Download or read book Ischemia reperfusion Injury of Skeletal Muscle written by Gary A. Fantini and published by R. G. Landes. This book was released on 1994 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication represents an up-to-date summary of the current understanding of reoxygenation injury in skeletal muscle and outlines future directions of those who will lead the way in this field. Skeletal muscle is generally more tolerant of ischemia reperfusion injury than other organ systems such as brain, heart, kidney, liver and bowel. Current knowledge regarding the pathophysiology of such injury has attracted correspondingly less attention and has been relatively slow to accumulate. This monograph brings together acknowledged leaders who have focused their research efforts on identifying mechanisms of reoxygenation injury in skeletal muscle; the virtual plethora of pathways and cytokines involved in the mediation of cellular injury is attested to by the number and diversity of chapters.
Download or read book Skeletal Muscle Ischemia reperfusion Injury Evidence for an Oxygen Derived Free Radical Mechanism of Injury written by Thomas F. Lindsay and published by . This book was released on 1988 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reperfusion Injury in Skeletal Muscle written by Sven Oredsson and published by . This book was released on 1994 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Fiber Type on Ischemia reperfusion Injury in Mouse Skeletal Muscle written by Melanie Dee Woitaske and published by . This book was released on 1996 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ischaemia Reperfusion Injury written by Pierce A. Grace and published by Wiley-Blackwell. This book was released on 1999-02-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ischaemia-Reperfusion Injury is concerned with the consequences of interrupting and restoring blood flow to tissues. Many common clinical conditions are caused by interruption of blood flow to tissues (eg, ischaemic heart disease, peripheral vascular disease, stroke); blood flow is also interrupted deliberately in many surgical procedures (eg, cardiac surgery, arterial surgery, transplant surgery, limb surgery with tourniquet). In treating such conditions or after performing such operations the aim of the clinician is to restore the blood supply to the ischaemic tissue. Paradoxically, restoration of blood flow to ischaemic tissues can lead to further tissue damage with the potential for severe local and systemic injury. This book focuses on the clinical, pathological and biochemical processes involved in ischaemia-reperfusion injury and gives an overview of the strategies that may be adopted to mitigate or prevent such injury. This book will be of interest to both clinicians and scientists who have to deal with or have interest in this difficult but important problem.
Download or read book Ischemia Reperfusion Injury written by M. C. J. de With and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Leukocytes in Skeletal Muscle Ischemia reperfusion Injury written by Ananth Kadambi and published by . This book was released on 1998 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Skeletal Muscle Circulation written by Ronald J. Korthuis and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References
Download or read book Compartment Syndrome written by Cyril Mauffrey and published by Springer Nature. This book was released on 2019-09-02 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compartment syndrome is a complex physiologic process with significant potential harm, and though an important clinical problem, the basic science and research surrounding this entity remains poorly understood. This unique open access book fills the gap in the knowledge of compartment syndrome, re-evaluating the current state of the art on this condition. The current clinical diagnostic criteria are presented, as well as the multiple dilemmas facing the surgeon. Pathophysiology, ischemic thresholds and pressure management techniques and limitations are discussed in detail. The main surgical management strategy, fasciotomy, is then described for both the upper and lower extremities, along with wound care. Compartment syndrome due to patient positioning, in children and polytrauma patients, and unusual presentations are likewise covered. Novel diagnosis and prevention strategies, as well as common misconceptions and legal ramifications stemming from compartment syndrome, round out the presentation. Unique and timely, Compartment Syndrome: A Guide to Diagnosis and Management will be indispensable for orthopedic and trauma surgeons confronted with this common yet challenging medical condition.
