Download or read book Iodine Labeled Plasma Proteins written by Erwin Regoeczi and published by CRC Press. This book was released on 2019-07-17 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1984, this book offers comprehensive insight into iodine labelled proteins in the blood. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of hematology and other practitioners in their respective fields.
Download or read book Iodine Labeled Plasma Protein written by and published by CRC-Press. This book was released on 2000-12-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book IODINE LABELED PLASMA PROTEIN written by Erwin Regoeczi and published by CRC-Press. This book was released on 1987-06-30 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book IODINE LABELED PLASMA PROTEIN written by and published by CRC-Press. This book was released on 1987-06-30 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iodine Labeled Plasma Proteins written by Erwin Regoeczi and published by CRC Press. This book was released on 2019-07-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1984, this book offers comprehensive insight into iodine labelled proteins in the blood. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of hematology and other practitioners in their respective fields.
Download or read book Radioiodination Theory Practice and Biomedical Applications written by Mrinal K. Dewanjee and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.
Download or read book Mammalian Protein Metabolism written by H. N. Munro and published by Academic Press. This book was released on 2014-05-12 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Protein Metabolism, Volume I focuses on the processes, methodologies, biosynthesis, protein formation, and reactions involved in mammalian protein metabolism. The selection first elaborates on the origin and growth of concepts of protein metabolism, including the development of nitrogen balance as a technique for the study of protein metabolism; identification of proteins as a chemical class; discovery of nitrogen and its biological consequences; and recognition of the importance of nitrogenous compounds. The text then examines protein digestion and absorption in nonruminants and digestion and absorption of nitrogenous compounds in ruminants. Topics include passage of nitrogenous compounds from the rumen; utilization of nitrogenous compounds in the rumen; and endogenous nitrogen entering the reticulum and rumen. The book examines free amino acids and peptides in tissues, metabolic fate of amino acids, protein biosynthesis in mammalian tissues, and metabolism of plasma proteins. Discussions focus on the distribution of proteins between plasma and lymph, interpretation of plasma radioactivities, amino acid activating enzymes, ribosomes and protein synthesis, pathways of amino acid degradation, and synthesis of urea. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.
Download or read book Alcohol and Abnormal Protein Biosynthesis written by Marcus A. Rothschild and published by Elsevier. This book was released on 2014-05-17 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Abnormal Protein Biosynthesis: Biochemical and Clinical focuses on the methods for measuring protein metabolism and the effects of alcohol and altered protein intake as they affect the heart, liver, skeletal muscle, and the brain. Organized into six sections, this book begins with an overview on malnutrition and alcoholism, as well as available techniques for the study of protein synthesis. Subsequent section details the adaptation of protein synthesis and transport to alcohol and malnutrition. Section three discusses the skeletal and cardiac muscle protein metabolism. The last three sections describe the reaction of hepatic protein synthesis to malnutrition and alcohol; effects of alcohol on brain RNA metabolism; and alcohol associated cardiac and hepatic disease.
Download or read book Protein Pharmacokinetics and Metabolism written by Bobbe L. Ferraiolo and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents. In addition, the development and improvement of analytical techniques enabling the detection of minute quantities of proteins in biological matrices have aided this process. In assembling this volume, we sought to provide a state-of-the-art as sessment of the pharmacokinetics and metabolism of protein therapeutics through complete reviews of selected examples. A comprehensive review of all protein therapeutics was not attempted; the majority -of the therapeutic protein classes and crucial scientific issues have been addressed, however. Therefore, we are confident that this volume will provide a useful reference for scientists in this field. The volume has been divided into two general parts. The first part (Chapters 1-3) is composed of general reviews of topics of importance in pharmacokinetic/metabolism studies of proteins: goals and analytical meth odologies, effects of binding proteins, and effects of antibody induction, respectively. The second part (Chapters 4-8) consists of specific, detailed reviews by therapeutic protein class: growth factors and hormones, cyto kines, cardiovascular proteins, hematopoietic proteins, and antibodies, respectively. The editors are grateful to the contributors for the patience, personal sacrifice and perseverance required to complete this volume. BoDDE L. FERRAIOLO MARJORIE A. MOHLER CAROL A. GLOFF ix Contents Chapter 1 Goals and Analytical Methodologies for Protein Disposition Studies Bobbe L. Ferraiolo and Marjorie A. Mohler 1. Introduction ................................................. .
