Download or read book Ir Genes and Ia Antigens written by Hugh Mcdevitt and published by Elsevier. This book was released on 2012-12-02 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ir Genes and Ia Antigens features papers that were presented at the Third Ir Gene Workshop held in Asilomar, California, December 13-16, 1976. The book is organized into seven parts that correspond to the seven sessions held during the workshop. The first session focused on the definition of the I-E and I-C subregions, and the mapping and cellular expression of complementing Ir genes. The second session included papers on the expression of gene products of the I region. The third session covered two major areas: (1) the biochemical characterization and primary structure of la antigens; and (2) the possible carbohydrate nature of la antigenic determinant. The studies presented in the fourth session focused on the role of I-region gene products in cellular interactions. The fifth session discussed the "recognition" functions controlled by the I region of the major histocompatibility complex (MHC). The sixth session featured papers on la-containing T cell factors. Finally, the seventh session examined the properties of T-cell antigen receptors.
Download or read book Ir Genes written by Carl W. Pierce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.
Download or read book Ia Antigens written by David Ferrone and published by CRC Press. This book was released on 2018-01-18 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide the reader with a ready source of information regarding Ia antigens in several animal species.The significance role played by the gene products of I regions in cell-cell interactions has stimulated interest in the characterization of Ia antigens. Through the effort of several investigations much information about the functional and structural properties of Ia antigens has been accumulated in recent years.
Download or read book A suggested mechanism of action of immune response gene products Ia antigens in activation of T and B lymphocytes written by Ronald Palacios and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ia Antigens written by David Ferrone and published by CRC Press. This book was released on 2019-07-23 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide the reader with a ready source of information regarding Ia antigens in several animal species.The significance role played by the gene products of I regions in cell-cell interactions has stimulated interest in the characterization of Ia antigens. Through the effort of several investigations much information about the functional and structural properties of Ia antigens has been accumulated in recent years.
Download or read book Handbook of Immune Response Genes written by Tak W. Mak and published by Springer Science & Business Media. This book was released on 1998-01-31 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the latest understanding of the immune system. Although material is geared toward advanced study, basic elements and concepts are discussed, making this a useful resource for both immunologists and nonspecialists as well as advanced students. Contains chapters on genes of the major histocompatibility complex, genes of the antigen processing pathways, T- and B-lymphocyte genes, autoimmune disorders, neoplasias involving translocation of antigen receptors genes, cytokines of the immune system, and leukocyte cluster of differentiation antigens. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book The Role of Products of the Histocompatibility Gene Complex in Immune Responses written by David H. Katz and published by Academic Press. This book was released on 2014-06-28 with total page 803 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines—genetics and immunogenetics, molecular biochemistry, and immunobiology—with clinical medicine overlapping these disciplines. This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.
Download or read book A Suggested Mechanism of Action of Immune Response Gene Products Ia Antigens in Activation of T and B Lymphocytes written by Ronald Palacios and published by . This book was released on 1982 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book H 2 Antigens written by C. David and published by Springer. This book was released on 2014-11-14 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Antigens written by Michael Sela and published by Academic Press. This book was released on 2014-05-10 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.
Download or read book Ia Antigens Mice written by and published by . This book was released on 1982 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ia Antigens Man and other species written by and published by . This book was released on 1982 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Immune System written by Eli E. Sercarz and published by Elsevier. This book was released on 2013-09-11 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune System: Genes Receptors, Signals provides information pertinent to the complexity of immune mechanisms. This book describes the immune response genes and products, which point to another multigene system controlling immune responsiveness. Organized into 37 chapters, this book begins with an overview of the details of antibody structure that continue to be of importance to an understanding of the regulation of the immune reactions. This text then examines the evidence that individual antibody species are capable of binding many structurally dissimilar haptens. Other chapters consider the conceptual framework generally accepted by immunologists, which states that antibodies are specific for the antigen used to elicit the immune response. This book discusses as well the mechanism underlying the biosynthesis of antibody binding sites, which is unprecedented in its adaptability. The final chapter deals with the genetic controls of specific immune responses. This book is a valuable resource for immunologists and research workers.
Download or read book Regulation of the Immune Response written by Pearay L. Ogra and published by S. Karger AG (Switzerland). This book was released on 1983 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Immune Gene Expression written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 1986-08-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progress in immune regulation has been far slower than in the molecular biology of the MHC Class II antigens. This is not surprising, since immune regulation is a very complex field at the crossroads of many disciplines.
Download or read book Ir Genes and Ia Antigenes written by Hugh O. MacDevitt and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lymphocyte Differentiation Recognition and Regulation written by David H. Katz and published by Academic Press. This book was released on 2014-06-28 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymphocyte Differentiation, Recognition, and Regulation provides an overview of the state of knowledge on cellular immunology. The focus is on animal work than on studies in man, although in certain areas human lymphocyte biology has been discussed in some detail. The book attempts to integrate information from diverse areas of cellular immunology, immunogenetics, and immunochemistry to form some cohesive concepts that can be perhaps utilized as a working foundation for students and investigators in various areas of immunology. The book begins with a general description of some of techniques and principles underlying the systems frequently employed in cellular immunology. This is followed by detailed analyses of lymphocyte differentiation, receptor function, and regulatory processes. The main points that emerge from such analyses are that the immune system is an infinitely complex and finely tuned network of cells, receptors, and molecules which interact with one another in a genetically controlled manner that is manifested ultimately in the process known as differentiation.