Download or read book Leukocyte Rheology and Oxidant mediated Ischemia reperfusion Injury in Skeletal Muscle written by Ananth Kadambi and published by . This book was released on 1995 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anti inflammatory Treatment Prevents Local and Systemic Effects of Skeletal Muscle Ischemia reperfusion Injury written by Claudia Dührkop-Sisewitsch and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effects of Ischemia reperfusion Aging on the Inflammatory Response to Skeletal Muscle Injury in Rats written by Ahmed A. Ghaly and published by . This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of RG CSF in Skeletal Muscle Ischaemia Reperfusion Injury written by James Leong Chin Sek and published by . This book was released on 2005 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Leukocyte capillary Plugging in Skeletal Muscle Ischemia reperfusion Injury written by Anthony G. Harris and published by . This book was released on 1994 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book SDF 1 IGF 1 Conjugated to a PEGylated Fibrin Matrix as a Treatment for an Ischemia Reperfusion Injury in Skeletal Muscle Repair written by Chantal Bich Phuong Pham and published by . This book was released on 2012 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ischemia/reperfusion (I/R) injury causes extensive damage to skeletal muscle, often resulting in prolonged functional deficits. This current study determines the efficacy of controlled release of SDF-1[alpha] and IGF-1 by conjugation to biodegradable, polyethylene glycol, (PEG)ylated fibrin gel matrix in skeletal muscle repair of an I/R injury. Male Sprague-Dawley rats underwent a 2-hour tourniquet induced I/R injury on their hind limbs. Twenty-four hours post injury the following treatments were administered: PEGylated fibrin gel (PEG-Fib), SDF-1 conjugated PEGylated fibrin gel (PEG-Fib/SDF-1), or dual protein IGF-1 and SDF-1 conjugated PEGylated fibrin gel (PEG-Fibrin/SDF-1/IGF-1. Following 14 days after injury, functional and histological evaluations were performed. There was no significant difference in maximum tetanic force production recovery between PEG-Fib and PEG-Fib/SDF-1 groups. However, PEG-Fib/SDF-1/IGF-1 group resulted in significant improvement of force production relative to the other treatment groups. The same results were found for specific tension. Histological analysis revealed a greater distribution of small myofibers in the PEG-Fib/SDF-1 group than the PEG-Fib group, while the PEG-Fib/SDF-1/IGF-1 group had the smallest distribution of small fibers and similar to controls (uninjured). There were also a greater number of centrally located nuclei in the PEG-Fib/SDF-1 group than the PEG-Fib group, while the PEG-Fib/SDF-1/IGF-1 group had similar values to controls. Although these results confirm the protective role of exogenous IGF-1, SDF-1 did not have an effect on skeletal muscle repair.
Download or read book Improving Muscle Regeneration After Ischemia Reperfusion Injury With A Beta3 Adrenergic Receptor Agonist written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: INTRODUCTION: Skeletal muscle ischemia-reperfusion injury (IRI) is commonly seen in limb crush injuries, compartment syndrome, vascular injuriesand other orthopedic injuries [1]. In spite of its excellent regeneration potential, regeneration of normal functional muscle is insufficient post-IRI, resulting inreduced or total loss of limb function. In our previous work, we have observed significant activation of brown/beige fat (BAT), as evidenced by increasedexpression of uncoupling protein 1 (UCP-1) after muscle IRI. Knocking out UCP-1 resulted in reduced muscle regeneration after IRI, suggesting a beneficialrole of BAT in muscle regeneration after IRI [2]. However, the underlying mechanism of BAT activation of IRI remains unknown. The u03b23 adrenergicreceptor (ADRB3) is a major regulator for UCP-1 expression in BAT. The goal of this study is to determine the role of ADRB3 signaling in regulating BATactivation and muscle regeneration after IRI using specific ADRBs agonist and antagonist in a mouse IRI model. We hypothesize that ADRB3 agonist canimprove muscle regeneration, while ADRB3 antagonist reduces muscle regeneration after IRI.METHODS: Unilateral hindlimb IRI was performed on 15 four month-old male UCP-1 reporter mice using a rubber band as described previously [3]. Therubber band was removed three hours after it was applied to allow reperfusion to the hindlimb. 10 mg/kg Amibegron (ADRB3 agonist), 5mg/kg SR-59230A(ADRB3 antagonist) or DMSO (vehicle control) was administered to mice through daily I.P. injection staring from the same day of IRI. Mice weresacrificed at 2 weeks after IRI. Four uninjured UCP-1 reporter mice were used as the controls. The animal protocol was in compliance with our InstitutionalAnimal Care and Use Committee (IACUC). After animals were sacrificed, white (epidydimal) fat, brown (interscapular) fat, beige (inguinal) fat and tibialisanterior (TA) muscles on the injury side were harvested. Muscle samples were flash-frozen in isopentane cooled with liquid nitrogen, while fat samples werefixed, dehydrated with 30% sucrose, and frozen in OCT medium before sectioning. Sections were stained with laminin and counter-stained with DAPI.Muscle fiber cross sectional area (CSA) was determined using the BioQuant Osteo software. RNA was extracted from part of the fat tissues with Trizolreagent. Multiple group T-test was performed to determine a statistically significant difference between the vehicle and treatment groups.RESULTS: At 2 weeks post IRI, amibegron increased UCP1 expression by 45 u00b1 4% and 19u00b14% in brown and beige fat, respectively. Treatment with SR-59230A decreased UCP1 expression by 31u00b14% and 61u00b14% in brown and beige fat, respectively (Figure 1B; p
