Download or read book Ion Solvent Interaction of Water Soluble Drugs in Binary Solvent Systems written by Dr. Prakash Chandra Pal and published by Newredmars Education Pvt Ltd. This book was released on 2017-12-16 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the outset, the author of the book welcomes his supervisor Prof. Dr. Smrutiprava Das who have joined me as coauthors of this text, a credit which would have been given earlier to them as they were helping in a latent way in the evolution of the book for the past six years. Six years have elapsed on the intellectual journey of writing a PhD thesis e-book in title “IonSolvent Interaction of Water Soluble Drugs in Binary Solvent Systems” in subject of chemistry. As chemical kinetics is growing at a dazzling pace, this edition has been demanding in a different way. In this 1 st edition, the book has been thoroughly described, enlarged and updated with chemical kinetics of ion-solvent interaction of water soluble drugs in binary solvent systems. Above and over all, this time the book has been presented in multicolour edition with profuse colour illustrations so as to increase its clarity, understand ability and legibility, especially of the diagrams. It is hoped that the present book, enlarged multicolour form, would serve in a still better way, the authors are keenly desirous of. Gratitude is expressed to the students and teachers, both from India and abroad, who have sent in their valuable suggestions which have been given due consideration. We are sincerely thankful to our publisher, Newredmars Education. We are also deeply indebted to my guide Prof. Dr. Smrutiprava Das for her sustained support of this endeavour from its inception; her wisdom has made all the difference. In fact, we are grateful to department of chemistry, Ravenshaw University, Odisha, India for their patience, buoyancy and encouragement of this venture which was more arduous than anticipated. Healthy criticism and suggestions for further improvement of the book are solicited.
Download or read book Water Insoluble Drug Formulation written by Ron Liu and published by CRC Press. This book was released on 2018-03-12 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1969 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Awards Index written by and published by . This book was released on with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics written by Patrick Augustijns and published by Springer Science & Business Media. This book was released on 2007-08-06 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.
Download or read book Structures and Interactions of Ionic Liquids written by Suojiang Zhang and published by Springer. This book was released on 2013-12-20 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structures, Bonding and Hydrogen Bonds, by Kun Dong, Qian Wang, Xingmei Lu, Suojiang Zhang Aggregation in System of Ionic Liquids, by Jianji Wang, Huiyong Wang Dissolution of Biomass Using Ionic Liquids, by Hui Wang, Gabriela Gurau, Robin D. Rogers Effect of the Structures of Ionic Liquids on Their Physical-Chemical Properties, by Yu-Feng Hu, Xiao-Ming Peng Microstructure study of Ionic liquids by spectroscopy, by Haoran Li Structures and Thermodynamic Properties of Ionic Liquids, by Tiancheng Mu, Buxing Han
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2730 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modern Physical Organic Chemistry written by Eric V. Anslyn and published by University Science Books. This book was released on 2006 with total page 1148 pages. Available in PDF, EPUB and Kindle. Book excerpt: In additionto covering thoroughly the core areas of physical organic chemistry -structure and mechanism - this book will escortthe practitioner of organic chemistry into a field that has been thoroughlyupdated.
Download or read book Handbook of Solubility Data for Pharmaceuticals written by Abolghasem Jouyban and published by CRC Press. This book was released on 2009-08-26 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1967 with total page 1794 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Anticancer Agents written by Alex A. Adjei and published by Academic Press. This book was released on 2006 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field Presents drug discovery strategies Discusses regulatory issues surrounding drug development
Download or read book Deep Eutectic Solvents written by Yizhak Marcus and published by Springer. This book was released on 2018-12-05 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one of the first books fully dedicated to the rapidly advancing and expanding research area of deep eutectic solvents. Written by the internationally recognized expert in solution chemistry, it supplies full information regarding preparation of these new eco-friendly solvents, their properties and applications. The current and potential applications of deep eutectic solvents as organic reaction media, catalytic system, in biomass processing, nanotechnology and metal finishing industry, as well as for extraction and separation are extensively discussed.This highly informative and carefully presented book will appeal to practicing chemists (organic chemists, polymer chemists, biochemists) as well as chemical engineers and environmental scientists.
Download or read book The Practice of Medicinal Chemistry written by Camille Georges Wermuth and published by Elsevier. This book was released on 2015-07-01 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. - Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field - Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts - Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research - An image bank is available for instructors at www.textbooks.elsevier.com
Download or read book Basic Physical Pharmacy written by Joseph K. H. Ma and published by Jones & Bartlett Publishers. This book was released on 2013 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Physical Pharmacy provides a thorough yet accessible overview of the principles of physical pharmacy and their application in drug formulation and administration. This definitive guide to physical pharmacy covers all types of pharmaceuticals, from traditional forms and dosages to nanotechnology-based novel dosage design.
Download or read book HPLC for Pharmaceutical Scientists written by Yuri V. Kazakevich and published by John Wiley & Sons. This book was released on 2007-02-16 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.
Download or read book Journal of the Chemical Society written by and published by . This book was released on 1991 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ionic Liquid Based Aqueous Biphasic Systems written by Mara G. Freire and published by Springer. This book was released on 2016-10-05 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive information on the fundamentals and applications of ionic-liquid-based aqueous biphasic systems, which have predominantly (and successfully) been employed as alternative platforms for the extraction, separation and purification of diverse high-value products. The book consists of an initial introduction providing a brief overview, from fundamentals to applications, followed by nine chapters addressing the respective phase diagrams (interpretation and characterization) and remarkable examples of their applications. It also includes two final chapters focusing on recent developments in the search for more environmentally-benign and biocompatible ionic-liquid-based aqueous biphasic systems, and on the progress made to date concerning the recovery, recycling and reuse of the phase-forming components, the goal being the development of cost-effective and sustainable processes. The book offers an interesting and useful guide for a broad readership in the fields of green chemistry, biotechnology, chemical engineering, and biochemistry, among others. Mara G. Freire is a Coordinator Researcher at CICECO - Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Portugal.
