines written by Shamim I. Ahmad and published by Springer Nature. This book was released on 2021-05-19 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.

Download or read book New Frontiers in Organoselenium Compounds written by Eder João Lenardão and published by Springer. This book was released on 2018-06-29 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advances in and perspectives on the use of organoselenium compounds, primarily highlighting the new frontiers in the field of Green Chemistry, their therapeutic and biological relevance and new materials. Throughout its 200 pages, readers will find an updated and comprehensive review of new aspects of organoselenium chemistry and biochemistry. Fully referenced and written in an easy to read style, it offers readers a primary resource for including organoselenium derivatives in their projects. This book will be of interest to specialists, students and researchers involved in a broad range of fields, from synthetic green chemistry to medicinal chemistry and the chemistry of natural products. The connection between organoselenium compounds and green chemistry, despite having only recently emerged, is one of the subjects of this book. The first chapter highlights the use of Se-containing molecules as reagents and catalysts in new green protocols to access important organic transformations. The book provides a wealth of examples of bioactive Se-containing molecules, especially focusing on those with potential therapeutic uses. The second chapter focuses on the state of the art concerning the role of organoselenium compounds as antioxidants, GPx mimics, and derivatives endowed with different bioactive properties. “Organoselenium in nature” is the title of the third chapter, which equips readers with essential information on the main natural organoselenium compounds and where they are found. Selected aspects of the metabolism of selenium in plants and microorganisms are also discussed. In closing, the book includes a chapter dedicated to recent advances concerning the nonbonding interactions between organochalcogen compounds. This is currently a hot topic in selenium chemistry and biochemistry, and here readers will find key insights into the chalcogen bond and its role in the biological activity of organoselenium compounds.

Download or read book Viral Genome Replication written by Craig E. Cameron and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.

Download or read book Model Organisms for Microbial Pathogenesis Biofilm Formation and Antimicrobial Drug Discovery written by Busi Siddhardha and published by Springer Nature. This book was released on 2020-03-28 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Download or read book Essentials of Cancer Genomic Computational Approaches and Precision Medicine written by Nosheen Masood and published by Springer Nature. This book was released on 2020-03-20 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Download or read book Immunotherapy A Novel Facet of Modern Therapeutics written by Sujata P. Sawarkar and published by Springer Nature. This book was released on 2020-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.