Download or read book Radioactive Tracers in Biology written by Martin D. Kamen and published by Elsevier. This book was released on 2013-10-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioactive Tracers in Biology: An Introduction to Trace Methodology, Second Edition focuses on the biochemical and physiological aspects of tracer research, including medical applications of tracer techniques, radioactivity, radiation hazards, and radioactive isotopes. The book first offers information on atomic nuclei, radioactivity, and the production of radioactive isotopes and radiation characteristics of tracer atoms. Discussions focus on nuclear reactions, neutron-induced and deuteron-induced transmutations, properties of atomic nuclei, and target techniques and radiochemistry. The manuscript also ponders on the procedures for radioactive assay and radiation hazards. The text examines the biochemical, medical, and physiological applications of tracer methodology. The manuscript also takes a look at radioactive hydrogen, short-lived and long-lived radioactive carbon, radioactive phosphorus and sulfur, and alkali metal and alkaline earth tracers. Topics include synthesis of organic intermediates for tracer carbon studies; biosynthesis of labeled carbon compounds; and general survey of alkali metal tracers. The publication is a dependable reference for readers interested in radioactive tracers.
Download or read book Protein Turnover written by G. E. W. Wolstenholme and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Download or read book Cancer Therapy with Radiolabeled Antibodies written by David M. Goldenberg and published by CRC Press. This book was released on 2018-01-18 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
Download or read book Guide to Protein Purification written by Murray P. Deutscher and published by Gulf Professional Publishing. This book was released on 1990 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guide to Protein Purification , designed to serve the needs of the student, experienced researcher and newcomer to the field, is a comprehensive manual that provides all the up-to-date procedures necessary for purifying, characterizing, and handling proteins and enzymes in one source. Key Features* Detailed procedures newly written for this volume* Extensive practical information* Rationale and strategies for protein and enzyme purification* Personal perspectives on enzyme purification by eminent researchersAmong the Topics Covered* General methods for handling proteins and enzymes * Extraction, subcellular fractionation, and solubilization procedures * Comprehensive purification techniques * Specialized purification procedures * Protein characterization * Immunological procedures * Computer analysis of protein structure.
Download or read book ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins written by Honghui Zhou and published by John Wiley & Sons. This book was released on 2015-10-26 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Download or read book Lipoprotein Kinetics and Modeling written by Mones Berman and published by Elsevier. This book was released on 2012-12-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoprotein Kinetics and Modeling contains some of the papers presented at a conference on the analysis and modeling of lipoprotein kinetic data held in Phoenix, Arizona. Contributions from both theorists and experimentalists who attended the conference focus on the developments in the use of mathematical modeling in analyzing the lipoprotein kinetics. The conference highlights the role of kinetic modeling in elucidating the dynamic processes involved in lipoprotein metabolism, the result of improper data analysis that can lead to erroneous physiological interpretations, and the emerging complexities in the lipoprotein system. Organized into six sections comprised of 37 chapters, this book begins with an overview of the theory and applications of kinetic analysis and modeling to lipoproteins. It then discusses the role of kinetic modeling in physiology, the kinetics of apoprotein B in humans, the use of kinetics in investigating the metabolism of very low and intermediate-density lipoproteins, and the models of plasma lipoprotein triglyceride kinetics. It explains the cholesterol kinetics and modeling, the kinetics of high density lipoprotein metabolism in humans, and various techniques for the analysis and modeling of lipoprotein kinetic data such as KABIS (kinetic analysis by interactive simulation) and CONSAM (conversational version of the SAAM modeling program). This book will be of interest to biologists, physiologists, clinical researchers and experts in computer technology and mathematics.
Download or read book The Hormones written by Gregory Pincus and published by Elsevier. This book was released on 2013-10-22 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hormones: Physiology, Chemistry, and Applications, Volume V provides information pertinent to the nature and function of hormones. This book provides a variety of topics, including pituitary hormones, thyroid, thyroid hormones, mammalian hormones, tumors and hormones, and some problems in endocrine medicine. Organized into seven chapters, this volume begins with an overview of the knowledge of the structure and other chemical aspects of the hormones. This text then examines the effects of growth hormone on nitrogen retention and body composition and discusses the metabolic basis for the nitrogen-retaining action of growth hormone. Other chapters consider the biochemical pathways of metabolism and their control in thyroid tissue. This book discusses as well tumor induction in endocrine organs following hormonal imbalance. The final chapter deals with the many and varied causes of the spontaneous endocrine disorders. This book is a valuable resource for organic chemists, biochemists, endocrinologists, morphologists, physiologists, students, and research workers.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt:
